Transcription factor 3′,5′-cyclic adenosine 5′-monophosphate-responsive element-binding protein (CREB) is decreased during human adrenal cortex tumorigenesis and fetal development

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 8, 2003, Pages 3958-3965

  Rosenberg, Dan ^a,b   Groussin, Lionel ^a   Jullian, Eric ^a   Perlemoine, Karine ^a   Medjane, Samir ^a   Louvel, Albert ^c   Bertagna, Xavier ^a   Bertherat, Jérôme ^a,c  

^a INSTITUT COCHIN   (France)

^b ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^c CHU Cochin ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SOMATOMEDIN B; TRANSCRIPTION FACTOR;

ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX TUMOR; ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CUSHING SYNDROME; FEMALE; FETUS DEVELOPMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ADOLESCENT; ADRENAL CORTEX NEOPLASMS; ADULT; AGED; BLOTTING, WESTERN; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PREGNANCY; TUMOR CELLS, CULTURED;

EID: 0041882181     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030070     Document Type: Article

References (44)

1. Arola J, Heikkila P, Voutilainen R, Kahri AI 1993 Role of adenylate cyclase-cyclic AMP-dependent signal transduction in the ACTH-induced biphasic growth effect of rat adrenocortical cells in primary culture. J Endocrinol 139: 451-461
2. Spencer SJ, Mesiano S, Lee JY, Jaffe RB 1999 Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling. J Clin Endocrinol Metab 84:1110-1115
3. Arai M, Widmaier EP 1993 Steroidogenesis in isolated adrenocortical cells during development in rats. Mol Cell Endocrinol 92:91-97
4. Zuber MX, John ME, Okamura T, Simpson ER, Waterman MR 1986 Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence J Biol Chem 261:2475-2482
5. Lacroix A, Ndiaye N, Tremblay J, Hamet P 2001 Ectopic and abnormal hormone receptors in adrenal Cushing syndrome. Endocr Rev 22:75-110
6. Groussin L, Perlemoine K, Contesse V, Lefebvre H, Tabarin A, Thieblot P, Schlienger JL, Luton JP, Bertagna X, Bertherat J 2002 The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors. J Clin Endocrinol Metab 87:1980-1985
7. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM 1991 Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 325:1688-1695
8. Schwindinger WF, Francomano CA, Levine MA 1992 Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci USA 89:5152-5156
9. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA 2000 Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 26:89-92
10. Casey M, Vaughan CJ, He J, Hatcher CJ, Winter JM, Weremowicz S, Montgomery K, Kucherlapati R, Morton CC, Basson CT 2000 Mutations in the protein kinase A Rlalpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 106:R31-R38
11. Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J 2002 Mutations of the PRKAR1A gene in Cushing syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 87:4324-4329
12. Rosenberg D, Groussin L, Jullian E, Perlemoine K, Bertagna X, Bertherat J 2002 Role of the PKA-regulated transcription factor CREB in development and tumorigenesis of endocrine tissues. Ann N Y Acad Sci 968:65-74
13. Reusch JE, Klemm DJ 2002 Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis. J Biol Chem 277:1426-1432
14. Zhang F, Rincon M, Flavell RA, Aune TM 2000 Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. J Immunol 165:1762-1770
15. Nguyen LQ, Kopp P, Martinson F, Stanfield K, Roth SI, Jameson JL 2000 A dominant negative CREB (cAMP response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function. Mol Endocrinol 14:1448-1461
16. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR 1991 Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624
17. Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton JP, Girard F, Le Bouc Y 1994 Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors. J Clin Endocrinol Metab 78:1444-1453
18. Gicquel C, Raffin-Sanson ML, Gaston V, Bertagna X, Plouin PF, Schlumberger M, Louvel A, Luton JP, Le Bouc Y 1997 Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. J Clin Endocrinol Metab 82:2559-2565
19. Gicquel C, Bertagna X, Gaston V, Coste J, Louvel A, Baudin E, Bertherat J, Chapuis Y, Duclos JM, Schlumberger M, Plouin PF, Luton JP, Le Bouc Y 2001 Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors. Cancer Res 61:6762-6767
20. Mesiano S, Jaffe RB 1997 Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 18:378-403
21. Groussin L, Massias JF, Bertagna X, Bertherat J 2000 Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R. J Clin Endocrinol Metab 85: 345-354
22. Bertherat J, Chanson P, Montminy M 1995 The cyclic adenosine 3′, 5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol 9:777-783
23. Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR 1993 Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol 13:4852-4859
24. Deutsch PJ, Jameson JL, Habener JF 1987 Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem 262:12169-12174
25. Wang XL, Bassett M, Zhang Y, Yin S, Clyne C, White PC, Rainey WE 2000 Transcriptional regulation of human 11beta-hydroxylase (hCYP11B1). Endocrinology 141:3587-3594
26. Weiss LM 1984 Comparative histologic study of 43 metastasizing and non-metastasizing adrenocortical tumors. Am J Surg Pathol 8:163-169
27. Beuschlein F, Reincke M, Karl M, Travis WD, Jaursch-Hancke C, Abdelhamid S, Chrousos GP, Allolio B 1994 Clonal composition of human adrenocortical neoplasms. Cancer Res 54:4927-4932
28. Kjellman M, Kallioniemi OP, Karhu R, Hoog A, Farnebo LO, Auer G, Larsson C, Backdahl M 1996 Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy. Cancer Res 56:4219-4223
29. Gicquel C, Leblond-Francillard M, Bertagna X, Louvel A, Chapuis Y, Luton JP, Girard F, Le Bouc Y 1994 Clonal analysis of human adrenocortical carcinomas and secreting adenomas. Clin Endocrinol (Oxf) 40:465-477
30. Peri A, Luciani P, Conforti B, Baglioni-Peri S, Cioppi F, Crescioli C, Ferruzzi P, Gelmini S, Arnaldi G, Nesi G, Serio M, Mantero F, Mannelli M 2001 Variable expression of the transcription factors cAMP response element-binding protein and inducible cAMP early repressor in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. J Clin Endocrinol Metab 86:5443-5449
31. Mayr B, Montminy M 2001 Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2:599-609
32. Taylor CT, Furuta GT, Synnestvedt K, Colgan SP 2000 Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci USA 97:12091-12096
33. Watson PA, Nesterova A, Burant CF, Klemm DJ, Reusch JE 2001 Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration. J Biol Chem 276:46142-46150
34. Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP 1999 Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. J Biol Chem 274:19447-19454
35. Beitner-Johnson D, Rust RT, Hsieh T, Millhorn DE 2000 Regulation of CREB by moderate hypoxia in PC12 cells. Adv Exp Med Biol 475:143-152
36. Marnett LJ 2000 Oxyradicals and DNA damage. Carcinogenesis 21:361-370
37. Harris AL 2002 Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47
38. Coulter CL, Goldsmith PC, Mesiano S, Voytek CC, Martin MC, Han VK, Jaffe RB 1996 Functional maturation of the primate fetal adrenal in vivo: I. Role of insulin-like growth factors (IGFs), IGF-I receptor, and IGF binding proteins in growth regulation. Endocrinology 137:4487-4498
39. Boulle N, Logie A, Gicquel C, Perin L, Le Bouc Y 1998 Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors. J Clin Endocrinol Metab 83:1713-1720
40. Bourcigaux N, Gaston V, Logie A, Bertagna X, Le Bouc Y, Gicquel C 2000 High expression of cyclin E and G1 CDK and loss of function of p57KIP2 are involved in proliferation of malignant sporadic adrenocortical tumors. J Clin Endocrinol Metab 85:322-330
41. Houglum K, Lee KS, Chojkier M 1997 Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99:1322-1328
42. Reusch JE, Colton LA, Klemm DJ 2000 CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol 20:1008-1020
43. Stenzel-Poore MP, Cameron VA, Vaughan J, Sawchenko PE, Vale W 1992 Development of Cushing syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130:3378-3386
44. Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos GP, Allolio B 1997 Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab 82:3054-3058