The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer

International Journal of Radiation Oncology Biology Physics

Volumn 57, Issue 1, 2003, Pages 84-89

  Crane, Christopher H ^a   Skibber, John M ^a   Birnbaum, Elisa H ^b   Feig, Barry W ^a   Singh, Anurag K ^b   Delclos, Marc E ^a   Lin, Edward H ^a   Fleshman, James W ^b   Thames, Howard D ^a   Kodner, Ira J ^b   Lockett, Mary Ann ^b   Picus, Joel ^b   Phan, Thinh ^a   Chandra, Anshu ^a   Janjan, Nora A ^a   Read, Thomas E ^b   Myerson, Robert J ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotherapy; Fluorouracil; Radiation therapy; Rectal neoplasms

Indexed keywords

BIOCHEMISTRY; DISEASE CONTROL; PATIENT MONITORING; RADIOTHERAPY; TUMORS;

RECTAL CANCERS;

ONCOLOGY;

FLUOROURACIL;

ADULT; AGED; ANUS SPHINCTER; ARTICLE; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTINUOUS INFUSION; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RECTUM CANCER; RELAPSE; STATISTICAL SIGNIFICANCE; SURVIVAL RATE;

EID: 0043067010     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)00532-7     Document Type: Article

References (19)

1. Kapiteijn E., Marijnen C.A., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 345:2001;638-646.
2. Preoperative short-term radiation therapy in operable rectal carcinoma. A prospective randomized trial. Cancer. 66:1990;49-55.
3. Improved survival with preoperative radiation therapy in resectable rectal cancer. Swedish Rectal Cancer Trial [see comments] [published erratum appears in N Engl J Med 1997;336:1539]. N Engl J Med 1997;336:980-987.
4. Martling A., Holm T., Johansson H., Rutqvist L.E., Cedermark B. The Stockholm II trial on preoperative radiation therapy in rectal carcinoma Long-term follow-up of a population-based study . Cancer. 92:2001;896-902.
5. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med. 312:1985;1465-1472.
6. Krook J.E., Moertel C.G., Gunderson L.L., et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. [see comments] N Engl J Med. 324:1991;709-715.
7. Grann A., Feng C., Wong D., et al. Preoperative combined modality therapy for clinically resectable uT3 rectal adenocarcinoma. Int J Radiat Oncol Biol Phys. 49:2001;987-995.
8. Valentini V., Coco C., Cellini N., et al. Preoperative chemoradiation for extraperitoneal T3 rectal cancer Acute toxicity, tumor response, and sphincter preservation . Int J Radiat Oncol Biol Phys. 40:1998;1067-1075.
9. Mohiuddin M., Regine W.F., John W.J., et al. Preoperative chemoradiation in fixed distal rectal cancer Dose time factors for pathological complete response . Int J Radiat Oncol Biol Phys. 46:2000;883-888.
10. Chan A., Wong A., Langevin J., Khoo R. Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys. 25:1993;791-799.
11. Vauthey J.N., Marsh R.W., Zlotecki R.A., et al. Recent advances in the treatment and outcome of locally advanced rectal cancer. Ann Surg. 229:1999;745-752. discussion 752-754.
12. Crane C.H., Skibber J.M., Feig B.W., et al. Response to preoperative chemoradiation increases the use of sphincter preserving surgery in locally advanced low rectal cancer. Cancer. 97:2003;514-517.
13. Bosset J.F., Magnin V., Maingon P., et al. Preoperative radiochemotherapy in rectal cancer Long-term results of a phase II trial . Int J Radiat Oncol Biol Phys. 46:2000;323-327.
14. Myerson R.J., Singh A., Birnbaum E.H., et al. Pretreatment clinical findings predict outcome for patients receiving preoperative radiation for rectal cancer. Int J Radiat Oncol Biol Phys. 50:2001;665-674.
15. Marsh R.D., Chu N.M., Vauthey J.N., et al. Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy. Cancer. 78:1996;217-225.
16. Myerson R.J., Michalski J.M., King M.L., et al. Adjuvant radiation therapy for rectal cancer Predictors of outcome . [see comments] [Comment in: Int J Radiat Oncol Biol Phys 1995;32:547-548.] Int J Radiat Oncol Biol Phys. 32:1995;41-50.
17. Myerson R.J., Zusag T.W., Kodner I.J., et al. Adjunctive radiation therapy for rectal carcinoma. Am J Clin Oncol. 15:1992;102-111.
18. Read T.E., Myerson R.J., Fleshman J.W., et al. Surgeon specialty is associated with outcome in rectal cancer treatment. Dis Colon Rectum. 45:2002;904-914.
19. Bujko K., Nowacki M., Bebenek M., et al. Randomized trial comparing high dose per fraction preoperative radiotherapy with immediate surgery vs. conventional preoperative radiochemotherapy with delayed surgery for patients with low rectal cancer. Radiother Oncol. 64:2002;S1-S47.