Structural analysis of the bacterial HPr kinase/phosphorylase V267F mutant gives insights into the allosteric regulation mechanism of this bifunctional enzyme

Journal of Biological Chemistry

Volumn 282, Issue 48, 2007, Pages 34952-34957

  Chaptal, Vincent ^a,c   Vincent, Fanny ^a   Gueguen Chaignon, Virginie ^a   Monedero, Vicente ^b,d   Poncet, Sandrine ^b   Deutscher, Josef ^b   Nessler, Sylvie ^a   Morera, Solange ^a  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b CNRS   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CARBON; CATALYST ACTIVITY; CONFORMATIONS; PHOSPHORYLATION;

ALLOSTERIC REGULATION; BIFUNCTIONAL ENZYMES; DEPHOSPHORYLATION;

ENZYME KINETICS;

BACTERIAL ENZYME; PHOSPHORYLASE; PHOSPHOTRANSFERASE;

ALLOSTERISM; ARTICLE; BACTERIAL STRAIN; BACTERIUM MUTANT; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; LACTOBACILLUS CASEI; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; CARBON; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KINETICS; LACTOBACILLUS CASEI; MUTAGENESIS; MUTATION; PHOSPHATES; PHOSPHORYLASES; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; SPECTROMETRY, FLUORESCENCE;

BACTERIA (MICROORGANISMS); EUKARYOTA; LACTOBACILLUS CASEI; POSIBACTERIA;

EID: 36848999708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705979200     Document Type: Article

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