NPY family of hormones: Clinical relevance and potential use in gastrointestinal disease

Current Topics in Medicinal Chemistry

Volumn 7, Issue 17, 2007, Pages 1710-1720

  Vona Davis, L C ^a   McFadden, D W ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Agonists; Antagonists; Clinical relevance; Gastrointestinal disease; Nonpeptides; NPY; Peptides; PP; PYY

Indexed keywords

ANTIBODY; BENEXTRAMINE; BIIIE 0246; BIM 43004C; BIM 43073D; GASTROINTESTINAL AGENT; GR 231118; IMMUNOGLOBULIN; N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; N ALPHA ACETYL [27 TRYPTOPHAN] PEPTIDE YY [22-36]; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y [31 LEUCINE 34 PROLINE]; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR ANTAGONIST; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y3 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR AGONIST; NEUROPEPTIDE Y5 RECEPTOR; PANCREAS POLYPEPTIDE; PEPTIDE YY; PEPTIDE YY [3-36]; PEPTIDE YY [34 PROLINE]; PEPTIDE YY ANTIBODY; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; BINDING AFFINITY; BINDING COMPETITION; CHRONIC PANCREATITIS; CROHN DISEASE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG TARGETING; ENTERITIS; GASTROINTESTINAL DISEASE; HORMONE RELEASE; HUMAN; INTESTINE EPITHELIUM; INTESTINE SECRETION; INTESTINE TRANSIT TIME; JEJUNOSTOMY; MALABSORPTION; MOLECULAR MIMICRY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN LOCALIZATION; REVIEW; SEQUENCE HOMOLOGY; SHORT BOWEL SYNDROME; STOMACH EMPTYING; STOMACH INJURY; STOMACH PROTECTION;

ANIMALS; GASTROINTESTINAL DISEASES; HUMANS; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE Y;

EID: 36249022720     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782340966     Document Type: Review

References (91)

1. El Salhy, M.; Suhr, O.; Danielsson, A. Peptide YY in gastrointestinal disorders. Peptides, 2002, 23(2), 397-402.
2. Balasubramaniam, A.; Tao, Z.; Zhai, W.; Stein, M.; Sheriff, S.; Chance, W.T. et al. Structure-activity studies including a Psi(CH(2)-NH) scan of peptide YY (PYY) active site, PYY(22-36), for interaction with rat intestinal PYY receptors: development of analogues with potent in vivo activity in the intestine. J. Med. Chem., 2000, 43(18), 3420-3427.
3. Silva, A.P.; Cavadas, C.; Grouzmann, E. Neuropeptide Y and its receptors as potential therapeutic drug targets. Clin. Chim. Acta, 2002, 326(1-2), 3-25.
4. Balasubramaniam, A. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr. Pharm. Des., 2003, 9(15), 1165-1175.
5. Balasubramaniam, A. Clinical potentials of neuropeptide Y family of hormones. Am. J. Surg., 2002, 183(4), 430-434.
6. Tatemoto, K.; Neuropeptide, Y. complete amino acid sequence of the brain peptide. Proc. Natl. Acad. Sci., USA, 1982, 79(18), 5485-5489.
7. Tatemoto, K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA, 1982, 79(8), 2514-2518.
8. El Salhy, M.; Wilander, E.; Grimelius, L.; Terenius, L.; Lundberg, J.M.; Tatemoto, K. The distribution of polypeptide YY (PYY) - and pancreatic polypeptide (PP) - immunoreactive cells in the domestic fowl. Histochemistry, 1982, 75(1), 25-30.
9. Tatemoto, K.; Carlquist, M.; Mutt, V. Neuropeptide. Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature, 1982, 296(5858), 659-660.
10. Taylor,I.L. Distribution and release of peptide YY in dog measured by specific radioimmunoassay. Gastroenterology, 1985, 88(3), 731-737.
11. Sheikh, S.P. Neuropeptide Y and peptide YY: major modulators of gastrointestinal blood flow and function. Am. J. Physiol., 1991, 261(5 Pt 1), G701-G715.
12. Sheikh, S.P.; Holst, J.J.; Skak-Nielsen, T.; Knigge, U.; Warberg, J. Theodorsson-Norheim E et al. Release of NPY in pig pancreas: dual parasympathetic and sympathetic regulation. Am. J. Physiol., 1988, 255(1 Pt 1), G46-G54.
13. Ekblad, E.; Hakanson, R.; Sundler, F. VIP and PHI aoexist with an NPY-like peptide in intramural neurones of the small intestine. Regul. Pept., 1984, 10(1), 47-55.
14. Lundberg, J.M.; Tatemoto, K.; Terenius, L.; Hellstrom, PM.; Mutt, V.; Hokfelt, T. et al. Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc. Natl. Acad. Sci. USA, 1982, 79(14), 4471-4475.
15. Greeley,G.H.,Jr.; Hill,F.L.; Spannagel,A.; Thompson, JC. Distribution of peptide YY in the gastrointestinal tract of the rat, dog and monkey. Regul. Pept., 1987, 19(5-6), 365-372.
16. Onolfo, J.P.; Lehy, T.; Labeille, D.; Gres, L. Growth pattern of the polypeptide-YY cell population in the upper digestive tract of the rat during the perinatal period and after weaning. Cell Tissue Res., 1989, 258(3), 569-576.
17. Laburthe, M. [Peptide YY and neuropeptide Y in the intestine: availability, biologic effects and epithelial receptors]. Arch. Int. Physiol. Biochim. Biophys., 1991, 99(5), A177.
18. Playford, R.J.; Cox, HM. Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte homeostasis. Trends Pharmacol. Sci., 1996, 17(12), 436-438.
19. Cox, H.M. Peptidergic regulation of intestinal ion transport. A major role for neuropeptide Y and the pancreatic polypeptides. Digestion, 1998, 59(4), 395-199.
20. Bilchik, A.J.; Hines, O.J.; Adrian, T.E.; McFadden, D.W.; Berger, J.J.; Zinner, M.J. et al. Peptide YY is a physiological regulator of water and electrolyte absorption in the canine small bowel in vivo. Gastroenterology, 1993, 105(5), 1441-1449.
21. Bilchik, A.J.; Hines, O.J.; Zinner, M.J.; Adrian, T.E.; Berger, J.J.; Ashley, S.W. et al. Peptide YY augments postprandial small intestinal absorption in the conscious dog. Am. J. Surg., 1994, 167(6), 570-574.
22. Gomez, G.; Zhang, T.; Rajaraman, S.; Thakore, KN.; Yanaihara, N.; Townsend, CM, JI. et al. Intestinal peptide YY: ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel. Am. J. Physiol., 1995, 268(1 Pt 1), G71-G81.
23. Pappas, T.N.; Debas, H.T.; Goto, Y.; Taylor, I.L. Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. Am. J. Physiol., 1985, 248(1 Pt 1), G118-G123.
24. Pappas, T.N.; Debas, H.T.; Taylor, IL. Enterogastrone-like effect of peptide YY is vagally mediated in the dog. J. Clin. Invest., 1986, 77(1), 49-53:
25. Adrian, T.E.; Savage, A.P.; Sagor, G.R.; Allen, J.M.; Bacarese-Hamilton, A.J.; Tatemoto, K. et al. Effect of peptide YY on gastric, pancreatic, and biliary function in lumans. Gastroenterology, 1985, 89(3), 494-499.
26. Guo, Y.S,; Singh, P.; Gomez, G.; Greeley, G.H, Jr.; Thompson, J.C. Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones, Gastroenterology, 1987, 92(5 Pt 1), 1202-1208.
27. Cox, H.M.; Cuthbert, A.W.; Hakanson, R.; Wahlestedt, C. The eftect of neuropeptide Y and peptide YY on electrogenic ion transport in rat intestinal epithelia. J. Physiol., 1988, 398, 65-80.
28. Friel, D.D.; Miller, R.J.; Walker, M.W. Neuropeptide Y: a powerful modulator of epithelial ion transport. Br. J. Pharmacol., 1986, 88(2), 425-431.
29. Louie, D.S.; Williams, J.A.; Owyang, C. Action of pancreatic polypeptide on rat pancreatic secretion: in vivo and in vitro. Am. J. Physiol., 1985, 249(4 Pt 1), G489-G495.
30. Joehl, R.J.; DeJoseph, M.R. Pancreatic polypeptide inhibits amylase release by rat pancreatic acini. J. Surg. Res., 1986, 40(4), 310-314.
31. Michel, M.C.; Beck-Sickinger, A.; Cox, H.; Doods, H.N.; Herzog, H.; Larhammar, D. et al. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev., 1998, 50(1), 143-150.
32. Cox, H.M.; Pollock, E.L.; Tough, I.R.; Herzog, H.; Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa. Peptides, 2001, 22(3), 445-452.
33. Cox, H.M.; Tough, I.R. Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. Br. J. Pharmacol., 2002, 135(6), 1505-1512.
34. Hyland, N.P.; Cox, H.M. The regulation of veratridine-stimulated electrogenic ion transport in mouse colon by neuropeptide Y (NPY), Y1 and Y2 receptors. Br. J. Pharmacol., 2005, 146(5), 712-722.
35. Eva, C.; Keinanen, K.; Monyer, H.; Seeburg, P.; Sprengel, R. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS. Lett., 1990, 271(1-2), 81-84.
36. Krause, J.; Eva, C.; Seeburg, PH.; Sprengel, R. Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol. Pharmacol., 1992, 41(5), 817-821.
37. Herzog, H.; Hort, Y.J.; Ball, H.J.; Hayes, G.; Shine, J.; Selbie, L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. USA, 1992, 89(13), 5794-5798.
38. Larhammar, D.; Blomqvist, A.G.; Yee, F.; Jazin, E.; Yoo, H.; Wahlested, C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J. Biol. Chem., 1992, 267(16), 10935-10938.
39. Sheikh, S.P.; Williams, J.A. Structural characterization of Y1 and Y2 receptors for neuropeptide Y and peptide YY by affinity cross-linking. J. Biol. Chem., 1990, 265(14), 8304-8310.
40. Inui, A.; Sano, K.; Miura, M.; Hirosue, Y.; Nakajima, M.; Okita, M. et al. Evidence for further heterogeneity of the receptors for neuropeptide-Y and peptide-YY in tumor cell lines derived from neural crest. Endocrinology, 1992, 131(5), 2090-2096.
41. Mao, Y.K.; Wang, Y.F.; Ward, G.; Cipris, S.; Daniel, E.E.; McDonald, T.J. Peptide YY receptor in submucosal and myenteric plexus synaptosomes of canine small intestine. Am. J Physiol., 1996, 271 (1Pt1), G3 6-G41.
42. Walsh, D.A.; Wharton, J.; Blake, D.R.; Polak, J.M. Localization and characterization of neuropeptide Y binding sites in porcine and human colon. Br. J. Pharmaco., 1993, 108(2), 304-311.
43. Wharton, J.; Gordon, L.; Byme, J.; Herzog, H.; Selbie, L.A.; Moore, K. et al. Expression of the human neuropeptide tyrosine Y1 receptor. Proc. Natl. Acad. Sci. USA, 1993, 90(2), 687 -691.
44. Gerald, C.; Walker, M.W.; Vaysse, P.J.; He, C.; Branchek, T.A.; Weinshank, R.L. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem., 1995, 270(45), 26758-26761.
45. Rose, P.M.; Fernandes, P.; Lynch, J.S.; Frazier, S.T.; Fisher, S.M.; Kodukula, K. et al. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem., 1995, 270(39), 22661-22664.
46. Gehlert, D.R.; Beavers, L.S.; Johnson, D.; Gackenheimer, S.L.; Schober, D.A.; Gadski, R.A. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol. Pharmacol., 1996, 49(2), 224-228.
47. Nakamura, M.; Aoki, Y.; Hirano, D. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim. Biophys. Acta. 1996, 1284(2), 134-137.
48. Bard, J.A.; Walker, M.W.; Branchek, T.A.; Weinshank, R.L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem., 1995, 270(45), 26762-26765.
49. Lundell, I.; Bloniqvist, A.G.;, Berglund, M.M.; Schober, D.A.; Johnson, D.; Statnick, M.A. et al. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem., 1995, 270(49), 29123-29128.
50. Gregor, P.; Millham, M.L.; Feng, Y.; DeCarr, L.B.; McCaleb, M.L.; Cornfield, L.J. Cloning and characterizahon of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett., 1996, 381(1-2), 58-62.
51. Yan, H.; Yang, J.; Marasco, J.; Yamaguchi, K.; Brenner, S.; Collins, F. et al. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc. Natl. Acad. Sci. USA, 1996, 93(10), 4661-4665.
52. Gue, M.; Junien, J.L.; Reeve, J.R. Jr.; Rivier, J.; Grandt, D.; Tache, Y. Reversal by NPY, PYY and 3-36 molecular forms of NPY and PYY of intracistemal CRF-induced inhibition of gastric acid secretion in rats. Br. J. Pharmacol., 1996, 118(2), 237-242.
53. Lloyd, K.C.; Grandt, D.; Aurang, K.; Eysselein, V.E.; Schimiczek, M.; Reeve, J.R. Jr. Inhibitorr effect of PYY on vagally stimulated acid secretion is mediated predominantly by Y1 receptors. Am. J. Physiol., 1996, 270(lPt1), G123-G127.
54. Gournain, M.; Voisin, T.; Lorinet, A.M.; Laburthe, M. Identification and distribution of mRNA encoding the Y1, Y2, Y4, and Y5 receptors for peptides of the PP-fold family in the rat intestine and colon. Biochem. Biophys. Res. Commun., 1998, 247(1), 52-56.
55. Holliday, N.D.; Pollock, E.L.; Tough, I.R.; Cox, H.M. PYY preference is a common characteristic of neuropeptide Y receptors expressed in human, rat, and mouse gastrointestinal epithelia. Can. J. Physiol. Pharmacol., 2000, 78(2), 126-133.
56. Goumain, M.; Voisin, T.; Lorinet, A.M.; Ducroc, R.; Tsocas, A.; Roze, C. et al. The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. Mol. Pharmacol., 2001, 60(1), 124-134.
57. Cox, H.M.; Tough, I.R.; Zandvliet, D.W,;, Holliday, N.D. Constitutive neuropeptide Y Y(4) receptor expression in human colonic adenocarcinoma cell lines. Br. J. Pharmacol., 2001, 132(1), 345-353.
58. Tough, I.R.; Holliday, N.D.; Cox, H.M. Y(4) receptors mediate the inhibitory, responses of pancreatic polypeptide in human and mouse colon mucosa. J. Pharmacol. Exp. Ther., 2006, 319(1), 20-30.
59. Balasubramaniam, A.; Mullins, D.E.; Lin, S.; Zhai, W.; Tao, Z.; Dhawan, V.C. et al. Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. J. Med. Chem., 2006, 49(8), 2661-2665.
60. Heilig, M.; Murison, R. Intracerebroventricular neuropeptide Y protects against stress-induced gastric erosion in the rat. Eur. J. Pharmacol., 1997, 137(1), 127-129.
61. Penner, S.B.; Smyth, D.D.; Glavin, G.B. Effects of neuropeptide Y and [Leu3lPro34] neuropeptide Y on experimental gastric lesion formation and gastric secretion in the rat. J. Pharmacol. Exp. Ther. 1993, 266(1), 339-343.
62. Kawakubo, K.; Yang, H.; Tache, Y. Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats. Am J. Physiol. Gastrointest. Liver, Physiol., 2002, 283(5), G1035-G1041.
63. Ferrier, L.; Segain, J.P.; Pacaud, P.; Cherbut, C.; Loirand, G.; Galmiche, J.P. et al. Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro. Cut, 2000, 46(3), 370-375.
64. Naveilhan, P.; Hassani, H.; Lucas,; Blakeman, K.H.; Hao, J.; Xu, XJ. et al. Reduced antinociception and plasma extravasation. in mice lacking a neuropeptide Y receptor. Nature, 2001, 409(6819), 513-517.
65. Hassani, H.; Lucas, G.; Rozell, B.; Ernfors, P. Attenuation of acute experipiental colitis by preventing NPY Y1 receptor signaling. Am. J. Physiol. Gastrointest. Liver. Physiol., 2005, 288(3), G550-G556
66. Van Der Veek, P.P.; Biemond, I.; Masclee, A.A. Proximal and distal gut hormone secretion in irriiable bowel syndrome. Scand. J. Gastroenterol., 2006, 41(2), 170-177.
67. Sakamoto, T.; Greeley, .G.H: Pancreatic polypeptide analogues: Peptide YY and NPY. In: Thompson JC, Greeley GH, Rayford PL, Townsend CM Jr., eds. Gastrointestinal Endocrinology. NY: McGraw-Hill, 1987; 332-337.
68. Litvak, D.A.; Iseki, H.; Evers, B.M.; Greeley, G.H. Jr.; Hellmich; M.R.; Iwase, K, et al. Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C. Dig. Dis. Sci., 1999, 44(3), 643-648.
69. Schmidt, P.T.,; Ljung T.; Hartmann, B.; Hare, K.J.; Holst, J.; Hellstrom, P.M: Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and in flammatory bowel disease: comparison with peptide YY. Eur. J. Gastroenierol. Hepatol., 2005, 17(2), 207-212.
70. Koch, T.R.; Roddy, D.R.; Go, V.L. Abnormalities of fasting serum concentrations of peptide YY in the idiopathic inflammatory bowel diseases. Am. J., Gastroenterol., 1987, 92(4), 321-326.
71. Tari, A.; Teshima, H.; Sumii, K.; Haruma, K.; Ohgoshi, H.; Yoshihara, M. et al. Peptide YY abnormalities in patients with ulcerative colitis. Jpn. J. Med., 1988, 27(1), 49-55.
72. Bilchik, A.J.; Hines, O.J.; Ashley, S.W.; Adrian, T.E.; Walsh, J.; Wong, H. et al. Peptide YY immunoneutralization inhibits meal-induced absorption in vivo. Surgery, 1994, 116(6), 1153-1157.
73. Nightingale, J.M.; Kamm, M.A.; van, d.S. Jr.; Ghatei, M.A.; Bloom, S.; Lennard-lones, J.E. Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying. Gut, 1996, 39(2),267-272.
74. McFadden, D.W.; Rudnicki, M.; Nussbaum, M.S.; Balasubramaniam, A.; Fischer, J.E. Independent release of peptide YY (PYY) into the circulation and ileal lumen of the awake dog. J. Surg. Res., 1989, 46(4), 380-385.
75. Liu, C.D.; Hines, O.J.; Whang, E.E.; Laird, E.C.; Skotzko, M.J.; Zinner, M.J. et al. Pancreatic peptide YY mRNA levels increase during adaptation after small intestinal resection. J. Surg. Res., 1995, 58(1),6-11.
76. Liu, C.D.; Hines, O.J.; Whang, E.E.; Balasubramaniam, A.; Newton, T.R.; Zinner, M.J. et al. A novel synthetic analog of peptide YY, BIM-43004, given intraluminally, is proabsorptive. J. Surg. Res., 1995, 59(1), 80-84.
77. Brunicardi, F.C.; Chaiken, R.L.; Ryan, A.S.; Seymour, N.E.; Hoffmann, J.A.; Lebovitz, H.E. et al. Pancreatic polypeptide administration improves abnormal glucose metabolism in patients with chronic pancreatitis. J. Clin. Endocrinol. Metab., 1996, 81(10), 3566-3572.
78. Goldstein, J.A.; Kirwin, J.D.; Seymour, N.E.; Trachtenberg, J.E.; Rademaker, E.A.; Andersen, D.K. Reversal of in vitro hepatic insulin resistance in chronic pancreatitis by pancreatic polypeptide in the rat. Surgery, 1989, 106(6), 1128-1132.
79. Seymour, N.E.; Volpert, A.R.; Lee, E.L.; Andersen, D.K.; Hernandez, C. Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide. Am. J. Surg., 1995, 169(1),105-109.
80. Spector, SA.; Frattini, J.C.; Nathan, J.D.; Wang, J.P.; Andersen, D.K. Seymour NE. Insulin receptor gene expression in chronic pancreatitis: The effect of pancreatic polypeptide. Surgical Forum., 48, 168. 1997. Ref Type: Abstract
81. Seymour, N.E.; Volpert, A.R.; Andersen, D.K. Regulation of hepatic insulin receptors by pancreatic polypeptide in fasting and feeding. J. Surg. Res., 1996, 65(1), 1-4.
82. Seymour, N.E.; Spector, S.A.; Andersen, DX.; Elm, M.S.; Whitcomb, D.C. Overexpression of hepatic pancreatic polypeptide receptors in chronic pancreatitis. J. Surg. Res., 1998, 76(1),47-52.
83. Adrian, T.E.; Savage, A.P.; Bacarese-Hamilton, A.J.; Wolfe, K.; Besterman, H.S.; Bloom, S.R. Peptide YY abnormalities in gastrointestinal diseases. Gastroenterology, 1986, 90(2), 379-384.
84. Grise, K.R.; McFadden, D.W. Peptide YY improves local and systemic parameters and prevents death in lethal necrotizing pancreatitis. Pancreas, 2002, 24(1), 90-95.
85. Kazanjian, KX.; Towfigh, S.; McFadden, D.W. Peptide YY exhibits a mitogenic effect on pancreatic cells while improving acute pancreatitis in vitro. J. Surg. Res., 2003, 114(1), 95-99.
86. Robinson, K.S.; Vona-Davis, L.; Riggs, D.; Jackson, B.; McFadden, D.W. Peptide YY attentuates. STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J. J. Am. Coll. Surg., 2006, 202(5),788-796.
87. Vona-Davis, L.; Yu, A.; Magabo, K.; Evans, T.; Jackson, B.; Riggs, D. et al. Peptide YY attenuates transcription factor activity in tumor necrosis factor-alpha-induced pancreatitis. J. Am. Coll. Surg., 2004, 199(1), 87-95.
88. Gallmeier, E.; Schafer, C.; Moubarak, P.; Tietz, A.; Plossl, I.; Huss, R. et al. JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells. J. Cell. Physiol., 2005, 203(1), 209-216.
89. Greten, F.R.; Weber, CK; Greten, T.F.; Schneider, G.; Wagner, M.; Adler, G. et al. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology, 2002, 123(6), 2052-2063.
90. Rizvi, I.A.; Robinson, K.; McFadden, D.W.; Riggs, D.R.; Jackson, B.J.; Vona-Davis, L. Peptide YY reverses TNF-alpha induced transcription factor binding of interfercn regulatory factor-1 and p53 in pancreatic acinar cells. J. Surg. Res., 2006, 136(1), 25-30.
91. Vona-Davis, L.; McFadden, D.W. PYY and the pancreas: Inhibition of tumor growth and inflammation. Peptides, 2007, 28(2),334-338.