S179D prolactin diminishes the effects of UV light on epidermal gamma delta T cells

Molecular and Cellular Endocrinology

Volumn 280, Issue 1-2, 2008, Pages 6-12

  Guzmán, Esther A ^a   Langowski, John L ^a   De Guzman, Ariel ^b   Muller, H Konrad ^c   Walker, Ameae M ^b   Owen, Laurie B ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TASMANIA   (Australia)

Author keywords

Gamma delta T cells; Langerhans cells; S179D prolactin; Ultraviolet light

Indexed keywords

PROLACTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL PROTECTION; CELL TYPE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOCOMPETENT CELL; LANGERHANS CELL; MALE; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLACTIN SECRETING CELL; PROTEIN PHOSPHORYLATION; T GAMMA DELTA CELL; T LYMPHOCYTE SUBPOPULATION; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ANIMALS; EPIDERMIS; IMMUNOLOGIC FACTORS; INFUSION PUMPS, IMPLANTABLE; LANGERHANS CELLS; MALE; MICE; MICE, INBRED C3H; PHOSPHORYLATION; PROLACTIN; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECOMBINANT PROTEINS; T-LYMPHOCYTES; ULTRAVIOLET RAYS;

EID: 36549019443     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2007.09.004     Document Type: Article

References (63)

1. Aberer W., Romani N., Elbe A., and Stingl G. Effects of physicochemical agents on murine epidermal Langerhans cells and Thy-1-positive dendritic epidermal cells. J. Immunol. 136 (1986) 1210-1216
2. Alcalay J., Craig J.N., and Kripke M.L. Alterations in Langerhans cells and Thy-1+ dendritic epidermal cells in murine epidermis during the evolution of ultraviolet radiation-induced skin cancers. Cancer Res. 49 (1989) 4591-4596
3. Almeida S.A., Petenusci S.O., Franci J.A., Rosa e Silva A.A., and Carvalho T.L. Chronic immobilization-induced stress increases plasma testosterone and delays testicular maturation in pubertal rats. Andrologia 32 (2000) 7-11
4. Aramburo C., Montiel J.L., Proudman J.A., Berghman L.R., and Scanes C.G. Phosphorylation of prolactin and growth hormone. J. Mol. Endocrinol. 8 (1992) 183-191
5. Bigby M., Kwan T., and Sy M.S. Ratio of Langerhans cells to Thy-1+ dendritic epidermal cells in murine epidermis influences the intensity of contact hypersensitivity. J. Invest. Dermatol. 89 (1987) 495-499
6. Bouchard B., Ormandy C.J., Di Santo J.P., and Kelly P.A. Immune system development and function in prolactin receptor-deficient mice. J. Immunol. 163 (1999) 576-582
7. Brooks C.L., Kim B.G., Aphale P., Kleeman B.E., and Johnson G.C. Phosphorylated variant of bovine prolactin. Mol. Cell. Endocrinol. 71 (1990) 117-123
8. Chen T.J., Kuo C.B., Tsai K.F., Liu J.W., Chen D.W., and Walker A.M. Development of recombinant human prolactin receptor antagonists by molecular mimicry of the phosphorylated hormone. Endocrinology 139 (1998) 609-616
9. Coss D., Kuo C.-Y.B., Yang L., Ingleton P., Luben R., and Walker A.M. Dissociation of Janus kinase 2 and signal transducer and activator of transcription 5 activation after treatment of Nb2 cells with a molecular mimic of phosphorylated prolactin. Endocrinology 140 (1999) 5087-5094
10. Dandle G.W., Clydesdale G.J., Radcliff F.J., and Muller H.K. Migration of Langerhans cells and gamma delta dendritic cells from UV-B-irradiated sheep skin. Immunol. Cell. Biol. 79 (2001) 41-48
11. Dardenne M., de Moraes Mdo C., Kelly P.A., and Gagnerault M.C. Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry. Endocrinology 134 (1994) 2108-2114
12. Dorshkind K., and Horseman N.D. Anterior pituitary hormones, stress, and immune system homeostasis. Bioessays 23 (2001) 288-294
13. Dugan A.L., Thellin O., Buckley D.J., Buckley A.R., Ogle C.K., and Horseman N.D. Effects of prolactin deficiency on myelopoiesis and splenic T lymphocyte proliferation in thermally injured mice. Endocrinology 143 (2002) 4147-4151
14. Dugan A.L., Malarkey W.B., Schwemberger S., Jauch E.C., Ogle C.K., and Horseman N.D. Serum levels of prolactin, growth hormone, and cortisol in burn patients: correlations with severity of burn, serum cytokine levels, and fatality. J. Burn Care Rehabil. 25 (2004) 306-313
15. Dugan A.L., Schwemberger S., Babcock G.F., Buckley D., Buckley A.R., Ogle C.K., and Horseman N.D. Effects of prolactin level on burn-induced aberrations in myelopoiesis. Shock 21 (2004) 151-159
16. Ebert L.M., Meuter S., and Moser B. Homing and function of human skin gamma delta T cells and NK cells: relevance for tumor surveillance. J. Immunol. 176 (2006) 4331-4336
17. Everett M.A., Yeargers E., Sayre R.M., and Olson R.L. Penetration of epidermis by ultraviolet rays. Photochem. Photobiol. 5 (1966) 533-542
18. Fisher M.S., and Kripke M.L. Systemic alteration induced in mice by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 1688-1692
19. Foitzik K., Krause K., Conrad F., Nakamura M., Funk W., and Paus R. Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. Am. J. Pathol. 168 (2006) 748-756
20. Girardi M., Oppenheim D.E., Steele C.R., Lewis J.M., Glusac E., Filler R., Hobby P., Sutton B., Tigelaar R.E., and Hayday A.C. Regulation of cutaneous malignancy by gamma delta T cells. Science 294 (2001) 605-609
21. Girardi M., Lewis J., Glusac E., Filler R.B., Geng L., Hayday A.C., and Tigelaar R.E. Resident skin-specific gamma delta T cells provide local, nonredundant regulation of cutaneous inflammation. J. Exp. Med. 195 (2002) 855-867
22. Guzman E., Langowski J.L., and Owen-Schaub L. Mad dogs, Englishmen and apoptosis: the role of cell death in UV-induced skin cancer. Apoptosis (2003) 315-325
23. Guzman E.A., Chen Y.-H., Langowski J.L., De Guzman A., Lo H.-L., Walter B., Muller H.K., Walker A.M., and Owen L.B. Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. J. Neuroimmunol. 170 (2005) 31-40
24. Halford C., Anderzen I., and Arnetz B. Endocrine measures of stress and self-rated health: a longitudinal study. J. Psychosom. Res. 55 (2003) 317-320
25. Hartmann D.P., Holaday J.W., and Bernton E.W. Inhibition of lymphocyte proliferation by antibodies to prolactin. FASEB J. 3 (1989) 2194-2202
26. Ho T.W.C., Kawaminami M., and Walker A.M. Secretion of phosphorylated and non-phosphorylated monomer prolactin isoforms during rat pregnancy and pseudopregnancy. Endocrine 1 (1993) 435-439
27. Ho T.W.C., Leong F.S., Olaso C.H., and Walker A.M. Secretion of specific nonphosphorylated and phosphorylated rat prolactin isoforms at different stages of the estrous cycle. Neuroendocrinology 58 (1993) 160-165
28. Horseman N.D., Zhao W., Montecino-Rodriguez E., Tanaka M., Nakashima K., Engle S.J., Smith F., Markoff E., and Dorshkind K. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted distribution of the prolactin gene. EMBO J. 16 (1997) 6926-6935
29. Ikuta K., Kina T., MacNeil I., Uchida N., Peault B., Chien Y.H., and Weissman I.L. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62 (1990) 863-874
30. Jameson J., Ugarte K., Chen N., Yachi P., Fuchs E., Boismenu R., and Havran W.L. A role for skin gamma delta T cells in wound repair. Science 296 (2002) 747-749
31. Johnson T.E., Vue M., Brekhus S., Khong A., Ho T.W.C., and Walker A.M. Unmodified prolactin (PRL) promotes PRL secretion and acidophil hypertrophy and is associated with pituitary hyperplasia in female rats. Endocrine (special edition on prolactin) 20 (2003) 101-110
32. Krown K.A., Wang Y.F., Ho T.W., Kelly P.A., and Walker A.M. Prolactin isoform 2 as an autocrine growth factor for GH3 cells. Endocrinology 131 (1992) 595-602
33. Kuo C.B., Wu W., Xu X., Yang L., Chen C., Coss D., Birdsall B., Nasseri D., and Walker A.M. Pseudophosphorylated prolactin (S179D PRL) inhibits growth and promotes beta-casein gene expression in the rat mammary gland. Cell Tissue Res. 309 (2002) 429-437
34. Lorenson M.Y., and Walker A.M. Structure-function relationships in prolactin. In: Horseman N. (Ed). Prolactin (2001), Kluwer Academic Publishers, Norwell 189-217
35. Lupulescu A. Enhancement of epidermal carcinoma formation by prolactin in mice. J. Natl. Cancer Inst. 74 (1985) 1335-1346
36. Matera L., Cesano A., Bellone G., and Oberholtzer E. Modulatory effect of prolactin on the resting and mitogen-induced activity of T, B, and NK lymphocytes. Brain Behav. Immunol. 6 (1992) 409-417
37. Matera L., Mori M., Geuna M., Buttiglieri S., and Palestro G. Prolactin in autoimmunity and antitumor defense. J. Neuroimmunol. 109 (2000) 47-55
38. Merad M., Manz M.G., Karsunky H., Wagers A., Peters W., Charo I., Weissman I.L., Cyster J.G., and Engleman E.G. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3 (2002) 1135-1141
39. Morelli A., Larregina A., Chuluyan I., Kolkowski E., and Fainboim L. Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells. Immunology 89 (1996) 126-134
40. Naylor M.J., Oakes S.R., Gardiner-Garden M., Harris J., Blazek K., Ho T.W., Li F.C., Wynick D., Walker A.M., and Ormandy C.J. Transcriptional changes underlying the secretory activation phase of mammary gland development. Mol. Endocrinol. 19 (2005) 1868-1883
41. Oetting W.S., Tuazon P.T., Traugh J.A., and Walker A.M. Phosphorylation of prolactin. J. Biol. Chem. 261 (1986) 1649-1652
42. Ouhtit A., Gorny A., Muller H.K., Owen-Schaub L., and Ananthaswamy H.N. Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis. Am. J. Pathol. 157 (2000) 1975-1981
43. Pellegrini L., Lebrun J.J., Ali S., and Kelly P.A. Expression of prolactin and its receptor in human lymphoid cells. Mol. Endocrinol. 6 (1992) 1023-1031
44. Schroeder M.D., Brockman J.L., Walker A.M., and Schuler L.A. Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL. Endocrinology 144 (2003) 5300-5307
45. Schwacha M.G., Ayala A., and Chaudry I.H. Insights into the role of gamma delta T lymphocytes in the immunopathogenic response to thermal injury. J. Leukocyte Biol. 67 (2000) 644-650
46. Simon J.C., Tigelaar R.E., Bergstresser P.R., Edelbaum D., and Cruz Jr. P.D. Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells. J. Immunol. 146 (1991) 485-491
47. Sontag Y., Guikers C.L., Vink A.A., de Gruijl F.R., van Loveren H., Garssen J., Roza L., Kripke M.L., van der Leun J.C., and van Vloten W.A. Cells with UV-specific DNA damage are present in murine lymph nodes after in vivo UV irradiation. J. Invest. Dermatol. 104 (1995) 734-738
48. Stingl G., Katz S.I., Clement L., Green, and Shevach E.M. Immunologic functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121 (1978) 2005-2013
49. Thorsness P.E., and Koshland Jr. D.E. Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. J. Biol. Chem. 262 (1987) 422-425
50. Toews G.B., Bergstresser P.R., and Streilein J.W. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J. Immunol. 124 (1980) 445-453
51. Tuazon P.T., Lorenson M.Y., Walker A.M., and Traugh J.A. p21-activated protein kinase gamma-PAK in pituitary secretory granules phosphorylates prolactin. FEBS Lett. 515 (2002) 84-88
52. Ueda E.K., Lo H.L., Batrolini P., and Walker A.M. S179D prolactin primarily uses the extrinsic pathway and mitogen-activated protein kinase signaling to induce apoptosis in human endothelial cells. Endocrinology 147 (2006) 4627-4637
53. Ueda E., Ozerdem U., Chen Y.H., Yaom M., Huang K.T., Sun H., Martins-Green M., Bartolini P., and Walker A.M. A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone. Endocr. Relat. Cancer 13 (2006) 95-111
54. Walker A.M. Therapeutic potential of S179D prolactin-from prostate cancer to angioproliferative disorders: the first selective prolactin receptor modulator. Expert Opin. Invest. Drugs 15 (2006) 1257-1267
55. Wang Y.F., and Walker A.M. Dephosphorylation of standard prolactin produces a more biologically active molecule: evidence for antagonism between nonphosphorylated and phosphorylated prolactin in the stimulation of Nb2 cell proliferation. Endocrinology 133 (1993) 2156-2160
56. Wang Y.F., Liu J.W., Mamidi M., and Walker A.M. Identification of the major site of rat prolactin phosphorylation as serine 177. J. Biol. Chem. 271 (1996) 2462-2469
57. Wu W., Coss D., Lorenson M.Y., Kuo C.B., Xu X., and Walker A.M. Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways. Biochemistry 42 (2003) 7561-7570
58. Wu W., Chen Y.-H., Ueda E., Tan D., Bartolini P., and Walker A.M. Different forms of prolactin have opposing effects on the expression of cell cycle regulatory proteins in differentiated mammary epithelial cells. Oncol. Res. 16 (2006) 75-84
59. Xu X., Kreye E., Kuo C.B., and Walker A.M. A molecular mimic of phosphorylated prolactin markedly reduced tumor incidence and size when DU145 human prostate cancer cells were grown in nude mice. Cancer Res. 61 (2001) 6098-6104
60. Xu X., Wu W., Williams V., Khong A., Chen Y.H., Deng C., and Walker A.M. Opposite effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin on morphology and the expression of prostate specific genes in the normal rat prostate. Prostate 54 (2003) 25-33
61. Yang L., Kuo C.B., Liu Y., Coss D., Xu X., Chen C., Oster-Granite M.L., and Walker A.M. Administration of unmodified prolactin (U-PRL) and a molecular mimic of phosphorylated prolactin (PP-PRL) during rat pregnancy provides evidence that the U-PRL:PP-PRL ratio is crucial to the normal development of pup tissues. J. Endocrinol. 168 (2001) 227-238
62. Yang L.S., Lii S., Kuo B., Buckley A., Buckley D., Chen C., Xu X., Coss D., and Walker A.M. Maternal prolactiin composition can permanently affect epidermal gamma delta T cell function in the offspring. Dev. Comp. Immunol. 26 (2002) 849-860
63. Zelena D., Foldes A., Mergl Z., Barna I., Kovacs K.J., and Makara G.B. Effects of repeated restraint stress on hypothalamo-pituitary-adrenocortical function in vasopressin deficient Brattleboro rats. Brain Res. Bull. 63 (2004) 521-530