Acute liver failure in two patients with regular alcohol consumption ingesting paracetamol at therapeutic dosage

Digestion

Volumn 75, Issue 4, 2007, Pages 232-237

  Krähenbühl, Stephan ^a   Brauchli, Yolanda ^a   Kummer, Oliver ^a   Bodmer, Michael ^a   Trendelenburg, Marten ^a   Drewe, Jürgen ^a   Haschke, Manuel ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Acetaminophen, therapeutic dosage; Alcohol; Liver failure, risk factors; Paracetamol

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; LACTULOSE; PARACETAMOL;

AGED; ALCOHOL CONSUMPTION; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; HOSPITALIZATION; HUMAN; LIVER FAILURE; MALE; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR;

ACETAMINOPHEN; AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; ANALGESICS, NON-NARCOTIC; FEMALE; HUMANS; LIVER FAILURE, ACUTE; MALE;

EID: 36749032693     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111032     Document Type: Article

References (41)

1. Garcia Rodriguez LA, Hernandez-Diaz S: Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology 2001;12:570-576.
2. Lewis SC, Langman MJ, Laporte JR, Matthews JN, Rawlins MD, Wiholm BE: Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: A meta-analysis based on individual patient data. Br J Clin Pharmacol 2002;54:320-326.
3. Perneger TV, Whelton PK, Klag MJ: Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med 1994;331:1675-1679.
4. Graham GG, Scott KF, Day RO: Tolerability of paracetamol. Drugs 2003;63(Spec No 2):43-46.
5. Temple AR, Benson GD, Zinsenheim JR, Schweinle JE: Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (6-12 months) safety of acetaminophen in adult patients with osteoarthritis. Clin Ther 2006;28:222-235.
6. Prescott LF: Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs 1983;25:290-314.
7. Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiodt FV, Ostapowicz G, Shakil AO, Lee WM: Acetaminophen-induced acute liver failure: Results of a united states multicenter, prospective study. Hepatology 2005;42:1364-1372.
8. Zimmerman HJ, Maddrey WC: Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure. Hepatology 1995;22:767-773.
9. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B: Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology 1994;19:1141-1148.
10. Crippin JS: Acetaminophen hepatotoxicity: potentiation by isoniazid. Am J Gastroenterol 1993;88:590-592.
11. Denison H, Kaczynski J, Wallerstedt S: Paracetamol medication and alcohol abuse: A dangerous combination for the liver and the kidney. Scand J Gastroenterol 1987;22:701-704.
12. Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA: Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen. Arch Intern Med 1985;145:2019-2023.
13. Kronenberg A, Krähenbühl S, Zimmermann A, Streuli R: Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage (in German). Schweiz Rundsch Med Prax 1998;87:1356-1360.
14. Kurtovic J, Riordan SM: Paracetamol-induced hepatotoxicity at recommended dosage. J Intern Med 2003;253:240-243.
15. Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB: Acetaminophen hepatotoxicity in alcoholics. A therapeutic mis-adventure. Ann Intern Med 1986;104:399-404.
16. Suchin SM, Wolf DC, Lee Y, Ramaswamy G, Sheiner PA, Facciuto M, Marvin MR, Kim-Schluger L, Lebovics E: Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation. Dig Dis Sci 2005;50:1836-1838.
17. Whitcomb DC, Block GD: Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 1994;272:1845-1850.
18. Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC: Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: A randomized controlled trial. JAMA 2006;296:87-93.
19. de Morais SM, Uetrecht JP, Wells PG: Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome. Gastroenterology 1992;102:577-586.
20. Prescott LF: Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000;49:291-301.
21. Rumack BH: Acetaminophen misconceptions. Hepatology 2004;40:10-15.
22. Girre C, Lucas D, Hispard E, Menez C, Dally S, Menez JF: Assessment of cytochrome p4502e1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. Biochem Pharmacol 1994;47:1503-1508.
23. Oneta CM, Lieber CS, Li J, Ruttimann S, Schmid B, Lattmann J, Rosman AS, Seitz HK: Dynamics of cytochrome p4502e1 activity in man: Induction by ethanol and disappearance during withdrawal phase. J Hepatol 2002;36:47-52.
24. Perrot N, Nalpas B, Yang CS, Beaune PH: Modulation of cytochrome p450 isozymes in human liver, by ethanol and drug intake. Eur J Clin Invest 1989;19:549-555.
25. Dahlin DC, Miwa GT, Lu AY, Nelson SD: N-acetyl-p-benzoquinone imine: a cytochrome p-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA 1984;81:1327-1331.
26. Esterline RL, Ray SD, Ji S: Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Biochem Pharmacol 1989;38:2387-2390.
27. Ramsay RR, Rashed MS, Nelson SD: In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria. Arch Biochem Biophys 1989;273:449-457.
28. Jaeschke H: How relevant are neutrophils for acetaminophen hepatotoxicity? Hepatology 2006;43:1191-1194.
29. Kon K, Kim JS, Jaeschke H, Lemasters JJ: Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 2004;40:1170-1179.
30. Lawson JA, Farhood A, Hopper RD, Bajt ML, Jaeschke H: The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 2000;54:509-516.
31. Liu ZX, Han D, Gunawan B, Kaplowitz N: Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 2006;43:1220-1230.
32. Scaffidi P, Misteli T, Bianchi ME: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-195.
33. Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF: Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: Comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos 2007;35:1223-1231.
34. Slattery JT, Wilson JM, Kalhorn TF, Nelson SD: Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther 1987;41:413-418.
35. Price VF, Jollow DJ: Mechanism of decreased acetaminophen glucuronidation in the fasted rat. Biochem Pharmacol 1988;37:1067-1075.
36. Court MH, Duan SX, von Moltke LL, Greenblatt DJ, Patten CJ, Miners JO, Mackenzie PI: Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 2001;299:998-1006.
37. Roberts BJ, Song BJ, Soh Y, Park SS, Shoaf SE: Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem 1995;270:29632-29635.
38. Caro AA, Cederbaum AI: Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004;44:27-42.
39. Lauterburg BH, Velez ME: Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988;29:1153-1157.
40. Slattery JT, Nelson SD, Thummel KE: The complex interaction between ethanol and acetaminophen. Clin Pharmacol Ther 1996;60:241-246.
41. Thummel KE, Slattery JT, Nelson SD: Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen. J Pharmacol Exp Ther 1988;245:129-136.