Conformational analysis of protein secondary structure during spray-drying of antibody/mannitol formulations

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 65, Issue 1, 2007, Pages 1-9

  Schüle, Stefanie ^a   Frieß, Wolfgang ^a   Bechtold Peters, Karoline ^b   Garidel, Patrick ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Circular dichroism; FTIR; Immunoglobulin; Mannitol; Spray drying

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; MANNITOL; PROTEIN;

ARTICLE; CHEMICAL BOND; CHROMATOGRAPHY; CIRCULAR DICHROISM; CORRELATION ANALYSIS; DRUG CONFORMATION; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; HYDROGEN BOND; INFRARED SPECTROSCOPY; LIQUID; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SPRAY DRYING; STRESS; STRUCTURE ANALYSIS; TEMPERATURE;

CHEMISTRY, PHARMACEUTICAL; CIRCULAR DICHROISM; DESICCATION; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; IMMUNOGLOBULIN G; MANNITOL; NEPHELOMETRY AND TURBIDIMETRY; POWDERS; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; WATER;

EID: 36649033018     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.08.014     Document Type: Article

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