Interaction between the Cdk2/Cyclin A complex and a small molecule derived from the prb2/p130 spacer domain: A theoretical model

Cell Cycle

Volumn 6, Issue 21, 2007, Pages 2591-2593

  Giordano, Antonio ^a,b,f   Bellacchio, Emanuele ^c,d   Bagella, Luigi ^a,e   Paggi, Marco G ^d  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF SIENA   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^e UNIVERSITY OF SASSARI   (Italy)

^f Temple University   (United States)

Author keywords

Cancer therapy; cdk2; Cell cycle; Cyclin A; Kinase inhibitors; pRb2 p130; Retinoblastoma family proteins; Small molecules

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P107; PROTEIN P130; PROTEIN PRB; PROTEIN PRB2; PROTEIN SPA310; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; BINDING SITE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; COMPLEX FORMATION; COMPUTER AIDED DESIGN; ENZYME ACTIVITY; ENZYME INHIBITION; HOMEOSTASIS; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; THEORETICAL MODEL;

EID: 36849053959     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.21.4878     Document Type: Review

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