Modulation of macrophage iron transport by Nramp1 (Slc11a1)

Immunobiology

Volumn 212, Issue 9-10, 2008, Pages 751-757

  Fritsche, Gernot ^a   Nairz, Manfred ^a   Theurl, Igor ^a   Mair, Sabine ^a   Bellmann Weiler, Rosa ^a   Barton, Howard C ^b   Weiss, Günter ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Dmt1; Ferroportin; iNOS; Iron; Nitric oxide; Nramp1; Transferrin

Indexed keywords

CD71 ANTIGEN; DIVALENT CATION; FERROPORTIN 1; INDUCIBLE NITRIC OXIDE SYNTHASE; IRON; IRON REGULATORY FACTOR; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; NITRIC OXIDE; PROTEIN SLC11A1; PROTON; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENETIC TRANSFECTION; HOMEOSTASIS; HOST RESISTANCE; IMMUNOMODULATION; IRON KINETICS; IRON TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 37049004190     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2007.09.014     Document Type: Article

References (27)

1. Atkinson P.G., and Barton C.H. High level expression of Nramp1G169 in RAW264.7 cell transfectants: analysis of intracellular iron transport. Immunology 96 (1999) 656-662
2. Biggs T.E., Baker S.T., Botham M.S., Dhital A., Barton C.H., and Perry V.H. Nramp1 modulates iron homoeostasis in vivo and in vitro: evidence for a role in cellular iron release involving de-acidification of intracellular vesicles. Eur. J. Immunol. 31 (2001) 2060-2070
3. Blackwell J.M., Goswami T., Evans C.A., Sibthorpe D., Papo N., White J.K., Searle S., Miller E.N., Peacock C.S., Mohammed H., and Ibrahim M. SLC11A1 (formerly NRAMP1) and disease resistance. Cell Microbiol. 3 (2001) 773-784
4. Chlosta S., Fishman D.S., Harrington L., Johnson E.E., Knutson M.D., Wessling-Resnick M., and Cherayil B.J. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect. Immun. 74 (2006) 3065-3067
5. Dlaska M., and Weiss G. Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. J. Immunol. 162 (1999) 6171-6177
6. Fritsche G., Dlaska M., Barton H., Theurl I., Garimorth K., and Weiss G. Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression. J. Immunol. 171 (2003) 1994-1998
7. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
8. Gutteridge J.M., Rowley D.A., and Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem. J. 199 (1981) 263-265
9. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell 117 (2004) 285-297
10. Jabado N., Jankowski A., Dougaparsad S., Picard V., Grinstein S., and Gros P. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J. Exp. Med. 192 (2000) 1237-1248
11. Kuhn D.E., Baker B.D., Lafuse W.P., and Zwilling B.S. Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169. J. Leukoc. Biol. 66 (1999) 113-119
12. Kuhn D.E., Lafuse W.P., and Zwilling B.S. Iron transport into mycobacterium avium-containing phagosomes from an Nramp1(Gly169)-transfected RAW264.7 macrophage cell line. J. Leukoc. Biol. 69 (2001) 43-49
13. Lee D.W., and Andersen J.K. Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr. Mol. Med. 6 (2006) 883-893
14. Leibold E.A., and Munro H.N. Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc. Natl. Acad. Sci. USA 85 (1988) 2171-2175
15. Ludwiczek S., Aigner E., Theurl I., and Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101 (2003) 4148-4154
16. Ludwiczek S., Theurl I., Bahram S., Schumann K., and Weiss G. Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J. Cell. Physiol. 204 (2005) 489-499
17. Mulero V., Searle S., Blackwell J.M., and Brock J.H. Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake. Biochem. J. 363 (2002) 89-94
18. Nairz M., and Weiss G. Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis. Wien Klin. Wochenschr. 118 (2006) 442-462
19. Nairz M., Theurl I., Ludwiczek S., Theurl M., Mair S.M., Fritsche G., and Weiss G. The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium. Cell. Microbiol. 9 (2007) 2126-2140
20. Oexle H., Kaser A., Most J., Bellmann-Weiler R., Werner E.R., Werner-Felmayer G., and Weiss G. Pathways for the regulation of interferon-gamma-inducible genes by iron in human monocytic cells. J. Leukoc. Biol. 74 (2003) 287-294
21. Schaible U.E., and Kaufmann S.H. Iron and microbial infection. Nat. Rev. Microbiol. 2 (2004) 946-953
22. Theurl I., Fritsche G., Ludwiczek S., Garimorth K., Bellmann-Weiler R., and Weiss G. The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 18 (2005) 359-367
23. Vidal S., Tremblay M.L., Govoni G., Gauthier S., Sebastiani G., Malo D., Skamene E., Olivier M., Jothy S., and Gros P. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182 (1995) 655-666
24. Vidal S.M., Malo D., Vogan K., Skamene E., and Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73 (1993) 469-485
25. Weinberg E.D. Iron loading and disease surveillance. Emerg. Infect. Dis. 5 (1999) 346-352
26. Weiss G., Goossen B., Doppler W., Fuchs D., Pantopoulos K., Werner-Felmayer G., Wachter H., and Hentze M.W. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J. 12 (1993) 3651-3657
27. Weiss G., Werner-Felmayer G., Werner E.R., Grunewald K., Wachter H., and Hentze M.W. Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J. Exp. Med. 180 (1994) 969-976