Opposing effects of Arkadia and Smurf on TGFβ1-induced IgA isotype expression

Molecules and Cells

Volumn 24, Issue 2, 2007, Pages 283-287

  Choi, Seo Hyun ^a   Seo, Goo Young ^a   Nam, Eun Hee ^a   Jeon, Seong Hyun ^a   Kim, Hyun A ^a   Park, Jae Bong ^b   Kim, Pyeung Hyeun ^a  

^a Kangwon National University   (South Korea)

^b Hallym University   (South Korea)

Author keywords

Arkadia; IgA; Smad7; Smurf; TGF 1

Indexed keywords

IMMUNOGLOBULIN A; PROTEIN ARKADIA; PROTEIN SMURF1; PROTEIN SMURF2; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR RUNX3; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL LINE; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN A; MICE; MODELS, BIOLOGICAL; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SMAD PROTEINS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 36549046519     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Afrakhte, M., Moren, A., Jossan, S., Itoh, S., Sampath, K., et al. (1998) Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. Biochem. Biophys. Res. Commun. 249, 505-511.
2. Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., et al. (2001) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276, 12477-12480.
3. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., et al. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21. 1. Science 271, 350-353.
4. Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y. Y., et al. (1997) The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 89, 1165-1173.
5. Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., et al. (1997) Smad6 inhibits signalling by the TGF-beta superfamily. Nature 389, 622-626.
6. Jin, Y. H., Jeon, E. J., Li, Q. L., Lee, Y. H., Choi, J. K., et al. (2004) Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J. Biol. Chem. 279, 29409-29417.
7. Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., et al. (2000) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol. Cell 6, 1365-1375.
8. Kim, K. I. and Baek, S. H. (2006) SUMOylation code in cancer development and metastasis. Mol. Cells 22, 247-253.
9. Kinoshita, K., Harigai, M., Fagarasan, S., Muramatsu, M., and Honjo, T. (2001) A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs. Proc. Natl. Acad. Sci. USA 98, 12620-12623.
10. Koinuma, D., Shinozaki, M., Komuro, A., Goto, K., Saitoh, M., et al. (2003) Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7. EMBO. J. 22, 6458-6470.
11. Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massague, J. (1996) Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 383, 832-836.
12. Li, S. C., Rothman, P. B., Zhang, J., Chan, C., Hirsh, D., et al. (1994) Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int. Immunol. 6, 491-497.
13. Lin, X., Liang, M., and Feng, X. H. (2000) Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. J. Biol. Chem. 275, 36818-36822.
14. Meyers, S., Lenny, N., Sun, W., and Hiebert, S. W. (1996) AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia. Oncogene 13, 303-312.
15. Moren, A., Imamura, T., Miyazono, K., Heldin, C. H., and Moustakas, A. (2005) Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J. Biol. Chem. 280, 22115-22123.
16. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., et al. (2000) Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563.
17. Nakao, A., Afrakhte, M., Moren, A., Nakayama, T., Christian, J. L., et al. (1997a) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389, 631-635.
18. Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., et al. (1997b) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO. J. 16, 5353-5362.
19. Park, S. R., Lee, J. H., and Kim, P. H. (2001) Smad3 and Smad4 mediate transforming growth factor-beta1-induced IgA expression in murine B lymphocytes. Eur. J. Immunol. 31, 1706-1715.
20. Park, S. R., Lee, E. K., Kim, B. C., and Kim, P. H. (2003) p300 cooperates with Smad3/4 and Runx3 in TGFbeta1-induced IgA isotype expression. Eur. J. Immunol. 33, 3386-3392.
21. Shi, M. J. and Stavnezer, J. (1998) CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter. J. Immunol. 161, 6751-6760.
22. Wu, R. Y., Zhang, Y., Feng, X. H., and Derynck, R. (1997) Heteromeric and hornomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521-2528.
23. Zhang, Y., Feng, X., We, R., and Derynck, R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383, 168-172.
24. Zhang, Y., Musci, T., and Derynck, R. (1997) The tumor suppressor Smad4/ DPC 4 as a central mediator of Smad function. Curr. Biol. 7, 270-276.
25. Zhang, Y., Chang, C., Gehling, D. J., Hemmati-Brivanlou, A., and Derynck, R. (2001) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA 98, 974-979.
26. Zhao, M., Qiao, M., Oyajobi, B. O., Mundy, G. R., and Chen, D. (2003) E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J. Biol. Chem. 278, 27939-27944.
27. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., and Thomsen, G. H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693.