Thiolytically cleavable dithiobenzyl urethane-linked polymer-protein conjugates as macromolecular prodrugs: Reversible PEGylation of proteins

Bioconjugate Chemistry

Volumn 18, Issue 6, 2007, Pages 1869-1878

  Zalipsky, Samuel ^a,b   Mullah, Nasreen ^a   Engbers, Charles ^a   Hutchins, Maria U ^a   Kiwan, Radwan ^a  

^a ALZA CORPORATION   (United States)

^b Intradigm Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CELL MEMBRANES; ESTERS; ETHYLENE; ETHYLENE GLYCOL; MACROMOLECULES; SULFUR COMPOUNDS;

'CURRENT; BIOCONJUGATES; METHYL GROUP; MODEL PROTEINS; NATIVE PROTEINS; PEGYLATION; POLYMER-PROTEIN CONJUGATES; PRODRUGS; PROTEIN LYSOZYME; URETHANE LINKAGE;

ENZYMES;

BENZYL DERIVATIVE; POLYMER; PRODRUG; PROTEIN; URETHAN DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL CELL WALL; CLEARANCE; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; DECOMPOSITION; DISULFIDE BOND; MACROMOLECULE; MALE; MOLECULAR STABILITY; NONHUMAN; PLASMA CLEARANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PROTEIN SYNTHESIS; RAT; STEREOCHEMISTRY;

BACTERIA (MICROORGANISMS); RATTUS;

EID: 36849047415     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc7001902     Document Type: Article

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