Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 3, 2008, Pages 443-451

  Fusi, Fabio ^a   Ferrara, Antonella ^a   Zalatnai, Attila ^b   Molnar, Joseph ^c   Sgaragli, Giampietro ^a   Saponara, Simona ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

ALIS 409; ALIS 421; Ca2+ influx; Rat aorta; Rat tail artery myocytes; Whole cell patch clamp

Indexed keywords

1,3 DIMETHYL 1,3 (4 FLUOROPHENYL) 1,3 [3 (4 BUTHYL)(1 PIPERAZINYL)PROPYL] 1,3 DISILOXAN; 1,3 DIMETHYL 1,3 4 FLUOROPHENYL 1,3 (MORFOLINOPROPYL) 1,3 DISILOXAN; ALIS 409; ALIS 421; CALCIUM CHANNEL L TYPE; NIFEDIPINE; PHENYLEPHRINE; POTASSIUM ION; RYANODINE; SILICON DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CALCIUM CURRENT; CALCIUM TRANSPORT; CANCER RESISTANCE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ELECTROPHYSIOLOGY; EXTRACELLULAR CALCIUM; IC 50; IN VITRO STUDY; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; AORTA, THORACIC; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENES, MDR; MALE; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOPLASMS; PATCH-CLAMP TECHNIQUES; PHENYLEPHRINE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SILOXANES;

EID: 37249059937     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0488-6     Document Type: Article

References (29)

1. Bean BP (1984) Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci USA 81:6388-6392
2. Catterall WA (1994) Molecular properties of a superfamily of plasma-membrane cation channels. Curr Opin Cell Biol 6:607-615
3. Clapham DE, Montell C, Schultz G, Julius D (2003) International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev 55:591-596
4. B receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension. Braz J Med Biol Res 35:1061-1068
5. Ding Z, Yang X, Pater A, Tang SC (2000) Resistance to apoptosis is correlated with the reduced caspase-3 activation and enhanced expression of antiapoptotic proteins in human cervical multidrug resistant cells. Biochem Biophys Res Commun 270:415-420
6. Eckert RE, Karsten AJ, Utz J, Ziegler M (2000) Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores. Urol Res 28:122-127
7. Fusi F, Marazova K, Pessina F, Gorelli B, Valoti M, Frosini M, Sgaragli GP (2000) On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings. Eur J Pharmacol 394:109-115
8. 2+ channel via superoxide anion generation. Br J Pharmacol 133:988-996
9. Fusi F, Saponara S, Valoti M, Dragoni S, D'Elia P, Sgaragli T, Alderighi D, Kawase M, Shah A, Motohashi N, Sgaragli G (2006) Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives. Curr Drug Targets 7:949-959
10. Gottesman MM, Fojo T, Bates SE (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2:48-58
11. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100
12. Hegyes P, Varga A, Molnar J, Mucsi I, Hever A, Szabo D, Kiesig S, Lage H, Gaal D, Nacsa J (2000) Substituted disiloxanes method for the production thereof and the use thereof for reversal of multidrug resistance (MDR). PCT/DE00/04110
13. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res 88:325-332
14. 2+ entry: toward a proliferation or a simplification? FASEB J 6:3085-3091
15. Karaki H, Ozaki H, Hori M, Mitsui-Saito M, Amano K-I, Harada K-I, Miyamoto S, Nakazawa H, Won K-J, Sato K (1997) Calcium movements, distribution, and function in smooth muscle. Pharmacol Rev 49:157-230
16. Kars MD, Iseri ÖD, Gündüz U, Ural AU, Arpaci F, Molnar J (2006) Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds. Anticancer Res 26:4559-4568
17. Kuriyama H, Kitamura K, Nabata H (1995) Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev 47:387-573
18. Longley DB, Johnston PG (2005) Molecular mechanisms of drug resistance. J Pathol 205:275-292
19. Low AM, Darby PJ, Kwan CY, Daniel EE (1993) Effects of thapsigargin and ryanodine on vascular contractility: cross-talk between sarcoplasmic reticulum and plasmalemma. Eur J Pharmacol 230:53-62
20. Molnar J, Mucsi I, Nacsa J, Hevér A, Gyémánt N, Ugocsai K, Hegyes P, Kiessig S, Gaal D, Lage H, Varga A (2004) New silicon compounds as resistance modifiers against multidrug-resistant cancer cells. Anticancer Res 24:865-871
21. Nobili S, Landini I, Giglioni B, Mini E (2006) Pharmacological strategies for overcoming multidrug resistance. Curr Drug Targets 7:861-879
22. Petkov GV, Fusi F, Saponara S, Gagov H, Sgaragli GP, Boev KK (2001) Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery. Acta Physiol Scand 173:257-265
23. Phillips AM, Bull A, Kelly LE (1992) Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron 8:631-642
24. Sakmann B, Neher E (eds) (1995) Single-channel recording. Plenum, New York
25. Sanders KM (2001) Mechanisms of calcium handling in smooth muscles. J Appl Physiol 91:1438-1449
26. Saponara S, Kawase M, Shah A, Motohashi N, Molnar J, Ugocsai K, Sgaragli G, Fusi F (2004) 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6- dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. Br J Pharmacol 141:415-422
27. Stansfeld C, Mathie A (1993) Recording membrane currents of peripheral neurones in short-term culture. In: Wallis DI (ed) Electrophysiology. A practical approach. IRL Press, Oxford, pp 3-28
28. i smooth muscle. Annu Rev Physiol 51:315-329
29. Zalatnai A, Molnár J (2006) Effect of Sila-409, a new organosilicon multidrug resistance modifier, on human pancreatic cancer xenografts. In Vivo 20:137-140