Isolation and characterization of human pituitary chorionic gonadotropin

Endocrinology

Volumn 137, Issue 4, 1996, Pages 1402-1411

  Birken, Steven ^a   Maydelman, Yacov ^a   Gawinowicz, Mary Ann ^a   Pound, Andrew ^a   Liu, Youping ^a   Hartree, Anne Stockell ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; GLYCOPROTEIN; SIALIC ACID; SULFATE;

ARTICLE; HORMONE SYNTHESIS; HUMAN; HYPOPHYSIS; PLACENTA; PREGNANCY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN ISOLATION;

EID: 0029959986     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.4.8625917     Document Type: Article

References (51)

1. Hussa RO 1987 The Clinical Marker hCG. Praeger, New York
2. Chen HC, Hodgen GD, Matsuura S, Lin LJ, Gross E, Reichert Jr LE, Birken S, Canfield RE, Ross GT 1976 Evidence for a gonadotropin from nonpregnant subjects that has physical, immunological, and biological similarities to human chorionic gonadotropin. Proc Natl Acad Sci USA 73:2885-2889
3. Armstrong EG, Ehrlich PH, Birken S, Schlatterer JP, Siris E, Hembree WC, Canfield RE 1984 Use of a highly sensitive and specific immunoradiometric assay for detection of human chorionic gonadotropin in urine of normal, non-pregnant and pregnant individuals. J Clin Endocrinol Metab 59:867-874
4. Akar AH, Gervasi G, Blacker C, Wehmann RE, Blithe DL, Nisula BC 1990 Human chorionic gonadotropin-like and β-core like materials in postmenopausal urine. J Endocrinol 125:477-484
5. Ayala AR, Nisula BC, Chen HC, Hodgen GD, Ross GT 1978 Highly sensitive radioimmunoassay for human chorionic gonadotropin in human urine. J Clin Endocrinol Metab 47:767-773
6. Braunstein GD, Kamdar V, Rasor J, Swaminathan N, Wade ME 1979 Widespread distribution of a chorionic gonadotropin-like substance in normal human tissues. J Clin Endocrinol Metab 49:917-925
7. Wahlstrom T, Stenman UH, Lundqvist C, Tanner P, Schroder J, Seppala M 1981 The use of monoclonal antibodies against human chorionic gonadotropin for immunoperoxidase staining of normal placenta, pituitary gland, and pituitary adenomas. J Histochem Cytochem 29:864-865
8. Adejuwon CA, Koide SS, Mitsudo SM, Segal SJ 1979 Apparent chorionic gonadotropin immunoreactivity in human non-placental tissues. In: Segal SJ (ed) Chorionic Gonadotropin. Plenum Press, New York, pp 411-419
9. O'Connor J, Birken S, Lustbader JW, Krichevsky A, Chen Y, Canfield RE 1994 Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements. Endocr Rev 15:650-683
10. Braunstein GD, Vaitukaitis JL, Carbone PP, Ross GT 1973 Ectopic production of human chorionic gonadotropin by neoplasms. Ann Intern Med 78:39-45
11. Hoermann R, Spoettl G, Moncayo R, Mann K 1990 Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary. J Clin Endocrinol Metab 71:179-186
12. Matsuura S, Takeuchi Y, Mochizuki M 1984 The preparation of an hCG-specific immunoadsorbent using hCG beta-carboxyl-terminal peptide antibody and its application to isolate HCG-like substances from human pituitary glands (in Japanese). Folia Endocrinol Jpn 60:800-813
13. Hartree AS, Shownkeen RC, Stevens VC, Matsuura S, Ohashi M, Chen HC 1983 Studies of the human chorionic gonadotrophin-like substance of human pituitary glands and its significance. J Endocrinol 96:115-126
14. Suginami H, Kawaoi A 1982 Immunohistochemical localization of a human chorionic gonadotropin-like substance in the human pituitary gland. J Clin Endocrinol Metab 55:1161-1166
15. Matsuura S, Ohashi M, Chen HC, Shownkeen RC, Hartree AS, Reichert Jr LE, Stevens VC, Powell JE 1980 Physicochemical and immunological characterization of an HCG-like substance from human pituitary glands. Nature 286:740-741
16. Hammond E, Griffin J, Odell WD 1991 A chorionic gonadotropin-secreting human pituitary cell. J Clin Endocrinol Metab 72:747-754
17. Matsuura S, Ohashi M, Chen HC, Shownkeen RC, Hartree AS, Reichert Jr LE, Stevens VC, Powell JE 1980 Physicochemical and immunological characterization of an HCG-like substance from human pituitary glands. Nature 286:740-741
18. Borkowski A, Muquardt C 1979 Human chorionic gonadotropin in the plasma of normal, nonpregnant subjects. N Engl J Med 301: 298-302
19. Rodgers M, Mitchell R, Lambert A, Peers N, Robertson WR 1992 Human chorionic gonadotrophin contributes to the bioactivity of Pergonal. Clin Endocrinol (Oxf) 37:558-64
20. Odell WD, Griffin J 1989 Pulsatile secretion of chorionic gonadotropin during the normal menstrual cycle. J Clin Endocrinol Metab 69:528-532
21. Odell WD, Griffin J 1987 Pulsatile secretion of human chorionic gonadotropin in normal adults. N Engl J Med 317:1688-1691
22. Baenziger JU 1994 Glycosylation and glycoprotein hormone function. In: Lustbader JW, Puett D, Ruddon RW (eds) Glycoprotein Hormones. Springer-Verlag, New York, pp 167-174
23. Van Strien A, van Wezenbeek P 1989 Presence of beta hCG mRNA in the human pituitary. Nucleic Acids Res 17:5406
24. Odell WD, Griffin J, Bashey HM, Snyder PJ 1990 Secretion of chorionic gonadotropin by cultured human pituitary cells. J Clin Endocrinol Metab 71:1318-1321
25. Sawitzke AL, Griffin J, Odell WD 1991 Purified preparations of human luteinizing hormone are contaminated with small amounts of a chorionic gonadotropin-like material. J Clin Endocrinol Metab 72:841-846
26. Hartree AS 1975 Purification of human pituitary glycoprotein hormones. In: O'Malley BW, Hardman JG (eds) Methods in Enzymology. Academic Press, New York, vol 37:381-389
27. Birken S, Chen Y, Gawinowicz MA, Agosto GM, Canfield RE, Hartree AS 1993 Structure and significance of human leuteinizing hormone-β core fragment purified from human pituitary extracts. Endocrinology 133:985-989
28. Krichevsky A, Birken S, O'Connor J, Acevedo HF, Bikel K, Lustbader J, Hartree A, Canfield RE 1994 Development, characterization, and application of monoclonal antibodies to the native and synthetic beta COOH-terminal portion of human chorionic gonadotropin (hCG) that distinguish between the native and desialylated forms of hCG. Endocrinology 143:1139-1145
29. Pollak S, Halpine S, Chait B, Birken S 1990 High resolution HPLC fingerprinting of purified hCG demonstrates that oxidation is a cause of hormone heterogeneity. Endocrinology 126:199-208
30. De Lean A, Munson PJ, Rodbard D 1992 Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235: E97-E102 (IBM version of program as distributed by Dr. Peter Munson, Laboratory of Theoretical and Physical Biology, NICHHD, Bethesda, MD)
31. Birken S, Krichevsky A, O'Connor J, Lustbader J, Canfield RE 1990 Chemistry and immunochemistry of hCG, its subunits and its fragments. In: Chin WW, Boime I (eds) Glycoprotein Hormones. Serono Symposia, Raven Press, Boston, pp 45-61
32. Birken S, Chen Y, Gawinowicz MA, Lustbader JW, Pollak S, Agosto G, Buck R, O'Connor J 1993 Separation of nicked human chorionic gonadotropin (hCG), intact hCG, and hCG beta fragment from standard reference preparations and raw urine samples. Endocrinology 133:1390-1397
33. Keutmann HT, Williams RM, Ryan RJ 1979 Structure of human luteinzing hormone beta subunit: evidence for a related carboxyl-terminal sequence among certain peptide hormones. Biochem Biophys Res Commun 90:842-848
34. Baenziger J U 1994 Protein-specific glycosyltransferases: how and why they do it. FASEB J 8:1019-1025 (Review)
35. Hartree AS, Renwick AGC 1992 Molecular structures of glycoprotein hormones and functions of their carbohydrate components. Biochem J 287:665-679
36. Ward DN, Wen T, Bousfield GR 1987 Sulfate and phosphate analysis in glycoproteins and other biologic compounds using ion chromatography. J Chromatogr 398:255-264
37. Bousfield GR, Ward DN 1992 Reduction and reoxidation of equine gonadotropin α-subunits. Endocrinology 131:2986-2998
38. Weisshaar G, Hiyama J, Renwick AGC 1991 Site-specific N-glycosylation of human chorionic gonadotrophin-structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. Glycobiology 1:393-404
39. Smith PL, Kaetzel D, Nilson J, Baenziger JU 1990 The sialylated oligosaccharides of recombinant bovine lutropin modulate hormone bioactivity. J Biol Chem 265:874-881
40. Szkudlinski MW, Thotakura R, Tropea JE, Grossmann M, Weintraub BD 1995 Asparagine-linked oligosaccharide structures determine clearance and organ distribution of pituitary and recombinant thyrotropin. Endocrinology 136:3325-3330
41. Baenziger JU, Kumar S, Brodbeck RM, Smith PL, Beranek MC 1992 Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides. Proc Natl Acad Sci USA 89:334-338
42. Fiete D, Srivastava V, Hindsgaul O, Baenziger JU 1991 A hepatic reticuloendothelial cell receptor specific for SO4-4GalNAc beta 1,4GlcNAc beta 1,2Man alpha that mediates rapid clearance of lutropin. Cell 67:1103-1110
43. Smith PL, Bousfield GR, Kumar S, Fiete D, Baenziger JU 1993 Equine lutropin and chorionic gonadotropin bear oligosaccharides terminating with SO4-4-GalNAc and Sia alpha 2,3Gal, respectively. J Biol Chem 268:795-802
44. Manzella SM, Dharmesh SM, Beranek MC, Swamson P, Baenziger JU 1995 Evolutionary conservation of the sulfated oligosaccharides on vertebrate glycoprotein hormone that control circulatory half-life. J Biol Chem 270:21665-21671
45. Matsui T, Mizuochi T, Titani K, Okinaga T, Hoshi M, Bousfield GR, Sugino H, Ward DN 1994 Structural analysis of N-linked oligosaccharides of equine chorionic gonadotropin and lutropin beta-subunits. Biochemistry 33:14039-14048
46. Matsui T, Sugino H, Miura M, Bousfield GR, Ward DN, Titani K, Mizuochi T 1991 Beta-subunits of equine chorionic gonadotropin and lutenizing hormone with an identical amino acid sequence have different asparagine-linked oligosaccharide chains. Biochem Biophysical Res Commun 174:940-945
47. Damm JBL, Hard K, Kammerling JP, Van Dedem GWK, Vliegenthart JFG 1990 Structure determination of the major N- and O-linked carbohydrate chains of the β-subunit from equine chrorionic gonadotropin. Eur J Biochem 189:175-183
48. Fares F, Suganuma N, Nishimori K, LaPolt PS, Hsueh AJW, Boime I 1992 Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin β subunit to follitropin β subunit. Proc Natl Acad Sci USA 89:4304-4308
49. Levy A, Biswas S, Burton PA, Lightman SL 1994 Expression of chorionic ganodotrophin in human pituitary adenomas. Eur J Endocrinol 131:615-622
50. Birken S, Gawinowicz MA, Kardana A, Cole LA 1991 The heterogeneity of hCG. II. Characteristics and origins of nicks in human chorionic gonadotropin reference standards. Endocrinology 129:1551-1558
51. Hoermann R, Spoettl G, Berger P, Mann K 1995 Immunoreactive human chorionic gonadotropin β core fragment in human pituitary. Exp Clin Endocrinol 103:324-331