On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings

European Journal of Pharmacology

Volumn 394, Issue 1, 2000, Pages 109-115

  Fusi, Fabio ^a   Marazova, Katia ^a   Pessina, Federica ^a   Gorelli, Beatrice ^a   Valoti, Massimo ^a   Frosini, Maria ^a   Sgaragli, Giampietro ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

BHA (3 t butyl 4 hydroxyanisole); Ca2+ homeostasis; Hindered phenol

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2',2' DIHYDROXY 3,3 DI T BUTYL 5,5' DIMETHOXYDIPHENYL; 3,5 DIBUTYL 4 HYDROXYANISOLE; BARIUM; BUTYLATED HYDROXYANISOLE; CALCIUM; CROMAKALIM; NIFEDIPINE; NORDIHYDROGUAIARETIC ACID; PAPAVERINE; PHENYLEPHRINE; POTASSIUM CHANNEL; PROPOFOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM HOMEOSTASIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ANIMALS; AORTA, THORACIC; BARIUM; BUTYLATED HYDROXYANISOLE; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; PARASYMPATHOLYTICS; PHENOLS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; VASODILATION;

EID: 0034615887     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00152-7     Document Type: Article

References (23)

1. + efflux in rabbit and guinea-pig arterial muscle. J. Physiol. 355:1984;43-63.
2. 2+ removal in smooth muscle. Pfluegers Arch. 431:1996;473-482.
3. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
4. Fusi F., Gorelli B., Valoti M., Marazova K., Sgaragli G.P. Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle. Eur. J. Pharmacol. 346:1998;237-243.
5. Fusi F., Sgaragli G.P., Murphy M.P. Interaction of butylated hydroxyanisole with mitochondrial oxidative phosphorylation. Biochem. Pharmacol. 43:1992;1203-1208.
6. Fusi F., Valoti M., Frosini F., Sgaragli G.P. 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) induces endothelium-dependent relaxation of rat thoracic aorta. Eur. J. Pharmacol. 366:1999;181-187.
7. Fusi F., Valoti M., Petkov G., Boev K.K., Sgaragli G.P. Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus. Eur. J. Pharmacol. 360:1998;43-50.
8. Fusi F., Valoti M., Sgaragli G.P., Murphy M.P. The interaction of antioxidants and structurally related compounds with mitochondrial oxidative phosphorylation. Methods Find. Exp. Clin. Pharmacol. 13:1991;599-603.
9. Gorelli B., Pessina F., Fusi F., Valoti M., Marazova K., Sgaragli G.P. Calcium antagonist property of some hindered phenols on rat aorta rings. Pharmacol. Res. 31(Suppl.):1995;206.
10. Gurney A. Mechanisms of drug-induced vasodilation. J. Pharm. Pharmacol. 46:1994;242-251.
11. 2+ homeostasis in vascular smooth muscle. J. Vasc. Res. 32:1995;207-219.
12. Janzen E.G., Wilcox A.L., Manoharan V. Reactions of nitric oxide with phenolic antioxidants and phenoxyl radicals. J. Org. Chem. 58:1993;3597-3599.
13. Karaki H. Use of tension measurements to delineate the mode of action of vasodilators. J. Pharmacol. Methods. 18:1987;1-21.
14. Karaki H., Ozaki H., Hori M., Mitsui-Saito M., Amano K.-I., Harada K.-I., Miyamoto S., Nakazawa H., Won K.-J., Sato K. Calcium movements, distribution, and function in smooth muscle. Pharmacol. Rev. 49:1997;157-230.
15. 2+ currents independently of lipoxygenase inhibition. Mol. Pharmacol. 38:1990;530-542.
16. Lincoln T.M., Cornwell T.L. Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels. 28:1991;129-137.
17. Norman N.R., Toombs C.F., Khan S.A., Buchanan L.V., Cimini M.G., Gibson J.K., Meisheri K.D., Shebuski R.J. Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue. Pharmacology. 49:1994;86-95.
18. Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P., Boev K.K. Effects of t-butyl phenols on calcium current in smooth muscle cells. Pharmacol. Res. 39(suppl.):1999;54.
19. + efflux and spontaneous activity in guinea-pig portal vein. Br. J. Pharmacol. 91:1987;569-578.
20. Sgaragli G.P., Della Corte L., Puliti R., De Sarlo F., Francalanci R., Guarna A., Dolara P., Komarynsky M. Oxidation of 2-t-butyl-4-methoxyphenol (BHA) by horseradish and mammalian peroxidase systems. Biochem. Pharmacol. 29:1980;763-769.
21. Sgaragli G.P., Valoti M., Fusi F., Palmi M., Mantovani P., De Santi M.M., Lorenzini L., Tosi P. Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol. 248:1993;121-129.
22. Sgaragli G.P., Valoti M., Gorelli B., Fusi F., Palmi M., Mantovani P. Calcium antagonist and antiperoxidant properties of some hindered phenols. Br. J. Pharmacol. 110:1993;369-377.
23. Valoti M., Sipex H.J. Jr., Sgaragli G., Mason R.P. Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds. Arch. Biochem. Biophys. 269:1989;423-432.