Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

Nature

Volumn 450, Issue 7170, 2007, Pages 731-735

  Gallo, Elena M ^a,b   Winslow, Monte M ^a,b,d   Canté Barrett, Kirsten ^a,b,e   Radermacher, Amy N ^a,b   Ho, Lena ^a,b   McGinnis, Lisa ^a,b   Iritani, Brian ^c   Neilson, Joel R ^a,b,d   Crabtree, Gerald R ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CALCINEURIN; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

ANTIBODY; APOPTOSIS; ENZYME; PEPTIDE; RODENT; SIGNAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FATE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; TRANSGENIC MOUSE;

MUS;

EID: 36749003787     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06305     Document Type: Article

References (28)

1. Palmer, E. Negative selection-clearing out the bad apples from the T-cell repertoire. Nature Rev. Immunol. 3, 383-391 (2003).
2. Starr, T. K., Jameson, S. C. & Hogquist, K. A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139-176 (2003).
3. Neilson, J. R., Winslow, M. M., Hur, E. M. & Crabtree, G. R. Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity 20, 255-266 (2004).
4. Cante-Barrett, K., Winslow, M. M. & Crabtree, G. R. Selective role of NFATc3 in positive selection of thymocytes. J. Immunol. 179, 103-110 (2007).
5. Alberola-Ila, J., Forbush, K. A., Seger, R., Krebs, E. G. & Perlmutter, R. M. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373, 620-623 (1995).
6. Costello, P. S., Nicolas, R. H., Watanabe, Y., Rosewell, I. & Treisman, R. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nature Immunol. 5, 289-298 (2004).
7. Fischer, A. M., Katayama, C. D., Pages, G., Pouyssegur, J. & Hedrick, S. M. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23, 431-443 (2005).
8. +) thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173, 323-332 (1991).
9. Fehling, H. J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 375, 795-798 (1995).
10. + stage are highly correlated in individual thymocytes. J. Exp. Med. 178, 1867-1875 (1993).
11. Penit, C. In vivo thymocyte maturation. BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model. J. Immunol. 137, 2115-2121 (1986).
12. Macian, F. et al. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109, 719-731 (2002).
13. Gallo, E. M., Cante-Barrett, K. & Crabtree, G. R. Lymphocyte calcium signaling from membrane to nucleus. Nature Immunol. 7, 25-32 (2006).
14. Iritani, B. M., Alberola-Ila, J., Forbush, K. A. & Perimutter, R. M. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors. Immunity 10, 713-722 (1999).
15. Aliahmad, P. et al. TOX provides a link between calcineurin activation and CD8 lineage commitment. J. Exp. Med. 199, 1089-1099 (2004).
16. Hogquist, K. A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994).
17. Hogquist, K. A. et al. Identification of a naturally occurring ligand for thymic positive selection. Immunity 6, 389-399 (1997).
18. Werlen, G., Hausmann, B. & Palmer, E. A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity. Nature 406, 422-426 (2000).
19. McNeil, L. K., Starr, T. K. & Hogquist, K. A. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc. Natl Acad. Sci. USA 102, 13574-13579 (2005).
20. Bouillet, P. et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415, 922-926 (2002).
21. + thymocytes. Nature 333, 742-746 (1988).
22. Baldwin, T. A., Sandau, M. M., Jameson, S. C. & Hogquist, K. A. The timing of TCR α expression critically influences T cell development and selection. J. Exp. Med. 202, 111-121 (2005).
23. Reynolds, L. F. et al. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J. Biol. Chem. 279, 18239-18246 (2004).
24. Purbhoo, M. A., Irvine, D. J., Huppa, J. B. & Davis, M. M. T cell killing does not require the formation of a stable mature immunological synapse. Nature Immunol. 5, 524-530 (2004).
25. 2+-dependent transcriptional induction of bim of cell death. J. Immunol. 176, 2299-2306 (2006).
26. Wei, M. L. & Cresswell, P. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature 356, 443-446 (1992).
27. Sturn, A., Quackenbush, J. & Trajanoski, Z. Genesis: cluster analysis of microarray data. Bioinformatics 18, 207-208 (2002).
28. Xanthoudakis, S. et al. An enhanced immune response in mice lacking the transcription factor NFAT1. Science 272, 892-895 (1996).