Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid

Annals of the New York Academy of Sciences

Volumn 1122, Issue , 2007, Pages 83-94

  Joksovic, Pavle M ^a   Covey, Douglas F ^b   Todorovic, Slobodan M ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Calcium; Neurosteroids; Nucleus reticularis; T type; Thalamus

Indexed keywords

CALCIUM CHANNEL T TYPE; STEROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; EPILEPSY; FEMALE; HYPOXEMIA; INFORMATION PROCESSING; ISCHEMIA; MALE; MEMBRANE POTENTIAL; NERVE POTENTIAL; NONHUMAN; RAT; SENSORY STIMULATION; THALAMUS NUCLEUS; VOLTAGE CLAMP;

RATTUS;

EID: 37049014870     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1403.006     Document Type: Conference Paper

References (27)

1. A receptor. J. Neurosci. 25: 11605-11613.
2. BEAN, B.P. 1989. Classes of calcium channels in vertebrate cells. Annu. Rev. Physiol. 51: 367-384.
3. BUDDE, T., T. MUNSCH & H.C. PAPE. 1998. Distribution of L-type calcium channels in rat thalamic neurons. Eur. J. Neurosci. 10: 586-597.
4. 2+ channel in vertebrate sensory neurons. Nature (Lond) 310: 501-502.
5. DEL TORO, R. et al. 2003. Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 278: 22316-22324.
6. DOGRUL, A. et al. 2003. Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain 105: 159-168.
7. FFRENCH-MULLEN, J.M., P. DANKS & K.T. SPENCE. 1994. Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein coupled mechanism. J. Neurosci. 14: 1963-1977.
8. A receptors. J. Med. Chem. 39: 4218-4232.
9. HESS, P. 1990. Calcium channels in vertebrate cells. Annu. Rev. Neurosci. 13: 337-356.
10. HUGUENARD, J.R. 1996. Low-threshold calcium currents in central nervous system neurons. Annu. Rev. Physiol. 58: 329-358.
11. 2+ currents of reticular thalamic neurons and their modulation by enflurane. J. Physiol. 566: 125-142.
12. 2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br. J. Pharmacol. 144: 59-70.
13. A receptor function. Trends Pharmacol. Sci. 16: 295-303.
14. LARESCHE, N. et al. 1998. On the action of the anti-absence drug ethosuximide in the rat and cat thalamus. J. Neurosci. 18: 4842-4853.
15. LLINAS, R.R. et al. 1999. Thalamocortical dysrhythmia: a neurological and neuropsychiatric syndrome characterized by magnetoencephalography. Proc. Natl. Acad. Sci. USA 96: 15222-15227.
16. MCCORMICK, D.A. & T. BAL. 1997. Sleep and arousal: thalamocortical mechanisms. Annu. Rev. Neurosci. 20: 185-215.
17. 2+ current in hippocampal and dorsal root ganglion neurons of the rat. Mol. Pharmacol. 54: 559-568.
18. NIKONENKO, I. et al. 2005. Inhibition of T-type calcium channels protects neurons from delayed ischemia-induced damage. Mol. Pharmacol. 68: 84-89.
19. A channels are responsible for the potent peripheral analgesic effects of 5α-reduced neuroactive steroids. Pain 114: 429-443.
20. PAXINOS, G. & C. WATSON. 1994. The Rat Brain in Stereotaxic Coordinates. Academic Press. Australia.
21. TODOROVIC, S.M. et al. 2001. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron 31: 75-85.
22. 2+ current in adult rat sensory neurons: effects of anticonvulsants and anesthetic agents. J. Neurophysiol. 79: 240-252.
23. 2+ current in adult rat sensory neurons by a steroid that lacks γ-aminobutyric acid modulatory activity. Mol. Pharmacol. 54: 918-927.
24. 2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol. Pharmacol. 66: 1223-1235.
25. STERIADE, M. 2005. Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends Neurosci. 28: 317-324.
26. A receptor antagonists. J. Neurosci. 22: 3366-3375.
27. ZORUMSKI, C.F. et al. 2000. Potential clinical uses of neuroactive steroids. Curr. Opin. Investig. Drugs 1: 360-369.