Bone fragility in men - Where are we?

Osteoporosis International

Volumn 17, Issue 11, 2006, Pages 1577-1583

  Seeman, E ^a   Bianchi, G ^b   Khosla, S ^c   Kanis, J A ^d   Orwoll, E ^e  

^a AUSTIN HEALTH   (Australia)

^b Mayo Clinic ^*  (Italy)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ALKALINE PHOSPHATASE BONE ISOENZYME; AMINO TERMINAL TELOPEPTIDE; BIOCHEMICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CARBOXY TERMINAL TELOPEPTIDE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; OSTEOCALCIN; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; RISEDRONIC ACID; TESTOSTERONE;

AGE DISTRIBUTION; AGING; ANDROGEN DEFICIENCY; BONE DENSITY; BONE FRAGILITY; BONE MINERAL; BONE REMODELING; BONE STRENGTH; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; ENZYME DEFICIENCY; FRACTURE; FRAGILITY FRACTURE; GENE DELETION; HEALTH ECONOMICS; HIP FRACTURE; HUMAN; INCIDENCE; MALE; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PREVALENCE; PRIORITY JOURNAL; PUBLIC HEALTH; QUALITY ADJUSTED LIFE YEAR; REVIEW; RISK FACTOR; SEX DIFFERENCE; VERTEBRA FRACTURE;

AGED; AGED, 80 AND OVER; FEMALE; FRACTURES, BONE; GONADAL STEROID HORMONES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; SEX DISTRIBUTION;

EID: 33749176102     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-006-0160-8     Document Type: Review

References (43)

1. Cooper C, Dennison EM, Leufkens HGM, Bishop N, Van Staa TP (2004) Epidemiology of childhood fractures in Britain: a study using the general practice research database. J Bone Miner Res 19:1976-1981
2. Johnell O, Kanis JA, Jonsson B, Oden A, Johansson H, De Laet C (2005) The burden of hospitalised fractures in Sweden. Osteoporos Int 16:222-228
3. Jiang HX, Majumdar SR, Dick DA, Moreau M, Raso J, Otto DD, Johnston DWC (2005) Development and initial validation of a risk score for predicting in-hospital and 1-year mortality in patients with hip fractures. J Bone Miner Res 20:494-500
4. Kanis JA, Oden A, Johnell O, De Laet C, Jonsson B, Oglesby AK (2003) The components of excess mortality after hip fracture. Bone 32:468-473
5. Khosla S, Lufkin EG, Hodgson SF, Fitzpatrick LA, Melton LJ (1994) Epidemiology and clinical-features of osteoporosis in young individuals. Bone 15:551-555
6. Orwoll ES, Klein RF (1995) Osteoporosis in men. Endocr Rev 16:87-116
7. Schuit SCE, van der Klift M, Weel AEAM, de Laet CEDH, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JPTM, Pols HAP (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34:195-202
8. Szulc P, Munoz F, Duboeuf F, Marchand F, Delmas PD (2005) Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study. Osteoporos Int 16:1184-1192
9. Sornay-Rendu E, Munoz F, Garnero P, Duboeuf F, Pierre D, Delmas PDD (2005) The identification of osteopenic women at high risk of fracture: the OFELY Study. J Bone Miner Res 20:1929-1943
10. Kanis JA, Johnell O, Oden A et al (2001) Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 12:989-995
11. Kanis JA, Oden A, Johnell O et al (2001) The burden of osteoporotic fractures: a method of setting intervention thresholds. Osteoporos Int 12:417-427
12. Kanis JA, Johnell O, Oden A et al (2005) Intervention thresholds for osteoporosis in men and women: a study based on data from Sweden. Osteoporos Int 16:6-14
13. Kanis JA, Borgstrom F, Zethraeus Z et al (2005) Intervention thresholds for osteoporosis in men and women. Bone 36:22-32
14. Duan Y, Turner CH, Kim BT, Seeman E (2001) Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res 16:2267-2274
15. Duan Y, Beck TJ, Wang X-F, Seeman E (2003) Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J Bone Miner Res 18:1766-1774
16. Wang XF, Duan Y, Beck T, Seeman ER (2005) Varying contributions of growth and ageing to racial and sex differences in femoral neck structure and strength in old age. Bone 36:978-986
17. Seeman E (2003) Periosteal bone formation - a neglected determinant of bone strength. New Eng J Med 349:320-323
18. Ahlborg HG Johnell O, Turner CH, Rannevik G, Karlsson MK (2003) Bone loss and bone size after the menopause. N Engl J Med 349:327-334
19. Ruff CB, Trinkaus E, Walker A, Larsen CS (1993) Postcranial robusticity in Homo. 1: temporal trends and mechanical interpretation. Am J Phys Anthropol 91:21-53
20. Balena R, Shih M-S, Parfitt (1992) Bone resorption and formation on the periosteal envelope of the ilium: a histomorphometric study in healthy women. J Bone Miner Res 7:1475-1482
21. Riggs BL, Melton LJ III, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S (2004) A population-based study of age and sex differences in bone volumetric density, size, geometry and structure at different skeletal sites. J Bone Miner Res 19:1945-1954
22. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ 3rd (2006) Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res 21:124-131
23. Aaron JE, Makins NB, Sagreiy K (1987) The microanatomy of trabecular bone loss in normal aging men and women. Clin Orth RR 215:260-271
24. Araujo AB, O'Donnell AB, Brambilla DJ, Simpson WB, Longcope C, Matsumoto AM, McKinlay JB (2004) Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts male aging study. J Clin Endocrinol Metab 89:5920-5926
25. Bouillon R, Bex M, Vanderschueren D, Boonen S (2004) Estrogens are essential for male pubertal periosteal bone expansion. J Clin Endocrinol Metab 89:6025-6029
26. Khosla S, Melton LJ, Riggs BL (2002) Estrogen and the male skeleton. J Clin Endocrinol Metab 87:1443-1450
27. Khosla S, Melton LJ, Atkinson EJ, O'Fallon WM (2001) Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men. J Clin Endocrinol Metab 86:3555-3561
28. Khosla S, Riggs BL, Robb RA, Camp JJ, Achenbach SJ, Oberg AL, Rouleau PA, Melton LJ III (2005) Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in men. J Clin Endocrinol Metab 90:5096-5103
29. Orwoll ES (2003) Toward an expanded understanding of the role of the periosteum in skeletal helath. J Bone Miner Res 18:949-954
30. Sims NA, Dupont S, Krust A, Clement-LaCroix P, Minet D, Resche-Rigon M, Gaillard Kelly M, Baron R (2002) Deletion of estrogen receptors reveals a regulatory role for estrogen receptors beta in bone remodeling in females but not in males. Bone 30:18-25
31. Sims NA, Clement-Lacroix P, Minet D, Fraslon-Vanhulle C, Gaillard-Kelly M, Resche-Rigon M, Baron R (2003) A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest 111:1319-1327
32. Szulc P, Garnero P, Marchand F, Duboeuf F, Delmas PD (2005) Biochemical markers of bone formation reflect endosteal bone loss in elderly men-MINOS study. Bone 36:13-21
33. Meier C, Nguyen TV, Center JR, Seibel MJ, Eisman JA (2005) Bone resorption and osteoporotic fractures in elderly men: the Dubbo Osteoporosis Epidemiology Study. J Bone Miner Res 20:579-587
34. Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, Adami S, Weber K, Lorenc R, Pietschmann P, Vandormael K, Lombardi A (2000) Alendronate for the treatment of osteoporosis in men. N Engl J Med 343:604-610
35. Sato Y, Iwamoto J, Kanoko T, Satoh K (2005) Risedronate sodium therapy for prevention of hip fracture in men 65 years or older after stroke. Arch Intern Med 165:1743-1748
36. Ringe JD, Faber H, Farahmand P, Dorst A (2005) Efficacy of risedronate in men with primary and secondary osteoporosis: results of a 1-year study. Rheumatol Int 7:1-5
37. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP (2000) Therapy of idiopathic osteoporosis in men with parathyroid hormone: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 85:3069-3076
38. Orwoll ES, Scheele WH, Paul S, Adami S, Syversen U, Diez-Perez A, Kaufman J-M, Clancy AD, Gaich GA (2003) The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Min Res 18:9-17
39. Kaufman J-M, Orwoll E, Goemaere S, San Martin J, Hossain A, Dalsky GP, Lindsay R, Mitlak BH (2005) Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy. Osteoporos Int 16:510-516
40. Finkelstein JS, Hayes A, Hunzelman JL, Wyland JJ, Lee H, Neer RM (2003) The effects of parathyroid hormone, alendronate, or both in men with osteoporosis. N Engl J Med 349:1216-1226
41. Kurland ES, Heller SL, Diamond B, McMahon DJ, Cosman F, Bilezikian JP (2004) The importance of bisphosphonate therapy in maintaining bone mass in men after therapy with teriparatide [human parathyroid hormone(1-34)]. Osteoporos Int 15:992-997
42. Amory JK, Watts NB, Easley KA, Sutton PR, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL (2004) Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone. J Clin Endocrinol Metab 89:503-510
43. Snyder PJ, Peachey H, Hannoush P, Berlin JA, Loh L, Holmes JH, Dlewati A, Staley J, JSantanna J, Kapoor SC, Attie MF, Haddad JG Jr (1999) Strom BL Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 84:1966-1972