The relationship between body composition and bone mineral content: Threshold effects in a racially and ethnically diverse group of men

Osteoporosis International

Volumn 19, Issue 1, 2008, Pages 29-38

  Travison, T G ^a   Araujo, A B ^a   Esche, G R ^a   McKinlay, J B ^a  

^a NEW ENGLAND RESEARCH INSTITUTES   (United States)

Author keywords

Aging; Bone; Bone densitometry; Epidemiology; Population studies

Indexed keywords

ADULT; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BONE MINERAL; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC GROUP; FEMUR NECK; HISPANIC; HUMAN; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; RACE DIFFERENCE; WAIST CIRCUMFERENCE;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; BODY COMPOSITION; BONE DENSITY; BOSTON; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMUR NECK; HISPANIC AMERICANS; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; RADIUS;

EID: 36649003507     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-007-0431-z     Document Type: Article

References (55)

1. National Institutes of Health (2001) Osteoporosis prevention, diagnosis, and therapy. National Institutes of Health Consensus Development Conference Statement. Jama 285:785-795
2. Amin S (2003) Male osteoporosis: epidemiology and pathophysiology. Curr Osteoporos Rep 1:71-77
3. Amin S, Felson, DT (2001) Osteoporosis in men. Rheum Dis Clin North Am 27:19-47
4. Wright VJ (2006) Osteoporosis in men. J Am Acad Orthop Surg 14:347-353
5. George A, Tracy JK, Meyer WA, Flores RH, Wilson PD, Hochberg MC (2003) Racial differences in bone mineral density in older men. J Bone Miner Res 18:2238-2244
6. Henry YM, Eastell R (2000) Ethnic and gender differences in bone mineral density and bone turnover in young adults: effect of bone size. Osteoporos Int 11:512-517
7. Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, Johnston CC Jr, Lindsay R (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468-489
8. Tracy JK, Meyer WA, Flores RH, Wilson PD, Hochberg MC (2005) Racial differences in rate of decline in bone mass in older men: the Baltimore men's osteoporosis study. J Bone Miner Res 20:1228-1234
9. Tracy JK, Meyer WA, Grigoryan M, Fan B, Flores RH, Genant HK, Resnik C, Hochberg MC (2006) Racial differences in the prevalence of vertebral fractures in older men: the Baltimore Men's Osteoporosis Study. Osteoporos Int 17:99-104
10. Seeman E, Bianchi G, Khosla S, Kanis JA, Orwoll E (2006) Bone fragility in men - where are we? Osteoporos Int
11. Heaney RP (1995) Bone mass, the mechanostat, and ethnic differences. J Clin Endocrinol Metab 80:2289-2290
12. Cauley JA (2002) The determinants of fracture in men. J Musculoskelet Neuronal Interact 2:220-221
13. Araujo AB, Travison TG, Harris SS, Holick MF, Turner AK, McKinlay JB (2007) Race/ethnic differences in bone mineral density in men. Osteoporos Int [Epub ahead of print]
14. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR (2005) Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 26:557-568
15. Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, Johnston CC Jr, Lindsay R (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468-489
16. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K (2005) Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials 26:569-585
17. Cauley JA, Fullman RL, Stone KL, Zmuda JM, Bauer DC, Barrett-Connor E, Ensrud K, Lau EM, Orwoll ES (2005) Factors associated with the lumbar spine and proximal femur bone mineral density in older men. Osteoporos Int 16:1525-1537
18. Coin A, Sergi G, Beninca P, Lupoli L, Cinti G, Ferrara L, Benedetti G, Tomasi G, Pisent C, Enzi G (2000) Bone mineral density and body composition in underweight and normal elderly subjects. Osteoporos Int 11:1043-1050
19. Edelstein SL, Barrett-Connor E (1993) Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol 138:160-169
20. Huuskonen J, Vaisanen SB, Kroger H, Jurvelin C, Bouchard C, Alhava E, Rauramaa R (2000) Determinants of bone mineral density in middle aged men: a population-based study. Osteoporos Int 11:702-708
21. Kirchengast S, Peterson B, Hauser G, Knogler W (2001) Body composition characteristics are associated with the bone density of the proximal femur end in middle- and old-aged women and men. Maturitas 39:133-145
22. Reid IR (2002) Relationships among body mass, its components, and bone. Bone 31:547-555
23. De Laet C, Kanis JA, Oden A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A (2005) Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 16:1330-1338
24. Bakhireva LN, Barrett-Connor E, Kritz-Silverstein D, Morton DJ (2004) Modifiable predictors of bone loss in older men: a prospective study. Am J Prev Med 26:436-442
25. Ensrud KE, Fullman RL, Barrett-Connor E, Cauley JA, Stefanick ML, Fink HA, Lewis CE, Orwoll E (2005) Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study. J Clin Endocrinol Metab 90:1998-2004
26. Hannan MT, Felson DT, Dawson-Hughes B, Tucker KL, Cupples LA, Wilson PW, Kiel DP (2000) Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 15:710-720
27. Bakker I, Twisk JW, Van Mechelen W, Kemper HC (2003) Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women. J Clin Endocrinol Metab 88:2607-2613
28. Capozza RF, Cointry GR, Cure-Ramirez P, Ferretti JL, Cure-Cure C (2004) A DXA study of muscle-bone relationships in the whole body and limbs of 2512 normal men and pre- and post-menopausal women. Bone 35:283-295
29. Ferretti JL, Capozza RF, Cointry GR, Garcia SL, Plotkin H, Alvarez Filgueira ML, Zanchetta JR (1998) Gender-related differences in the relationship between densitometric values of whole-body bone mineral content and lean body mass in humans between 2 and 87 years of age. Bone 22:683-690
30. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X (2006) Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr 83:146-154
31. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW (2007) Relationship of obesity with osteoporosis. J Clin Endocrinol Metab 92:1640-1646
32. Reid IR, Plank LD, Evans MC (1992) Fat mass is an important determinant of whole body bone density in premenopausal women but not in men. J Clin Endocrinol Metab 75:779-782
33. Lim S, Joung H, Shin CS, Lee HK, Kim KS, Shin EK, Kim HY, Lim MK, Cho SI (2004) Body composition changes with age have gender-specific impacts on bone mineral density. Bone 35:792-798
34. Taaffe DR, Cauley JA, Danielson M, Nevitt MC, Lang TF, Bauer DC, Harris TB (2001) Race and sex effects on the association between muscle strength, soft tissue, and bone mineral density in healthy elders: the Health, Aging, and Body Composition Study. J Bone Miner Res 16:1343-1352
35. Van Langendonck L, Claessens AL, Lefevre J, Thomis M, Philippaerts R, Delvaux K, Lysens R, Vanden Eynde B, Beunen G (2002) Association between bone mineral density (DXA), body structure, and body composition in middle-aged men. Am J Hum Biol 14:735-742
36. Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd (1996) Relationship between body composition and bone mass in women. J Bone Miner Res 11:857-863
37. Stewart KJ, Deregis JR, Turner KL, Bacher AC, Sung J, Hees PS, Tayback M, Ouyang P (2002) Fitness, fatness and activity as predictors of bone mineral density in older persons. J Intern Med 252:381-388
38. Pluijm SM, Visser M, Smit JH, Popp-Snijders C, Roos JC, Lips P (2001) Determinants of bone mineral density in older men and women: body composition as mediator. J Bone Miner Res 16:2142-2151
39. Ravn P, Cizza G, Bjarnason NH, Thompson D, Daley M, Wasnich RD, McClung M, Hosking D, Yates AJ, Christiansen C (1999) Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res 14:1622-1627
40. Wang MC, Bachrach LK, Van Loan M, Hudes M, Flegal KM, Crawford PB (2005) The relative contributions of lean tissue mass and fat mass to bone density in young women. Bone 37:474-481
41. Wu F, Ames R, Clearwater J, Evans MC, Gamble G, Reid IR (2002) Prospective 10-year study of the determinants of bone density and bone loss in normal postmenopausal women, including the effect of hormone replacement therapy. Clin Endocrinol (Oxf) 56:703-711
42. McKinlay JB, Link, CL (2007 [Epub ahead of print]) Measuring the Urologic Iceberg: Design and Implementation of The Boston Area Community Health (BACH) Survey. Eur Urol
43. Washburn RA, McAuley E, Katula J, Mihalko SL, Boileau RA (1999) The physical activity scale for the elderly (PASE): evidence for validity. J Clin Epidemiol 52:643-651
44. Reuben DB, Siu AL (1990) An objective measure of physical function of elderly outpatients. The Physical Performance Test. J Am Geriatr Soc 38:1105-1112
45. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:M85-94
46. Wallman K (1997) Data on race and ethnicity: Revising the federal standard. Am Stat 31-35
47. Kish L (1965) Sampling Organizations And Groups Of Unequal Sizes. Am Sociol Rev 30:564-572
48. Hastie TJ, Tibshurani, RJ (1990) Generalized additive models. Chapman and Hall/CRC, Boca Raton
49. Chen Z, Lohman TG, Stini WA, Ritenbaugh C, Aickin M (1997) Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women? J Bone Miner Res 12:144-151
50. Frost HM (2003) Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 275:1081-1101
51. Frost HM (1996) Perspectives: a proposed general model of the "mechanostat" (suggestions from a new skeletal-biologic paradigm). Anat Rec 244:139-147
52. Seeman E (2001) Clinical review 137: Sexual dimorphism in skeletal size, density, and strength. J Clin Endocrinol Metab 86:4576-4584
53. Bolotin HH (2001) Inaccuracies inherent in dual-energy X-ray absorptiometry in vivo bone mineral densitometry may flaw osteopenic/ osteoporotic interpretations and mislead assessment of antiresorptive therapy effectiveness. Bone 28:548-555
54. Bolotin HH, Sievanen, H, Grashuis, JL (2003) Patient-specific DXA bone mineral density inaccuracies: quantitative effects of nonuniform extraosseous fat distributions. J Bone Miner Res 18:1020-1027
55. Morley JE (2006) Is weight loss harmful to older men? Aging Male 9:135-137