Dietary melibiose regulates Th cell response and enhances the induction of oral tolerance

Bioscience, Biotechnology and Biochemistry

Volumn 71, Issue 11, 2007, Pages 2774-2780

  Tomita, Kyoko ^a   Nagura, Taizo ^b   Okuhara, Yasuhide ^a   Nakajima Adachi, Haruyo ^c   Shigematsu, Norihiro ^a   Aritsuka, Tsutomu ^b   Kaminogawa, Shuichi ^d   Hachimura, Satoshi ^c  

^a Central Research Development Laboratory Fancl Corporation   (Japan)

^b Nippon Beet Sugar Mfg Co Ltd   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NIHON UNIVERSITY   (Japan)

Author keywords

Allergic disease; Melibiose; Oral tolerance; T cell response

Indexed keywords

ALLERGIES; ANTIGENS; CYTOLOGY; ENZYME INHIBITION;

MELIBIOSE; ORAL TOLERANCE; SUBCUTANEOUS IMMUNIZATION; T CELL RESPONSE;

ANTIGEN-ANTIBODY REACTIONS;

LYMPHOCYTE ANTIGEN RECEPTOR; MELIBIOSE; OVALBUMIN;

ANIMAL; ARTICLE; CARBOHYDRATE DIET; DRUG EFFECT; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; MOUTH; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; DIETARY CARBOHYDRATES; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MELIBIOSE; MICE; MICE, TRANSGENIC; MOUTH; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; TH2 CELLS;

MUS; MUS MUSCULUS;

EID: 36448986819     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70372     Document Type: Article

References (29)

1. Mosmann, T. R., and Coffman, R. L., TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann. Rev. Immunol., 7, 145-173 (1989).
2. Murphy, K. M., and Reiner, S. L., The lineage decisions of helper T cells. Nat. Rev. Immunol., 2, 933-944 (2002).
3. Fitch, F. W., McKisic, M. D., Lancki, D. W., and Gajewski, T. F., Differential regulation of murine T lymphocyte subsets. Annu. Rev. Immunol., 11, 29-48 (1993).
4. Shida, K., Makino, K., Morishita, A., Takamizawa, K., Hachimura, S., Ametani, A., Sato, T., Kumagai, Y., Habu, S., and Kaminogawa, S., Lactobacillus casei inhibits antigen-induced IgE secretion through regulation of cytokine production in murine splenocyte cultures. Int. Arch. Allergy Immunol., 115, 278-287 (1998).
5. Shida, K., Takahashi, R., Iwadate, E., Takamizawa, K., Yasui, H., Sato, T., Habu, S., Hachimura, S., and Kaminogawa, S., Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin. Exp. Allergy, 32, 563-570 (2002).
6. Murosaki, S., Yamamoto, Y., Ito, K., Inokuchi, T., Kusaka, H., Ikeda, H., and Yoshikai, Y., Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice. J. Allergy Clin. Immunol., 102, 57-64 (1998).
7. Kalliomäki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P., and Isolauri, E., Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet, 357, 1076-1079 (2001).
8. Björksten, B., Sepp, E., Julge, K., Voor, T., and Mikelsaar, M., Allergy development and the intestinal microflora during the first year of life. J. Allergy Clin. Immunol., 108, 516-520 (2001).
9. Van Loo, J., Cummings, J., Delzenne, N., Englyst, H., Franck, A., Hopkins, M., Kok, N., Macfarlane, G., Newton, D., Quigley, M., Roberfroid, M., van Vliet, T., and van den Heuvel, E., Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project (DGXII AIRII-CT94-1095). Br. J. Nutr., 81, 121-132 (1999).
10. Hidaka, H., Tashiro, Y., and Eida, T., Proliferation of Bifidobacteria by oligosaccharides and their useful effect on human health. Bifidobacteria Microflora, 10, 65-79 (1991).
11. Sako, T., Matsumoto, K., and Tanaka, R., Recent progress on research and applications of non-digestible galacto-oligosaccharides. Int. Dairy J., 9, 69-80 (1999).
12. Nagura, T., Hachimura, S., Hashiguchi, M., Ueda, Y., Kanno, T., Kikuchi, H., Sayama, K., and Kaminogawa, S., Suppressive effect of dietary raffinose on T-helper 2 cell-mediated immunity. Br. J. Nutr., 88, 421-426 (2002).
13. Nagura, T., Shimizu, Y., Sayama, K., and Benno, Y., Effect of melibiose on the fecal flora, with special reference to Bifidobacterium spp. and fecal properties in healthy volunteers. Bifidus (in Japanese), 9, 151-159 (1996).
14. Kaneko, I., Hayamizu, K., Tomita, K., Kikuchi, H., Nagura, T., Shigematsu, N., and Chiba, T., Pilot study of melibiose in patients with adolescent or adult-type atopic detmatitis. J. Appl. Glicosci. (in Japanese), 51, 123-128 (2004).
15. Sato, T., Sasahara, T., Nakamura, Y., Osaki, T., Hasegawa, T., Tadakuma, T., Arata, Y., Kumagai, Y., Katsuki, M., and Habu, S., Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice. Eur. J. Immunol., 24, 1512-1516 (1994).
16. Shida, K., Hachimura, S., Ametani, A., Ishimori, M., Ling, M., Hashiguchi, M., Ueda, Y., Sato, T., Kumagai, Y., Takamizawa, K., Habu, S., and Kaminogawa, S., Serum IgE response to orally ingested antigen: a novel IgE response model with allergen-specific T-cell receptor transgenic mice. J. Allergy Clin. Immunol., 105, 788-795 (2000).
17. Nagafuchi, S., Hachimura, S., Totsuka, M., Takahashi, T., Goto, M., Yajima, T., Kuwata, T., Habu, S., and Kaminogawa, S., Dietary nucleotides can up-regulate antigen-specific Th1 immune responses and suppress antigen-specific IgE responses in mice. Int. Arch. Allergy Immunol., 122, 33-41 (2000).
18. Sudo, N., Aiba, Y., Takaki, A., Tanaka, K., Yu, X. N., Oyama, N., Koga, Y., and Kubo, C., Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity. Clin. Exp. Allergy, 30, 979-987 (2000).
19. Faria, A. M., and Weiner, H. L., Oral tolerance. Immunol. Rev., 206, 232-259 (2005).
20. Weiner, H. L., Oral tolerance. Proc. Natl. Acad. Sci. USA, 91, 10762-10765 (1994).
21. Marth, T., Strober, W., and Kelsall, B. L., High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol., 157, 2348-2357 (1996).
22. Yoshida, T., Hachimura, S., and Kaminogawa, S., The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation. Clin. Immunol. Immunopathol., 82, 207-215 (1997).
23. kip1 degradation. J. Immunol., 169, 4723-4731 (2002).
24. Ise, W., Nakamura, K., Shimizu, N., Goto, H., Fujimoto, H., Kaminogawa, S., and Hachimura, S., Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation. J. Immunol., 175, 829-838 (2005).
25. Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C., and Koga, Y., The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol., 159, 1739-1745 (1997).
26. Wannemuehler, M. J., Michalek, S. M., Jirillo, E., Williamson, S. I., Hirasawa, M., and McGhee, J. R., LPS regulation of the immune response: bacteroides endotoxin induces mitogenic, polyclonal, and antibody responses in classical LPS responsive but not C3H/He. J mice. J. Immunol., 133, 299-305 (1984).
27. Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., and Itoh, K., Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect. Immun., 67, 3504-3511 (1999).
28. Sonoyama, K., Watanabe, H., Watanabe, J., Yamaguchi, N., Yamashita, A., Hashimoto, H., Kishino, E., Fujita, K., Okada, M., Mori, S., Kitahata, S., and Kawabata, J., Allergic airway eosinophilia is suppressed in ovalbumin-sensitized Brown Norway rats fed raffinose and alpha-linked galactooligosaccharide. J. Nutr., 135, 538-543 (2005).
29. Watanabe, H., Sonoyama, K., Watanabe, J., Yamaguchi, N., Kikuchi, H., Nagura, T., Aritsuka, T., Fukumoto, K., and Kasai, T., Reduction of allergic airway eosinophilia by dietary raffinose in Brown Norway rats. Br. J. Nutr., 92, 247-255 (2004).