-
1
-
-
0035257236
-
Association study designs for complex diseases
-
Cardon, L. R. and Bell, J. I. (2001) Association study designs for complex diseases. Nat. Rev. Genet. 2, 91-99.
-
(2001)
Nat. Rev. Genet
, vol.2
, pp. 91-99
-
-
Cardon, L.R.1
Bell, J.I.2
-
2
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch, N. and Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516-1517.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
3
-
-
0035179971
-
Replication validity of genetic association studies
-
Ioannidis, J. P., Ntzani, E. E., Trikalinos, T. A., and Contopoulos-Ioannidis, D. G. (2001) Replication validity of genetic association studies. Nat. Genet. 29, 306-309.
-
(2001)
Nat. Genet
, vol.29
, pp. 306-309
-
-
Ioannidis, J.P.1
Ntzani, E.E.2
Trikalinos, T.A.3
Contopoulos-Ioannidis, D.G.4
-
4
-
-
0029001682
-
Extreme discordant sib pairs for mapping quantitative trait loci in humans
-
Risch, N. and Zhang, H. (1995) Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268, 1584-1589.
-
(1995)
Science
, vol.268
, pp. 1584-1589
-
-
Risch, N.1
Zhang, H.2
-
5
-
-
20244380171
-
Complement factor H polymorphism in age-related macular degeneration
-
Klein, R. J., Zeiss, C., Chew, E. Y., et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389.
-
(2005)
Science
, vol.308
, pp. 385-389
-
-
Klein, R.J.1
Zeiss, C.2
Chew, E.Y.3
-
6
-
-
0037373275
-
Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
-
Botstein, D. and Risch, N. (2003) Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat. Genet, 33, 228-237.
-
(2003)
Nat. Genet
, vol.33
, pp. 228-237
-
-
Botstein, D.1
Risch, N.2
-
7
-
-
0035094764
-
Variation is the spice of life
-
Kruglyak, L. and Nickerson, D. A. (2001) Variation is the spice of life. Nat. Genet. 27, 234-236.
-
(2001)
Nat. Genet
, vol.27
, pp. 234-236
-
-
Kruglyak, L.1
Nickerson, D.A.2
-
8
-
-
0042881041
-
Mathematical multi-locus approaches to localizing complex human trait genes
-
Hoh, J. and Ott, J. (2003) Mathematical multi-locus approaches to localizing complex human trait genes. Nat. Rev. Genet. 4, 701-709.
-
(2003)
Nat. Rev. Genet
, vol.4
, pp. 701-709
-
-
Hoh, J.1
Ott, J.2
-
9
-
-
25144501575
-
Genetic association studies
-
Cordell, H. J. and Clayton, D. G. (2005) Genetic association studies. Lancet 366, 1121-1131.
-
(2005)
Lancet
, vol.366
, pp. 1121-1131
-
-
Cordell, H.J.1
Clayton, D.G.2
-
10
-
-
25844510235
-
Shaking the tree: Mapping complex disease genes with linkage disequilibrium
-
Palmer, L. J. and Cardon, L. R. (2005) Shaking the tree: mapping complex disease genes with linkage disequilibrium. Lancet 366, 1223-1234.
-
(2005)
Lancet
, vol.366
, pp. 1223-1234
-
-
Palmer, L.J.1
Cardon, L.R.2
-
11
-
-
0036226789
-
Patterns of human diversity, within and among continents, inferred from biallelic DNA polymorphisms
-
Romualdi, C., Balding, D., and Nasidze, E. S., et al. (2002) Patterns of human diversity, within and among continents, inferred from biallelic DNA polymorphisms. Genome Res. 12, 602-612.
-
(2002)
Genome Res
, vol.12
, pp. 602-612
-
-
Romualdi, C.1
Balding, D.2
Nasidze, E.S.3
-
12
-
-
13844313862
-
Whole-genome patterns of common DNA variation in three human populations
-
Hinds, D. A., Stuve, L. L., Nilsen, G. B., et al. (2005) Whole-genome patterns of common DNA variation in three human populations. Science 307, 1072-1079.
-
(2005)
Science
, vol.307
, pp. 1072-1079
-
-
Hinds, D.A.1
Stuve, L.L.2
Nilsen, G.B.3
-
13
-
-
0000244010
-
The apportionment of human diversity
-
Dobzhansky, T, Hecht, M, and Steere, W, eds, Appleton-Century-Crofts, New York, NY, pp
-
Lewontin, R. (1972) The apportionment of human diversity. In: Evolutionary Biology, (Dobzhansky, T., Hecht, M., and Steere, W., eds.), Appleton-Century-Crofts, New York, NY, pp. 381-398.
-
(1972)
Evolutionary Biology
, pp. 381-398
-
-
Lewontin, R.1
-
14
-
-
0037456771
-
Race and genomics
-
Cooper, R.S., Kaufman, J. S., and Ward, R. (2003) Race and genomics. N. Engl. J. Med. 348, 1166-1170.
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 1166-1170
-
-
Cooper, R.S.1
Kaufman, J.S.2
Ward, R.3
-
15
-
-
0042845884
-
Genetics. FDA races in wrong direction
-
Haga, S. B. and Venter, J. C. (2003) Genetics. FDA races in wrong direction. Science 301, 466.
-
(2003)
Science
, vol.301
, pp. 466
-
-
Haga, S.B.1
Venter, J.C.2
-
16
-
-
0035188058
-
Population genetic structure of variable drug response
-
Wilson, J. F., Weale, M. E., Smith, A. C., et al. (2001) Population genetic structure of variable drug response. Nat. Genet. 29, 265-269.
-
(2001)
Nat. Genet
, vol.29
, pp. 265-269
-
-
Wilson, J.F.1
Weale, M.E.2
Smith, A.C.3
-
17
-
-
0036381531
-
-
Risch, N., Burchard, E., Ziv, E., and Tang, H. (2002) Categorization of humans in biomedical research: genes, race and disease. Genome Biol. 3, comment 2007.
-
Risch, N., Burchard, E., Ziv, E., and Tang, H. (2002) Categorization of humans in biomedical research: genes, race and disease. Genome Biol. 3, comment 2007.
-
-
-
-
18
-
-
0037456772
-
The importance of race and ethnic background in biomedical research and clinical practice
-
Burchard, E. G., Ziv, E., Coyle, N., et al. (2003) The importance of race and ethnic background in biomedical research and clinical practice. N. Engl. J. Med. 348, 1170-1175.
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 1170-1175
-
-
Burchard, E.G.1
Ziv, E.2
Coyle, N.3
-
19
-
-
0035919656
-
Haplotype variation and linkage disequilibrium in 313 human genes
-
Stephens, J. C., Schneider, J. A., Tanguay, D. A., et al. (2001) Haplotype variation and linkage disequilibrium in 313 human genes. Science 293, 489-493.
-
(2001)
Science
, vol.293
, pp. 489-493
-
-
Stephens, J.C.1
Schneider, J.A.2
Tanguay, D.A.3
-
20
-
-
0037147189
-
Genetic structure of human populations
-
Rosenberg, N. A., Pritehard, J. K., Weber, J., et al. (2002) Genetic structure of human populations. Science 298, 2381-2385.
-
(2002)
Science
, vol.298
, pp. 2381-2385
-
-
Rosenberg, N.A.1
Pritehard, J.K.2
Weber, J.3
-
21
-
-
19944432946
-
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
-
Tang, H., Quertermous, T., Rodriguez, B., et al. (2005) Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am. J. Hum, Genet. 76, 268-275.
-
(2005)
Am. J. Hum, Genet
, vol.76
, pp. 268-275
-
-
Tang, H.1
Quertermous, T.2
Rodriguez, B.3
-
22
-
-
11244279011
-
An Icelandic example of the impact of population structure on association studies
-
Helgason, A., Yngvadottir, B., Hrafnkelsson, B., Gulcher, J., and Stefansson, K. (2005) An Icelandic example of the impact of population structure on association studies. Nat. Genet. 37, 90-95.
-
(2005)
Nat. Genet
, vol.37
, pp. 90-95
-
-
Helgason, A.1
Yngvadottir, B.2
Hrafnkelsson, B.3
Gulcher, J.4
Stefansson, K.5
-
23
-
-
2442677652
-
Genetic signatures of strong recent positive selection at the lactase gene
-
Bersaglieri, T., Saberti, P. C., Patterson, N., et al. (2004) Genetic signatures of strong recent positive selection at the lactase gene. Am, J. Hum. Genet. 74, 1111-1120.
-
(2004)
Am, J. Hum. Genet
, vol.74
, pp. 1111-1120
-
-
Bersaglieri, T.1
Saberti, P.C.2
Patterson, N.3
-
24
-
-
23044468633
-
Demonstrating stratification in a European American population
-
Campbell, C. D., Ogbuni, E. L., Lunetta, K. L., et al. (2005) Demonstrating stratification in a European American population. Nat. Genet. 37, 868-872.
-
(2005)
Nat. Genet
, vol.37
, pp. 868-872
-
-
Campbell, C.D.1
Ogbuni, E.L.2
Lunetta, K.L.3
-
25
-
-
79959524146
-
A haplotype map of the human genome
-
International HapMap Consortium
-
International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437, 1299-1320.
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
-
26
-
-
0034619822
-
Mitochondrial genome variation and the origin of modern humans
-
Ingman, M., Kaessmann, H., Paabo, S., and Gyllensten, U. (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408, 708-713.
-
(2000)
Nature
, vol.408
, pp. 708-713
-
-
Ingman, M.1
Kaessmann, H.2
Paabo, S.3
Gyllensten, U.4
-
27
-
-
18344366125
-
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups
-
Herrnstadt, C., Elson, J. L., Fahy, E., et al. (2002) Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am. J. Hum. Genet. 70, 1152-1171.
-
(2002)
Am. J. Hum. Genet
, vol.70
, pp. 1152-1171
-
-
Herrnstadt, C.1
Elson, J.L.2
Fahy, E.3
-
28
-
-
17744393686
-
Mitochondrial DNA mutations in human disease
-
Taylor, R. W. and Turnbull, D. M. (2005) Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 6, 389-402.
-
(2005)
Nat. Rev. Genet
, vol.6
, pp. 389-402
-
-
Taylor, R.W.1
Turnbull, D.M.2
-
29
-
-
20844455582
-
Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays
-
Matsuzaki, H., Dong, S., Loi, H., et al. (2004) Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays. Nat. Methods 1, 109-111.
-
(2004)
Nat. Methods
, vol.1
, pp. 109-111
-
-
Matsuzaki, H.1
Dong, S.2
Loi, H.3
-
30
-
-
12144286180
-
Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array
-
Matsuzaki, H., Loi, H., Dong, S., et al. (2004) Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array. Genome Res. 14, 414-425.
-
(2004)
Genome Res
, vol.14
, pp. 414-425
-
-
Matsuzaki, H.1
Loi, H.2
Dong, S.3
-
31
-
-
18144425478
-
A genome-wide scalable SNP genotyping assay using microarray technology
-
Gunderson, K. L., Steemers, F. J., Lee, G., Mendoza, L. G., and Chee, M. S. (2005) A genome-wide scalable SNP genotyping assay using microarray technology. Nat. Genet. 37, 549-554.
-
(2005)
Nat. Genet
, vol.37
, pp. 549-554
-
-
Gunderson, K.L.1
Steemers, F.J.2
Lee, G.3
Mendoza, L.G.4
Chee, M.S.5
-
32
-
-
31344476038
-
Whole-genome genotyping with the single-base extension assay
-
Steemers, F. J., Chang, W., Lee, G., Barker, D. L., Shen, R., and Gunderson, K. L. (2006) Whole-genome genotyping with the single-base extension assay. Nat. Methods 3, 31-33.
-
(2006)
Nat. Methods
, vol.3
, pp. 31-33
-
-
Steemers, F.J.1
Chang, W.2
Lee, G.3
Barker, D.L.4
Shen, R.5
Gunderson, K.L.6
-
33
-
-
2642538502
-
The DNA sequence and comparative analysis of human chromosome 10
-
Deloukas, P., Earthrowl, M. E., Grafham, D. V., et al. (2004) The DNA sequence and comparative analysis of human chromosome 10. Nature 419, 375-381.
-
(2004)
Nature
, vol.419
, pp. 375-381
-
-
Deloukas, P.1
Earthrowl, M.E.2
Grafham, D.V.3
-
34
-
-
36549003926
-
-
Unpublished
-
Klein, R. S. (Unpublished).
-
-
-
Klein, R.S.1
-
36
-
-
0033947901
-
Circumventing multiple testing: A multilocus Monte Carlo approach to testing for association
-
McIntyre, L. M., Martin, E. R., Simonsen, K. L., and Kaplan, N. L. (2000) Circumventing multiple testing: a multilocus Monte Carlo approach to testing for association. Genet. Epidemiol. 19, 18-29.
-
(2000)
Genet. Epidemiol
, vol.19
, pp. 18-29
-
-
McIntyre, L.M.1
Martin, E.R.2
Simonsen, K.L.3
Kaplan, N.L.4
-
37
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamim, Y. and Hochberg, Y. (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statist. Soc. B. 57, 289-300.
-
(1995)
J. R. Statist. Soc. B
, vol.57
, pp. 289-300
-
-
Benjamim, Y.1
Hochberg, Y.2
-
38
-
-
0038449175
-
Analysis of multilocus models of association
-
Devlin, B., Roeder, K., and Wasserman, L. (2003) Analysis of multilocus models of association. Genet. Epidemiol. 25, 36-47.
-
(2003)
Genet. Epidemiol
, vol.25
, pp. 36-47
-
-
Devlin, B.1
Roeder, K.2
Wasserman, L.3
-
39
-
-
0000553457
-
pValue adjustments for multiple tests in multivariate binomial models
-
Westfall, P. and Young, S. (1989) pValue adjustments for multiple tests in multivariate binomial models. J. Am. Stat. Assoc. 84, 780-786.
-
(1989)
J. Am. Stat. Assoc
, vol.84
, pp. 780-786
-
-
Westfall, P.1
Young, S.2
-
40
-
-
18444369013
-
The structure of haplotype blocks in the human genome
-
Gabriel, S. B., Schaffner, S. F., Nguyen, H., et al. (2002) The structure of haplotype blocks in the human genome. Science 296, 2225-2229.
-
(2002)
Science
, vol.296
, pp. 2225-2229
-
-
Gabriel, S.B.1
Schaffner, S.F.2
Nguyen, H.3
-
41
-
-
13144282294
-
Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies
-
Lin, S., Chakravarti, A., and Cutler, D. J. (2004) Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat. Genet. 36, 1181-1188.
-
(2004)
Nat. Genet
, vol.36
, pp. 1181-1188
-
-
Lin, S.1
Chakravarti, A.2
Cutler, D.J.3
-
42
-
-
0036844238
-
Distribution of recombination crossovers and the origin of haplotype blocks: The interplay of population history, recombination, and mutation
-
Wang, N., Akey, J. M., Zhang, K., Chakraborty, R., and Jin, L. (2002) Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am. J. Hum, Genet. 71, 1227-1234.
-
(2002)
Am. J. Hum, Genet
, vol.71
, pp. 1227-1234
-
-
Wang, N.1
Akey, J.M.2
Zhang, K.3
Chakraborty, R.4
Jin, L.5
-
43
-
-
0242691208
-
A comparison of bayesian methods for haplotype reconstruction from population genotype data
-
Stephens, M. and Donnelly, P. (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am. J. Hum. Genet. 73, 1162-1169.
-
(2003)
Am. J. Hum. Genet
, vol.73
, pp. 1162-1169
-
-
Stephens, M.1
Donnelly, P.2
-
44
-
-
0035071957
-
A new statistical method for haplotype reconstruction from population data
-
Stephens, M., Smith, N. J., and Donnelly, P. (2001) A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978-989.
-
(2001)
Am. J. Hum. Genet
, vol.68
, pp. 978-989
-
-
Stephens, M.1
Smith, N.J.2
Donnelly, P.3
-
45
-
-
33344458848
-
A comparison of phasing algorithms for trios and unrelated individuals
-
Marchini, J., Cutler, D., Patterson, N., et al. (2006) A comparison of phasing algorithms for trios and unrelated individuals. Am. J. Hum. Genet. 78, 437-450.
-
(2006)
Am. J. Hum. Genet
, vol.78
, pp. 437-450
-
-
Marchini, J.1
Cutler, D.2
Patterson, N.3
-
46
-
-
0023425198
-
A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila
-
Templeton, A. R., Boerwinkle, E., and Sing, C. F. (1987) A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping. I. Basic theory and an analysis of alcohol dehydrogenase activity in Drosophila. Genetics 117, 343-351.
-
(1987)
Genetics
, vol.117
, pp. 343-351
-
-
Templeton, A.R.1
Boerwinkle, E.2
Sing, C.F.3
-
47
-
-
0036155238
-
A perspective on epistasis: Limits of models displaying no main effect
-
Culverhouse, R., Suarez, B. K., Lin, J., and Reich, T. (2002) A perspective on epistasis: limits of models displaying no main effect. Am. J. Hum. Genet. 70, 461-471.
-
(2002)
Am. J. Hum. Genet
, vol.70
, pp. 461-471
-
-
Culverhouse, R.1
Suarez, B.K.2
Lin, J.3
Reich, T.4
-
48
-
-
0034973569
-
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
-
Ritchie, M. D., Halm, L. W., Roodi, N., et al. (2001) Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am. J. Hum. Genet. 69, 138-147.
-
(2001)
Am. J. Hum. Genet
, vol.69
, pp. 138-147
-
-
Ritchie, M.D.1
Halm, L.W.2
Roodi, N.3
-
49
-
-
0000046644
-
An extension of the concept of partitioning hereditary variance for analysis of covariates among relatives when epistasis is present
-
Cockerham, C. C. (1954) An extension of the concept of partitioning hereditary variance for analysis of covariates among relatives when epistasis is present. Genetics 39, 859-882.
-
(1954)
Genetics
, vol.39
, pp. 859-882
-
-
Cockerham, C.C.1
-
50
-
-
0036797562
-
Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans
-
Cordell, H. J. (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum. Mol. Genet. 11, 2463-2468.
-
(2002)
Hum. Mol. Genet
, vol.11
, pp. 2463-2468
-
-
Cordell, H.J.1
-
51
-
-
21044450087
-
Application of logistic regression to case-control association studies involving two causative loci
-
North, B. V., Curtis, D., and Sham, P. C. (2005) Application of logistic regression to case-control association studies involving two causative loci. Hum. Hered. 59, 79-87.
-
(2005)
Hum. Hered
, vol.59
, pp. 79-87
-
-
North, B.V.1
Curtis, D.2
Sham, P.C.3
-
52
-
-
0003100430
-
The dynamics of racial intermixture; an analysis based on the American Negro
-
Glass, B. and Li, C. C. (1953) The dynamics of racial intermixture; an analysis based on the American Negro. Am. J. Hum. Genet. 5, 1-20.
-
(1953)
Am. J. Hum. Genet
, vol.5
, pp. 1-20
-
-
Glass, B.1
Li, C.C.2
-
53
-
-
2442585696
-
The effects of human population structure on large genetic association studies
-
Marchini, J., Cardon, L. R., Phillips, M. S., and Donnelly, P. (2004) The effects of human population structure on large genetic association studies. Nat. Genet. 36, 512-517.
-
(2004)
Nat. Genet
, vol.36
, pp. 512-517
-
-
Marchini, J.1
Cardon, L.R.2
Phillips, M.S.3
Donnelly, P.4
-
54
-
-
0026030165
-
The genetic structure of admixed populations
-
Long, J. C. (1991) The genetic structure of admixed populations. Genetics 127, 417-428.
-
(1991)
Genetics
, vol.127
, pp. 417-428
-
-
Long, J.C.1
-
55
-
-
0028913523
-
An E-M algorithm and testing strategy for multiple-locus haplotypes
-
Long, J. C., Williams, R. C., and Urbanek, M. (1995) An E-M algorithm and testing strategy for multiple-locus haplotypes. Am. J. Hum. Genet. 56, 799-810.
-
(1995)
Am. J. Hum. Genet
, vol.56
, pp. 799-810
-
-
Long, J.C.1
Williams, R.C.2
Urbanek, M.3
-
56
-
-
2342597140
-
A high-density admixture map for disease gene discovery in african americans
-
Smith, M. W., Patterson, N., Lautenberger, J. A., et al. (2004) A high-density admixture map for disease gene discovery in african americans. Am. J. Hum. Genet. 74, 1001-1013.
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 1001-1013
-
-
Smith, M.W.1
Patterson, N.2
Lautenberger, J.A.3
-
57
-
-
2342622086
-
Methods for high-density admixture mapping of disease genes
-
Patterson, N., Hattangadi, N., Lane, B., et al. (2004) Methods for high-density admixture mapping of disease genes. Am. J. Hum. Genet. 74, 979-1000.
-
(2004)
Am. J. Hum. Genet
, vol.74
, pp. 979-1000
-
-
Patterson, N.1
Hattangadi, N.2
Lane, B.3
-
58
-
-
0037648359
-
Control of confounding of genetic associations in stratified populations
-
Hoggart, C. J., Parra, E. J., Shriver, M. D., et al. (2003) Control of confounding of genetic associations in stratified populations. Am. J. Hum. Genet. 72, 1492-1504.
-
(2003)
Am. J. Hum. Genet
, vol.72
, pp. 1492-1504
-
-
Hoggart, C.J.1
Parra, E.J.2
Shriver, M.D.3
-
59
-
-
3042569525
-
Complete MHC haplotype sequencing for common disease gene mapping
-
Stewart, C. A., Horton, R., Allcock, R. J., et al. (2004) Complete MHC haplotype sequencing for common disease gene mapping. Genome Res. 14, 1176-1187.
-
(2004)
Genome Res
, vol.14
, pp. 1176-1187
-
-
Stewart, C.A.1
Horton, R.2
Allcock, R.J.3
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