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Organic Letters

Volumn 9, Issue 24, 2007, Pages 4959-4962

Lewis acid- and organocatalyst-cocatalyzed multicomponent reactions of 2-alkynylbenzaldehydes, amines, and ketones

(2) Ding, Qiuping a Wu, Jie a,b

a FUDAN UNIVERSITY (China)

b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; BENZALDEHYDE DERIVATIVE; G 1617; ISOQUINOLINE DERIVATIVE; KETONE; MESYLIC ACID DERIVATIVE; PROLINE; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

AMINES; BENZALDEHYDES; CATALYSIS; ISOQUINOLINES; KETONES; MESYLATES; MOLECULAR STRUCTURE; PROLINE;

EID: 36849062645 PISSN: 15237060 EISSN: None Source Type: Journal
DOI: 10.1021/ol7020669 Document Type: Article

Times cited : (210)

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- General procedure for one-pot reaction of 2-alkynylbenzaldehyde 1, amine 2, and ketone 3 catalyzed by silver triflate and proline: A solution of 2-alkynylbenzaldehyde 1 (0.30 mmol, amine 2 (0.30 mmol, 1.0 equiv, ketone 3 (1.50 mmol, 5.0 equiv, AgOTf (0.03 mmol, 10 mol , proline (0.03 mmol, 10 mol , in C2H5OH (1.5 mL) was stirred at 50-60 °C under N2 for a period of time. After completion of the reaction as indicated by TLC, the solvent was evaporated and then quenched with water (10 mL, extracted with EtOAc 2 × 10 mL, and dried by anhydrate Na2SO4. Evaporation of the solvent followed by purification on silica gel provided the corresponding product 4, For details, please see Supporting Information
- 4. Evaporation of the solvent followed by purification on silica gel provided the corresponding product 4. (For details, please see Supporting Information.)

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