DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation

Toxicology and Applied Pharmacology

Volumn 225, Issue 3, 2007, Pages 329-336

  Li, Chien Chun ^a   Lii, Chong Kuei ^a   Liu, Kai Li ^a   Yang, Jaw Ji ^a   Chen, Haw Wen ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

CAR; Constitutive androstane receptor; CYP 2B1; DHA; Docosahexaenoic acid; Hepatocytes; PUFAs

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B1; DOCOSAHEXAENOIC ACID; PHENOBARBITAL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE IDENTIFICATION; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT;

ANIMALS; BINDING SITES; CYTOCHROME P-450 CYP2B1; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; IMMUNOPRECIPITATION; MALE; PHENOBARBITAL; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TIME FACTORS; TRANSCRIPTION FACTORS;

RATTUS;

EID: 36448950841     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.08.009     Document Type: Article

References (48)

1. Arlt V.M., Henderson C.J., Wolf C.R., Schmeiser H.H., Phillips D.H., and Stiborova M. Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases. Cancer Lett. 234 (2006) 220-231
2. Bauer D., Wolfram N., Kahl G.F., and Hirsch-Ernst K.I. Transcriptional regulation of CYP2B1 induction in primary rat hepatocyte cultures: repression by epidermal growth factor is mediated via a distal enhancer region. Mol. Pharmacol. 65 (2004) 172-180
3. Calviello G., Resci F., Serini S., Piccioni E., Toesca A., Boninsegna A., Monego G., Ranelletti F.O., and Palozza P. Docosahexaenoic acid induces proteasome-dependent degradation of {beta}-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis 28 (2007) 1202-1209
4. Dentin R., Benhamed F., Pégorier J.P., Foufelle F., Viollet B., Vaulont S., Girard J., and Postic C. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J. Clin. Invest. 115 (2005) 2843-2854
5. Dvorak Z., Maurel P., Vilarem M.J., Ulrichova J., and Modriansky M. Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes. Cell Biol. Toxicol. 23 (2007) 63-73
6. Faucette S.R., Sueyoshi T., Smith C.M., Negishi M., Lecluyse E.L., and Wang H. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. J. Pharmacol. Exp. Ther. 317 (2006) 1200-1209
7. Frank C., Gonzalez M.M., Oinonen C., Dunlop T.W., and Carlberg C. Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor. J. Biol. Chem. 278 (2003) 43299-43310
8. Handschin C., and Meyer U.A. Induction of drug metabolism: the role of nuclear receptors. Pharmacol. Rev. 55 (2003) 649-673
9. Honkakoski P., and Negishi M. Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J. Biochem. Mol. Toxicol. 12 (1998) 3-9
10. Honkakoski P., Moore R., Washburn K.A., and Negishi M. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene. Mol. Pharmacol. 53 (1998) 597-601
11. Hosseinpour F., Moore R., Negishi M., and Sueyoshi T. Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor. Mol. Pharmacol. 69 (2006) 1095-1102
12. Huang W., Zhang J., Chua S.S., Qatanani M., Han Y., Granata R., and Moore D.D. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4156-4161
13. Iwase M., Kurata N., Ehana R., Nishimura Y., Masamoto T., and Yasuhara H. Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro. Human Exp. Toxicol. 25 (2006) 715-721
14. Joannard F., Galisteo M., Corcos L., Guillouzo A., and Lagadic-Gossmann D. Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatase. Cell Biol. Toxicol. 16 (2000) 325-337
15. Jump D.B., Botolin D., Wang Y., Xu J., Christian B., and Demeure O. Fatty acid regulation of hepatic gene transcription. J. Nutr. 135 (2005) 2503-2506
16. Kawamoto T., Sueyoshi T., Zelko I., Moore R., Washburn K., and Negishi M. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol. 19 (1999) 6318-6322
17. Kawamura A., Yoshida Y., Kimura N., Oda H., and Kakinuma A. Phosphorylation/dephosphorylation steps are crucial for the induction of CYP2B1 and CYP2B2 gene expression by phenobarbital. Biochem. Biophys. Res. Commun. 264 (1999) 530-536
18. Kim Y.J., and Takahashi R. Role of polyunsaturated fatty acids for misfolding protein aggregations: implication for neurodegenerative diseases. Ann. N.Y. Acad. Sci. 1086 (2006) 11-20
19. Kim J., Min G., and Kemper B. Chromatin assembly enhances binding to the CYP2B1 phenobarbital-responsive unit (PBRU) of nuclear factor-1, which binds simultaneously with constitutive androstane receptor (CAR)/retinoid X receptor (RXR) and enhances CAR/RXR-mediated activation of the PBRU. J. Biol. Chem. 276 (2001) 7559-7567
20. Kim H.K., Choi S., and Choi H. Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. J. Nutr. Biochem. 15 (2004) 485-492
21. Koike C., Moore R., and Negishi R. Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. Mol. Pharmacol. 71 (2007) 1217-1221
22. Le Jossic-Corcos C., Gonthier G., Zaghini I., Logette E., Shechter S., and Bournot P. Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. Biochem. J. 385 (2005) 787-794
23. Li C.C., Li C.K., Liu K.L., Yang J.J., and Chen H.W. N-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. J. Nutr. Biochem. 17 (2006) 707-715
24. Lin J.H. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm. Res. 23 (2006) 1089-1116
25. Machida T., Hiramatsu M., Hamaue N., Minami M., and Hirafuji M. Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J. Pharm. Sci. 99 (2005) 113-116
26. Malaplate-Armand C., Ferrari L., Masson C., Visvikis-Siest S., Lambert H., and Batt A.M. Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor genes in response to cocaine in human U373 MG astrocytoma cells. Toxicol. Lett. 159 (2005) 203-211
27. Marc N., Galisteo M., Lagadic-Gossmann D., Fautrel A., Joannard F., Guillouzo A., and Corcos L. Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture. Involvement of calcium- and cAMP-dependent pathways. Eur. J. Biochem. 267 (2000) 963-970
28. Mashour G.A., Drissel S.N., Frahm S., Farassati F., Martuza1 R.L., Mautner V.F., Kindler-Rohrborn A., and Kurtz A. Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. Oncogene 24 (2005) 2367-2374
29. Miao J., Fang S., Bae Y., and Kemper J.K. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. J. Biol. Chem. 281 (2006) 14537-14546
30. Pascussi J.M., Coniat M.B.L., Maurel P., and Vilarem M.J. Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. Mol. Endocrinol. 17 (2003) 42-55
31. Pascussi J.M., Dvorak Z., Gerbal-Chaloin S., Assenat E., Maurel P., and Vilarem M.J. Pathophysiological factors affecting CAR gene expression. Drug Metab. Rev. 35 (2003) 255-268
32. Posti K., Leinonen S., Tetri S., Kottari S., Viitala P., Pelkonen O., and Raunio H. Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases. Eur. J. Biochem. 264 (1999) 19-26
33. Pustylnyak V.O., Gulyaeva L.F., and Lyakhovich V.V. CAR expression and inducibility of CYP2B genes in liver of rats treated with PB-like inducers. Toxicology 216 (2005) 147-153
34. Pustylnyak V.O., Zakharova L.Y., Mikhailova O.N., Rice R.H., Gulyaeva L.F., and Lyakhovich V.V. In vivo effects of protein kinase and phosphatase inhibitors on CYP2B induction in rat liver. Toxicology 207 (2005) 315-322
35. Reschly E.J., and Krasowski M.D. Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds. Curr. Drug Metab. 7 (2006) 349-365
36. Reseland J.E., Haugen F., Hollung K., Solvoll K., Halvorsen B., Brude I.R., Nenseter M.S., Christiansen E.N., and Drevon C.A. Reduction of leptin gene expression by dietary polyunsaturated fatty acids. J. Lipid Res. 42 (2001) 743-750
37. Seglen P.O. Preparation of isolated rat liver cells. Methods Biol. 13 (1976) 29-83
38. Shelby M.K., and Klaassen C.D. Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways. Drug Metab. Dispos. 34 (2006) 1772-1778
39. Shindo S., Numazawa S., and Yoshida T. A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction. Biochem. J. 401 (2007) 735-741
40. Spector A.A., and Yorek M.A. Membrane lipid composition and cellular function. J. Lipid Res. 26 (1985) 1015-1035
41. Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., and Negishi M. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274 (1999) 6043-6046
42. Suchankova G., Tekle M., Saha A.K., Ruderman N.B., Clarke S.D., and Gettys T.W. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem. Biophys. Res. Commun. 326 (2005) 851-858
43. Trombetta A., Maggiora M., Martinasso G., Cotogni P., Canuto R.A., and Muzio G. Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs. Chem. Biol. Interact. 165 (2007) 239-250
44. Wang H., and Negishi M. Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. Curr. Drug Metab. 4 (2003) 515-525
45. Wang H., Faucette S., Moore R., Sueyoshi T., Negishi M., and LeCluyse E. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J. Biol. Chem. 279 (2004) 29295-29301
46. Yamamoto Y., Kawamoto T., and Negishi M. The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch. Biochem. Biophys. 409 (2003) 207-211
47. Yang J.J., and Krauss R.S. Extracellular ATP induces anchorage-independent expression of cyclin A and rescues the transformed phenotype of a ras-resistant mutant cell line. J. Biol. Chem. 272 (1997) 3103-3108
48. You L. Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. Chem. Biol. Interact. 147 (2004) 233-246