Involvement of serotonin mechanisms in the antinociceptive effect of S(+)-ketoprofen

Drug Development Research

Volumn 57, Issue 4, 2002, Pages 187-192

  Díaz Reval, Ma Irene ^a   Ventura Martínez, Rosa ^a   Déciga Campos, Myrna ^a   Terrón, José A ^a   Cabré, Francesc ^b,c   López Muñoz, Francisco J ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b Menarini Research   (Spain)

^c Laboratories VITA SA   (Spain)

Author keywords

Analgesia; Antinociception; PIFIR model; S(+) ketoprofen; Supraspinal

Indexed keywords

KETOPROFEN; METHYLCELLULOSE; METITEPINE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 7 RECEPTOR; SODIUM CHLORIDE; TROPISETRON; URIC ACID;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DRUG MECHANISM; MALE; NONHUMAN; RAT; SEROTONINERGIC SYSTEM;

EID: 0036997988     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10147     Document Type: Article

References (31)

1. Bardini L, Lavarenne J, Eschalier A. 2000. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain 86:11-18.
2. Barnes NM, Sharpe TS. 1999. A review of central 5HT receptors and their function. Neuropharmcology, 38:1083-1152.
3. Beltrán J, Martin-Mola E, Fugueroa M, Granados J, Sanmarti R, Artigas R, Torres F, Forns M, Mauleón D. 1998. Comparison of dexketoprofen trometamol and ketoprofen in the treatment of osteoarthritis in the knee. J Clin Pharmacol 38:74S-80S.
4. Björkman B. 1995, Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Acta Anaesthesiol Scand Sup 39:1-44.
5. Björkman RL, Hedner T, Hallman KM, Henning M, Hedner J. 1992. Localization of the central antinociceptive effects of diclofenac in the rat. Brain Res 590:66-73.
6. Cabré F, Fernández MF, Calvo L, Ferrer X, García ML, Mauleón D. 1998. Analgesic, antiinflammatory, and antipyretic effects of S(+)-ketoprofen in vivo. J Clin Pharmacol 12:3S-10S.
7. Carabaza A, Cabré F, Rotllan E, Gómez M, Gutiérrez M, García L, Mauleón D. 1996. Stereoselective inhibition of inducible cyclooxigenase by chiral nonsteroidal antiinflammatory drugs. J Clin Pharmacol 36:505-512.
8. Cooper SA. 1983. New peripherally-acting oral analgesic agents. Ann Rev Pharmacol Toxicol 23:617-647.
9. Covino BG, Dubner R, Gybels J, Kosterlitz HW, Liebeskind JC, Sternbach RA, Vyklicky L, Yamamura H, Zimmermann M. 1980. Ethical standards for investigations of experimental pain in animals. Pain 9:141-143.
10. Duarte IDG, Lorenzetti BB, Ferreira SH. 1990. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur J Pharmacol 186:289-293.
11. Ezeuridia M, Cortejosos FJ, Lanzón R, Ugalde FJ, Herruzo A, Artigas R, Fernández MF, Torres F, Mauleón D. 1998. Comparison of the efficacy and tolerability of dexketoprofen and ketoprofen in the treatment of primary dysmenorrhea. J Clin Pharmacol 38:65S-74S.
12. 3 receptor antagonist. Neurosci Lett 95:313-317.
13. Granados-Soto V, Flores-Murrieta FJ, Castañeda-Hernández G, López-Muñoz FJ. 1995. Evidence for the involvement of nitric oxide in the analgesic effect of ketorolac. Eur J Pharmacol 277:281-284.
14. Herrero JF, Parrado A, Cervero F. 1997. Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes. Neuropharmacology 36:1425-1431.
15. Hoyer D, Clarke DE, Fozard JR, Harting PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PPA. 1994. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203.
16. Hoyo-Vadillo C, Pérez-Urizar J, López-Muñoz FJ. 1995. Usefulness of the pain-induced functional impairment model to relate plasma levels of analgesic to their efficacy in rats. J Pharm Pharmacol 47:462-465.
17. López-Muñoz FJ. 1994. Surface of synergistic interaction between dipyrone and morphine in the PIFIR model. Drug Dev Res 33:26-32.
18. López-Muñoz FJ, Salazar LA, Castañeda-Hernández G, Villarreal JE. 1993. A new model to assess analgesic activity: pain-induced functional impairment in the rat (PIFIR model). Drug Dev Res 28:169-175.
19. López-Muñoz FJ, Ventura B, Díaz MI, Fernández-Guasti A, Tost D, Cabré F, Mauleón D. 1998. Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. J Clin Pharmacol 38:11S-21S.
20. Malmberg AB, Yaksh TL. 1994. Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test. Eur J Pharmacol 256:205-209.
21. McGurk B, Robinson P, Rajayogeswaran V, De Luca, Casini A, Artigas R, Muñoz G, Mualeón D. 1998. Clinical comparison of dexketoprofen trometamol, ketoprofen and placebo in post-operative dental pain. J Clin Pharmacol 38:46S-54S.
22. Netter P, Lapicque F, Bannwarth B, Tamisier JN, Thomas P, Royer BJ. 1985. Diffusion of intramuscular ketoprofen into the cerebrospinal fluid. Eur J Clin Pharmacol 29:319-321.
23. Neugebauer V, Geisslinger G, Rümenapp P, Weiretter F, Szelenyi I, Brune K, Schaible HG. 1995. Antinociceptive effects of R(-) and S(+)-Flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by ah acute knee joint inflammation. J Pharmacol Exp Ther 275:618-628.
24. Paxinos G, Watson C. 1982. The rat brain in stereotaxic coordinates. New York: Academic Press.
25. Pini LA, Vitale G, Sandrini M. 1997. Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid. Pharmacology 54:84-91.
26. Rowland M, Tozer TN. 1989. Clinical pharmacokinetics: concepts and applications. 2nd ed. Philadelphia: Lea & Febiger.
27. Suesa N, Fernandez MF, Gutierrez M, Rufat MJ, Rotllan E, Calvo L, Mauleón D, Carganico G. 1993. Stereoselective cyclooxygenase inhibition in cellular models by the enantiomers of ketoprofen. Chirality 5:589-595.
28. Tjolsen A, Lund A, Hole K. 1991. Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. Eur J Pharmacol 193:193-201.
29. Willer JC, De Broucker T, Bussel B, Roby-Brami A, Harrewyn JM. 1989. Central analgesic effect of ketoprofen in humans: electro-physiological evidence for a supraspinal mechanism in a double-blind and cross-over study. Pain 38:1-7.
30. Yaksh TL, Rudy TA. 1976. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17:1031-1036.
31. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in concious animals. Pain 16:109-110.