Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity

European Journal of Immunology

Volumn 37, Issue 11, 2007, Pages 3190-3196

  Castriconi, Roberta ^a   Dondero, Alessandra ^a   Negri, Francesca ^b   Bellora, Francesca ^a   Nozza, Paolo ^b   Carnemolla, Barbara ^c   Raso, Alessandro ^b   Moretta, Lorenzo ^a,b   Moretta, Alessandro ^a   Bottino, Cristina ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Activating NK receptors; Ligands for activating NK receptors; Medulloblastoma; Natural killer cells; Tumor markers

Indexed keywords

CD133 ANTIGEN; CD146 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LIGAND; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NATURAL KILLER CELL RECEPTOR;

ADOLESCENT; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CHILD; CONTROLLED STUDY; CYTOLYSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MEDULLOBLASTOMA; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KILLER CELLS, NATURAL; LIGANDS; MEDULLOBLASTOMA; PEPTIDES; RECEPTORS, IMMUNOLOGIC; TUMOR MARKERS, BIOLOGICAL;

EID: 36249027072     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737546     Document Type: Article

References (30)

1. Kuhl, J., Doz, F. and Taylor, R. E., Embryonic tumors. In Walker, D., Perilongo, G., Punt, J. A. G., Taylor, G. E. (Eds.), Brain and spinal tumors of childhood. Arnold, London 2004. pp. 314-330.
2. Giangaspero, F., Bigner, S. H., Kleihues, P., Pietsch, T. and Trojanowski, J. Q., Medulloblastoma. In Kleihues, P., Cavenee, W. K. (Eds.), Pathology and Genetics: Tumors of the Nervous System. WHO Classification of Tumors.LARC, Lyon 2000, pp. 129-137.
3. Eberhart, C. E. and Burger, P. C., Anaplasia and grading in medullo-blastomas. Brain. Pathol. 2003. 13: 376-385.
4. Gilbertson, R. J., Medulloblastoma: signalling a change in treatment. Lancet Oncol. 2004. 5: 209-218.
5. Bottino, C., Castriconi, R., Moretta, L. and Moretta, A., Cellular ligands of activating NK receptors. Trends Immunol. 2005. 26: 221-226.
6. Lanier, L. L., NK cell recognition. Annu. Rev. Immunol. 2005. 23: 225-274.
7. Ljunggren, H. G. and Malmberg, K. J., Prospects for the use of NK cells in immunotherapy of human cancer. Nat. Rev. Immunol. 2007. 7: 329-339.
8. Barber, D. F., Faure, M. and Long, E. O., LFA-1 contributes an early signal for NK cell cytotoxicity. J. Immunol. 2004. 173: 3653-3659.
9. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727-729.
10. Cosman, D., Müllberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M. and Chalupny, N. J., ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001. 14: 123-133.
11. Bottino, C., Castriconi, R., Pende, D., Rivera, P., Nanni, M., Carnemolla, B., Cantoni, C. et al., Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 2003. 198: 557-567.
12. Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S. and Colonna, M., CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 2004. 172: 3994-3998
13. Castriconi, R., Dondero, A., Corrias, M. V., Lanino, L., Pende, D., Moretta, L., Bottino, C. and Moretta, A., Natural killer cell-mediated killing of freshly isolated neuroblastoma. cells: Critical role of DNAM-1/PVR interaction. Cancer Res. 2004. 64: 9180-9184.
14. Pende, D., Spaggiari, G. M., Marcenaro, S., Martini, S., Rivera, P., Capobianco, A., Falco, M. et al., Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: Evidence for the involvement of the poliovirus receptor (CD155) and nectin-2 (CD112). Blood 2005. 105: 2066-2073.
15. Tahara-Hanaoka, S., Shibuya, K., Kai, H., Miyamoto, A., Morikawa, Y., Ohkochi, N., Honda, S.-i. and Shibuya, A., Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor. Blood 2006. 107: 1491-1496.
16. Hayakawa, Y. and Smyth, M. J. NKG2D and cytotoxic effector function in tumor immune surveillance. Semin. Immunol. 2006. 18: 176-185.
17. George, R. E., Loudon, W. G., Moser, R. P., Bruner, J. M., Steck, P. A. and Grimm, E. A., In vitro cytolysis of primitive neuroectodermal tumors of the posterior fossa (medulloblastoma) by lymphokine-activated killer cells. J. Neurosurg. 1988. 69: 403-409.
18. Silvani, A., Salmaggi, A., Parmiani, G. and Boiardi, A., Successful adoptive immunotherapy with lymphokine-activated killer cells in the treatment of medulloblastoma disseminated via cerebrospinal fluid: case report. Neurosurgery 1994. 34: 1078-1080.
19. Kang, S. G., Ryu, C. H., Jeun, S. S., Park, C. K., Shin, H. J., Kim, J. H., Kim, M. C. and Kang, J. K., Lymphokine activated killer cells from umbilical cord blood show higher antitumor effect against anaplastic astrocytoma cell line (U87) and medulloblastoma cell line (TE671) than lymphokine activated killer cells from peripheral blood. Childs Nerv. Syst. 2004. 20: 154-162.
20. Singh, S. K., Clarke, I. D., Terasaki, M., Bonn, V. E, Hawkins, C., Squire, J. and Dirks, P. B., Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003. 63: 5821-5828.
21. Singh, S. K., Hawkins, C., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M. et al., Identification of human brain tumor initiating cells. Nature 2004. 432: 396-401.
22. Ross, R. A. and Spengler, B. A., Human neuroblastoma stem cells. Semin. Cancer Biol. 2007. 17: 241-247
23. Shih, I. M., The role of CD146 (Mel-CAM) in biology and pathology. J. Pathol. 1999. 189: 4-11.
24. Mills, L., Tellez, C., Huang, S., Baker, C., McCarty, M., Green, L., Gudas, J. M., Feng, X. and Bar-Eli, M., Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 2002. 62: 5106-5114.
25. Burger, J. A. and Kipps, T. J., CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006. 107: 1761-1767.
26. Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A. and Locati, M., The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004. 25: 677-686.
27. Castriconi, R., Dondero, A., Augugliaro, R., Cantoni, C., Carnemolla, B., Sementa, A. R., Negri, F. et al., Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. USA 2004;. 101: 12640-12645.
28. Schulz, G., Cheresh, D. A., Varki, N. M., Yu, A., Staffileno, L. K. and Reisfeld, R. A., Detection of ganglioside GD2 in tumor tissues and sera of neuroblastoma patients. Cancer Res. 1984. 44: 5914-5920.
29. Hakomori, S., Tumor-associated carbohydrate antigens. Annu. Rev. Immunol. 1984. 2: 103-126.
30. - immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry. Anticancer Res. 2006. 26: 3281-3287.