Alterations of blood rheology during and after exercise are both consequences and modifiers of body's adaptation to muscular activity

Science and Sports

Volumn 22, Issue 6, 2007, Pages 251-266

  Brun, J F ^a   Connes, P ^b   Varlet Marie, E ^a  

^a INSERM   (France)

^b Laboratoire ACTES   (Guadeloupe)

Author keywords

Blood viscosity; Erythrocyte deformability; Exercise

Indexed keywords

FREE RADICAL; OXYGEN;

ADAPTATION; BLOOD FLOW; BLOOD RHEOLOGY; BLOOD VISCOSITY; CIRCULATION; ENDURANCE SPORT; ERYTHROCYTE; EXERCISE; FLUID SHIFT; HEART FUNCTION; HEMATOCRIT; HUMAN; LEUKOCYTE ACTIVATION; METABOLISM; MUSCLE CONTRACTION; NUTRITION; OVERTRAINING SYNDROME; OXIDATIVE STRESS; OXYGEN DIFFUSION; OXYGEN SUPPLY; OXYGEN TRANSPORT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHORT SURVEY; SITTING; SPORTS MEDICINE; STRENGTH;

EID: 36849023485     PISSN: 07651597     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.scispo.2007.09.010     Document Type: Short Survey

References (92)

1. Aissa Benhaddad A., Bouix D., et al. Early hemorheologic aspects of overtraining in elite athletes. Clin Hemorheol Microcirc 20 (1999) 117-125
2. Ajmani R.S., Fleg J.F., et al. Role of oxidative stress on hemorheological and biochemical changes induced during treadmill exercise. J Mal Vasc 25 suppl B (2000) 144-145
3. Aloulou I., Varlet-Marie E., et al. Hemorheologic effects of low intensity endurance training in sedentary patients suffering from the metabolic syndrome. Clin Hemorheol Microcirc 35 (2006) 333-339
4. 2 diffusing capacity and resistance to flow in rabbit lungs. J Appl Physiol 78 (1995) 778-783
5. Bouix D., Peyreigne C., et al. Fibrinogen is negatively correlated with aerobic working capacity in football players. Clin Hemorheol Microcirc (1997) 17 [abstract]
6. Bouix D., Peyreigne C., et al. Relationships among body composition, hemorheology and exercise performance in rugby men. Clin Hemorheol Microcirc 19 (1998) 245-254
7. Bricout V., Guinot M., et al. Apports des examens biologiques dans le diagnostic du surentraînement. Science et Sports 21 (2006) 319-350
8. Brun J.F., Fons C., et al. Could exercise-induced increase in blood viscosity at high shear rate be entirely explained by hematocrit and plasma viscosity changes?. Clin hemorheol Microcirc 13 (1993) 187-199
9. Brun J.F., Bouchahda C., et al. The paradox of hematocrit in exercise physiology: which is the 'normal' range from an hemorheologist's viewpoint?. Clin Hemorheol Microcirc 22 (2000) 287-303
10. Brun J.F., Bouchahda C., et al. Aspects hémorhéologiques de l'activation leucoplaquettaire dans les pathologies athéromateuses, applications cliniques. J Mal Vasc 25 (2000) 349-355
11. Brun J.F., Fons C., et al. Influence of circulating lactate on blood rheology during exercise in professional football players. Rev Port Hemorreol 5 (1991) 219-229
12. Brun J.F., Khaled S., et al. Triphasic effects of exercise on blood rheology: which relevance to physiology and pathophysiology?. Clin Hemorheol Microcirc 19 (1999) 89-104
13. Brun J.F., Lagoueyte C., et al. A correlation between hematocrit increase and perceived exertion in exercising healthy subjects". J Blood Rheol 4 (1990) 51-64
14. Brun J.F., Micallef J.P., et al. Hemorheologic effects of light prolonged exercise. Clin Hemorheol Microcirc 14 (1994) 807-818
15. Brun J.F., Supparo I., et al. Effects of a standardized breakfast compared to fasting on the hemorheologic responses to submaximal exercise. Clin Hemorheol Microcirc 15 (1995) 213-220
16. Brun J.F., Varlet-Marie E., et al. Blood fluidity is related to the ability to oxidize lipids at exercise. Clin Hemorheol Microcirc 30 (2004) 339-343
17. Brun J.F. Exercise hemorheology as a three acts play with metabolic actors: is it of clinical relevance?. Clin Hemorheol Microcirc 26 (2002) 155-174
18. Brun J.F. Hormones, metabolism and body composition as major determinants of blood rheology: potential pathophysiological meaning. Clin Hemorheol Microcirc 26 2 (2002) 63-79
19. Brun J.F. Le surentraînement: à la recherche d'un outil d'évaluation standardisé utilisable en routine. Science et Sports 18 (2003) 282-286
20. Cabel M., Meiselman H.J., et al. Contribution of red cell aggregation to venous vascular resistance in skeletal muscle. Am J Physiol Heart Circ Physiol 272 (1997) H1020-H1032
21. Caillaud C., Connes P., et al. Does haemorheology explain the paradox of hypoxemia during exercise in elite athletes or thoroughbred horses?. Clin Hemorheol Microcirc 26 3 (2002) 175-181
22. Cassan D, Brun JF, et al. Relationships between hemorheological and metabolic adaptation to exercise in female rugby players: importance of erythrocyte rheology", in IIIrd international conference on Haemorheology, July 29-31, Yaroslavl, Russia, 2001. Proceedings by A. Muravyov, I. Tikhomirova, V. Yakusevitch, L.G. Zaitsev, A.G. Gushin, I.A. Bakanova, D.V. Borisov, O.N. Semenova, p. 58.
23. Charm S.E., Paz H., et al. Reduced plasma viscosity among joggers compared with non-joggers. Biorheology 15 (1979) 185-191
24. Church T.S., Lavie C.J., et al. Improvements in blood rheology after cardiac rehabilitation and exercise training in patients with coronary heart disease. Am Heart J 143 (2002) 349-355
25. Connes P., Bouix D., et al. Is hemoglobin desaturation related to blood viscosity in athletes during exercise?. Int J Sports Med 25 (2004) 569-574
26. Connes P., Bouix D., et al. Opposite effects of in vitro lactate on erythrocyte deformability in athletes and untrained subjects. Clin Hemorheol Microcirc 31 (2004) 311-318
27. Connes P., Caillaud C., et al. Red cell rigidity paradoxically decreases during maximal exercise in endurance athletes unless they are prone to exercise-induced hypoxaemia. J Mal Vasc 25 suppl. B (2000) 165
28. Connes P., Caillaud C., et al. Injections of recombinant human erythropoietin increases lactate influx into erythrocytes. J Appl Physiol 97 (2004) 326-332
29. Connes P, Caillaud C, et al. Maximal exercise and lactate do not change red blood cell aggregation in well-trained athletes. Clin Hemorheol Microcirc, 2007.
30. Connes P., Martin C., et al. Nocturnal autonomic nervous system activity impairment in sickle cell trait carriers. Clin Physiol Funct Imaging 26 (2006) 87-91
31. Connes P., Monchanin G., et al. Oxygen uptake kinetics during heavy submaximal exercise: effect of sickle cell trait with or without alpha-thalassemia. Int J Sports Med 27 (2006) 517-525
32. Connes P., Perrey S., et al. Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following four weeks recombinant human erythropoietin (r-HuEPO) treatment. Pflugers Arch 447 (2003) 231-238
33. Connes P., Sara F., et al. Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?. Jpn J Physiol 55 (2005) 385-387
34. Connes P., Sara F., et al. Effects of short supramaximal exercise on hemorheology in sickle cell trait carriers. Eur J Appl Physiol 97 (2006) 143-150
35. 2-max is/is not limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 100 (2006) 2099
36. Connes P. Exercise-induced hypoxemia as a consequence of hemorheological alterations?. Biorheology 42 (2005) 92 [abstract]
37. Deem S., Hedges R.G., et al. Mechanisms of improvement in pulmonary gas exchange during isovolemic hemodilution. J Appl Physiol 87 (1999) 132-141
38. Dintenfass L. Influence of plasma proteins on the in vivo and in vitro rheological properties of blood. Clin Hemorheol Microcirc 5 (1985) 191-206
39. Doyle M.P., and Walker B.R. Stiffened erythrocytes augment the pulmonary hemodynamic response to hypoxia. J Appl Physiol 69 (1990) 1270-1275
40. Dudaev V.A., Diukov I.V., et al. Effect of physical training on lipid metabolism and the rheologic properties of the blood of patients with ischemic heart disease. Kardiologiia 26 (1986) 55-60
41. Dumortier M., Perez-Martin A., et al. Regular exercise (3 × 45 min/wk) decreases plasma viscosity in sedentary obese, insulin resistant patients parallel to an improvement in fitness and a shift in substrate oxidation balance. Clin Hemorheol Microcirc 26 (2002) 219-229
42. Dupuy-Fons C., Brun J.F., et al. Relationships between blood rheology and transcutaneous oxygen pressure in peripheral occlusive arterial disease. Clin Hemorheol Microcirc 15 (1995) 191-199
43. El-Sayed M.S., Ali N., et al. Interaction between alcohol and exercise: physiological and haematological implications. Sports Med 35 3 (2005) 257-269
44. El-Sayed M.S., Ali N., et al. Haemorheology in exercise and training. Sports Med 35 (2005) 649-670
45. El-Sayed M.S. Adverse effects of alcohol ingestion post exercise on blood rheological variables during recovery. Clin Hemorheol Microcirc 24 (2001) 227-232
46. Ernst E., Daburger L., et al. The kinetics of blood rheology during and after prolonged standardized exercise. Clin Hemorheol Microcirc 11 (1991) 429-439
47. Ernst E., and Matrai A. Intermittent claudication, exercise, and blood rheology. Circulation 76 (1987) 1110-1112
48. Ernst E. Changes in blood rheology produced by exercise. J Am Med Assoc 253 (1985) 2962-2963
49. Ernst E. Influence of regular physical activity on blood rheology. Eur Heart J 8 suppl G (1987) 59-62
50. Eterovic D., Pintaric I., et al. Determinants of plasma viscosity in primary hyperlipoproteinemias. Clin Hemorheol Microcirc 15 (1995) 841-850
51. Favre-Juvin A., Les membres du groupe surentraînement de la SFMS (X Bigard, JF Brun, V Bricout, JL Chatard, P Flore, M Guinot, N Koulman, G Lac, M Rousseau-Blanchi, and B Serrurier). Le surentraînement : place de l'interrogatoire dans le diagnostic. Science et Sports 20 (2005) 314-316
52. Frank A.O., Chuong C.J., et al. A finite-element model of oxygen diffusion in the pulmonary capillaries. J Appl Physiol 82 (1997) 2036-2044
53. Galea G., and Davidson R.J. Hemorheology of marathon running. Int J Sports Med 6 (1985) 136-138
54. Gaudard A., Varlet-Marie E., et al. Nutrition as a determinant of blood rheology and fibrinogen in athletes. Clin Hemorheol Microcirc 30 (2004) 1-8
55. Gaudard A., Varlet-Marie E., et al. Hemorheological correlates of fitness and unfitness in athletes: moving beyond the apparent "paradox of hematocrit"?. Clin Hemorheol Microcirc 28 3 (2003) 161-173
56. Gaudard A., Varlet-Marie E., et al. Exercise-induced central retinal vein thrombosis: possible involvement of hemorheological disturbances. A case report. Clin Hemorheol Microc 27 (2002) 115-122
57. Guézennec C.Y., Nadaud J.F., et al. Influence of polyunsaturated fatty acid diet on the hemorheological response to physical exercise in hypoxia. Int J Sports Med 10 (1989) 286-291
58. Hsia C.C., Chuong C.J., et al. Red cell distortion and conceptual basis of diffusing capacity estimates: finite element analysis. J Appl Physiol 83 (1997) 1397-1404
59. Khaled S., Brun J.F., et al. Effects of zinc supplementation on blood rheology during exercise. Clin Hemorheol Microcirc 20 (1997) 1-10
60. Khaled S., Brun J.F., et al. Increased blood viscosity in iron-depleted elite athletes. Clin Hemorheol Microcirc 18 (1998) 309-318
61. Koenig W., Sund M., et al. Leisure-time physical activity but not work-related physical activity is associated with decreased plasma viscosity. Results from a large population sample. Circulation 95 (1997) 335-341
62. Lacombe C., Bucherer C., et al. Effets hémorhéologiques consécutifs a des exercices physiques controlés sur ergocyle. Hemorheologic effects following ergometric-controlled physical exercise. J Mal Vasc 16 (1991) 79-82
63. Le Gallais D., Prefaut C., et al. Sickle cell trait as a limiting factor for high-level performance in a semi-marathon. Int J Sports Med 15 (1994) 399-402
64. Letcher R.L., Pickering T.G., et al. Effects of exercise on plasma viscosity in athletes and sedentary normal subjects. Clin Cardiol 4 (1981) 172-179
65. Monchanin G., Serpero L.D., et al. Effects of a progressive and maximal exercise on plasma levels of adhesion molecules in athletes with sickle cell trait with or without {alpha}-thalassemia. J Appl Physiol 102 (2007) 169-173
66. Noakes T.D., Peltonen J.E., et al. Evidence that a central governor regulates exercise performance during acute hypoxia and hyperoxia. J Exp Biol 204 (2001) 3225-3234
67. Obiefuna P.C. Rouleaux formation in sickle cell traits. J Trop Med Hyg 94 (1991) 42-44
68. Oostenbrug G.S., Mensink R.P., et al. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E. J Appl Physiol 83 (1997) 746-752
69. Osterloh K., Gaehtgens P., et al. Determination of microvascular flow pattern formation in vivo. Am J Physiol Heart Circ Physiol 278 (2000) H1142-H1152
70. Parthasarathi K., and Lipowsky H.H. Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability. Am J Physiol 277 6 Pt 2 (1999) H2145-H2157
71. Perez-Martin A., Dumortier M., et al. Multivariate analysis of relationships between insulin sensitivity and blood rheology: is plasma viscosity a marker of insulin resistance?. Clin Hemorheol Microcirc 25 (2001) 91-103
72. Raynaud E., Pérez-Martin A., et al. Relationships between fibrinogen and insulin resistance. Atherosclerosis 150 (2000) 365-370
73. Schmid-Schönbein H., Desai-Röhrig L., et al. Synergetics of blood flow in exercising skeletal muscle in man: cooperative effects of rheology, neurogenic vasoconstriction and mechanical effects of muscle pumps. Biorheology 39 (2002) [abstract]
74. Schmid-Schönbein H., Foerster M., et al. Percolation theory as the rational basis of clinical hemorheology: the role of "abnormal" flow behavior of blood elements on the homogeneity of perfusion, gas exchange and metabolism. Biorheology (2002) 39 [abstract]
75. Schmid-Schönbein H. Wege des Infarzierens. Neue erkenntinisse durch die in-vivo-rheoskopie [Paths to infarction; new findings through in-vivo-rheoscopy]. Internist (Berl) 42 (2001) 1196-1200
76. Senturk U.K., Yalcin O., et al. Effect of antioxidant vitamin treatment on the time course of hematological and hemorheological alterations after an exhausting exercise episode in human subjects. J Appl Physiol 98 (2005) 1272-1279
77. Smith L.L. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress?. Med Sci Sports Exerc 32 (2000) 317-331
78. Teillet T., Pilardeau P., et al. Variation des protéines plasmatiques pendant un exercice de courte durée. Science et Sports 6 (1991) 173-178
79. Temiz A., Baskurt O.K., et al. Leukocyte activation, oxidant stress and red blood cell properties after acute, exhausting exercise in rats. Clin Hemorheol Microcirc 22 (2000) 253-259
80. Thiriet P., Le Hesran J.Y., et al. Sickle cell trait performance in a prolonged race at high altitude. Med Sci Sports Exerc 26 (1994) 914-918
81. Thoth K., Ernst E., et al. Hemorheological and hemodynamical effects of fish oil (Ameu) in patients with ischemic heart disease and hyperlipoproteinemia. Clin Hemorheol Microcirc 15 (1995) 867-875
82. Tripette J, Hardy-Dessources MD, et al. "Does prolonged and heavy exercise impair blood rheology in sickle cell trait carriers?", in Proceedings of the 2nd Eurosummer School on Biorheology & Symposium on Micro Mechanobiology of Cells, Tissues and Systems, September 17-20, Varna, Bulgaria, 2006.
83. Tuomilehto J., Lindstrom J., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344 18 (2001) 1343-1350
84. Van der Brug C., Peters H., et al. Hemorheological response to prolonged exercise: no effects of different kinds of feedings. Int J Sports Med 16 (1995) 231-237
85. Vandewalle H., Lacombe C., et al. Blood viscosity after a 1-h submaximal exercise with and without drinking. Int J Sports Med 9 (1988) 104-107
86. Varlet-Marie E., and Brun J.F. Reciprocal relationships between blood lactate and hemorheology in athletes: another hemorheologic paradox?. Clin Hemorheol Microcirc 30 (2004) 331-337
87. Varlet-Marie E., Gaudard A., et al. Is the feeling of heavy legs in overtrained athletes related to impaired hemorheology?. Clin Hemorheol Microcirc 28 (2003) 151-159
88. Varlet-Marie E., Gaudard A., et al. Reduction of red blood cell disaggregability during submaximal exercise: correlation with fibrinogen. Clin Hemorheol Microcirc 28 (2003) 139-149
89. Varlet-Marie E., Maso F., et al. Hemorheological disturbances in the overtraining syndrome. Clin Hemorheol Microcirc 30 (2004) 211-218
90. Varlet-Marie E., Mercier J., et al. Is plasma viscosity a predictor of overtraining in athletes?. Clin Hemorheol Microcirc 35 (2006) 329-332
91. Vicaut E., Hou X., et al. Red blood cell aggregation and microcirculation in rat cremaster muscle. Int J Microcirc 14 (1994) 14-21
92. Wasserman D.H., Lickley H.L.A., et al. Effect of hematocrit reduction on hormonal and metabolic responses to exercise. J Appl Physiol 58 (1985) 1257-1262