HSPA1A is an important regulator of the stability and function of ZNF198 and its oncogenic derivative, ZNF198-FGFR1

Journal of Cellular Biochemistry

Volumn 102, Issue 5, 2007, Pages 1308-1317

  Kasyapa, Chitta S ^a   Kunapuli, Padmaja ^a   Cowell, John K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

HSPA1A; KNK437; Myeloproliferative disease; ZNF198 FGFR1

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HEAT SHOCK PROTEIN 70; MESSENGER RNA; PROTEASOME; STAT3 PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; CELL FUNCTION; CHROMOSOME REARRANGEMENT; FUSION GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

BENZHYDRYL COMPOUNDS; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE FUSION; GENE LIBRARY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KIDNEY; PRECIPITIN TESTS; PYRROLIDINONES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 36849068476     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21362     Document Type: Article

References (28)

1. Bagatell R, Whitesell L. 2004. Altered Hsp90 function in cancer: A unique therapeutic opportunity. Mol Cancer Ther 8:1021-1030.
2. Baumann H, Kunapuli P, Tracy E, Cowell JK. 2003. The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors. J Biol Chem 278(18):16198-16208.
3. Beere HM, Green DR. 2001. Stress management - Heat shock protein-70 and the regulation of apoptosis. Trends Cell Biol 11(1):6-10.
4. Daugaard M, Jaattela M, Rohde M. 2005. Hsp 70-2is required for tumor cell growth and survival. Cell Cycle 7:877-880.
5. Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ. 2000. FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood 95(5):1788-1796.
6. Guo F, Rocha K, Bali P, Pranpat M, Fiskus W, Boyapalle S, Kumaraswamy S, Balasis M, Greedy B, Armitage ES, Lawrence N, Bhalla K. 2005. Abrogation of heat shock protein 70 induction as a strategy to increase anti-leukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin. Cancer Res 65(22): 10536-10544.
7. Hartl FU, Hayer-Hartl M. 2002. Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 295(5561):1852-1858.
8. Heath C, Cross NC. 2004. Critical role of STAT5 activation in transformation mediated by ZNF198-FG FR1. J Biol Chem 279(8):6666-6673.
9. Isaacs JS, Xu W, Neckers L. 2003. Heat shock protein 90 as a molecular target for cancer therapeutics. Cancer Cell 3:213-217.
10. Jaattela M. 1999. Escaping cell death: Survival proteins in cancer. Exp Cell Res 248(1):30-43.
11. Kasyapa CS, Kunapuli P, Hawthorn L, Cowell JK. 2006. Induction of the plasminogen activator inhibitor-2 in cells expressing the ZNF198-FGFR1 fusion kinase that is involved in atypical myeloproliferative disease. Blood 107(9):3693-3699.
12. Kasyapa CS, Kunapuli P, Cowell JK. 2005. Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease. Exp Cell Res 309(1):78-85.
13. Kim D, Kim SH, Li GC. 1999. Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression. Biochem Biophys Res Commun 254:264-268.
14. Kunapuli P, Somerville R, Still IH, Cowell JK. 2003. ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins. Oncogene 22:3417-3423.
15. Kunapuli P, Kasyapa C, Hawthorn L, Cowell JK. 2004. LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the Erk1/2 pathway. J Biol Chem 279:23151-23157.
16. Kunapuli P, Kasyapa CS, Chin SF, Cowell JK. 2006. ZNF198, a zinc finger protein rearranged in myeloproliferative disease,localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. Exp Cell Res 312:3739-3751.
17. Lee DH, Goldberg AL. 1998. Proteasome inhibitors: Valuable new tools for cell biologists. Trends Cell Biol 10:397-403.
18. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, Sun S, Kulp D, Siani-Rose MA. 2003. NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 31:82-86.
19. Macdonald D, Reiter A, Cross NC. 2002. The 8p11 myeloproliferative syndrome: A distinct clinical entity caused by constitutive activation of FG FR1. Acta Haematol 107:101-107.
20. Mayer MP, Bukau B. 2005. Hsp70 chaperones: Cellular functions and molecular mechanism. Cell Mol Life Sci 6:670-684.
21. Milner CM, Campbell RD. 1990. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32:242-251.
22. Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pebusque MJ. 1999. Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation. J Biol Chem 274(38):26922-26930.
23. Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ. 1999. The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood 93(4):1381-1389.
24. Rabbitts TH. 1994. Chromosomal translocations in human cancer. Nature 372:143-149.
25. Smedley D, Demiroglu A, Abdul-Rauf M, Heath C, Cooper C, Shipley J, Cross NC. 1999. ANF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS1 and 5. Neoplasia 4:349-355.
26. Still IH, Cowell JK. 1998. The t(8;13) atypical myeloproliferative disorder: Further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13. Blood 92(4):1456-1458.
27. Tavaria M, Gabriele T, Kola I, Anderson RL. 1996. A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones 1:23-28.
28. Yokota S, Kitahara M, Nagata K. 2000. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res 60(11):2942-2948.