Interaction between alcohol and exercise: Physiological and haematological implications

Sports Medicine

Volumn 35, Issue 3, 2005, Pages 257-269

  El Sayed, Mahmoud S ^a   Ali, Nagia ^b   Ali, Zeinab El Sayed ^c  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b BALL STATE UNIVERSITY   (United States)

^c Rowlands Pharmacy   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMINO ACID; CITRATE SYNTHASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LACTATE DEHYDROGENASE; PYRUVATE KINASE;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; AMINO ACID METABOLISM; BLOOD CLOTTING; BLOOD RHEOLOGY; BLOOD VISCOSITY; BRAIN; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; ENERGY METABOLISM; ENZYME ACTIVITY; EXERCISE; FIBRINOLYSIS; GLUCOSE METABOLISM; HEALTH HAZARD; HEMATOLOGY; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; LIVER; LIVER MITOCHONDRION; MUSCLE CAPILLARY; MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; PERFORMANCE; PHYSIOLOGY; REVIEW; SPORT; SPORT INJURY; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOGENESIS;

ALCOHOL DRINKING; BRAIN; CENTRAL NERVOUS SYSTEM; EXERCISE; HEMORHEOLOGY; HEMOSTASIS; HUMANS; LIVER; MUSCLE, SKELETAL; SPORTS;

EID: 16244367426     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-200535030-00005     Document Type: Review

References (98)

1. Gilman AG, Goodman LS, Rawl TW. The pharmacological basis of therapeutics. 7th ed. New York: McMillan, 1985
2. Lyons FP. Can regular alcohol consumption increase the risk of injury [dissertation]? Devon: University of Exeter, 1998
3. O'Brien CP. Alcohol and sports: impact of social drinking on recreational and competitive sports performance. Sports Med 1993; 15: 71-7
4. Royal College of Physicians. The medical consequences of alcohol abuse: a great and growing evil. London: Royal College of Physicians, 1987
5. American College of Sports Medicine. ACSM's guidelines for exercise testing and prescription. 4th ed. Philadelphia (PA): Lea and Febiger, 1991
6. Lieber CS. Metabolism of alcohol. In: Liber CS, editor. Medical and complications of alcoholism. New York: Plenum Medical Book Co., 1992
7. Preedy VR, Salisbury JR, Peters TJ. Alcoholic muscle diseases: features and mechanisms. J Pathol 1994; 173: 310-5
8. Ardies CM, Morris GS, Erickson CK, et al. Effects of exercise and ethanol on liver mitochondrial function. Life Sci 1987; 1640: 1053-61
9. Ardies CM, Morris GS, Erickson CK, et al. Both acute and chronic exercise enhance in vivo ethanol clearance in rats. J Appl Physiol 1989; 66: 555-60
10. Husain K, Somani SM. Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rats. J Appl Toxicol 1997; 17: 189-94
11. Husain K, Somani SM. Response of cardiac antioxidant system to alcohol in the rat. Alcohol 1998; 14: 301-7
12. Vila L, Ferrando A, Voces J, et al. Effect of chronic ethanol ingestion and exercise training on skeletal muscle in rat. Drug Alcohol Depend 2001; 64: 27-33
13. Cook EB, Adebiyi LAY, Preedy VR, et al. Chronic effects of alcohol on muscle metabolism in the rat. Biochem Biophys Acta 1992; 1180: 207-14
14. Spolarics Z, Bagby GJ, Pekala PH, et al. Acute alcohol administration attenuates insulin-mediated glucose use by skeletal muscle. Am J Physiol 1994; 267: E886-91
15. Trounce I, Byrne E, Dennet X. Biochemical and moephological studies of skeletal muscle in experimental chronic alcoholic myopathy. Acta Neurol Scand 1990; 82: 386-91
16. Saltin B, Kiens B, Savarg G, et al. Role of haemoglobin and capilliarisation for oxygen delivery and extraction in muscular exercise. Acta Physiol Scand 1986; 566: 21-32
17. Friedman HS, Geller SA, Lieber CS. The effect of alcohol on the heart, skeletal and smooth muscles. In: Lieber CS, editor. Medical disorders of alcoholism: pathogenesis and treatment. Philadelphia (PA): Saunders, 1982
18. Altura BM, Altura BT, Gebrewold A. Comparative effects of ethanol, acetaldehyde and acetate on arterioles and venules in skeletal muscle: direct in situ studies on the microcirculation and their possible relationship to alcoholic myopathy. Microcirc Endothelium Lymphatics 1990; 6: 107-26
19. Preedy VR, Duane P, Peters TJ. Comparison of the acute effects of ethanol on liver and skeletal muscle protein synthesis in the rat. Alcohol Alcohol 1988; 23: 155-62
20. Langohr HD, Wietholter H, Peiffer J. Muscle wasting in chronic alcoholics: comparative histochemical studies. J Neurol Neurosurg Psychiatry 1983; 46: 248-54
21. El-Sayed MS, Sale C, Jones P, et al. Blood haemostasis in exercise and training. Med Sci Sports Exerc 2000; 32: 918-25
22. El-Sayed MS. Alcohol ingestion and blood haemostasis in exercise. Alcohol Res 2002; 7: 187-8
23. Lee AJ, Flanagan PA, Rumley A, et al. Relationship between alcohol intake and tissue plasminogen activator antigen and other haemostatic factors in the general population. Fibrinolysis 1995; 8: 49-54
24. Ridker PM, Vaughan DE, Stampfer MJ, et al. Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. JAMA 1994; 272: 929-33
25. Hillbom M, Haapaniemi H, Juvela S, et al. Recent alcohol consumption, cigarette smoking, and cerebral infarction in young adults. Stroke 1995; 26: 40-5
26. Gorelick PB, Rodin MB, Langenberg P, et al. Is acute alcohol ingestion a risk factor for ischemic stroke? Results of a controlled study in middle-aged and elderly stroke patients at three urban medical centers. Stroke 1987; 18: 359-64
27. Folsom AR, Wu KK, Davis CE, et al. Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis 1991; 91: 191-205
28. Hendriks HF, Veenstra J, Velthuis-te Wierik EJ, et al. Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. BMJ 1994; 308: 1003-8
29. Pikaar NA, van der Beek EJ, van Dokkum W, et al. Effect of moderate alcohol consumption on platelet aggregation. Metabolism 1987; 36: 538-43
30. Numminen H, Syrjala M, Benthin G, et al. The effect of a Large dose of alcohol on the haemostatic systems and its circadian variations. Stroke 2000; 6: 1269-77
31. Elmer O, Goransson G, Zoucas E. Impairment of primary hemostasis and platelet function after alcohol ingestion in man. Haemostasis 1984; 14: 223-8
32. Pietraszek MH, Serizawa K, Takada Y, et al. Effect of acute alcohol ingestion on the fibrinolytic activity. Fibrinolysis 1991; 5: 249-52
33. Gutgesell M, Canterbury R. Alcohol usage in sport and exercise. Addict Biol 1999; 4: 373-83
34. El-Sayed MS, Eastland P, Lin X, et al. The effect of moderate alcohol ingestion on blood coagulation and fibrinolysis at rest and in response to exercise. J Sports Sci 1999; 17: 513-20
35. El-Sayed MS, Nieuwenhuizen W. The effect of alcohol ingestion on the exercise-induced changes in fibrin and fibrinogen degradation products in man. Blood Coagul Fibrinolysis 2000; 11: 359-65
36. Johansen KM, Skorpe S, Oslen JO, et al. The effect of red wine on the fibrinolytic system and the cellular activation reactions before and after exercise. Thromb Res 1999; 96: 355-63
37. El-Sayed M, Omar A, Lin X. Post-exercise alcohol ingestion perturbs blood haemostasia during recovery. Thromb Res 2000; 99: 523-30
38. Hillbom M, Kaste M, Rasi V. Can ethanol intoxication affects hemocoagulation to increase the risk of brain infarction in young adults? Neurology 1983; 33: 381-4
39. Lindola J, Ylikahri R, Fyhrquist F, et al. Plasma vasopressin in ethanol intoxication and hangover. Acta Physiol Scand 1978; 104: 180-7
40. Ireland MA, Vandongen R, Davidson L, et al. Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines. Clin Sci 1984; 66: 643-8
41. Catto AJ, Grant PJ. Risk factors for cerebrovascular disease and the role of coagulation and fibrinolysis. Blood Coagul Fibrinolysis 1995; 6: 497-510
42. Hendriks HF, Veenstra J, Velthius-te Wierik EJ, et al. Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. BMJ 1994; 308: 1003-6
43. Meade TW, Ruddock V, Stirling Y, et al. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 1996; 342: 1076-9
44. Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol 1997; 38: 2080-5
45. El-Sayed MS. Effects of exercise on blood coagulation, fibrinolysis and platelet aggregation. Sports Med 1996; 22: 282-98
46. Hillbom M, Kangasaho M, Kaste M, et al. Acute ethanol ingestion increases platelet reactivity: is there a relationship to stroke? Stroke 1985; 16: 19-23
47. O'Brien CPO, Lyons F. Alcohol and the athlete. Sports Med 2000; 29: 295-300
48. El-Sayed M. Effects of alcohol ingestion post-exercise on platelet aggregation. Thromb Res 2002; 105: 147-51
49. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation 1979; 60: 473-85
50. Gaziano JM, Buring JE, Breslow JL, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med 1993; 329: 1829-34
51. Gordon PM, Goss FL, Visich PS, et al. The acute effects of exercise intensity on HDL-C metabolism. Med Sci Sports Exerc 1994; 26: 671-7
52. Goldberg L, Elliott DI. The effect of exercise on lipid metabolism in men and women. Sports Med 1987; 4: 307-21
53. Pronk NP. Short term effects of exercise on plasma lipids and lipoproteins in humans. Sports Med 1993; 16: 431-48
54. Barboriak JJ. Alcohol, lipids and heart disease. Alcohol 1984; 1: 341-5
55. Nilsson-Ehle P. Alcohol-induced alterations in lipoprotein lipase activity and plasma lipoproteins. In: Avogaro P, Sirtori CR, Tremoli E, editors. Metabolic effects of alcohol. Amesterdam: Elsevier/North-Holland Biomedical Press, 1979: 175-86
56. Schneider J, Panne E, Braun H, et al. Ethanol-induced hyperlipoproteinemia: crucial role preceding ethanol intake in the removal of chylomicrons. J Lab Clin Med 1983; 101: 114-21
57. Crouse JR, Grundy SM. Effects of alcohol on plasma lipoproteins and cholesterols and triglycerides metabolism in men. J Lipid Res 1984; 25: 486-96
58. Erkelens DW, Brunzell JD. Effects of controlled alcohol feeding otriglycerides in patients with outpatient alcohol hypertriglyceridemia. J Hum Nutr 1980; 24: 470-5
59. Veenstra J, Okhuizen T, Van de Pol H, et al. Effects of moderate dose of alcohol on lipids and lipoproteins postprandially and in the fasting state. Alcohol Alcohol 1990; 25: 371-7
60. El-Sayed MS, AL-Bayatti MF. Effects of alcohol ingestion following exercise on postprandial lipemia. Alcohol 2001; 23: 15-21
61. Steinberg D, Pearson TA, Kuller LH. Alcohol and atherosclerosis. Ann Intern Med 1991; 114: 967-76
62. Marmot M, Brunner E. Alcohol and cardiovascular disease; the status of U-shaped curve. BMJ 1991; 303: 565-8
63. El-Sayed MS. Effects of exercise and training on blood rheology. Sports Med 1998; 26: 281-92
64. El-Sayed MS. Adverse effects of alcohol ingestion post exercise on blood rheological variables during recovery. Clinical Hemorheol Microcirc 2001; 24: 227-32
65. Baker RC, Jerrels TR. Recent developments in alcoholism: immunological aspects. Recent Dev Alcohol 1993; 11: 249-71
66. Roselle G. Alcohol and the immune system. Alcohol Health Res World 1992; 16: 16-22
67. Morland B, Morland H. The interaction of alcohol with human monocyte IgG receptors, characterised by monoclonal antibodies raised against two distinct receptor subgroups. Scand J Immunol 1989; 29: 573-7
68. Ewald SJ, Shao H. Etahnol increases apoptotic cell death of thymocytes in vitro. Alcohol Clin Exp Res 1993; 17: 359-65
69. Cook RT, Feng L, Vandersteen D, et al. Ethanol and NK cells I: activity and immunophenotype in alcoholic humans. Alcohol Clin Exp Res 1997; 21: 974-80
70. MacGregor RR, Louria DB. Alcohol and infection. Curr Clin Top Infect Dis 1997; 17: 291-315
71. D'Souza NB, Nelson S, Summer WR, et al. Alcoholism modulates alveolar turner necrosis factor alpha, superoxide anion, and nitric oxide secretion in the rat. Alcohol Clin Exp Res 1996; 20: 156-63
72. Spitzer J, Bautista A. Alcohol, cytokines and immunodeficiency. In: Friedman H, Klein TW, Specter S, editors. Drugs of abuse, immunity, and AIDS. New York: Plenum Press, 1993; 335: 159-64
73. Hansagi H, Romelsjo A, Gerhardsson de Verdier N, et al. Alcohol consumption and stroke mortality: 20-year follow up of 15077 men and women. Stroke 1995; 26: 1768-73
74. Doll R, Peto R, Hall E, et al. Mortality in relation to consumption of alcohol: 13 years' observtion on male British doctors. BMJ 1994; 309: 911-8
75. Knuiman MW, Vu HTV. Risk factors for stroke mortality in men and women; the Busselton study. J Cardivasc Risk 1996; 3: 447-52
76. Hart CL, Smith GD, Hole DJ, et al. Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of Scottish men with 21 year follow up. BMJ 1999; 318: 1725-9
77. Chenet L, McKee M, Leon D, et al. Alcohol and cardiovascular mortality in Moscow; new evidence of a causal association. J Epidemiol Comm Health 1998; 52: 772-4
78. Groenbaek Deis A, Sorensen TIA, Becker U, et al. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ 1995; 310: 1165-9
79. Caicoya M, Rodriguez T, Corrales C, et al. Alcohol and stroke: a community case-control study in Asturias, Spain. J Clin Epidemiol 1990; 52: 677-84
80. Somani SM, Husain K. Interaction of exercise training and chronic ethanol ingestion on antioxidant system of rat brain regions. J Appl Toxicol 1997; 17: 329-36
81. Fernandez-Sola J, Estruch R, Grau JM, et al. The relationship of alcoholic cardiomyopathy to cardiomyopathy. Ann Intern Med 1994; 120: 529-36
82. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organisation/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 1996; 93: 841-2
83. Henry WL, Gardin JM, Ware JH. Echocardiographic measurements in normal subjects from infancy to old age. Circulation 1980; 62: 1054-61
84. Kupari M, Koskinen P, Suokas A. Left ventricular size, mass and function in relation to the duration and quantity of heavy drinking in alcoholics. Am J Cardiol 1991; 67: 274-9
85. Manolio TA, Baughman KL, Rodeheffer R. Prevalence and aetiology of idiopathic dilated cardiomyopathy. Am J Cardiol 1992; 69: 1459-66
86. Ettinger PO, Wu CF, De La Cruz C, et al. Arrythmias and the 'holiday heart'; alcohol-associated cardiac rhythm disorders. Am Heart J 1978; 95: 555-62
87. Patterson E, Dormer KJ, Scheriag BJ, et al. Long-term intercoronary ethanol administration electrophysiologic and morphologic effects. Alcohol 1987; 4: 375-84
88. Greenspon AJ, Schaal SF. The 'holiday heart': electrophysiologic studies of alcohol effects in alcoholics. Ann Intern Med 1983; 98: 135-9
89. Keil U, Chambless L, Remmers A. Alcohol and blood pressure: results from the Luebeck Blood Pressure Study. Prev Med 1989; 18: 1-10
90. Rupp H, Brilla CG, Maisch B. Hypertension and alcohol: central and peripheral mechanisms. Herz 1996; 21: 258-64
91. Husain K, Somani SM. Responses of cardiac antioxidant system to alcohol and exercise training in the rat. Alcohol 1997; 14: 301-7
92. Kurose I, Higuchi H, Kato S, et al. Ethanol-induced oxidative stress in the liver. Alcohol Clin Exp Res 1996; 20: 77A-85A
93. Gavaler JS, Arria AM. Increased susceptibility of women to alcoholic liver disease: artifactual or real? In: Hall P, editor. Alcoholic liver disease; pathology and pathogenesis. 2nd ed. London: Edward Arnold, 1995: 299-316
94. National Institute on Alcohol Abuse and Alcoholism. Alcohol alert no. 19: alcohol and the liver [PH 329]. Rockville (MD): The Institute, 1993
95. DeBakey SF, Stinson FS, Grant BF, et al. Surveillance report 41: liver cirrhosis mortality in the United States, 1970-93. Bethesda (MD): National Institute on Alcohol Abuse and Alcoholism, 1996
96. Grose RD, Nolan J, Dillon JF, et al. Exercise-induced left ventricular dysfunction in alcoholic and non-alcoholic cirrhosis. J Hepatol 1995; 22: 326-32
97. Kelbaek H, Rabol A, Brynjolf I, et al. Haemodynamic response to exercise in patients with alcoholic liver cirrhosis. Clin Physiol 1987; 7: 35-41
98. Wong F, Girgrah N, Graba J, et al. The cardiac response to exercise in cirrhosis. Gut 2001; 49: 268-75