Cerebrospinal fluid proteomes: From neural development to neurodegenerative diseases

Current Proteomics

Volumn 4, Issue 2, 2007, Pages 89-106

  Parada, Carolina ^a   Parvas, Maryam ^a   Bueno, David ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Ageing; Central nervous system; Cerebrospinal fluid; CSF proteome; Embryogenesis; Neurodegeneration

Indexed keywords

MAMMALIA; RATTUS;

EID: 36448994432     PISSN: 15701646     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016407782194611     Document Type: Review

References (100)

1. Abdi, F., Quinn, J. F., Jankovic, J., McIntosh, M., Leverenz, J. B., Peskind, E., Nixon, R., Nutt, J., et al. (2006). Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders. J. Alzheimers Dis. 9: 293-348.
2. Agrawal, S. and Schaffer, D. V. (2005). In situ stem cell therapy: novel targets, familiar challenges. Trends Biotechnol. 23: 78-83.
3. Alonso, M. I., Gato, A., Moro, J. A. and Barbosa, E. (1998). Disruption of proteoglycans in neural tube fluid by beta-D-xyloside alters brain enlargement in chick embryos. Anat. Rec. 252: 499-508.
4. Alonso, M. I., Gato, A., Moro, J. A., Martin, P. and Barbosa, E. (1999). Involvement of Sulfated Proteoglycans in Embryonic Brain Expansion at Earliest Stages of Development in Rat Embryos. Cells Tissues Organs 165: 1-9.
5. Alvarez-Buylla, A. and Garcia-Verdugo, J. M. (2002). Neurogenesis in Adult Subventricular Zone. J. Neurosci. 22: 629-34.
6. Andersen, J. M., Myhre, O. and Fonnum, F. (2003). Discussion of the Role of the Extracellular Signal-Regulated Kinase-Phospholipase A2 Pathway in Production of Reactive Oxygen Species in Alzheimer's Disease. Neurochem. Res. 28: 319-26.
7. Anthony, S. G., Schipper, H. M., Tavares, R., Hovanesian, V., Cortez, S. C., Stopa, E. G. and Johanson, C. E. (2003). Stress protein expression in the Alzheimer-diseased choroid plexus. J. Alzheimers Dis. 5: 171-77.
8. Bally-Cuif, L. and Boncinelli, E. (1997). Transcription factors and head formation in vertebrates. BioEssays 19: 127-35.
9. Bellairs, R. and Osmond, M. (2005). Atlas of Chick Development. Elsevier Academy Press, London.
10. Birecree, E., King, L. E. J. and Nanney, L. B. (1991). Epidermal growth factor and its receptor in the developing human nervous system. Brain Res. Dev. Brain Res. 60: 145-54.
11. Biroccio, A., Boccio, P., Panella, M., Bernardini, S., Di Ilio, C., Gambi, D., Stanzione, P., Sacchetta, P., et al. (2006). Differential post-translational modifications of transthyretin in Alzheimer's disease: A study of the cerebral spinal fluid. Proteomics 6: 2305-13.
12. Brocklehurst, G. (1979). The significance of the evolution of the cerebrospinal fluid system. Ann. Rev. Coll. Surg. Engl. 61: 349-56.
13. Brown, P. D., Davies, S. L., Speake, T. and Millar, I. D. (2004). Molecular mechanisms of cerebrospinal fluid production. Neuroscience 129: 955-68.
14. Carro, E., Trejo, J. L., Spuch, C., Bohl, D., Heard, J. M. and Torres-Aleman, I. (2006). Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: New cues into the human disease? Neurobiol. Aging 27: 1618-31.
15. Checiu, I., Prelipceanu, O. and Popescu, O. (1984). The role of cerebrospinal fluid during embryonic development. A biochemical study. Morphol. Embryol. 30: 243-50.
16. Chodobski, A. and Szmydynger-Chodobska, J. (2001). Choroid plexus: Target for polypeptides and site of their synthesis. Microsc. Res. Tech. 52: 65-82.
17. Chodorowska, G., Glowacka, A. and Tomczyk, M. (2004). Leukemia inhibitory factor (LIF) and its biological activity. Ann. Univ. Mariae Curie Sklodowska. 59: 189-93.
18. Copp, A. J., Greene, N. D. and Murdoch, J. N. (2003) The genetic basis of mammalian neurulation. Nat. Rev. Genet. 4: 784-93.
19. Copp, A. J. (2005). Neurulation in the cranial region - normal and abnormal. J. Anat. 207: 623-35.
20. Davidsson, P., Paulson, L., Hesse, C., Blennow, K. and Nilsson, C. L. (2001). Proteome studies of human cerebrospinal fluid and brain tissue using a preparative two-dimensional electrophoresis approach prior to mass spectrometry. Proteomics 1: 444-52.
21. Davidsson, P. and Sjogren, M. (2006). Proteome studies of CSF in AD patients. Mech. Ageing Dev. 127: 133-37.
22. Davidsson, P., Sjogren, M., Andreasen, N., Lindbjer, M., Nilsson, C. L., Westman-Brinkmalm, A. and Blennow, K. (2002). Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins. Brain Res. Mol. Brain Res. 109: 128-33.
23. Davidsson, P. and Sjögren, M. (2005). The use of proteomics in biomarker discovery in neurodegenerative diseases. Dis. Markers 21: 81-92.
24. Desmond, M. E. and Jacobson, A. G. (1977). Embryonic brain enlargement requires cerebrospinal fluid pressure. Dev. Biol. 57: 188-98.
25. Desmond, M. E. (1985) Reduced number of brain cells in so-called neural overgrowth. Anat. Rec. 212: 195-8.
26. Desmond, M. E. and Levitan, M. L. (2002). Brain expansion in the chick embryo initiated by experimentally produced occlusion of the spinal neurocoel. Anat. Rec. 268: 147-59.
27. Devarajan, K. and Rusak, B. (2004). Oxytocin levels in the plasma and cerebrospinal fluid of male rats: effects of circadian phase, light and stress. Neursci. Lett. 367: 144-7.
28. Di Terlizzi, R. and Platt, S. (2006). The function, composition and analysis of cerebrospinal fluid in companion animals: part I - function and composition. Vet. J. 172: 422-31.
29. Dziegielewska, K. M., Evans, C. A., Fossan, G., Lorscheider, F. L., Malinowska, D. H., Mollgard, K., Reynolds, M. L, Saunders, N. R. et al. (1980). Proteins in cerebrospinal fluid and plasma of fetal sheep during development. J. Physiol. (Lond.). 300: 441-55.
30. Dziegielewska, K. M., Evans, C. A., Lai, P. C., Lorscheider, F. L., Malinowska, D. H., Mollgard, K. and Saunders, N. R. (1981). Proteins in cerebrospinal fluid and plasma of fetal rats during development. Dev. Biol. 83: 193-200.
31. Emerich, D. F., Skinner, S. J. M., Borlongan, C. V., Vasconcellos, A. V. and Thanos, C. G. (2005). The choroid plexus in the rise, fall and repair of the brain. BioEssays 27: 262-74.
32. Emerich, D. F., Vasconcellos, A. V., Elliott, R. B., Skinner, S. J. and Borlongan, C. V. (2004). The choroid plexus: function, pathology and therapeutic potential of its transplantation. Expert Opin. Biol. Ther. 4: 1191-201.
33. Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A. and Gage, F. (1998). Neurogenesis in the adult human hippocampus. Nat. Med. 4: 1313-7.
34. Esterle, T. and Sanders-Bush, E. (1992). Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. J. Neurosci. 12: 4775-82.
35. Ferrante, F. and Amenta, F. (1987). Enzyme histochemistry of the choroid plexus in old rats. Mech. Ageing Dev. 41: 65-72.
36. Fielitz, W., Esteves, A. and Moro, R. (1984). Protein composition of cerebrospinal fluid in the developing chick embryo. Brain Res. 315: 111-5.
37. Finehout, E. J., Franck, Z., Choe, L. H., Relkin, N. and Lee, K. H. (2007). Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease. Ann. Neurol. 61: 120-29.
38. Forero, D., Cassadesus, G., Perry, G. and Arboleda, H. (2006) Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J. Cell Mol. Med. 10: 796-805.
39. Gao, B. and Meier, P. J. (2001). Organic anion transport across the choroid plexus. Microsc. Res. Tech. 52: 60-4.
40. Gato, A., Martín, P., Alonso, M. I., Martín, C., Pulgar, M. A. and Moro, J. A. (2004). Analysis of cerebro-spinal fluid protein composition in early developmental stages in chick embryos. J. Exp. Zoolog. Part A Comp. Exp. Biol. 301: 280-9.
41. Gato, A., Moro, J. A., Alonso, M. I., Bueno, D., De La Mano, A. and Martín, C. (2005). Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos. Anat. Rec. 284A, 475-84.
42. Ghersi-Egea, J. F., Strazielle, N., Murat, A., Edwards, J. and Belin, M. F. (2001). Are blood-brain interfaces efficient in protecting the brain from reactive molecules? Adv. Exp. Med. Biol. 500: 359-64.
43. Gilbert, S. F. (2006). Developmental Biology, 8th edition. Sinauer Associates, Sunderland, Massachusetts.
44. Gotz, M. and Stricker, S. H. (2006). Go with the flow: signaling from the ventricle directs neuroblast migration. Nat. Neurosci. 9: 470-2.
45. Gremo, F. and Presta, M. (2000). Role of fibroblast growth factor-2 in human brain: a focus on development. Int. J. Dev. Neurosci. 18: 271-9.
46. Hamburger, V. and Hamilton, H. L. (1951) A series of normal stages in the development of the chick embryo. J. Morphology 88: 49-92
47. Hammack, B. N., Fung, K. Y., Hunsucker, S. W., Duncan, M. W., Burgoon, M. P., Owens, G. P. and Gilden, D. H. (2004). Proteomic analysis of multiple sclerosis cerebrospinal fluid. Mult. Scler. 10: 245-60.
48. Hansson, S., Puchades, M., Blennow, K., Sjogren, M. and Davidsson, P. (2004). Validation of a prefractionation method followed by two-dimensional electrophoresis - Applied to cerebrospinal fluid proteins from frontotemporal dementia patients. Proteome Sci. 2: 7.
49. Hao, R., Norgren, R. B. J., Lau, Y. S. and Pfeiffer, R. F. (1995). Cerebrospinal fluid of Parkinson's disease patients inhibits the growth and function of dopaminergic neurons in culture. Neurology 45: 138-42.
50. Hatta, T., Matsumoto, A., Ono, A., Udagawa, J., Nimura, M., Hashimoto, R. and Otani, H. (2006). Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos. Neuroreport 17: 1863-6.
51. Hu, H. (1999). Chemorepulsion of Neuronal Migration by Slit2 in the Developing Mammalian Forebrain. Neuron 23: 703-11.
52. Hu, Y., Malone, J. P., Fagan, A. M., Townsend, R. R. and Holtzman, D. M. (2005). Comparative Proteomic Analysis of Intra- and Interindividual Variation in Human Cerebrospinal Fluid. Mol. Cell Proteomics 4: 2000-9.
53. Jones, H. C. and Dolman, G. S. (1979). The structure of the roof of the fourth ventricle in pigeon and chick brains by light and electron microscopy. J. Anat. 128:13-29.
54. Kurzrock, R., Estrov, Z., Wetzler, M., Gutterman, J. U., Talpaz, M. (1991). LIF: not just a leukemia inhibitory factor. Endocr. Rev. 12: 208-17.
55. Lehmensiek, V., Sussmuth, S. D., Brettschneider, J., Tauscher, G., Felk, S., Gillardon, F. and Tumani, H. (2007). Proteome analysis of cerebrospinal fluid in Guillain-Barre syndrome (GBS). J. Neuroimmunol. 185, 190-4.
56. Lois, C. and Alvarez-Buylla, A. (1994). Long-distance neuronal migration in the adult mammalian brain. Science 164: 1145-8.
57. Martin, C., Bueno, D., Alonso, M. I., Moro, J. A., Callejo, S., Parada, C., Martín, P., Carnicero, E., et al. (2006). FGF2 plays a key role in Embryonic Cerebrospinal Fluid trophic properties over Chick Embryo Neuroepithelial Stem Cells. Dev. Biol. 297: 402-16.
58. Martinez, S. (2001). The isthmic organizer and brain regionalization. Int. J. Dev. Biol. 44: 367-71.
59. Mashayekhi, F., Draper, C. E., Bannister, C. M., Pourghasem, M., Owen-Lynch, P. J. and Miyan, J. A. (2002). Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: a role for CSF. Brain 125: 1859-74.
60. Mashayekhi, F. and Salehi, Z. (2006). The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex. Eur. J. Neurol. 13: 266-72.
61. Mashayekhi, F. and Salehin, Z. (2006). Cerebrospinal fluid nerve growth factor levels in patients with Alzheimer's disease. Ann. Saudi Med. 26: 278-9.
62. Miklossy, J., Kraftsik, R., Pillevuit, O., Lepori, D., Genton, C. and Bosman, F. T. (1998). Curly fiber and tangle-like inclusions in the ependyma and choroid plexus - a pathogenetic relationship with the cortical Alzheimer-type changes? J. Neuropathol. Exp. Neurol. 57: 1202-12.
63. Miyan, J., Zendah, M., Mashayekhi, F. and Owen-Lynch, P. J. (2006). Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development. Cerebrospinal Fluid Res. 3: 2.
64. Miyan, J. A., Nabiyouni, M. and Zendah, M. (2003). Development of the brain: a vital role for cerebrospinal fluid. Can. J. Physiol. Pharmacol. 81: 317-28.
65. Mollgard, K., Jacobsen, M., Jacobsen, G. K., Clausen, P. P. and Saunders, N. R. (1979). Immunohistochemical evidence for an intracellular localization of plasma proteins in human foetal choroid plexus and brain. Neurosci. Lett. 14: 85-90.
66. Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S. and van der Kooy, D. (1994). Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron 13: 1071-82.
67. Murillo-Rodriguez, E., Désarnaud, F. and Prospéro- García, O. (2006). Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. Life Sci. 79: 30-7.
68. Noben, J. P., Dumont, D., Kwasnikowska, N., Verhaert, P., Somers, V., Hupperts, R., Stinissen, P. and Robben, J. (2006). Lumbar cerebrospinal fluid proteome in multiple sclerosis: characterization by ultrafiltration, liquid chromatography, and mass spectrometry. J. Proteome Res. 5: 71647-57.
69. Nussbaum, R. L. and Ellis, C. E. (2003). Alzheimer's disease and Parkinson's disease. N. Engl. J. Med. 348: 1356-64.
70. Owen-Lynch, P. J., Draper, C. E., Mashayekhi, F., Bannister, C. M. and Miyan, J. A. (2003). Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat. Brain 126: 623-31.
71. Pan, S., Zhu, D., Quinn, J. F., Peskind, E., Montine, T. J., Lin, B., Goodlett, D. R., Taylor, G., et al. (2007). A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry. Proteomics 7: 469-73.
72. Parada, C., Martín, C., Alonso, M. I., Moro, J. A., Bueno, D. and Gato, A. (2005a). Embryonic cerebrospinal fluid collaborates with the isthmic organizer to regulate mesencephalic gene expression. J. Neurosci. Res. 82: 333-45.
73. Parada, C., Gato, A. and Bueno, D. (2005b). Mammalian Embryonic Cerebrospinal Fluid Proteome Has Greater Apolipoprotein and Enzyme Pattern Complexity than the Avian Proteome. J. Proteome Res. 4: 2420-8.
74. Parada, C., Gato, A., Aparicio, M. and Bueno, D. (2006). Proteome analysis of chick embryonic cerebrospinal fluid. Proteomics 6: 312-20.
75. Perlow, M. J., Chiueh, C. C., Lake, C. R. and Wyatt, R. J. (1980). Increased dopamine and norepinephrine concentrations in primate CSF following amphetamine and phenylethylamine administration. Brain Res. 186: 469-73.
76. Preston, J. E. (2001). Ageing choroid plexus-cerebrospinal fluid system. Microsc. Res. Tech. 52: 31-7.
77. Puchades, M., Hansson, S., Nilsson, C. L., Andreasen, N., Blennow, K. and Davidsson, P. (2003). Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease. Brain Res. Mol. Brain Res. 118: 140-6.
78. Rubin, L. L., and Staddon, J. M. (1999). The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 22: 11-28.
79. Sawamoto, K., Wichterle, H., Gonzalez-Perez, O., Cholfin, J. A., Yamada, M., Spassky, N., Murcia, N. S., Garcia-Verdugo, J. M., et al. (2006). New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain. Science 311: 629-32.
80. Serot, J. M., Bene, M. C. and Faure, G. C. (2003). Choroid plexus, ageing of the brain, and Alzheimer's disease. Front. Biosci. 8: 515-21.
81. Serot, J. M., Béné, M. C., Foliguet, B. and Faure, G. C. (2000). Morphological alterations of the choroid plexus in late-onset Alzheimer's disease. Acta Neuropathol. 99: 105-8.
82. Serot, J. M., Christmann, D., Dubost, T. and Couturier, M. (1997). Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry. 63: 506-8.
83. Shuangshoti, S. and Netsky, M. G. (1970). Human choroid plexus: morphologic and histochemical alterations with age. Am. J. Anat. 128: 73-96.
84. Smith, J. L. and Schoenwolf, G. C. (1997). Neurulation: coming to closure. Trends Neurosci. 20: 510-7.
85. Stern, C. D. (2001). Initial patterning of the central nervous system: how many organizers? Nat. Rev. Neurosci. 2: 92-8.
86. Stern, C. D. (2002). Induction and initial patterning of the nervous system - the chick embryo enters the scene. Curr. Opin. Genet. Dev. 12, 447-51.
87. Stopa, E. G., Berzin, T. M., Kim, S., Song, P., Kuo-LeBlanc, V., Rodriguez-Wolf, M., Baird, A. and Johanson, C. E. (2001). Human Choroid Plexus Growth Factors: What Are the Implications for CSF Dynamics in Alzheimer's Disease? Exp. Neurol. 167: 40-7.
88. Strazielle, N. and Ghersi-Egea, J. F. (2000). Choroid plexus in the central nervous system: biology and physiopathology. J. Neuropathol. Exp. Neurol. 59: 561-74.
89. Tauc, M., Vignon, X. and Bouchaud, C. (1984). Evidence for the effectiveness of the blood--CSF barrier in the fetal rat choroid plexus. A freeze-fracture and peroxidase diffusion study. Tissue Cell 16: 65-74.
90. Thouvenot, E., Lafon-Cazal, M., Demettre, E., Jouin, P., Bockaert, J. and Marin, P. (2006). The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells. Proteomics 6: 5941-52.
91. Tsutsumi, M., Skinner, M. and Sanders-Bush, E. (1989). Transferrin gene expression and synthesis by cultured choroid plexus epithelial cells. Regulation by serotonin and cyclic adenosine 3′,5′- monophosphate. J. Biol. Chem. 264: 9626-31.
92. Vigh, B., Manzano e Silva, M. J., Frank, C. L., Vincze, C., Czirok, S. J., Szabo, A., Lukats, A. and Szel, A. (2004). The system of cerebrospinal fluid-contacting neurons. Its supposed role in the nonsynaptic signal transmission of the brain. Histol. Histopathol. 19, 607-28.
93. Wakai, S. and Hirokawa, N. (1978). Development of the blood-brain barrier to horseradish peroxidase in the chick embryo. Cell Tissue Res. 195: 195-203.
94. Weiner, H. L. (1995). The role of growth factor receptors in central nervous system development and neoplasia. Neurosurgery 37: 179-93.
95. Wen, G. Y., Wisniewski, H. M. and Kascsak, R. J. (1999). Biondi ring tangles in the choroid plexus of Alzheimer's disease and normal aging brains: a quantitative study. Brain Res. 832: 40-6.
96. Wenner, B. R., Lovell, M. A. and Lynn, B. C. (2004). Proteomic analysis of human ventricular cerebrospinal fluid from neurologically normal, elderly subjects using two-dimensional LC-MS/MS. J. Proteome Res. 3: 97-103.
97. You, J. S., Gelfanova, V., Knierman, M. D., Witzmann, F. A., Wang, M. and Hale, J. E. (2005). Meetings: Proteomics 5: 326-7.
98. Zappaterra, M. D., Lisgo, S. N., Lindsay, S., Gygi, S. P. and Walsh, C. A., Ballif B.A. A Comparative Proteomic Analysis of Human and Rat Embryonic Cerebrospinal Fluid. J. Proteome Res. (in press, 2007).
99. Zhang, J., Goodlett, D. R., Peskind, E. R., Quinn, J. F., Zhou, Y., Wang, Q., Pan, C., Yi, E., et al. (2005a). Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiol. Aging 26: 207-27.
100. Zhang, J., Goodlett, D. R. and Montine, T. J. (2005b). Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases. J. Alzheimers Dis. 8: 377-86.