Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication

Toxicology

Volumn 233, Issue 1-3 SPEC. ISS., 2007, Pages 40-46

  Kronman, Chanoch ^a   Cohen, Ofer ^a   Raveh, Lily ^a   Mazor, Ohad ^a   Ordentlich, Arie ^a   Shafferman, Avigdor ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Acetylcholinesterase; Bioscavenger; Immunogenicity; Polyethylene glycol; Soman

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; PEGYLATED RECOMBINANT HUMAN ACETYLCHOLINESTERASE; RECOMBINANT HUMAN ACETYLCHOLINESTERASE; SOMAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ANTIGENICITY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG EFFICACY; HUMAN; HUMAN CELL; INTOXICATION; LD 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

ACETYLCHOLINESTERASE; ANIMALS; ANTIBODIES; CELL LINE; CHOLINESTERASE INHIBITORS; CLONING, MOLECULAR; DRUG CARRIERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HALF-LIFE; HUMANS; LETHAL DOSE 50; MALE; MICE; MICE, INBRED ICR; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; SOMAN; SUBSTRATE SPECIFICITY;

ANIMALIA; BOVINAE; MACACA MULATTA; MUS;

EID: 33947655504     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.08.036     Document Type: Article

References (18)

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