메뉴 건너뛰기




Volumn 42, Issue 11, 2007, Pages 887-896

Activated protein C, an anticoagulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases

Author keywords

Activated protein C; Mitogen activated protein kinases; Severe acute pancreatitis

Indexed keywords

ACTIVATED PROTEIN C; AMYLASE; COMPLEMENTARY DNA; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SEMAPIMOD; SODIUM CHLORIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 36348969579     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-007-2104-2     Document Type: Article
Times cited : (31)

References (30)
  • 1
    • 0033804768 scopus 로고    scopus 로고
    • Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications
    • 10986216 10.1136/gut.47.4.546 1:CAS:528:DC%2BD3cXnsVCru74%3D
    • J Mayer B Rau F Gansauge HG Beger 2000 Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications Gut 47 546-52 10986216 10.1136/gut.47.4.546 1:CAS:528:DC%2BD3cXnsVCru74%3D
    • (2000) Gut , vol.47 , pp. 546-552
    • Mayer, J.1    Rau, B.2    Gansauge, F.3    Beger, H.G.4
  • 2
    • 19944424483 scopus 로고    scopus 로고
    • Pancreatic proteases in serum induce leukocyte-endothelial adhesion and pancreatic microcirculatory failure
    • 15855822 10.1159/000085278 1:CAS:528:DC%2BD2MXktVKqs7g%3D
    • T Keck V Friebe AL Warshaw BA Antoniu G Waneck S Benz 2005 Pancreatic proteases in serum induce leukocyte-endothelial adhesion and pancreatic microcirculatory failure Pancreatology 5 241-50 15855822 10.1159/ 000085278 1:CAS:528:DC%2BD2MXktVKqs7g%3D
    • (2005) Pancreatology , vol.5 , pp. 241-250
    • Keck, T.1    Friebe, V.2    Warshaw, A.L.3    Antoniu, B.A.4    Waneck, G.5    Benz, S.6
  • 3
    • 33646491336 scopus 로고    scopus 로고
    • Disturbances of the microcirculation in acute pancreatitis
    • 16607683 10.1002/bjs.5316 1:STN:280:DC%2BD283gvFCgtg%3D%3D
    • CM Cuthbertson C Christophi 2006 Disturbances of the microcirculation in acute pancreatitis Br J Surg 93 518-30 16607683 10.1002/bjs.5316 1:STN:280:DC%2BD283gvFCgtg%3D%3D
    • (2006) Br J Surg , vol.93 , pp. 518-530
    • Cuthbertson, C.M.1    Christophi, C.2
  • 4
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen activated protein kinase pathway
    • 9069255 10.1016/S0955-0674(97)80061-0 1:CAS:528:DyaK2sXisVWntLk%3D
    • MJ Robinson MH Cobb 1997 Mitogen activated protein kinase pathway Curr Opin Cell Biol 9 180-6 9069255 10.1016/S0955-0674(97)80061-0 1:CAS:528:DyaK2sXisVWntLk%3D
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 5
    • 0036221384 scopus 로고    scopus 로고
    • MAP kinases in the immune response
    • 11861597 10.1146/annurev.immunol.20.091301.131133 1:CAS:528:DC%2BD38XjtlWgt70%3D
    • C Dong RJ Davis RA Flavell 2002 MAP kinases in the immune response Annu Rev Immunol 20 55-72 11861597 10.1146/annurev.immunol.20.091301.131133 1:CAS:528:DC%2BD38XjtlWgt70%3D
    • (2002) Annu Rev Immunol , vol.20 , pp. 55-72
    • Dong, C.1    Davis, R.J.2    Flavell, R.A.3
  • 6
    • 33645893489 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2
    • 16493686 10.1002/jnr.20803 1:CAS:528:DC%2BD28XktVKqt70%3D
    • PS Sapieha WW Hauswirth A Di Polo 2006 Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2 J Neurosci Res 83 985-95 16493686 10.1002/jnr.20803 1:CAS:528:DC%2BD28XktVKqt70%3D
    • (2006) J Neurosci Res , vol.83 , pp. 985-995
    • Sapieha, P.S.1    Hauswirth, W.W.2    Di Polo, A.3
  • 7
    • 0033743875 scopus 로고    scopus 로고
    • Reactive oxygen species activate mitogen-activated protein kinases in pancreatic acinar cells
    • 11075992 10.1097/00006676-200011000-00008 1:STN:280:DC%2BD3M7itV2gsA%3D%3D
    • A Dabrowski C Boguslowicz M Dabrowska 2000 Reactive oxygen species activate mitogen-activated protein kinases in pancreatic acinar cells Pancreas 21 376-84 11075992 10.1097/00006676-200011000-00008 1:STN:280:DC%2BD3M7itV2gsA%3D%3D
    • (2000) Pancreas , vol.21 , pp. 376-384
    • Dabrowski, A.1    Boguslowicz, C.2    Dabrowska, M.3
  • 8
    • 0242361289 scopus 로고    scopus 로고
    • Cholinergic receptor induction and JNK activation in acute pancreatitis
    • 14599627 10.1016/j.amjsurg.2003.07.016 1:CAS:528:DC%2BD3sXos1Omt7k%3D
    • I Samuel S Zaheer RA Fisher 2003 Cholinergic receptor induction and JNK activation in acute pancreatitis Am J Surg 186 569-74 14599627 10.1016/ j.amjsurg.2003.07.016 1:CAS:528:DC%2BD3sXos1Omt7k%3D
    • (2003) Am J Surg , vol.186 , pp. 569-574
    • Samuel, I.1    Zaheer, S.2    Fisher, R.A.3
  • 9
    • 20444427991 scopus 로고    scopus 로고
    • The anticoagulant protein C pathway
    • 15943976 10.1016/j.febslet.2005.03.001
    • B Dahlback BO Villoutreix 2005 The anticoagulant protein C pathway FEBS Lett 579 3310-6 15943976 10.1016/j.febslet.2005.03.001
    • (2005) FEBS Lett , vol.579 , pp. 3310-3316
    • Dahlback, B.1    Villoutreix, B.O.2
  • 10
    • 0032824727 scopus 로고    scopus 로고
    • Regulation of murine protein C gene expression in vivo: Effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta
    • 10544917 1:CAS:528:DyaK1MXmsFansLs%3D
    • K Yamamoto T Shimokawa T Kojima DJ Loskutoff H Saito 1999 Regulation of murine protein C gene expression in vivo: Effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta Thromb Haemost 82 1297-301 10544917 1:CAS:528:DyaK1MXmsFansLs%3D
    • (1999) Thromb Haemost , vol.82 , pp. 1297-1301
    • Yamamoto, K.1    Shimokawa, T.2    Kojima, T.3    Loskutoff, D.J.4    Saito, H.5
  • 11
    • 3042820686 scopus 로고    scopus 로고
    • Prevention of endothelial cell injury by activated protein C: The molecular mechanism(s) and therapeutic implications
    • 15320513 10.2174/1570161043476429 1:CAS:528:DC%2BD2cXisVajtbw%3D
    • K Okajima 2004 Prevention of endothelial cell injury by activated protein C: The molecular mechanism(s) and therapeutic implications Curr Vasc Pharmacol 2 125-33 15320513 10.2174/1570161043476429 1:CAS:528:DC%2BD2cXisVajtbw%3D
    • (2004) Curr Vasc Pharmacol , vol.2 , pp. 125-133
    • Okajima, K.1
  • 12
    • 26444604781 scopus 로고    scopus 로고
    • Drotrecogin alpha (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment
    • 16215381 10.1097/01.CCM.0000181729.46010.83 1:CAS:528:DC%2BD2MXhtVymt7bE
    • JL Vincent GR Bernard R Beale C Doig C Putensen JF Dhainaut 2005 Drotrecogin alpha (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment Crit Care Med 33 2266-77 16215381 10.1097/01.CCM.0000181729.46010.83 1:CAS:528:DC%2BD2MXhtVymt7bE
    • (2005) Crit Care Med , vol.33 , pp. 2266-2277
    • Vincent, J.L.1    Bernard, G.R.2    Beale, R.3    Doig, C.4    Putensen, C.5    Dhainaut, J.F.6
  • 13
    • 11444257317 scopus 로고    scopus 로고
    • Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers
    • 15614127 10.1097/01.shk.0000144422.32647.b6 1:CAS:528:DC%2BD2MXotFCjsA%3D%3D
    • T Iba A Kidokoro M Fukunaga K Sugiyama T Sawada H Kato 2005 Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers Shock 23 25-9 15614127 10.1097/01.shk.0000144422.32647.b6 1:CAS:528:DC%2BD2MXotFCjsA%3D%3D
    • (2005) Shock , vol.23 , pp. 25-29
    • Iba, T.1    Kidokoro, A.2    Fukunaga, M.3    Sugiyama, K.4    Sawada, T.5    Kato, H.6
  • 14
    • 3242744594 scopus 로고    scopus 로고
    • Disorders of hemostasis during the surgical management of severe necrotizing pancreatitis
    • 15257107 10.1097/00006676-200408000-00010
    • D Radenkovic D Bajec A Karamarkovic B Stefanovic N Milic S Ignjatovic 2004 Disorders of hemostasis during the surgical management of severe necrotizing pancreatitis Pancreas 29 152-6 15257107 10.1097/ 00006676-200408000-00010
    • (2004) Pancreas , vol.29 , pp. 152-156
    • Radenkovic, D.1    Bajec, D.2    Karamarkovic, A.3    Stefanovic, B.4    Milic, N.5    Ignjatovic, S.6
  • 15
    • 0033375143 scopus 로고    scopus 로고
    • Protein C activation during the initial phase of experimental acute pancreatitis in the rabbit
    • 10805548 10.1159/000018774 1:STN:280:DC%2BD3c3mtlaqug%3D%3D
    • LH Ottesen EM Bladbjerg M Osman SB Lausten NO Jacobsen J Gram 1999 Protein C activation during the initial phase of experimental acute pancreatitis in the rabbit Dig Surg 16 486-95 10805548 10.1159/000018774 1:STN:280:DC%2BD3c3mtlaqug%3D%3D
    • (1999) Dig Surg , vol.16 , pp. 486-495
    • Ottesen, L.H.1    Bladbjerg, E.M.2    Osman, M.3    Lausten, S.B.4    Jacobsen, N.O.5    Gram, J.6
  • 16
    • 33746086050 scopus 로고    scopus 로고
    • Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis
    • 16847238 10.1001/archsurg.141.7.670 1:CAS:528:DC%2BD28XnsFGgtLs%3D
    • G Alsfasser AL Warshaw SP Thayer B Antoniu M Laposata KB Lewandrowski 2006 Decreased inflammation and improved survival with recombinant human activated protein C treatment in experimental acute pancreatitis Arch Surg 141 670-6 16847238 10.1001/archsurg.141.7.670 1:CAS:528:DC%2BD28XnsFGgtLs%3D
    • (2006) Arch Surg , vol.141 , pp. 670-676
    • Alsfasser, G.1    Warshaw, A.L.2    Thayer, S.P.3    Antoniu, B.4    Laposata, M.5    Lewandrowski, K.B.6
  • 17
    • 20444370043 scopus 로고    scopus 로고
    • The effect of activated protein C on experimental acute necrotizing pancreatitis
    • 10.1186/cc3485
    • L Yamanel MR Mas B Comert AT Isik S Aydin N Mas 2005 The effect of activated protein C on experimental acute necrotizing pancreatitis Crit Care 9 184-90 10.1186/cc3485
    • (2005) Crit Care , vol.9 , pp. 184-190
    • Yamanel, L.1    Mas, M.R.2    Comert, B.3    Isik, A.T.4    Aydin, S.5    Mas, N.6
  • 18
    • 0027980422 scopus 로고
    • Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody
    • 8311136 10.1016/0002-9610(94)90076-0 1:CAS:528:DyaK2cXjt1Wit7Y%3D
    • HP Grewal A Mohey el Din L Gaber M Kotb AO Gaber 1994 Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody Am J Surg 167 214-8 8311136 10.1016/ 0002-9610(94)90076-0 1:CAS:528:DyaK2cXjt1Wit7Y%3D
    • (1994) Am J Surg , vol.167 , pp. 214-218
    • Grewal, H.P.1    Mohey el Din, A.2    Gaber, L.3    Kotb, M.4    Gaber, A.O.5
  • 19
    • 3242808323 scopus 로고    scopus 로고
    • Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats
    • 15257108 10.1097/00006676-200408000-00011 1:CAS:528:DC%2BD2cXmvF2ksL4%3D
    • L Leindler E Morschl F Laszlo Y Mandi T Takacs K Jarmai 2004 Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats Pancreas 29 157-61 15257108 10.1097/ 00006676-200408000-00011 1:CAS:528:DC%2BD2cXmvF2ksL4%3D
    • (2004) Pancreas , vol.29 , pp. 157-161
    • Leindler, L.1    Morschl, E.2    Laszlo, F.3    Mandi, Y.4    Takacs, T.5    Jarmai, K.6
  • 20
    • 33644829101 scopus 로고    scopus 로고
    • Anti-cytokine strategies in acute pancreatitis: Pathophysiological insights and clinical implications
    • 16358948 1:CAS:528:DC%2BD28XjsV2ktw%3D%3D
    • BM Rau CM Kruger MK Schilling 2005 Anti-cytokine strategies in acute pancreatitis: Pathophysiological insights and clinical implications Rocz Akad Med Bialymst 50 106-15 16358948 1:CAS:528:DC%2BD28XjsV2ktw%3D%3D
    • (2005) Rocz Akad Med Bialymst , vol.50 , pp. 106-115
    • Rau, B.M.1    Kruger, C.M.2    Schilling, M.K.3
  • 21
    • 33646410087 scopus 로고    scopus 로고
    • Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis
    • 16635917 10.1080/00365520500318965 1:CAS:528:DC%2BD28XjvVaktbg%3D
    • C Shi X Zhao A Lagergren M Sigvardsson X Wang R Andersson 2006 Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis Scand J Gastroenterol 41 472-80 16635917 10.1080/00365520500318965 1:CAS:528:DC%2BD28XjvVaktbg%3D
    • (2006) Scand J Gastroenterol , vol.41 , pp. 4724-4780
    • Shi, C.1    Zhao, X.2    Lagergren, A.3    Sigvardsson, M.4    Wang, X.5    Andersson, R.6
  • 22
    • 0032544234 scopus 로고    scopus 로고
    • Regulation of interleukin-1β induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
    • 9733787 10.1074/jbc.273.38.24832 1:CAS:528:DyaK1cXmtlyqtbs%3D
    • K Miyazawa A Mori H Miyata M Akahane Y Ajisawa H Okudaira 1998 Regulation of interleukin-1β induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase J Biol Chem 273 24832-8 9733787 10.1074/jbc.273.38.24832 1:CAS:528:DyaK1cXmtlyqtbs%3D
    • (1998) J Biol Chem , vol.273 , pp. 24832-24838
    • Miyazawa, K.1    Mori, A.2    Miyata, H.3    Akahane, M.4    Ajisawa, Y.5    Okudaira, H.6
  • 23
    • 0034710810 scopus 로고    scopus 로고
    • Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis
    • 11027531 10.1006/bbrc.2000.3530 1:CAS:528:DC%2BD3cXntFOrtL8%3D
    • T Hofken N Keller F Fleischer 2000 Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis Biochem Biophys Res Commun 276 680-5 11027531 10.1006/ bbrc.2000.3530 1:CAS:528:DC%2BD3cXntFOrtL8%3D
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 680-685
    • Hofken, T.1    Keller, N.2    Fleischer, F.3
  • 24
    • 1542515334 scopus 로고    scopus 로고
    • Therapeutic modulation of signal transduction pathways
    • 10.1097/00054725-200402001-00011
    • M Lowenberg MP Peppelenbosch DW Hommes 2004 Therapeutic modulation of signal transduction pathways Inflamm Bowel Dis 10 52-7 10.1097/ 00054725-200402001-00011
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 52-57
    • Lowenberg, M.1    Peppelenbosch, M.P.2    Hommes, D.W.3
  • 25
    • 0033860691 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome
    • 10921596 10.1097/00003246-200007000-00064 1:CAS:528:DC%2BD3MXntFKgsr8%3D
    • W Denham J Yang H Wang G Botchkina KJ Tracey J Norman 2000 Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome Crit Care Med 28 2567-72 10921596 10.1097/00003246-200007000-00064 1:CAS:528:DC%2BD3MXntFKgsr8%3D
    • (2000) Crit Care Med , vol.28 , pp. 2567-2572
    • Denham, W.1    Yang, J.2    Wang, H.3    Botchkina, G.4    Tracey, K.J.5    Norman, J.6
  • 26
    • 1642469355 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • A Bonni A Brunet AE West SR Datta MA Takasu ME Greenberg 2003 Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms Science 278 29317-26
    • (2003) Science , vol.278 , pp. 29317-29326
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 27
    • 3142680906 scopus 로고    scopus 로고
    • Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
    • 15166095 10.1161/01.RES.0000133680.87668.FA 1:CAS:528:DC%2BD2cXlt1Cru7o%3D
    • M Uchiba K Okajima Y Oike Y Ito K Fukudome H Isobe 2004 Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo Circ Res 95 34-41 15166095 10.1161/01.RES.0000133680.87668.FA 1:CAS:528:DC%2BD2cXlt1Cru7o%3D
    • (2004) Circ Res , vol.95 , pp. 34-41
    • Uchiba, M.1    Okajima, K.2    Oike, Y.3    Ito, Y.4    Fukudome, K.5    Isobe, H.6
  • 28
    • 21544447526 scopus 로고    scopus 로고
    • Regulation of blood coagulation by the protein C anticoagulant pathway: Novel insights into structure-function relationships and molecular recognition
    • 15860736 10.1161/01.ATV.0000168421.13467.82
    • B Dahlback BO Villoutreix 2005 Regulation of blood coagulation by the protein C anticoagulant pathway: Novel insights into structure-function relationships and molecular recognition Arterioscler Thromb Vasc Biol 25 1311-20 15860736 10.1161/01.ATV.0000168421.13467.82
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1311-1320
    • Dahlback, B.1    Villoutreix, B.O.2
  • 29
    • 34250372944 scopus 로고    scopus 로고
    • Protein C is an autocrine growth factor for human skin keratinocytes
    • 17293597 10.1074/jbc.M610740200 1:CAS:528:DC%2BD2sXks1Ggtbc%3D
    • M Xue D Campbell CJ Jackson 2007 Protein C is an autocrine growth factor for human skin keratinocytes J Biol Chem 282 13610-6 17293597 10.1074/ jbc.M610740200 1:CAS:528:DC%2BD2sXks1Ggtbc%3D
    • (2007) J Biol Chem , vol.282 , pp. 13610-13616
    • Xue, M.1    Campbell, D.2    Jackson, C.J.3
  • 30
    • 13444303827 scopus 로고    scopus 로고
    • Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
    • 15699841 10.1097/01.CCM.0000153415.04995.88 1:CAS:528:DC%2BD2MXhtFCqsr4%3D
    • T Iba A Kidokoro M Fukunaga K Nagakari A Shirahama Y Ida 2005 Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model Crit Care Med 33 368-72 15699841 10.1097/01.CCM.0000153415.04995.88 1:CAS:528:DC%2BD2MXhtFCqsr4%3D
    • (2005) Crit Care Med , vol.33 , pp. 368-372
    • Iba, T.1    Kidokoro, A.2    Fukunaga, M.3    Nagakari, K.4    Shirahama, A.5    Ida, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.