Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes

Molecular Genetics and Metabolism

Volumn 84, Issue 4, 2005, Pages 354-362

  Meira, Débora Dummer ^a   Marinho Carvalho, Mônica M ^a   Teixeira, Cesar A ^a   Veiga, Venício F ^a   Da Poian, Andrea T ^a   Holandino, Carla ^a   De Freitas, Marta S ^b   Sola Penna, Mauro ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

6 Phosphofructo 1 kinase; Actin; Aldolase; Breast cancer; PFK; Treatment

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CLOTRIMAZOLE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCOLYTIC ENZYME;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; BRIGHT FIELD MICROSCOPY; CANCER CELL CULTURE; CELL ADHESION; CELL STRAIN MCF 7; CELL VIABILITY; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; ENZYME LOCALIZATION; GIEMSA STAIN; GLYCOLYSIS; HUMAN; HUMAN CELL; IC 50; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

MINK CELL FOCUS-FORMING VIRUS;

EID: 15244341038     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymgme.2004.11.012     Document Type: Article

References (35)

1. T.P. El-Bacha, and M. Sola-Penna Alterações no metabolismo de células neoplásicas A.T. Da Poian P.C. Carvalho-Alves Hormônios e Metabolismo: Integração e correlaçõ es clínicas 2002 Editora Atheneu São Paulo, SP 319 332
2. E.F. Greiner, M. Guppy, and K. Brand Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production J. Biol. Chem. 269 1994 31484 31490
3. M.E. Beckner, M.L. Stracke, L.A. Liotta, and E. Schiffmann Glycolysis as primary energy source in tumor cell chemotaxis J. Natl. Cancer Inst. 82 1990 1836 1840
4. K. Kubota From tumor biology to clinical Pet: a review of positron emission tomography (PET) in oncology Ann. Nucl. Med. 15 2001 471 486
5. A. Gennari, S. Donati, B. Salvadori, A. Giorgetti, P.A. Salvadori, O. Sorace, G. Puccini, P. Pisani, M. Poli, D. Dani, E. Landucci, G. Mariani, and P.F. Conte Role of 2-[18F]-fuorodeoxyglucose (FDG) positron emission tomography (PET) in the early assessment of response to chemotherapy in metastatic breast cancer patients Clin. Breast Cancer 1 2000 156 161
6. A. Lehotzky, M. Telegdi, K. Liliom, and J. Ovádi Interaction of phosphofructokinase with tubulin and microtubules. Quantitative evaluation of the mutual effects J. Biol. Chem. 268 1993 10888 10894
7. R. Beitner The role of glucose-1,6-diphosphin in the regulation of carbohydrate metabolism in muscle Trends Biochem. Sci. 4 1979 228 230
8. 2+ and calmodulin Int. J. Biochem. 25 1993 297 305
9. G.B. Vértessy, D. Bánkfalvi, J. Kovács, P. Lôv, A. Lehotzky, and J. Ovádi Pyruvate kinase as a microtubule destabilizing factor in vitro Biochem. Biophys. Res. Commun. 254 1999 430 435
10. F. Clarke, P. Stephan, D. Morton, and J. Weidemann Glycolytic enzyme organization via the cytoskeleton and its role in metabolic regulation R. Beitner Regulation of Carbohydrate Metabolism vol. 2 1985 CRC Press Boca Raton, FL 1 31
11. V. Adams, L. Gri.n, J. Towbin, B. Gelb, K. Worley, and E.R.B. McCabe Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane Biochem. Med. Metab. Biol. 45 1991 271 291
12. R. Beitner Calmodulin antagonists and cell energy metabolism in health and disease Mol. Genet. Metab. 64 1998 161 168
13. 2+ on binding of the glycolytic enzymes, phosphofructokinase and aldolase, to muscle cytoskeleton Biochem. Med. Metab. Biol. 49 1993 173 181
14. M. Chen-Zion, Y. Bassukevitz, and R. Beitner Sequence of insulin effects on cytoskeletal and cytosolic phosphofructokinase, mitochondrial hexokinase, glucose 1,6-bisphosphate and fructose 2,6-bisphosphate levels, and the antagonistic action of calmodulin inhibitors, in diaphragm muscle Int. J. Biochem. 24 1992 1661 1667
15. M. Chen-Zion, T. Livnat, and R. Beitner Insulin rapidly stimulates binding of phosphofructokinase and aldolase to muscle cytoskeleton Int. J. Biochem. 24 1992 821 826
16. G.G. Alves, and M. Sola-Penna Epinephrine modulates cellular distribution of muscle phosphofructokinase Mol. Genet. Metab. 78 2003 302 306
17. A.P.P. Silva, G.G. Alves, A.H.B. Araújo, and M. Sola-Penna Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle Ann. Acad. Bras. Ciências 76 2004 541 548
18. T.P. El-Bacha, M.M.T. Menezes, M.C. Azevedo e Silva, M. Sola-Penna, and A.T. Da Poian Mayaro virus infection alters glucose metabolism in cultured cells through activation of the enzyme 6-phosphofructo-1-kinase Mol. Cell. Biochem. 266 2004 191 198
19. T.P. El-Bacha, M.S. Freitas, and M. Sola-Penna Cellular distribution of phosphofructokinase activity and implications to metabolic regulation in human breast cancer Mol. Genet. Metab. 79 2003 294 299
20. S. Mac Neil, R.A. Dawson, G. Crocker, W.F.G. Tucker, B. Bittiner, J.G. Singleton, T. Hunter, and D.F. Tierney Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity Br. J. Dermatol. 128 1993 143 150
21. L. Hegemann, S.M. Toso, K.I. Lahijani, G.F. Webster, and J. Uitto Direct interaction of antifungal azole-derivatives with calmodulin: a possible mechanism for their therapeutic activity J. Invest. Dermatol. 100 1993 343 346
22. J. Penso, and R. Beitner Clotrimazole decreases glycolysis and the viability of lung carcinoma and colon adenocarcinoma cells Eur. J. Pharmacol. 451 2002 227 235
23. J. Penso, and R. Beitner Detachment of glycolytic enzymes from cytoskeleton of Lewis lung carcinoma and colon adenocarcinoma cells induced by clotrimazole and its correlation to cell viability and morphology Mol. Genet. Metab. 76 2002 181 188
24. G. Kopperschlager, T. Kriegel, and G. Birkenmeier Interaction of murine monoclonal subunit-specific antibodies with phosphofructokinase-1 from Saccharomyces cerevisiae FEBS Lett. 363 1995 17 21
25. R.I. Freshney, in: Wiley-Liss Inc. Publications (Ed.) Culture of Animal Cells: A Manual of Basic Technique, 1994
26. C. Holandino, V.F. Veiga, M.L. Rodrigues, M.M. Morales, M.A.M. Capella, and C.S. Alviano Direct current decreases cell viability but not P-glycoprotein expression and function in human multidrug resistant leukaemic cell Biolectromagnetics 22 2001 470 478
27. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays J. Immunol. Meth. 65 1983 55 63
28. M. Sola-Penna, A.C. Santos, G.G. Alves, T.P. El-Bacha, J. Faber-Barata, M.F. Pereira, F.C. Serejo, A.T. Da Poian, and M.M. Sorenson A radioassay for phosphofructokinase-1 in cell extracts and purified enzyme J. Biochem. Biophys. Methods 50 2002 129 140
29. S. Gonin-Giraud, A-L. Mathieu, S. Diocou, M. Tomkowiak, G. Delorme, and J. Marvel Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation Cell Death Differ. 9 2002 1147 1157
30. J.M. Garland, and A. Halestrap Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest J. Biol. Chem. 272 1997 4680 4688
31. W. Bursch, K. Hochegger, L. Török, B. Marian, A. Ellinger, and R.S. Hermann Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments J. Cell Sci. 113 2000 1189 1198
32. L.P. Kong Thoo, A.M. Dance, C. Bestwick, and L. Milne The biological activities of new polyamine derivatives as potential therapeutic agents Biochem. Soc. Trans. 31 2003 407 410
33. R. Mannhold, and H. Timmerman Putative therapeutic applications of calmodulin antagonists Pharm. Weekbl. Sci. 14 1992 161 166
34. G.A. Piazza, and R.W. Wallace Calmodulin accelerates the rate of polymerization of human platelet actin and alters the structural characteristics of actin filaments Proc. Natl. Acad. Sci. USA 82 1985 1683 1687
35. T.B. Deb, C.M. Coticchia, and R.B. Dickson Calmodulin-mediated activation of Akt regulates survival of c-Myc over-expressing mouse mammary carcinoma cells J. Biol. Chem. 279 2004 38903 38911