Effects of sibutramine on gastric emptying, intestinal motility and rectal tone in dogs

Digestive Diseases and Sciences

Volumn 53, Issue 1, 2008, Pages 155-162

  Xu, Junying ^a   Chen, Jiande D Z ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b GI Research   (United States)

Author keywords

Appetite; Food intake; Gastric emptying; Gastrointestinal motility; Small bowel contraction

Indexed keywords

SIBUTRAMINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG MECHANISM; FEMALE; FOOD INTAKE; INTESTINE CONTRACTION; INTESTINE MOTILITY; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; RECTUM; STOMACH EMPTYING; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; APPETITE DEPRESSANTS; COMPLIANCE; CYCLOBUTANES; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GASTRIC EMPTYING; MYOELECTRIC COMPLEX, MIGRATING; OBESITY; RECTUM;

EID: 37249074388     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9837-x     Document Type: Article

References (38)

1. Kopelman PG (2000) Obesity as a medical problem. Nature 404:635-643
2. McLoughlin C (2005) Pharmacological treatments for obesity. Prof Nurse 20:50-51
3. Padwal R, Li SK, Lau DC (2003) Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes 27:1437-1446
4. Ryan DH, Kaiser P, Bray GA (1995) Sibutramine: a novel new agent for obesity treatment. Obes Res 4:553S-559S
5. Brown M, Bing C, King P, Pickavance L, Heal D, Wilding J (2001) Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wister rats. Independently of hypothalamic neuropptid Y. Br J Pharmacol 132:1898-1940
6. Barkeling B, Elfhag K, Rooth P, Rossner S (2003) Short-term effects of sibutramine (Reductil) on appetite and eating behaviour and the long-term therapeutic outcome. Int J Obes 27:693-700
7. Casado A, Rodriguez M, Portillo MP et al (2003) Sibutramine decreases body weight gain and increases energy expenditure in obese Zucker rats without change in NPY and orexins. Nutr Neurosci 6:103-111
8. Lean ME (2001) How does sibutramine work?. Int J Obes Suppl 25:S8-S11
9. Halford JC, Harrold JA, Lawton CL, Blundell JE (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets 6:201-213
10. Pal GK, Kannan N, Pal P (2004) Effects of injection of serotonin into nucleus caudatus on food and water intake and body weight in albino rats. Indian J Physiol Pharmacol 48:437-445
11. Ritter RC (2004) Gastrointestinal mechanisms of satiation for food. Physiol Behav 81:249-273
12. Grundy D, Schumann M (2004) Serotonin in the gut: pretty when it gets down to the nitty gritty. Neurogastroenterol Motil 16:507-509
13. Xu JY, Chen JDZ (2006) Peripheral mechanisms of sibutramine involving proximal gastric motility in dogs. Obes Res 14:1363-1370
14. Xu XH, Wang ZS, Hayes J, Chen JDZ (2002) Is there a one-to-one correlation between gastric emptying of liquids and gastric myoelectrical or motor activity in dogs?. Dig Dis Sci 47:365-372
15. Abolfathi Z, Conture J, Vallee F, LeBel M, Tanguay M, Masson E (2004) A pilot study to evaluate the pharmacokinetics of sibutramine in healthy subjects under fasting and fed conditions. J Pharm Pharmaceut Sci 7:345-349
16. Jackson HC, Bearham HC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ (1997) Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenalin reuptake inhibitor, sibutramine, in the rat. Br J Pharmacol 121:1613-1618
17. Chen JDZ, McCallum RW (1994) Electrogastrographic parameters and their clinical significance. In: Chen JDZ, McCallum RW (eds) The electrogastrography: principles and clinical applications. New York, Raven, pp 45-73
18. Xu XH, Wang ZS, Hayes J, Chen JDZ (2002) Is there a one-to-one correlation between gastric emptying of liquids and gastric myoelectrical or motor activity in dogs?. Dig Dis Sci 47:365-372
19. Lin X, Peters LJ, Hayes J, Chen JD (2000) Entrainment of segmental small intestinal slow waves with electrical stimulation in dogs. Dig Dis Sci 45:652-656
20. Liu S, Wang L, Chen JD (2005) Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs. Am J Physiol Gastrointest Liver Physiol 288:G1195-G1198
21. Whitehead WE, Delvaux M (1997) Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal. Dig Dis Sci 42:223-241
22. Ryan DH (2003) Use of sibutramine to treat obesity. Prim Care 30:405-426
23. Mitchell JE, Gosnell BA, Roerig JL et al (2003) Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm. Obes Res 11:599-602
24. Chapelot D, Marmonier C, Thomas T, Hanotin C (2000) Modalities of the food intake-reducing effect of sibutramine in humans. Physiol Behav 68:299-308
25. Xing JH, Chen JDZ (2004) Alteration of gastrointestinal motility in obesity. Obes Res 12:1723-1732
26. Cecil JE (2001) Oral, gastric and intestinal influences on the control of appetite and feeding in human. Appetite 36:235-236
27. Beglinger C, Degen L (2004) Fat in the intestine as a regulator of appetite-role of CCK. Physiol Behav 83:617-621
28. Strader AD, Woods SC (2005) Gastrointestinal hormones and food intake. Gastroenterology 128:175-191
29. Delgado-aros S, Camilleri M, Cremonini F, Ferber I, Stephens D, Burton DD (2004) Contributions of gastric volumes and gastric emptying to meal size and postmeal symptom in functional dyspepsia. Gastroenterology 127:1685-1694
30. Welch IM, Cunningham KM, Read NW (1988) Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology 94:401-404
31. Tso P, Chen Q, Fujimoto K, Fukagawa K, Sakata T (1995) Apolipoprotein A-IV: a circulating satiety signal produced by the small intestine. Obes Res 3:689S-695S
32. Meyer JH, Tabrizi Y, DiMaso N, Hlinka M, Raybould HE (1998) Length of intestinal contact on nutrient-driven satiety. Am J Physiol 275:R1308-R1319
33. Ehman GK, Albert DJ, Jamiesson JL (1971) Injections into the duodenum and the induction of satiety in the rat. Can J Psychol 25:147-166
34. Welch IM, Sepple CP, Read NW (1988) Comparisons of the effects on satiety and eating behavior of infusion of lipid into the different regions of the small intestine. Gut 29:306-311
35. Yox DP, Ritter RC (1988) Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol 255:R569-R574
36. Steens J, Van Der Schaar PJ, Penning C, Brussee J, Masclee AA (2002) Compliance, tone and sensitivity of the rectum in different subtypes of irritable bowel syndrome. Neurogastroenterol Motil 14:241-247
37. Karlbom U, Lundin E, Graf W, Pahlman L (2004) Anorectal physiology in relation to clinical subgroups of patients with severe constipation. Colorectal Dis 6:343-349
38. Fox M, Thumshirn M, Menne D, Stutz B, Fried M, Schwizer M (2004) The pathophysiology of faecal spotting in obese subjects during treatment with orlistat. Aliment Pharmacol Ther 19:311-321