Biochemical evaluation of glycoprotein components, lysosomal enzymes and marker enzymes upon Kalpaamruthaa administration in experimental mammary carcinoma rats

Journal of Health Science

Volumn 53, Issue 6, 2007, Pages 644-654

  Ramprasath, Vanu Ramkumar ^a   Akila, Gopalakrishnan ^a   Shanthi, Palanivelu ^a   Sachdanandam, Panchanatham ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Glycoprotein; Lysosomal enzyme; Mammary carcinoma

Indexed keywords

5' NUCLEOTIDASE; ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BETA GALACTOSIDASE; BETA GLUCURONIDASE; CATHEPSIN D; GAMMA GLUTAMYLTRANSFERASE; GLYCOPROTEIN; HEXOSAMINE; HEXOSE; KALPAAMRUTHAA EXTRACT; LACTATE DEHYDROGENASE; LYSOSOME ENZYME; N ACETYL BETA GLUCOSAMINIDASE; PLANT EXTRACT; SIALIC ACID; TUMOR MARKER; UNCLASSIFIED DRUG;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AYURVEDA; BREAST CARCINOMA; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; KIDNEY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER; NONHUMAN; RAT; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

EID: 36949018958     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.53.644     Document Type: Article

References (63)

1. Selvam, S. and Nagini, S. (1995) Administration of the plasticizer di(2-ethyl hexyl) phthalate alters glycoconjugate profile. Indian J. Physiol. Pharmacol., 39, 252-254.
2. Brockhausen, I. (1999) Pathways of O-glycan biosynthesis in cancer cells. Biochim. Biophys. Acta, 1473, 67-95.
3. Dennis, J. W., Kosh, K., Bryce, D. M. and Breitman, M. L. (1989) Oncogenes conferring metastatic potential induce increased branching of asn-linked oligosaccharides in rat 2 fibroblasts. Oncogene, 4, 853-860.
4. Kim, Y. J. and Varki, A. (1997) Perspectives on the significance of altered glycosylation of glycoproteins in cancer, Glycoconj. J., 14, 569-576.
5. Ciatto, S., Cataliotti, L. and Cardona, G. (1992) Risk of infiltrating breast cancer subsequent to lobular carcinoma in situ. Tumori, 78, 244-246.
6. Garcia, M., Derocq, D., Pujol, P. and Rochefort H. (1990) Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency, Oncogene, 5, 1809-1814.
7. Seth, R. K., Kharb, S. and Kharb, D. P. (2003) Serum biochemical markers in carcinoma breast. Indian J. Med. Sci., 57, 350-354.
8. Burke, R. E., Harris, S. C. and McGuire, W. L. (1978) Lactate dehydrogenase in estrogen-responsive human breast cancer cells. Cancer Res., 38, 2773-2776.
9. Horwitz, K. B. and Freidenberg, G. R. (1985) Growth inhibition and increase of insulin receptors in antiestrogen-resistant T47DCO human breast cancer cells by progestins: implications for endocrine therapies. Cancer Res., 45, 167-173.
10. Dao, T. L., IP, C. and Pater, J. (1980) Serum sialyl transferase and 5′-nucleotidase as reliable biomarkers in women with breast cancer. J. Natl. Cancer Inst., 65, 529-534.
11. Veena, K., Shanthi, P. and Sachdanandam, P. (2006) Anticancer effect of Kalpaamruthaa on mammary carcinoma in rats with reference to glycoprotein components, lysosomal and marker enzymes. Biol. Pharm. Bull., 29, 565-569.
12. Kirthikar, K. R. and Basu, B. D. (1933) Indian Medicinal Plants (2nd edn) (Basu, L. M., Ed.), M/s Bishen Sigh, Mahendra Palsingh Allahabad, vol.1, pp.667-670.
13. Vijayalakshmi, T., Muthulakshmi, V. and Sachdanandam, P. (1996) Effect of milk extract of Semecarpus anacardium nut on adjuvant arthritis. A dose dependent study in Wistar albino rats. Gen. Pharmacol., 27, 1223-1226.
14. Sujatha, V. and Sachdanandam, P. (2000) Protective effect of nut milk Semecarpus anacardium Linn. Extract against mammary carcinoma. National Seminar on Frontiers of Research and Development in Medicinal Plant sciences, Lucknow, Journal of Medicinal Aromatic Plant Sciences, 22, 1-10.
15. Arathi, G. and Sachdanandam, P. (2003) Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. J. Pharm. Pharmacol., 55, 1283-1290.
16. Vijayalakshmi, T., Muthulakshmi, V. and Sachdanandam, P. (1997) Effect of milk extract of Semecarpus anacardium nuts on glycohydrolases and lysosomal stability in adjuvant arthritis in rats. J. Ethnopharmacol., 58, 1-8.
17. Ramprasath, V. R., Shanthi, P. and Sachdanandam, P. (2005) Semecarpus anacardium Linn. nut milk extract, an indigenous drug preparation, modulates reactive oxygen/nitrogen species levels and antioxidative system in adjuvant arthritic rats. Mol. Cell. Biochem., 276, 97-104.
18. Premalatha, B., Muthulakshmi, V., Vijayalakshmi, T. and Sachdanandam, P. (1997) Productive role of Serankottai nei, a Siddha preparation, on cell membranes, aflatoxin B1 induced hepatocellular carcinoma bearing rats. Indian Drugs, 34, 385-389.
19. Khan, M. T., Lampronti, I., Martello, D., Bianchi, N., Jabbar, S., Choudhuri, M. S., Datta, B. K. and Gambari, R. (2002) Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines. Int. J. Oncol., 21, 187-192.
20. Zhang, T., Chen, X., Qu, L., Wu, J., Cui, R. and Zhao, Y. (2004) Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorg. Med. Chem., 12, 6097-6105.
21. Frei, B. (1994) Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am. J. Med., 97, 5S-13S.
22. Wang, W., VanAlstyne, P. C., Irons, K. A., Chen, S., Stewart, J. W. and Birt, D. F. (2004) Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines, Nutr. Cancer, 48, 106-114.
23. Neibes, P. (1972) Determination of enzymes and degradation products of glycosaminoglycan metabolism in healthy and various subjects. Clin. Chim. Acta, 42, 399-408.
24. Warren, L. (1959) The thiobarbituric acid assay of sialic acids. J. Biol. Chem., 234, 1971-1975.
25. Wagner, W. D. (1979) A more sensitive assay discriminating galactosamine and glucosamine in mixtures. Anal. Biochem., 94, 394-396.
26. King, J. (1965) The hydrolases-acid and alkaline phosphatases. In Practical Clinical Enzymology (King, J. C., Ed.), Van D Nostrand Co. Ltd., London, pp.199-208.
27. Sapolsky, A. L., Altman, R. D. and Howell, D. S. (1973) Cathepsin D activity in normal and osteoarthritic human cartilage. Fed. Proc., 32, 1489-1493.
28. Kawai, Y. and Anno, K. (1971) Mucopolysaccharide - degrading enzymes from the liver of squid Ommastrephes solani pacificus. I. Hyaluronidase. Biochim. Biophys. Acta, 242, 428-436.
29. Marhur, N. (1976) Rapid colorimetric assay of β-D-glucosaminidase and N-acetyl-β-D-glucosaminidase in human urine. Clin. Chim. Acta, 73, 453-461.
30. King, J. (1965) The Transferases-alanine and aspartate transaminases. In Practical Clinical Enzymology (King, J. C., Ed.), Van D Nostrand Co. Ltd., London, pp.121-138.
31. King, J. (1965) The dehydrogenase of oxidoreductase-lactate dehydrogenase. In Practical Clinical Enzymolozy (King, J. C., Ed.), Van D Nostrand Co. Ltd., London, pp.83-93.
32. Rosalki, S. B. and Rau, D. (1972) Serum gamma-glutamyl transpeptidase activity in alcoholism. Clin. Chim. Acta, 39, 41-47.
33. +)-ATPase of rat liver. Biochem. Biophys. Acta, 282, 447-452.
34. Fiske, C. H. and Subbarow, Y. (1925) The colorimetric determination of phosphorus. J. Biol. Chem., 66, 375-400.
35. Lowry, O. H., Rosenbrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
36. Nangia-Makker, P., Makker, P., Conklin, J., Hogan, V. and Raz, A. (2002) Carbohydrate-binding proteins in cancer and their ligands as therapeutic agents. Trends Mol. Med., 8, 187-192.
37. Aranganathan, S., Senthil, K. and Nalini, N. (2005) A case control study of glycoprotein status in ovarian carcinoma. Clin. Biochem., 38, 535-539.
38. Patel, P. S., Adhvarya, S. G. and Balar, D. B. (1990) Individual and combined usefulness of lipid associated sialic mucoid proteins and hexoses as tumour markers in breast carcinoma. Cancer Lett., 51, 203-208.
39. Manju, V., Balasubramanian, V. and Nalini, N. (2002) Oxidative stress and tumour markers in cervical cancer patients. J. Biochem. Mol. Biol. Biophys., 6, 387-390.
40. Elangovan, V., Nalini, R., Balasubramanian, S., Sekar, N. and Govindasamy, S. (1994) Studies on the antiproliferative effect of some naturally occurring bioflavanoidal compounds against human carcinoma of larynx and sarcoma- 180 cell lines. Indian J. Pharmacol., 26, 266-269.
41. Limtrakul, P., Khantamat, O. and Pintha, K. (2005) Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J. Chemother., 17, 86-95.
42. Beem, E. P., Hillebrand, M. J., Benckhuijsen, C. and Overdijk, B. (1987) Origin of the increased activity of beta-glucuronidase in the soluble fraction of rat mammary tumours during ovariectomy-induced regression. Cancer Res., 47, 3980-3987.
43. Pelletier, G. and Novikoff, A. B. (1972) Localization of phosphatase activities in the rat anterior pituitary gland. J. Histochem. Cytochem., 20, 1-12.
44. Capony, F., Rougeot, C., Montcourrier, P., Cavaillès, V., Salazar, G. and Rochefort, H. (1989) Increased secretion, altered processing and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res., 49, 3904-3909.
45. Westley, B. R. and May, F. E. (1999) Prognostic value of cathepsin D in breast cancer, Br. J. Cancer, 79, 189-190.
46. Mathieu, M., Rochefort, H., Barenton, B., Prebois, C. and Vignon, F. (1990) Interactions of cathepsin-D and insulin-like growth factor-II (IGF-II) on the IGF-II/mannose-6-phosphate receptor in human breast cancer cells and possible consequences on mitogenic activity of IGF-II. Mol. Endocrinol., 4, 1327-1335.
47. Kalra, J., Chaudary, A. K., Massey, L. and Prasad, K. (1990) Effect of oxygen free radicals, hypoxia and pH on the release of liver lysosomal enzymes. Mol. Cell. Biochem., 94, 1-8.
48. Bhuvarahamurthy, V., Balasubramanian, N., VijayaKumar, S. and Govindswamy, S. (1995) Effect of radiation on serum glycoproteins and glycosidases in patients with cervical carcinoma. Int. J. Gynaecol. Obstet., 48, 49-54.
49. Niebes, P. and Ponard, G. (1975) Stabilization of rat liver lysosomes by (+)-cyanidenol-3 in vivo. Biochem. Pharm., 24, 905-909.
50. Havsteen, B. (1983) Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharm., 32, 1141-1148.
51. Decharneux, T., Dubois, F., Beauloye, C., Wattiaux-De Coninck, S. and Wattiaux, R. (1992) Effect of various flavonoids on lysosomes subjected to an oxidative or an osmotic stress. Biochem. Pharmacol., 44, 1243-1248.
52. Saija, A., Scalese, M., Lanza, M., Marzullo, D., Bonina, F. and Castelli, F. (1995) Flavonoids as antioxidant agents: importance of their interaction with biomembranes. Free Radic. Biol. Med., 19, 481-486.
53. Arora, A., Byrem, T. M., Nair, M. G. and Strasburg, G. M. (2000) Modulation of liposomal membrane fluidity by flavonoids and isoflavonoids. Arch. Biochem. Biophys., 373, 102-109.
54. Veena, K., Shanthi, P. and Sachdanandam, P. (2006) The biochemical alterations following administration of Kalpaamruthaa and Semecarpus anacardium in mammary carcinoma. Chem. Biol. Interact., 161, 69-78.
55. Rajkapoor, B., Murugesh, N., Chodon, D. and Sakthisekaran, D. (2005) Chemoprevention of Nnitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides. Biol. Pharm. Bull., 28, 364-366.
56. El-Beshbishy, H. A. (2005) The effect of dimethyl dimethoxy biphenyl dicarboxylate (DDB) against tamoxifen-induced liver injury in rats: DDB use is curative or protective. J. Biochem. Mol. Biol., 8, 300-306.
57. Thyss, A. V. N., Ramaioli, A. V. G., Cambon, P., Sahneider, M. and Lalanne, C. M. (1981) Comparitive study of gamma-glutamyl transferase, alkaline phosphatase and its ?1 isoenzyme as biological indicators of liver metastases. Clin. Chim. Acta, 115, 349-358.
58. Stieber, P., Nagel, D., Ritzke, C., Rossler, N., Kirsch, C. M., Eisermann, W. and Fatch-Moghadam, A. (1992) A significance of bone alkaline phosphatase, carcinoembryonic antigen in the detection of bone metastases during the follow up of patients suffering from breast carcinoma. Eur. J. Clin. Chem. Clin. Biochem., 30, 809-814.
59. McIntyre, N. and Rosalki, S. (1992) Biochemical investigations in the management of liver diseases. In Hepatobiliary diseases (Prieto, J., Rodes, J. and Shafritz, P.A., Eds.), Springer-Verlag, Berline, pp.39-71.
60. Helmy, M. H., El-Moneim, N. A. A., El-Baki, M. M. A. A., El-Zoghby, S. M. (1998) Clinical value of serum lactate dehydrogenase, ceruloplasmin, cathepsin-D and lipid bound sialic acid in monitoring patients with malignant lymphomas. Med. Sci. Res., 26, 613-617.
61. Walia, M., Mahajan, M. and Singh, K. (1995) Serum adenosine deaminase, 5′-nucleotidase, alkaline phosphatase in breast cancer patients. Indian J. Med. Res., 101, 247-249.
62. Patwardhan, B., Ghoo, R. B. and David, S. B. (1988) A newanaerobic inhibitor of herbal origin. Indian J. Pharm. Sci., 50, 130-132.
63. Sanz, M. J., Ferrandiz, M. L., Cejudo, M., Terenciom, M. C., Gil, B., Bustos, G., Ubeda, A., Gunasekaran, R. and Alcaraz, N. J. (1994) Influence of a series of natural flavonoids on free radical generating system and oxidative stress. Zenobiotica, 24, 689-699.