Evaluation of biomarkers of occupational exposure to toluene at low levels

International Archives of Occupational and Environmental Health

Volumn 81, Issue 3, 2008, Pages 253-262

  Kawai, Toshio ^a   Ukai, Hirohiko ^b   Inoue, Osamu ^c   Maejima, Yuki ^d   Fukui, Yoshinari ^b   Ohashi, Fumiko ^b   Okamoto, Satoru ^b   Takada, Shiro ^b   Sakurai, Haruhiko ^a   Ikeda, Masayuki ^b  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

^b KYOTO INDUSTRIAL HEALTH ASSOCIATION   (Japan)

^c TOHOKU ROSAI HOSPITAL   (Japan)

^d WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Blood; Exposure biomarkers; Hippuric acid; Occupational exposure; Organic solvents; Toluene; Urine

Indexed keywords

ACETIC ACID ETHYL ESTER; BIOLOGICAL MARKER; ETHYLBENZENE; HEXANE; HIPPURIC ACID; TOLUENE; XYLENE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; BLOOD ANALYSIS; BLOOD SAMPLING; CHEMICAL INDUSTRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; INTERMETHOD COMPARISON; MALE; NON INVASIVE MEASUREMENT; OCCUPATIONAL EXPOSURE; RECEIVER OPERATING CHARACTERISTIC; URINALYSIS;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; JAPAN; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; TOLUENE; URINALYSIS;

EID: 36549027420     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-007-0203-2     Document Type: Article

References (42)

1. Aitio A (1996) Chapter 2: Quality assurance. 2.2.1.3 Sampling. In: MI Mikheev (ed) Biological monitoring of chemical exposure in the workplace, vol 1. World Health Organization, Geneva, pp 22-24
2. American Conference of Governmental Industiral Hygienists (2006) TLVs and BEIs; toluene in the 2006 notice of intended changes. ACGIH, Cincinnati
3. Angerer J, Schildbach M, Krämer A (1998) S- p -Toluylmercapturic acid in the urine of workers exposed to toluene: A new biomarker for toluene exposure. Arch Toxicol 72:119-123
4. Antti-Poika M, Juntunen J, Matikainen E, Suoranta H, Hanninen H, Seppalainen AM, Liira J (1985) Occupational exposure to toluene: Neurotoxic effects with special emphasis on drinking habits. Int Arch Occup Environ Health 56:31-40
5. De Rosa E, Brugnone F, Bartolucci GB, Perbellini L, Bellomo ML, Gori GP, Sigon M, Corona PC (1985) The validity of urinary metabolites as indicators of low exposures to toluene. Int Arch Occup Environ Health 56:135-145
6. De Rosa E, Bartolucci GB, Sigon M, Callegaro R, Perbellini L, Brugnone F (1987) Hippuric acid and ortho-cresol as biological indicators of occupational exposure to toluene. Am J Ind Med 11:529-537
7. Deutsche Forschungsgemeinschaft (2006) List of MAK and BAT values, 2006. Wiley-VCH, Weiheim
8. Fletcher RW, Fletcher SW (2005) Chap 3. Diagnosis. In: Clinical epidemiology, 4th edn. Lippincott Wiliams & Wilkins, Philadelphia, pp 35-58
9. Hasegawa K, Shiojima S, Koizumi A, Ikeda M (1983) Hippuric acid and o-cresol in the urine of workers exposed to toluene. Int Arch Occup Environ Health 52:197-208
10. Hirayama T, Ikeda M (1979) Applicability of activated carbon felt to the dosimetry of solvent vapor mixture. Am Ind Hyg Ass J 40:1091-1096
11. Ichihara K (1990) Comparison of two regression parameters. In: Statistics for bioscience (in Japanese). Nankodo Publishers, Tokyo, pp 218-223
12. Ikeda M (1999) Solvents in urine as exposure markers. Toxicol Lett 108:99-106
13. Ikeda M, Ohtsuji H (1969) Significance of urinary hippuric acid determination as an index of toluene exposure. Br J Ind Med 26:244-246
14. Inoue O, Seiji K, Watanabe T, Nakatsuka H, Jin C, Liu S-J, Ikeda M (1993) Effects of smoking and drinking on excretion of hippuric acid among toluene-exposed workers. Int Arch Occup Environ Health 64:425-430
15. Inoue O, Seiji K, Watanabe T, Chen Z, Huang M-Y, Xu X-P, Qiao X, Ikeda M (1994) Effects of smoking and drinking habits on urinary o-cresol excretion after occupational exposure to toluene vapor among Chinese workers. Am J Ind Med 25:697-708
16. Inoue O, Kanno E, Kudo S, Kakizaki M, Kataoka M, Kawai T, Ukai H, Ikeda M (1998) High-pressure liquid chromatographic determination of toluene in urine as a marker of occupational exposure to toluene. Int Arch Occup Environ Health 71:302-308
17. Inoue O, Kanno E, Kasai K, Ukai H, Okamoto S, Ikeda M (2004) Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. Toxicol Lett 147:177-186
18. Japan Society for Occupational Health (2006) Recommendation of occupational exposure limits (2006-2007). Jpn J Ind Health 48:290-306
19. Juntunen J, Matikainen E, Antti-Poika M, Hsuoranta H, Valle M (1985) Nervous system effects of long-term occupational exposure to toluene. Acta Neurol Scand 72:512-517
20. Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Ikeda M (1992a) Urinalysis vs. blood analysis, as a tool for biological monitoring of solvent exposure. Toxicol Lett 63:333-343
21. Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Iguchi H, Uchida Y, Iwami O, Ikeda M (1992b) Comparative evaluation of urinalysis and blood analysis as means of detecting exposure to organic solvents at low concentrations. Int Arch Occup Environ Health 64:223-234
22. Kawai T, Mizunuma K, Yasugi T, Horiguchi S, Ikeda M (1994) Toluene in blood as a marker of choice for low-level exposure to toluene. Int Art Occup Environ Health 66:309-315
23. Kawai T, Mizunuma K, Okada Y, Horiguchi S, Ikeda M (1996) Toluene itself as the best urinary marker of toluene exposure. Int Arch Occup Environ Health 68:289-297
24. Knox JW, Nelson JR (1966) Permanent encephalopathy from toluene inhalation. New Engl J Med 275:1494-1496
25. Lauwerys R (1983) Toluene. In: Alessio L, Berlin A, Roi R, Boni M (eds) Human biological monitoring of industrial chemicals, vol 1. Joint Reserch Centre Ispra Establishment, CEC, pp 159-175
26. Lee B-K, Lee S-H, Lee K-M, Cho K-S, Ahn K-D, Kim S-B, Ukai H, Nakatsuka H, Watanabe T, Ikeda M (1988) Dose-dependent increase in subjective symptom prevalence among toluene-exposed workers. Ind Health 26:11-23
27. Levine L, Fahy P (1945) Evaluation of urinary lead concentrations. I. The significance of the specific gravity. J Ind Hyg Toxicol 27:217-223
28. Moon C-S, Lee J-T, Chun J-H, Ikeda M (2001) Use of solvents in industries in Korea; experience in Sinpyeong-Jangrim industrial complex. Int Arch Occup Envion Health 74:148-152
29. Nise G (1992) Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing. Int Arch Occup Envion Health 63:377-381
30. Ogata M, Taguchi T (1987) Quantitation of urinary metabolites of toluene, xylene, styrene, ethylbenzene, benzene and phenol by automated high performance liquid chromatography. Int Arch Occup Environ Health 59:263-272
31. Samoto H, Fukui Y, Ukai H, Okamoto S, Takada S, Ohashi F, Moriguchi J, Ezaki T, Ikeda M (2006) Field survey on types of organic solvents used in enterprises of various sizes. Int Arch Occup Environ Health 79:558-567
32. Shiojima S, Hasegawa K, Ishihara N, Ikeda M (1983) Subclinical increases in serum transaminase activities among female workers exposed to toluene at sub-OEL levels. Ind Health 21:123-126
33. Skender L, Brčić I, Karačič V (2004) Urine analysis for the evaluation of environmental exposures to aromatic hydrocarbons. Arch Environ Health 59:237-244
34. Sugita M, Tsuchiya K (1995) Estimation of variation among individuals of biological half-times of cadmium calculated from accumulation data. Environ Res 68:31-37
35. Takeuchi A, Kawai T, Zhang Z-W, Miyama Y, Sakamoto K, Higashikawa K, Ikeda M (2002) Toluene, xylenes and xylene isomers in urine as biological indicators of low-level exposure to each solvent; a comparative study. Int Arch Occup Environ Health 75:387-393
36. Truchon G, Tardif R, Brodeur J (1999) o-Cresol: A good indicator of exposure to low levels of toluene. Appl Occup Environ Hyg 14:677-681
37. Ukai H, Takada S, Inui S, Imai Y, Kawai T, Shimbo S, Ikeda M (1993) Dose-dependent increase in subjective symptoms among toluene-exposed workers. Environ Res 60:274-289
38. Ukai H, Inui S, Takada S, Dendo J, Ogawa J, Isobe K, Ashida T, Tamura M, Tabuki K, Ikeda M (1997) Types of organic solvents used in small- to medium-scale industries in Japan; a nation-wide field survey. Int Arch Occup Environ Health 70:385-592
39. Ukai H, Kawai T, Inoue O, Maejima Y, Fukui Y, Ohashi F, Okamoto S, Takada S, Sakurai H, Ikeda M (2007) Comparative evaluation of biomarkers of occupational exposure to toluene. Int Arch Occup Environ Health 81:81-93
40. Vitali M, Ensabella F, Stella D, Guidotti M (2006) Exposure to organic solvents among handicraft car painters: A pilot study in Italy. Ind Health 44:310-317
41. Yasugi T, Endo G, Monna T, Odachi T, Yamaoka K, Kawai T, Horiguchi S, Ikeda M (1998) Types of organic solvents used in workplaces and work environment conditions with special references to reproducibility of work environment classification. Ind Health 36:223-233
42. Yin S-N, Li G-L, Hu Y-T, Zhang X-M, Jin C, Inoue O, Seiji K, Kasahara M, Nakatsuka H, Ikeda M (1987) Symptoms and signs of workers exposed to benzene, toluene or the combination. Ind Health 25:13-130