Mechanisms of CCK signaling from gut to brain

Current Opinion in Pharmacology

Volumn 7, Issue 6, 2007, Pages 570-574

  Raybould, Helen E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; GHRELIN; LEPTIN; OREXIN;

BODY WEIGHT; DIET RESTRICTION; ENTERITIS; FAT INTAKE; FOOD INTAKE; GASTROINTESTINAL TRACT FUNCTION; HOMEOSTASIS; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; INCREASED APPETITE; INTESTINE INNERVATION; LIPID ABSORPTION; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SATIETY; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; STOMACH EMPTYING; VAGUS NERVE STIMULATION;

ANIMALS; BRAIN; CHOLECYSTOKININ; EATING; GASTROINTESTINAL TRACT; HUMANS; RECEPTORS, CHOLECYSTOKININ; SIGNAL TRANSDUCTION; VAGUS NERVE;

EID: 36549061906     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.09.006     Document Type: Review

References (35)

1. Dockray G.J. Gastrointestinal hormones: cholecystokinin, somatostatin and ghrelin. In: Johnson L.R. (Ed). Physiology of the Gastrointestinal Tract vol. 1 (2006), Elsevier Academic Press 91-120
2. Beyak M., Bulmer D.C.E., Jiang W., Keating C., Rong W., and Grundy D. Extrinsic sensory afferent nerves innervating the gastrointestinal tract. In: Johnson L.R. (Ed). Physiology of the Gastrointestinal Tract vol. 1 (2006), Elsevier Academic Press 685-726
3. Berthoud H.R., Blackshaw L.A., Brookes S.J., and Grundy D. Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract. Neurogastroenterol Motil 16 Suppl 1 (2004) 28-33
4. Strader A.D., and Woods S.C. Gastrointestinal hormones and food intake. Gastroenterology 128 (2005) 175-191
5. Raybould H.E., Glatzle J., Freeman S.L., Whited K., Darcel N., Liou A., and Bohan D. Detection of macronutrients in the intestinal wall. Auton Neurosci 30 (2006) 28-33
6. Moran T.H., and Kinzig K.P. Gastrointestinal satiety signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286 (2004) G183-G188
7. Little T.J., Horowitz M., and Feinle-Bisset C. Role of cholecystokinin in appetite control and body weight regulation. Obes Rev. 6 (2005) 297-306
8. Kopin A.S., Mathes W.F., McBride E.W., Nguyen M., Al-Haider W., Schmitz F., Bonner-Weir S., Kanarek R., and Beinborn M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103 (1999) 383-391
9. Bi S., Scott K.A., Kopin A.S., and Moran T.H. Differential roles for cholecystokinin A receptors in energy balance in rats and mice. Endocrinology 14 (2004) 3873-3880 Bi S
10. Chen J., Behles R.R., Hyun J., Kopin A.S., and Moran T.H. Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors. Am J Physiol Regul Integr Comp Physiol 293 (2007) R55-R63. This study compares CCK1R null mice with a strain of rat that is also deficient in the CCK1R but in contrast to the mice has an obese, hyperphagic phenotype. The authors show that the difference is due to difference in expression of NPY in the hypothalamus.
11. Whited K.L., Thao D., Lloyd K.C., Kopin A.S., and Raybould H.E. Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. Am J Physiol Gastrointest Liver Physiol 291 (2006) G156-G162
12. Wang D.Q., Schmitz F., Kopin A.S., and Carey M.C. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. J Clin Invest 114 (2004) 521-528
13. Donovan M, Paulino G, Raybould HE: CCK1 receptor is essential for normal meal patterning in mice fed high fat diet. Physiol Behav 2007 (in press). This study shows that CCK1R null mice have a decreased time to initiation of the first meal following a short fast; the mechanism is unclear but may involve altered expression of receptors for orexigenic peptides such as ghrelin or cannabinoids by vagal afferents occurring in the absence of CCK1R control.
14. Cummings D.E., and Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 117 (2007) 13-23
15. Peters J.H., Simasko S.M., and Ritter R.C. Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin. Physiol Behav 89 (2006) 477-485
16. Wang L., Barachina M.D., Martínez V., Wei J.Y., and Taché Y. Synergistic interaction between CCK and leptin to regulate food intake. Regul Pept 92 (2000) 79-85
17. Buyse M., Ovesjö M.L., Goïot H., Guilmeau S., Péranzi G., Moizo L., Walker F., Lewin M.J., Meister B., and Bado A. Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 14 (2001) 64-72
18. Burdyga G., Spiller D., Morris R., Lal S., Thompson D.G., Saeed S., Dimaline R., Varro A., and Dockray G.J. Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience 109 (2002) 339-347
19. Date Y., Murakami N., Toshinai K., Matsukura S., Niijima A., Matsuo H., Kangawa K., and Nakazato M. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123 (2002) 1120-1128
20. Burdyga G., Lal S., Spiller D., Jiang W., Thompson D., Attwood S., Saeed S., Grundy D., Varro A., Dimaline R., and Dockray G.J. Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 124 (2003) 129-139
21. Burdyga G., Lal S., Varro A., Dimaline R., Thompson D.G., and Dockray G.J. Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 24 (2004) 2708-2715. The first demonstration that the expression of receptor for an orexigenic peptide by vagal afferent neurons could be modulated by fasting and refeeding and that this response was dependent on the CCK1R.
22. Koda S., Date Y., Murakami N., Shimbara T., Hanada T., Toshinai K., Niijima A., Furuya M., Inomata N., Osuye K., and Nakazato M. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146 (2005) 2369-2375
23. Nakagawa A., Satake H., Nakabayashi H., Nishizawa M., Furuya K., Nakano S., Kigoshi T., Nakayama K., and Uchida K. Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Auton Neurosci 110 (2004) 36-43
24. Nelson D.W., Sharp J.W., Brownfield M.S., Raybould H.E., and Ney D.M. Localization and activation of glucagon-like peptide-2 receptors on vagal afferents in the rat. Endocrinology 148 (2007) 1954-1962
25. Burdyga G., Varro A., Dimaline R., Thompson D.G., and Dockray G.J. Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1289-G1297
26. Date Y., Toshinai K., Koda S., Miyazato M., Shimbara T., Tsuruta T., Niijima A., Kangawa K., and Nakazato M. Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 146 (2005) 3518-3525. Demonstration of a functional interaction between CCK and ghrelin in control of food intake.
27. Kobelt P., Tebbe J.J., Tjandra I., Stengel A., Bae H.G., Andresen V., van der Voort I.R., Veh R.W., Werner C.R., Klapp B.F., et al. CCK inhibits the orexigenic effect of peripheral ghrelin. Am J Physiol Regul Integr Comp Physiol 288 (2005) R751-R758
28. Savastano D.M., and Covasa M. Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats. J Nutr 135 (2005) 1953-1959. Comprehensive study of the mechanism by which maintenance of rats on high-fat, high-energy diets leads to a decrease in the sensitivity of the gut-brain axis to both dietary lipid and CCK. It is possible that this plays a role in exacerbating increased food intake and weight gain on a high-fat diet.
29. Little T.J., Horowitz M., and Feinle-Bisset C. Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity. Am J Clin Nutr 86 (2007) 531-541
30. Whited K.L., Tso P., and Raybould H.E. Involvement of apolipoprotein A-IV and CCK1 receptors in exogenous PYY3-36-induced stimulation of intestinal feedback. Endocrinology 148 (2007) 4695-4703
31. Talsania T., Anini Y., Siu S., Drucker D.J., and Brubaker P.L. Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice. Endocrinology 146 (2005) 3748-3756. Studies demonstrated that a long-acting synthetic GLP-1 receptor agonist, exendin, acts synergistically with PYY3-36 to inhibit food intake. The first demonstration that two short-term satiety peptides can interact to alter food intake.
32. Tracey K.J. Physiology and immunology of the cholinergic anti-inflammatory pathway. J Clin Invest 117 (2007) 289-296
33. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., and Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405 (2000) 458-462. First demonstration that stimulation of the efferent vagus nerve could decrease the release of inflammatory cytokines and improve symptoms in an experimental model of sepsis; the authors went on to show that this was mediated by a nicotinic, cholinergic receptor on macrphages.
34. Luyer M.D., Jacobs J.A., Vreugdenhil A.C., Hadfoune M., Dejong C.H., Buurman W.A., and Greve J.W. Enteral administration of high-fat nutrition before and directly after hemorrhagic shock reduces endotoxemia and bacterial translocation. Ann Surg 239 (2004) 257-264
35. Luyer M.D., Greve J.W., Hadfoune M., Jacobs J.A., Dejong C.H., and Buurman W.A. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med 202 (2005) 1023-1029. Studies provide evidence that the vagal cholinergic anti-inflammatory pathway can be activated by lipid in the intestine, via a CCK1R dependent pathway, presumably involving activation of vagal afferents.