Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats

Behavioural Brain Research

Volumn 187, Issue 1, 2008, Pages 100-108

  Tait, David Scott ^a   Brown, Verity J ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

192 IgG saporin; Attentional set shifting; Basal forebrain; GABAergic; Ibotenic acid; Reversal learning

Indexed keywords

EXCITOTOXIN; IBOTENIC ACID; IMMUNOGLOBULIN G; IMMUNOTOXIN; IMMUNOTOXIN 192; SAPORIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION; BRAIN DAMAGE; CHOLINERGIC NERVE CELL; COMPARATIVE STUDY; CONTROLLED STUDY; FOOD; FOREBRAIN; LEARNING; MALE; MARMOSET; MONKEY; NONHUMAN; ODOR; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; RAT; REWARD; STIMULUS; TASK PERFORMANCE;

ANIMALS; ANTIBODIES, MONOCLONAL; ATTENTION; CELL COUNT; CONDITIONING, OPERANT; CUES; DATA INTERPRETATION, STATISTICAL; DISCRIMINATION LEARNING; EXCITATORY AMINO ACID AGONISTS; GAMMA-AMINOBUTYRIC ACID; IBOTENIC ACID; MALE; ODORS; PARASYMPATHETIC NERVOUS SYSTEM; PROSENCEPHALON; PSYCHOMOTOR PERFORMANCE; RATS; REVERSAL LEARNING; RIBOSOME INACTIVATING PROTEINS, TYPE 1; STEREOTAXIC TECHNIQUES; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 36749100867     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.08.035     Document Type: Article

References (31)

1. Barcelo F., and Knight R.T. Both random and perseverative errors underlie WCST deficits in prefrontal patients. Neuropsychologia 40 (2002) 349-356
2. Birrell J.M., and Brown V.J. Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20 (2000) 4320-4324
3. Book A.A., Wiley R.G., and Schweitzer J.B. 192 IgG-saporin: I. Specific lethality for cholinergic neurons in the basal forebrain of the rat. J Neuropathol Exp Neurol 53 (1994) 95-102
4. Burk J.A., and Sarter M. Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. Neuroscience 105 (2001) 899-909
5. Cabrera S.M., Chavez C.M., Corley S.R., Kitto M.R., and Butt A.E. Selective lesions of the nucleus basalis magnocellularis impair cognitive flexibility. Behav Neurosci 120 (2006) 298-306
6. Carnes K.M., Fuller T.A., and Price J.L. Sources of presumptive glutamatergic/aspartatergic afferents to the magnocellular basal forebrain in the rat. J Comp Neurol 302 (1990) 824-852
7. Chen K.C., Baxter M.G., and Rodefer J.S. Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set-shifting. Eur J Neurosci 20 (2004) 1081-1088
8. Chudasama Y., and Robbins T.W. Dissociable contributions of the orbitofrontal and infralimbic cortex to pavlovian autoshaping and discrimination reversal learning: further evidence for the functional heterogeneity of the rodent frontal cortex. J Neurosci 23 (2003) 8771-8780
9. Clarke H.F., Dalley J.W., Crofts H.S., Robbins T.W., and Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion. Science 304 (2004) 878-880
10. Dias R., Robbins T.W., and Roberts A.C. Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380 (1996) 69-72
11. Dunnett S.B., Whishaw I.Q., Jones G.H., and Bunch S.T. Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats. Neuroscience 20 (1987) 653-669
12. Everitt B.J., and Robbins T.W. Central cholinergic systems and cognition. Annu Rev Psychol 48 (1997) 649-684
13. Fine A., Hoyle C., Maclean C.J., Levatte T.L., Baker H.F., and Ridley R.M. Learning impairments following injection of a selective cholinergic immunotoxin, ME20.4 IgG-saporin, into the basal nucleus of Meynert in monkeys. Neuroscience 81 (1997) 331-343
14. Gaykema R.P., van Weeghel R., Hersh L.B., and Luiten P.G. Prefrontal cortical projections to the cholinergic neurons in the basal forebrain. J Comp Neurol 303 (1991) 563-583
15. Gritti I., Mainville L., and Jones B.E. Codistribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat. J Comp Neurol 329 (1993) 438-457
16. Gritti I., Mainville L., Mancia M., and Jones B.E. GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat. J Comp Neurol 383 (1997) 163-177
17. Johnson D.A., Zambon N.J., and Gibbs R.B. Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm. Brain Res 943 (2002) 132-141
18. Maes J.H., Damen M.D., and Eling P.A. More learned irrelevance than perseveration errors in rule shifting in healthy subjects. Brain Cogn 54 (2004) 201-211
19. Manns I.D., Alonso A., and Jones B.E. Rhythmically discharging basal forebrain units comprise cholinergic, GABAergic, and putative glutamatergic cells. J Neurophysiol 89 (2003) 1057-1066
20. Manns I.D., Mainville L., and Jones B.E. Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex. Neuroscience 107 (2001) 249-263
21. McAlonan K., and Brown V.J. Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat. Behav Brain Res 146 (2003) 97-103
22. McGaughy J., Kaiser T., and Sarter M. Behavioral vigilance following infusions of 192-IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density. Behav Neurosci 110 (1996) 247-265
23. Muir J.L., Everitt B.J., and Robbins T.W. Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology (Berl) 118 (1995) 82-92
24. Page K.J., Everitt B.J., Robbins T.W., Marston H.M., and Wilkinson L.S. Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: differential dependence on cholinergic neuronal loss. Neuroscience 43 (1991) 457-472
25. Pang K.C., and Nocera R. Interactions between 192-IgG-saporin and intraseptal cholinergic and GABAergic drugs: role of cholinergic medial septal neurons in spatial working memory. Behav Neurosci 113 (1999) 265-275
26. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 4th ed. (1998), Academic Press, San Diego
27. Roberts A.C., Robbins T.W., Everitt B.J., and Muir J.L. A specific form of cognitive rigidity following excitotoxic lesions of the basal forebrain in marmosets. Neuroscience 47 (1992) 251-264
28. Sarter M., Bruno J.P., and Givens B. Attentional functions of cortical cholinergic inputs: what does it mean for learning and memory?. Neurobiol Learn Mem 80 (2003) 245-256
29. Tzavos A., Jih J., and Ragozzino M.E. Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning. Behav Brain Res 154 (2004) 245-253
30. Wrenn C.C., and Wiley R.G. The behavioral functions of the cholinergic basal forebrain: lessons from 192-IgG-saporin. Int J Dev Neurosci 16 (1998) 595-602
31. Zaborszky L., Gaykema R.P., Swanson D.J., and Cullinan W.E. Cortical input to the basal forebrain. Neuroscience 79 (1997) 1051-1078