Potentiation of acetaminophen hepatotoxicity by phenytoin, leading to liver transplantation

Digestive Diseases and Sciences

Volumn 50, Issue 10, 2005, Pages 1836-1838

  Suchin, Scott M ^a   Wolf, David C ^a   Lee, Young ^a   Ramaswamy, Gita ^a   Sheiner, Patricia A ^a   Facciuto, Marcelo ^a   Marvin, Michael R ^a   Kim Schluger, Leona ^a   Lebovics, Edward ^a  

^a NONE

Author keywords

Acetaminophen; Fulminant hepatic failure; Liver transplant; Phenytoin

Indexed keywords

ACETYLCYSTEINE; PARACETAMOL; PHENYTOIN;

ADULT; ANAMNESIS; ARTICLE; CASE REPORT; DRUG BLOOD LEVEL; DRUG OVERDOSE; DRUG POTENTIATION; HUMAN; INGESTION; LABORATORY TEST; LIVER FAILURE; LIVER TOXICITY; LIVER TRANSPLANTATION; MALE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SEIZURE; SUICIDE ATTEMPT;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; ANTICONVULSANTS; DRUG SYNERGISM; HUMANS; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; MALE; PHENYTOIN;

EID: 26244468998     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2947-4     Document Type: Article

References (7)

1. Rumack BH, Matthew H: Acetaminophen poisoning and toxicity. Pediatrics 55:871-876, 1975
2. Rumack BH: Acetaminophen hepatotoxicity: The first 35 years. Clin Toxicol 20:3-20, 2002
3. Bray GP, Harrison PM, O'Grady JG, Tredger JM, Williams R: Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum Exp Toxicol 11:265-270, 1992
4. Minton NA, Henry JA, Frankel RJ: Fatal paracetamol poisoning in an epileptic. Hum Toxicol 7:33-34, 1988
5. McClements BM, Hyland M, Callender, ME, Blair TL: Management of paracetamol poisoning complicated by enzyme induction due to alcohol or drugs. Lancet 335:1526, 1990
6. Schiodt FV, Atillasoy E, Shakil AO, Schiff ER, Caldwell C, Kowdley KV, Stribling R, Crippin JS, Flamm S, Somberg KA, Rosen H, McCashland TM, Hay JE, Lee WM: Etiology and outcome for 295 patients with acute liver failure in the United States. Liver Transplant Surg 5:29-34, 1999
7. Perucca E, Richens A: Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs. Br J Clin Pharmacol 7:201-206, 1979