Zinc protection against pneumolysin toxicity on rat cochlear hair cells

Audiology and Neurotology

Volumn 13, Issue 1, 2007, Pages 65-70

  Franco Vidal, Valérie ^a,b   Beurg, Maryline ^b   Darrouzet, Vincent ^a,b   Bébéar, Jean Pierre ^a,b   Skinner, Liam J ^b   Dulon, Didier ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b HÔPITAL PELLEGRIN   (France)

Author keywords

Hair cells; Meningitis; Pneumolysin; Toxicity; Zinc

Indexed keywords

CALCIUM; PNEUMOLYSIN; ZINC;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL CULTURE; CELL MEMBRANE; COCHLEA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; HAIR CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; WISTAR RAT;

ANIMALS; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HAIR CELLS, AUDITORY; HEARING LOSS; ORGAN CULTURE TECHNIQUES; PNEUMOCOCCAL INFECTIONS; RATS; RATS, WISTAR; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; TRACE ELEMENTS; ZINC;

EID: 37249064163     PISSN: 14203030     EISSN: 14219700     Source Type: Journal    
DOI: 10.1159/000108763     Document Type: Article

References (29)

1. Alouf JE: Cholesterol-binding cytolytic protein toxins. Int J Med Microbiol 2000;290:351-356.
2. Beurg M, Hafidi A, Skinner L, Cowan G, Hondarrague Y, Mitchell TJ, Dulon D: The mechanism of pneumolysin-induced cochlear hair cell death in the rat. J Physiol 2005;568:211-227.
3. Bodmer D, Brors D, Pak K, Bodmer M, Ryan AF: Gentamicin-induced hair cell death is not dependent on the apoptosis receptor Fas. Laryngoscope 2003;113:452-455.
4. 2 mediate brain cell apoptosis during meningitis. J Clin Invest 2002;109:19-27.
5. Comis SD, Osborne MP, Stephen J, Tarlow MJ, Hayward TL, Mitchell TJ, Andrew PW, Boulnois GJ: Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae. Acta Otolaryngol 1993;113:152-159.
6. Dodge PR, Davis H, Feigin RD, Holmes SJ, Kaplan SL, Jubelirer DP, Stechenberg BW, Hirsh SK: Prospective evaluation of hearing impairment as a sequela of acute bacterial meningitis. N Engl J Med 1984;311:869-874.
7. Fortnum HM: Hearing impairment after bacterial meningitis: a review. Arch Dis Child 1992;67:1128-1133.
8. Fraker PJ: Roles for cell death in zinc deficiency. J Nutr 2005;135:359-362.
9. Gilbert RJ, Jimenez JL, Chen S, Tickle IJ, Rossjohn J, Parker M, Andrew PW, Saibil HR: Two structural transitions in membrane pore formation by pneumolysin, the poreforming toxin of Streptococcus pneumoniae. Cell 1999;97:647-655.
10. Kesser BW, Hashisaki GT, Spindel JH, Ruth RA, Scheld WM: Time course of hearing loss in an animal model of pneumococcal meningitis. Otolaryngol Head Neck Surg 1999;120:628-637.
11. Kopke RD, Liu W, Gabaizadeh R, Jacono A, Feghali J, Spray D, Garcia P, Steinman H, Malgrange B, Ruben RJ, Rybak L, Van de Water TR: Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 1997;18:559-571.
12. Korchev YE, Bashford CL, Pasternak CA: Differential sensitivity of pneumolysin-induced channels to gating by divalent cations. J Membr Biol 1992;127:195-203.
13. Korchev YE, Bashford CL, Pederzolli C, Pasternak CA, Morgan PJ, Andrew PW, Mitchell TJ: A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers. Biochem J 1998;329:571-577.
14. Kumar S, Awasthi S, Jain A, Srivastava RC: Blood zinc levels in children hospitalized with severe pneumonia: a case control study. Indian Pediatr 2004;41:486-491.
15. Low W, Dazert S, Baird A, Ryan AF: Basic fibroblast growth factor (FGF-2) protects rat cochlear hair cells in organotypical culture from aminoglycoside injury. J Cell Physiol 1996;167:443-450.
16. Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, Khaled MA: Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 2004;79:430-436.
17. Milton AG, Zalewski PD, Ratnaike RN: Zinc protects against arsenic-induced apoptosis in a neuronal cell line, measured by DEVD-caspase activity. Biometals 2004;17:707-713.
18. Naganska E, Matyja E: Apoptotic neuronal changes enhanced by zinc chelator - TPEN in organotypic rat hippocampal cultures exposed to anoxia. Folia Neuropathol 2006;44:125-132.
19. Saunders FK, Mitchell TJ, Walker JA, Andrew PW, Boulnois GJ: Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity. Infect Immun 1989;57:2547-2552.
20. Skinner LJ, Beurg M, Mitchell TJ, Darrouzet V, Aran JM, Dulon D: Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the guinea pig cochlea. Acta Otolaryngol 2004;124:1000-1007.
21. Sobkowicz HM, Loftus JM, Slapnick SM: Tissue culture of the organ of Corti. Acta Otolaryngol Suppl 1993;502:3-36.
22. Spreer A, Kerstan H, Bottcher T, Gerber J, Siemer A, Zysk G, Mitchell TJ, Eiffert H, Nau R: Reduced release of pneumolysin by Streptococcus pneumonia e in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother 2003;47:2649-2654.
23. Strand TA, Briles DE, Gjessing HK, Maage A, Bhan MK, Sommerfelt H: Pneumococcal pulmonary infection, septicaemia and survival in young zinc-depleted mice. Br J Nutr 2001;86:301-306.
24. Strand TA, Hollingshead SK, Julshamn K, Briles DE, Blomberg B, Sommerfelt H: Effects of zinc deficiency and pneumococcal surface protein a immunization on zinc status and the risk of severe infection in mice. Infect Immun 2003;71:2009-2013.
25. Stringaris AK, Geisenhainer J, Bergmann F, Balshusemann C, Lee U, Zysk G, Mitchell TJ, Keller BU, Kuhnt U, Gerber J, Spreer A, Bahr M, Michel U, Nau R: Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis 2002;11:355-368.
26. Thorne PR, Carlisle L, Zajic G, Schacht J, Altschuler RA: Differences in the distribution of F-actin in outer hair cells along the organ of Corti. Hear Res 1987;30:253-265.
27. Tilley SJ, Orlova EV, Gilbert RJ, Andrew PW, Saibil HR: Structural basis of pore formation by the bacterial toxin pneumolysin. Cell 2005;121:247-256.
28. Truong-Tran AQ, Grosser D, Ruffin RE, Murgia C, Zalewski PD: Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation. Biochem Pharmacol 2003;66:1459-1468.
29. Winter AJ, Comis SD, Osborne MP, Tarlow MJ, Stephen J, Andrew PW, Hill J, Mitchell TJ: A role for pneumolysin but not neuraminidase in the hearing loss and cochlear damage induced by experimental pneumococcal meningitis in guinea pigs. Infect Immun 1997;65:4411-4418.