Toluene itself as the best urinary marker of toluene exposure

International Archives of Occupational and Environmental Health

Volumn 68, Issue 5, 1996, Pages 289-297

  Kawai, Toshio ^a   Mizunuma, Kazunori ^a,b   Okada, Yoko ^a   Horiguchi, Shun'ichi ^a   Ikeda, Masayuki ^b  

^a Osaka Occupational Health Service Center   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Exposure marker; Hippuric acid; o cresol; Toluene; Urinalysis

Indexed keywords

HIPPURIC ACID; ORTHO CRESOL; SOLVENT; TOLUENE;

ARTICLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; REGRESSION ANALYSIS; URINALYSIS; VAPOR;

EID: 0030056098     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00409413     Document Type: Article

References (22)

1. American Conference of Governmental Industrial Hygienists (1994) 1994-1995 Threshold limit values and biological exposure indices. ACGIH, Cincinnati
2. Antti-Poika M, Kalliokoski P, Hänninen O (1987) Toluene. In: Snyder R (ed) Browning's toxicity and metabolism of industrial solvents, 2nd edn. Elsevier, Amsterdam, pp 38-63
3. Deutsche Forschungsgemeinschaft (1994) List of MAK and BAT values 1994. VCH, Weinheim
4. Ghittori S, Imbriani M, Pezzagno G, Capodaglio E (1987) The urinary concentration of solvents as a biological indicator of exposure; proposal for the biological equivalent exposure limit for nine solvents. Am Ind Hyg Assoc J 48:786-790
5. Gill R, Hatchett SE, Osselton MD, Wilson HK, Ramsey JD (1988) Sample handling and storage for quantitative analysis of volatile compounds in blood: the determination of toluene in headspace gas chromatography. J Anal Toxicol 12:141-146
6. Hirayama T, Ikeda M (1979) Applicability of carbon felt to the dosimetry of solvent mixture. Am Ind Hyg Assoc J 40:1091-1096
7. Ikeda M, Kumari M, Aksoy M (1984) Application of carbon felt dosimetry to field studies distant from analytical laboratory. Ind Health 22:53-58
8. Inoue T, Takeuchi Y, Hisanaga N, Ono Y, Iwata M, Ogata M, Saito K, Sakurai H, Hara I, Matsushita T, Ikeda M (1983) A nation-wide survey on organic solvent components in various solvent products: Part I. Homogeneous products such as thinners, degreasers and reagents. Ind Health 21:175-183
9. Inoue O, Seiji K, Watanabe T, Nakatsuka H, Jin C, Liu S-J, Ikeda M (1993) Effects of smoking and drinking on excretion of hippuric acid among toluene-exposed workers. Int Arch Occup Environ Health 64:425-430
10. Inoue O, Seiji K, Watanabe T, Chen Z, Huang M-Y, Xu X-P, Qiao X, Ikeda M (1994) Effects of smoking and drinking habits on urinary o-cresol excretion after occupational exposure to toluene among Chinese workers. Int Arch Occup Environ Health 65:343-350
11. Jackson S (1966) Creatinine in urine as an index of urinary excretion rate. Health Phys 12:843-850
12. Japan Association of Industrial Health (1994) Recommended occupational exposure limits (in Japanese with English translation). Jpn J Ind Health 36:236-260
13. Kasahara M, Ikeda M (1987) Spontaneous desorption of organic solvents from carbon cloth. Ind Health 25:73-81
14. Kawabata H, Esaki T, Kasai S, Furuki K, Asaeda T, Ukai H, Takada S, Tanaka K, Inui S, Ikeda M (1995) Environmental monitoring results in 422 organic solvent workplaces in 142 plants (in Japanese). J Occup Health 37 (Suppl): S421
15. Kawai T (1989) Urinary phenol as a marker of exposure to benzene (in Japanese). Aromatics 41:274-281
16. Kawai T, Mizunuma K, Yasugi T, Horiguchi S, Uchida Y, Iwami O, Iguchi H, Ikeda M (1991) Urinary methylhippuric acid isomer levels after occupational exposure to a xylene mixture. Int Arch Occup Environ Health 63:69-75
17. Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Iguchi H, Uchida Y, Iwami O, Ikeda M (1992) Comparative evaluation of urinalysis and blood analysis as means of detecting exposure to organic solvents at low concentrations. Int Arch Occup Environ Health 64:223-234
18. Kawai T, Mizunuma K, Yasugi T, Horiguchi S, Ikeda M (1995) Toluene in blood as a marker of choice for low-level exposure to toluene. Int Arch Occup Environ Health 66:309-315
19. Kumai M, Koizumi A, Saito K, Sakurai H, Inoue T, Takeuchi Y, Hara I, Ogata M, Matsushita T, Ikeda M (1983) A nationwide survey on organic solvent components in various solvent products: Part II. Heterogeneous products such as paints, inks and adhesives. Ind Health 21:185-197
20. Mizunuma K, Kawai T, Horiguchi S, Ikeda M (1995) Urinary methylchloroform rather than urinary metabolites as an indicator of occupational exposure to methylchloroform. Int Arch Occup Environ Health 67:19-25
21. Nise G (1992) Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing. Int Arch Occup Environ Health 63:377-381
22. Rainsford SG, Lloyd Davies TA (1965) Urinary excretion of phenol by men exposed to vapour of benzene: a screening test. Br J Ind Med 22:21-26