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Volumn 70, Issue 1, 2008, Pages 102-110

Preoperative Chemoradiotherapy for Rectal Cancer: Randomized Trial Comparing Oral Uracil and Tegafur and Oral Leucovorin Vs. Intravenous 5-Fluorouracil and Leucovorin

Author keywords

5 fluorouracil; Preoperative chemoradiation; Randomized trial; Rectal cancer; UFT

Indexed keywords

CHEMOTHERAPY; PATHOLOGY; PATIENT MONITORING; RADIOTHERAPY; TOXICITY;

EID: 37049017365     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.05.068     Document Type: Article
Times cited : (35)

References (49)
  • 1
    • 84944371744 scopus 로고
    • Adjuvant therapy for patients with colon and rectal cancer
    • NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 264 (1990) 1444-1450
    • (1990) JAMA , vol.264 , pp. 1444-1450
    • NIH consensus conference1
  • 2
    • 0027986558 scopus 로고
    • The long-term effect of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel function
    • Kollmorgen C.F., Meagher A.P., Wolff B.G., et al. The long-term effect of adjuvant postoperative chemoradiotherapy for rectal carcinoma on bowel function. Ann Surg 220 (1994) 676-682
    • (1994) Ann Surg , vol.220 , pp. 676-682
    • Kollmorgen, C.F.1    Meagher, A.P.2    Wolff, B.G.3
  • 3
    • 1842377447 scopus 로고    scopus 로고
    • Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial
    • Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 336 (1997) 980-987
    • (1997) N Engl J Med , vol.336 , pp. 980-987
  • 4
    • 0035975394 scopus 로고    scopus 로고
    • Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    • Kapiteijn E., Marijnen C.A., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345 (2001) 638-646
    • (2001) N Engl J Med , vol.345 , pp. 638-646
    • Kapiteijn, E.1    Marijnen, C.A.2    Nagtegaal, I.D.3
  • 5
    • 0032521002 scopus 로고    scopus 로고
    • Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, and sphincter preservation
    • Valentini V., Coco C., Cellini N., et al. Preoperative chemoradiation for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys 40 (1998) 1067-1075
    • (1998) Int J Radiat Oncol Biol Phys , vol.40 , pp. 1067-1075
    • Valentini, V.1    Coco, C.2    Cellini, N.3
  • 6
    • 0033984573 scopus 로고    scopus 로고
    • Preoperative radiochemotherapy in rectal cancer: Long-term results of a phase II trial
    • Bosset J.F., Magnin V., Maingon P., et al. Preoperative radiochemotherapy in rectal cancer: Long-term results of a phase II trial. Int J Radiat Oncol Biol Phys 46 (2000) 323-327
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 323-327
    • Bosset, J.F.1    Magnin, V.2    Maingon, P.3
  • 7
    • 0043067010 scopus 로고    scopus 로고
    • The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer
    • Crane C.H., Skibber J.M., Birnbaum E.H., et al. The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 57 (2003) 84-89
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 84-89
    • Crane, C.H.1    Skibber, J.M.2    Birnbaum, E.H.3
  • 8
    • 0027221463 scopus 로고
    • Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma
    • Chan A., Wong A., Langevin J., et al. Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys 25 (1993) 791-799
    • (1993) Int J Radiat Oncol Biol Phys , vol.25 , pp. 791-799
    • Chan, A.1    Wong, A.2    Langevin, J.3
  • 9
    • 0037445116 scopus 로고    scopus 로고
    • Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 phase II trial
    • Gerard J.P., Chapet O., Nemoz C., et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: The Lyon R0-04 phase II trial. J Clin Oncol 21 (2003) 1119-1124
    • (2003) J Clin Oncol , vol.21 , pp. 1119-1124
    • Gerard, J.P.1    Chapet, O.2    Nemoz, C.3
  • 10
    • 0034212424 scopus 로고    scopus 로고
    • Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer
    • Janjan N.A., Crane C.N., Feig B.W., et al. Prospective trial of preoperative concomitant boost radiotherapy with continuous infusion 5-fluorouracil for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 47 (2000) 713-718
    • (2000) Int J Radiat Oncol Biol Phys , vol.47 , pp. 713-718
    • Janjan, N.A.1    Crane, C.N.2    Feig, B.W.3
  • 11
    • 0141675100 scopus 로고    scopus 로고
    • Response to preoperative chemoradiation in stage II and III rectal cancer
    • Brown C.L., Ternent C.A., Thorson A.G., et al. Response to preoperative chemoradiation in stage II and III rectal cancer. Dis Colon Rectum 46 (2003) 1189-1193
    • (2003) Dis Colon Rectum , vol.46 , pp. 1189-1193
    • Brown, C.L.1    Ternent, C.A.2    Thorson, A.G.3
  • 12
    • 0032850210 scopus 로고    scopus 로고
    • Phase II study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer
    • De la Torre A., Ramos S., Valcarcel F.J., et al. Phase II study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer. Int J Radiat Oncol Biol Phys 45 (1999) 629-634
    • (1999) Int J Radiat Oncol Biol Phys , vol.45 , pp. 629-634
    • De la Torre, A.1    Ramos, S.2    Valcarcel, F.J.3
  • 13
    • 0027156342 scopus 로고
    • Determination of the optimal dose of 5-fluorouracil when combined with low dose D,L-leucovorin and irradiation in rectal cancer: Results of three consecutive phase II studies. EORTC Radiotherapy Group
    • Bosset J.F., Pavy J.J., Hamers H.P., et al. Determination of the optimal dose of 5-fluorouracil when combined with low dose D,L-leucovorin and irradiation in rectal cancer: Results of three consecutive phase II studies. EORTC Radiotherapy Group. Eur J Cancer 29A (1993) 1406-1410
    • (1993) Eur J Cancer , vol.29 A , pp. 1406-1410
    • Bosset, J.F.1    Pavy, J.J.2    Hamers, H.P.3
  • 14
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 54 (1958) 457-481
    • (1958) J Am Stat Assoc , vol.54 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 15
    • 0033616908 scopus 로고    scopus 로고
    • Estimation of failure probabilities in the presence of competing risks: New representations of old estimators
    • Gooley T.A., Leisenring W., Crowley J., et al. Estimation of failure probabilities in the presence of competing risks: New representations of old estimators. Stat Med 18 (1999) 695-706
    • (1999) Stat Med , vol.18 , pp. 695-706
    • Gooley, T.A.1    Leisenring, W.2    Crowley, J.3
  • 16
    • 0020617786 scopus 로고
    • Patterns of recurrence of rectal cancer after potentially curative surgery
    • Rich T., Gunderson L.L., Lew R., et al. Patterns of recurrence of rectal cancer after potentially curative surgery. Cancer 52 (1983) 1317-1329
    • (1983) Cancer , vol.52 , pp. 1317-1329
    • Rich, T.1    Gunderson, L.L.2    Lew, R.3
  • 17
    • 0020554732 scopus 로고
    • Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: Implications in treatment planning with adjuvant radiation therapy
    • Mendenhall W.M., Million R.R., and Pfaff W.W. Patterns of recurrence in adenocarcinoma of the rectum and rectosigmoid treated with surgery alone: Implications in treatment planning with adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 9 (1983) 977-985
    • (1983) Int J Radiat Oncol Biol Phys , vol.9 , pp. 977-985
    • Mendenhall, W.M.1    Million, R.R.2    Pfaff, W.W.3
  • 18
    • 0021325541 scopus 로고
    • Patterns of pelvic recurrence following definitive resections of rectal cancer
    • Pilipshen S.J., Heilweil M., Quan S.H., et al. Patterns of pelvic recurrence following definitive resections of rectal cancer. Cancer 53 (1984) 1354-1362
    • (1984) Cancer , vol.53 , pp. 1354-1362
    • Pilipshen, S.J.1    Heilweil, M.2    Quan, S.H.3
  • 19
    • 0023089095 scopus 로고
    • Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery
    • Mendenhall W.M., Million R.R., Bland K.I., et al. Initially unresectable rectal adenocarcinoma treated with preoperative irradiation and surgery. Ann Surg 205 (1987) 41-44
    • (1987) Ann Surg , vol.205 , pp. 41-44
    • Mendenhall, W.M.1    Million, R.R.2    Bland, K.I.3
  • 20
    • 0022969524 scopus 로고
    • Preoperative radiation therapy for rectal cancer. An effective therapy in need of a clinical trial
    • Fortier G.A., Constable W.C., Meyers H., et al. Preoperative radiation therapy for rectal cancer. An effective therapy in need of a clinical trial. Arch Surg 121 (1986) 1380-1385
    • (1986) Arch Surg , vol.121 , pp. 1380-1385
    • Fortier, G.A.1    Constable, W.C.2    Meyers, H.3
  • 21
    • 0020513906 scopus 로고
    • Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas
    • Dosoretz D.E., Gunderson L.L., Hedberg S., et al. Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas. Cancer 52 (1983) 814-818
    • (1983) Cancer , vol.52 , pp. 814-818
    • Dosoretz, D.E.1    Gunderson, L.L.2    Hedberg, S.3
  • 22
    • 0025969534 scopus 로고
    • High dose preoperative irradiation for cancer of the rectum, 1976-1988
    • Mohiuddin M., and Marks G. High dose preoperative irradiation for cancer of the rectum, 1976-1988. Int J Radiat Oncol Biol Phys 20 (1991) 37-43
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 37-43
    • Mohiuddin, M.1    Marks, G.2
  • 23
    • 0019983773 scopus 로고
    • Effect of preoperative irradiation on resectability of colorectal carcinomas
    • Emami B., Pilepich M., Willett C., et al. Effect of preoperative irradiation on resectability of colorectal carcinomas. Int J Radiat Oncol Biol Phys 8 (1982) 1295-1299
    • (1982) Int J Radiat Oncol Biol Phys , vol.8 , pp. 1295-1299
    • Emami, B.1    Pilepich, M.2    Willett, C.3
  • 24
    • 0022876509 scopus 로고
    • Survival after postoperative combination treatment of rectal cancer
    • Douglass Jr. H.O., Moertel C.G., Mayer R.J., et al. Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315 (1986) 1294-1295
    • (1986) N Engl J Med , vol.315 , pp. 1294-1295
    • Douglass Jr., H.O.1    Moertel, C.G.2    Mayer, R.J.3
  • 25
    • 0026071185 scopus 로고
    • Effective surgical adjuvant therapy for high-risk rectal carcinoma
    • Krook J.E., Moertel C.G., Gunderson L.L., et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324 (1991) 709-715
    • (1991) N Engl J Med , vol.324 , pp. 709-715
    • Krook, J.E.1    Moertel, C.G.2    Gunderson, L.L.3
  • 26
    • 3042760073 scopus 로고    scopus 로고
    • Intergroup 0144-phase III trial of 5-FU based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer: Bolus 5-FU vs prolonged venous infusion (PVI) before and after XRT + PVI vs bolus 5-FU + leucovorin (LV) + levamisole (LEV) before and after XRT + bolus 5-FU + LV
    • Smalley S.R., Benedetti J., Williamson S., et al. Intergroup 0144-phase III trial of 5-FU based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer: Bolus 5-FU vs prolonged venous infusion (PVI) before and after XRT + PVI vs bolus 5-FU + leucovorin (LV) + levamisole (LEV) before and after XRT + bolus 5-FU + LV. J Clin Oncol 22 (2003) 251
    • (2003) J Clin Oncol , vol.22 , pp. 251
    • Smalley, S.R.1    Benedetti, J.2    Williamson, S.3
  • 27
    • 17344384995 scopus 로고    scopus 로고
    • Combined chemo- and radiotherapy vs. radiotherapy alone in the treatment of primary, nonresectable adenocarcinoma of the rectum
    • Frykholm G.J., Pahlman L., and Glimelius B. Combined chemo- and radiotherapy vs. radiotherapy alone in the treatment of primary, nonresectable adenocarcinoma of the rectum. Int J Radiat Oncol Biol Phys 50 (2001) 427-434
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 427-434
    • Frykholm, G.J.1    Pahlman, L.2    Glimelius, B.3
  • 28
    • 22144488561 scopus 로고    scopus 로고
    • Pre-operative (preop) radiotherapy (RT) + 5FU/folinic acid (FA) in T3-T4 rectal cancers: results of the FFCD 9203 randomized trial
    • Gerard J., Bonnetain F., Conroy T., et al. Pre-operative (preop) radiotherapy (RT) + 5FU/folinic acid (FA) in T3-T4 rectal cancers: results of the FFCD 9203 randomized trial. J Clin Oncol (Proc ASCO) 23 (2005) 247s
    • (2005) J Clin Oncol (Proc ASCO) , vol.23
    • Gerard, J.1    Bonnetain, F.2    Conroy, T.3
  • 29
    • 33748676449 scopus 로고    scopus 로고
    • Chemotherapy with preoperative radiotherapy in rectal cancer
    • Bosset J.F., Collette L., Calais G., et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355 (2006) 1114-1123
    • (2006) N Engl J Med , vol.355 , pp. 1114-1123
    • Bosset, J.F.1    Collette, L.2    Calais, G.3
  • 30
    • 0031017851 scopus 로고    scopus 로고
    • Patient preferences for oral versus intravenous palliative chemotherapy
    • Liu G., Franssen E., Fitch M.I., et al. Patient preferences for oral versus intravenous palliative chemotherapy. J Clin Oncol 15 (1997) 110-115
    • (1997) J Clin Oncol , vol.15 , pp. 110-115
    • Liu, G.1    Franssen, E.2    Fitch, M.I.3
  • 31
    • 0036159485 scopus 로고    scopus 로고
    • Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: A randomised crossover trial in advanced colorectal cancer
    • Borner M.M., Schoffski P., de Wit R., et al. Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: A randomised crossover trial in advanced colorectal cancer. Eur J Cancer 38 (2002) 349-358
    • (2002) Eur J Cancer , vol.38 , pp. 349-358
    • Borner, M.M.1    Schoffski, P.2    de Wit, R.3
  • 32
    • 0031727480 scopus 로고    scopus 로고
    • Uracil-ftorafur: An oral fluoropyrimidine active in colorectal cancer
    • Sulkes A., Benner S.E., and Canetta R.M. Uracil-ftorafur: An oral fluoropyrimidine active in colorectal cancer. J Clin Oncol 16 (1998) 3461-3475
    • (1998) J Clin Oncol , vol.16 , pp. 3461-3475
    • Sulkes, A.1    Benner, S.E.2    Canetta, R.M.3
  • 33
    • 16344374754 scopus 로고    scopus 로고
    • Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer
    • Diaz-Gonzalez J.A., Calvo F.A., Cortes J., et al. Preoperative chemoradiation with oral tegafur within a multidisciplinary therapeutic approach in patients with T3-4 rectal cancer. Int J Radiat Oncol Biol Phys 61 (2005) 1378-1384
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1378-1384
    • Diaz-Gonzalez, J.A.1    Calvo, F.A.2    Cortes, J.3
  • 34
    • 0036875812 scopus 로고    scopus 로고
    • The rational development of capecitabine from the laboratory to the clinic
    • Pentheroudakis G., and Twelves C. The rational development of capecitabine from the laboratory to the clinic. Anticancer Res 22 (2002) 3589-3596
    • (2002) Anticancer Res , vol.22 , pp. 3589-3596
    • Pentheroudakis, G.1    Twelves, C.2
  • 35
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • Van Cutsem E., Twelves C., Cassidy J., et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study. J Clin Oncol 19 (2001) 4097-4106
    • (2001) J Clin Oncol , vol.19 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 36
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff P.M., Ansari R., Batist G., et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study. J Clin Oncol 19 (2001) 2282-2292
    • (2001) J Clin Oncol , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 37
    • 33646443236 scopus 로고    scopus 로고
    • Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06
    • Lembersky B.C., Wieand H.S., Petrelli N.J., et al. Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06. J Clin Oncol 24 (2006) 2059-2064
    • (2006) J Clin Oncol , vol.24 , pp. 2059-2064
    • Lembersky, B.C.1    Wieand, H.S.2    Petrelli, N.J.3
  • 38
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz L.B., Cox J.V., Blanke C., et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343 (2000) 905-914
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 39
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18 (2000) 2938-2947
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 40
    • 34247180454 scopus 로고    scopus 로고
    • Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer
    • Rödel C., Liersch T., Hermann R.M., et al. Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer. J Clin Oncol 25 (2007) 110-117
    • (2007) J Clin Oncol , vol.25 , pp. 110-117
    • Rödel, C.1    Liersch, T.2    Hermann, R.M.3
  • 41
    • 33644846430 scopus 로고    scopus 로고
    • Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012
    • Mohiuddin M., Winter K., Mitchell E., et al. Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. J Clin Oncol 24 (2006) 650-655
    • (2006) J Clin Oncol , vol.24 , pp. 650-655
    • Mohiuddin, M.1    Winter, K.2    Mitchell, E.3
  • 42
    • 22744435494 scopus 로고    scopus 로고
    • Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer
    • Willett C.G., Chung D., Sahani D., et al. Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer. J Clin Oncol 22 Suppl (2006) 3589
    • (2006) J Clin Oncol , vol.22 , Issue.SUPPL , pp. 3589
    • Willett, C.G.1    Chung, D.2    Sahani, D.3
  • 43
    • 33745622869 scopus 로고    scopus 로고
    • Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation
    • Calvo F.A., Serrano F.J., Diaz-Gonzalez J.A., et al. Improved incidence of pT0 downstaged surgical specimens in locally advanced rectal cancer (LARC) treated with induction oxaliplatin plus 5-fluorouracil and preoperative chemoradiation. Ann Oncol 17 (2006) 1103-1110
    • (2006) Ann Oncol , vol.17 , pp. 1103-1110
    • Calvo, F.A.1    Serrano, F.J.2    Diaz-Gonzalez, J.A.3
  • 44
    • 6044226542 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for rectal cancer
    • Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
    • (2004) N Engl J Med , vol.351 , pp. 1731-1740
    • Sauer, R.1    Becker, H.2    Hohenberger, W.3
  • 45
    • 3242716904 scopus 로고    scopus 로고
    • Sphincter preservation following preoperative radiotherapy for rectal cancer: Report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy
    • Bujko K., Nowacki M.P., Nasierowska-Guttmejer A., et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: Report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72 (2004) 15-24
    • (2004) Radiother Oncol , vol.72 , pp. 15-24
    • Bujko, K.1    Nowacki, M.P.2    Nasierowska-Guttmejer, A.3
  • 46
    • 37049006293 scopus 로고    scopus 로고
    • Preoperative uracil/tegafur and concomitant radiotherapy in locally advanced rectal cancer: Updated results with 5-year follow-up
    • Fernandez-Martos C., Aparicio J., Bosch C., et al. Preoperative uracil/tegafur and concomitant radiotherapy in locally advanced rectal cancer: Updated results with 5-year follow-up. J Clin Oncol 24 Suppl (2006) 3573
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL , pp. 3573
    • Fernandez-Martos, C.1    Aparicio, J.2    Bosch, C.3
  • 47
    • 33644696400 scopus 로고    scopus 로고
    • A phase II study of capecitabine and concomitant boost radiotherapy (XRT) in patients (pts) with locally advanced rectal cancer
    • Lin E.H., Skibber J., Delclos M., et al. A phase II study of capecitabine and concomitant boost radiotherapy (XRT) in patients (pts) with locally advanced rectal cancer. J Clin Oncol 23 (2005) 3593
    • (2005) J Clin Oncol , vol.23 , pp. 3593
    • Lin, E.H.1    Skibber, J.2    Delclos, M.3
  • 48
    • 24944465683 scopus 로고    scopus 로고
    • Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer
    • Kim J.C., Kim T.W., Kim J.H., et al. Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 63 (2005) 346-353
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 346-353
    • Kim, J.C.1    Kim, T.W.2    Kim, J.H.3
  • 49
    • 31544461568 scopus 로고    scopus 로고
    • Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: A multicentric phase II study
    • De Paoli A., Chiara S., Luppi G., et al. Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: A multicentric phase II study. Ann Oncol 17 (2006) 246-251
    • (2006) Ann Oncol , vol.17 , pp. 246-251
    • De Paoli, A.1    Chiara, S.2    Luppi, G.3


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