Functional characterization of the fission yeast phosphatidylserine synthase gene, pps1, reveals novel cellular functions for phosphatidylserine

Eukaryotic Cell

Volumn 6, Issue 11, 2007, Pages 2092-2101

  Matsuo, Yasuhiro ^a   Fisher, Edward ^b   Patton Vogt, Jana ^b   Marcus, Stevan ^a  

^a UNIVERSITY OF ALABAMA   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHOLINE; ETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHATIDYLSERINE SYNTHASE; PPS1 PROTEIN, S POMBE; SCHIZOSACCHAROMYCES POMBE PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL FRACTIONATION; CELL WALL; CHEMISTRY; CYTOKINESIS; CYTOLOGY; CYTOSKELETON; DRUG EFFECT; ENZYMOLOGY; GENE DELETION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIAL VIABILITY; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN TRANSPORT; SCHIZOSACCHAROMYCES; SEQUENCE HOMOLOGY;

ACTINS; AMINO ACID SEQUENCE; CDPDIACYLGLYCEROL-SERINE O-PHOSPHATIDYLTRANSFERASE; CELL WALL; CHOLINE; CLONING, MOLECULAR; CYTOKINESIS; CYTOSKELETON; ETHANOLAMINE; GENE DELETION; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; PHENOTYPE; PHOSPHATIDYLSERINES; PROTEIN TRANSPORT; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBCELLULAR FRACTIONS;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 36849086908     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00300-07     Document Type: Article

References (39)

1. Alfa, C., P. Fantes, J. Hyams, M. McLeod, and E. Warbrick. 1993. Experiments with fission yeast: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. Arellano, M., M. H. Valdivieso, T. M. Calonge, P. M. Coll, A. Duran, and P. Perez. 1999. Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rholp and rho2p and differentially regulate cell integrity. J. Cell Sci. 112:3569-3578.
3. Atkinson, K., S. Fogel, and S. A. Henry. 1980. Yeast mutant defective in phosphatidylserine synthesis. J. Biol. Chem. 255:6653-6661.
4. Atkinson, K. D., B. Jensen, A. I. Kolat, E. M. Storm, S. A. Henry, and S. Fogel. 1980. Yeast mutants auxotrophic for choline or ethanolamine. J. Bacteriol. 141:558-564.
5. Bae-Lee, M. S., and G. M. Carman. 1984. Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase. J. Biol. Chem. 259:10857-10862.
6. Bevers, E. M., P. Comfurius, and R. F. Zwaal. 1983. Changes in membrane phospholipid distribution during platelet activation. Biochim. Biophys. Acta 736:57-66.
7. Bittova, L., R. V. Stahelin, and W. Cho. 2001. Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity. J. Biol. Chem. 276:4218-4226.
8. Carson, M. A., K. D. Atkinson, and C. J. Waechter. 1982. Properties of particulate and solubilized phosphatidylserine synthase activity from Saccharomyces cerevisiae. Inhibitory effect of choline in the growth medium. J. Biol. Chem. 257:8115-8121.
9. Chang, F., A. Woollard, and P. Nurse. 1996. Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring. J. Cell Sci. 109:131-142.
10. + of Schizosaccharomyces pombe homologous to hsp110/SSE subfamily. Gene 210:143-150.
11. Delhaize, E., D. M. Hebb, K. D. Richards, J. M. Lin, P. R. Ryan, and R. C. Gardner. 1999. Cloning and expression of a wheat (Triticum aestivum L.) phosphatidylserine synthase cDNA. Overexpression in plants alters the composition of phospholipids. J. Biol. Chem. 274:7082-7088.
12. Elliott, J. I., A. Surprenant, F. M. Marelli-Berg, J. C. Cooper, R. L. Cassady-Cain, C. Wooding, K. Linton, D. R. Alexander, and C. F. Higgins. 2005. Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nat. Cell Biol. 7:808-816.
13. Emoto, K., and M. Umeda. 2000. An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J. Cell Biol. 149:1215-1224.
14. Finkielstein, C. V., M. Overduin, and D. G. Capelluto. 2006. Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1. J. Biol. Chem. 281:27317-27326.
15. Ghosh, S., W. Q. Xie, A. F. Quest, G. M. Mabrouk, J. C. Strum, and R. M. Bell. 1994. The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras. J. Biol. Chem. 269:10000-10007.
16. Hamamatsu, S., I. Shibuya, M. Takagi, and A. Ohta. 1994. Loss of phosphatidylserine synthesis results in aberrant solute sequestration and vacuolar morphology in Saccharomyces cerevisiae. FEBS Lett. 348:33-36.
17. Iwamoto, K., S. Kobayashi, R. Fukuda, M. Umeda, T. Kobayashi, and A. Ohta. 2004. Local exposure of phosphatidylethanolamine on the yeast plasma membrane is implicated in cell polarity. Genes Cells 9:891-903.
18. + gene encodes a phospholipid methyltransferase. Genetics 150: 553-562.
19. Kohlwein, S. D., K. Kuchler, C. Sperka-Gottlieb, S. A. Henry, and F. Paltauf. 1988. Identification of mitochondrial and microsomal phosphatidylserine synthase in Saccharomyces cerevisiae as the gene product of the CHO1 structural gene. J. Bacteriol. 170:3778-3781.
20. Krawchuk, M. D., and W. P. Wahls. 1999. High-efficiency gene targeting in Schizosaccharomyces pombe using a modular, PCR-based approach with long tracts of flanking homology. Yeast 15:1419-1427.
21. Kuge, O., K. Saito, and M. Nishijima. 1997. Cloning of a Chinese hamster ovary (CHO) cDNA encoding phosphatidylserine synthase (PSS) II, overexpression of which suppresses the phosphatidylserine biosynthetic defect of a PSS I-lacking mutant of CHO-K1 cells. J. Biol. Chem. 272:19133-19139.
22. Letts, V. A., L. S. Klig, M. Bae-Lee, G. M. Carman, and S. A. Henry. 1983. Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase. Proc. Natl. Acad. Sci. USA 80:7279-7283.
23. Madeo, F., E. Frohlich, and K. U. Frohlich. 1997. A yeast mutant showing diagnostic markers of early and late apoptosis. J. Cell Biol. 139:729-734.
24. Marcus, S., A. Polverino, E. Chang, D. Robbins, M. H. Cobb, and M. H. Wigler. 1995. Shkl, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 92:6180-6184.
25. Maundrell, K. 1990. nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine. J. Biol. Chem. 265:10857-10864.
26. Nikawa, J. I., and S. Yamashita. 1981. Characterization of phosphatidylserine synthase from Saccharomyces cerevisiae and a mutant defective in the enzyme. Biochim. Biophys. Acta 665:420-426.
27. Pidoux, A. L., and J. Armstrong. 1993. The BiP protein and the endoplasmic reticulum of Schizosaccharomyces pombe: fate of the nuclear envelope during cell division. J. Cell Sci. 105:1115-1120.
28. Rose, M. D., F. Winston, and P. Hieter. 1990. Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Schlegel, R. A., and P. Williamson. 2001. Phosphatidylserine, a death knell. Cell Death Differ. 8:551-563.
30. Stone, S. J., Z. Cui, and J. E. Vance. 1998. Cloning and expression of mouse liver phosphatidylserine synthase-1 cDNA. Overexpression in rat hepatoma cells inhibits the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis. J. Biol. Chem. 273:7293-7302.
31. Stone, S. J., and J. E. Vance. 1999. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem. J. 342:57-64.
32. + gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol. Cell. Biol. 16:6752-6764.
33. Trotter, P. J., J. Pedretti, and D. R. Voelker. 1993. Phosphatidylserine decarboxylase from Saccharomyces cerevisiae. Isolation of mutants, cloning of the gene, and creation of a null allele. J. Biol. Chem. 268:21416-21424.
34. Trotter, P. J., J. Pedretti, R. Yates, and D. R. Voelker. 1995. Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiae. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. J. Biol. Chem. 270:6071-6080.
35. Vance, J. E., and R. Steenbergen. 2005. Metabolism and functions of phosphatidylserine. Prog. Lipid Res. 44:207-234.
36. Weerheim, A. M., A. M. Kolb, A. Sturk, and R. Nieuwland. 2002. Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography. Anal. Biochem. 302: 191-198.
37. Williams, J. G., and C. R. McMaster. 1998. Scanning alanine mutagenesis of the CDP-alcohol phosphotransferase motif of Saccharomyces cerevisiae cholinephosphotransferase. J. Biol. Chem. 273:13482-13487.
38. Wolf, A., C. Schmitz, and A. Bottger. 2007. Changing story of the receptor for phosphatidylserine-dependent clearance of apoptotic cells. EMBO Rep. 8:465-469.
39. Zwaal, R. F., P. Comfurius, and E. M. Bevers. 1998. Lipid-protein interactions in blood coagulation. Biochim. Biophys. Acta 1376:433-453.