An SNP in the goat CSN2 promoter region is associated with the absence of β-casein in milk

Animal Genetics

Volumn 38, Issue 6, 2007, Pages 655-658

  Cosenza, G ^a   Pauciullo, A ^a   Colimoro, L ^a   Mancusi, A ^a   Rando, A ^b   Di Berardino, D ^a   Ramunno, L ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

Author keywords

casein; Goat; Null allele; Promoter; SNP

Indexed keywords

CASEIN;

ANIMAL; ARTICLE; CHEMISTRY; FEMALE; GENETICS; GENOTYPE; GOAT; METABOLISM; MILK; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BASE SEQUENCE; CASEINS; DNA MUTATIONAL ANALYSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GENOTYPE; GOATS; MILK; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS);

CAPRA HIRCUS;

EID: 36749021688     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2007.01649.x     Document Type: Article

References (20)

1. Caroli A., Chiatti F., Chessa S., Rignanese D., Bolla P. Pagnacco G. (2006) Focusing on the goat casein complex. Journal of Dairy Science 89, 3178 87.
2. Chianese L., Garro G., Nicolai M.A. et al. (1993) The nature of β-casein heterogeneity in caprine milk. Lait 73, 533 47.
3. Cosenza G., Pauciullo A., Gallo D., Di Berardino D. Ramunno L. (2005) A SspI PCR-RFLP detecting a silent allele at the goat CSN2 locus. Journal of Dairy Research 72, 456 9.
4. Cunsolo V., Galliano F., Muccilli V., Saletti R., Marletta D., Bordonaro S. Foti S. (2005) Detection and characterization by high-performance liquid chromatography and mass spectrometry of a goat β-casein associated with a CSN2 null allele. Rapid Communications in Mass Spectrometry: RCM 19, 2943 9.
5. van Eenennaam A.L. Medrano J.F. (1991) Differences in allelic protein expression in the milk of heterozygous κ-casein cows. Journal of Dairy Science 74, 1491 6.
6. Galliano F., Saletti R., Cunsolo V., Foti S., Marletta D., Bordonaro S. D'Urso G. (2004) Identification and characterization of a new β-casein variant in goat milk by high-performance liquid chromatography with electrospray ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry. Rapid Communications in Mass Spectrometry: RCM 18, 1972 82.
7. Goossens M. Kan Y.W. (1981) DNA analysis in the diagnosis of hemoglobin disorders. Methods in Enzymology 76, 805 17.
8. Grosclaude F., Mahé M.F., Brignon G., Di Stasio L. Jeunet R. (1987) A Mendelian polymorphism underlying quantitative variations of goat αs1-casein. Genetics Selection Evolution 19, 399 412.
9. Kuss A.W., Gogol J., Bartenschlager H. Geldermann H. (2005) Polymorphic AP-1 binding site in bovine CSN1S1 shows quantitative differences in protein binding associated with milk protein expression. Journal of Dairy Science 88, 2246 52.
10. Mahé M.F. Grosclaude F. (1993) Polymorphism of β-casein in the Creole goat of Guadeloupe: evidence for a null allele. Genetics Selection Evolution 21, 127 9.
11. Martin P., Szymanowska M., Zwierzchowski L. Leroux C. (2002) The impact of genetic polymorphisms on the protein composition of ruminant milks. Reproduction, Nutrition, Development 42, 433 59.
12. Neveu C., Mollé D., Moreno J., Martin P. Léonil J. (2002) Heterogeneity of Caprine beta-casein elucidated by RP-HPLC/MS: genetic variants and phosphorylations. Journal of Protein Chemistry 21, 557 67.
13. Pappalardo M., Rando A., Di Gregorio P., Masina P. Ramunno L. (1997) A MseI RFLP in the 5′ DNA region of the goat β-casein gene. Animal Genetics 28, 242.
14. Persuy M.A., Printz C., Medrano J.F. Mercier J.C. (1999) A single nucleotide deletion resulting in a premature stop codon is associated with marked reduction of transcripts from a goat β-casein null allele. Animal Genetics 30, 444 51.
15. Prinzenberg E.M., Weimann C., Brandt H., Bennewitz J., Kalm E., Schwerin M. Erhardt G. (2003) Polymorphism of the bovine CSN1S1 promoter: linkage mapping, intragenic haplotypes, and effects on milk production traits. Journal of Dairy Science 86, 2696 705.
16. Ramunno L., Mariani P., Pappalardo M., Rando A., Capuano M., Di Gregorio P. Cosenza G. (1995) Un gene ad effetto maggiore sul contenuto di caseina β nel latte di capra. Proceedings XI Congress National Scientific Association of Animal Production (ASPA), 185 6.
17. Ramunno L., Cosenza G., Rando A., Pauciullo A., Illario R., Gallo D., Di Berardino D. Masina P. (2005) Comparative analysis of gene sequence of goat CSN1S1 F and N alleles and characterization of CSN1S1 transcript variants in mammary gland. Gene 345, 289 99.
18. Rijnkels M. (2002) Multispecies comparison of the casein gene loci and evolution of casein gene family. Journal of Mammary Gland Biology and Neoplasia 7, 327 45.
19. Roberts B., Di Tullio P., Vitale J., Hehir K. Gordon K. (1992) Cloning of the goat β-casein-encoding gene and expression in transgenic mice. Gene 121, 255 62.
20. Szymanowska M., Malewski T. Zwierzchowski L. (2004) Transcription factor binding to variable nucleotide sequences in 5′ flanking regions of bovine casein genes. International Dairy Journal 14, 103 15.