Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

Digestive Diseases and Sciences

Volumn 44, Issue 3, 1999, Pages 643-648

  Litvak, David A ^a,b   Iseki, Hideaki ^a,b   Evers, B Mark ^a,b   Greeley Jr , George H ^a,b   Hellmich, Mark R ^a,b   Iwase, Kazuhiro ^a,b   Balasubramaniam, Ambikaipakan ^a,b   Townsend Jr , Courtney M ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Intestinal absorption; Peptide YY; Proabsorptive agent; PYY analog

Indexed keywords

BIM 43004C; BIM 43073D; PEPTIDE YY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG SCREENING; FEMALE; HORMONE ACTION; INTESTINE ABSORPTION; NONHUMAN; PRIORITY JOURNAL;

EID: 0033049952     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026686214004     Document Type: Article

References (31)

1. 1. Shanbhogue LKR, Molenaar JC: Short bowel syndrome: Metabolic and surgical management. Br J Surg 81:486-499, 1994
2. 2. Byrne TA, Persinger RL, Young LS, Ziegler TR, Wilmore DW: A new treatment for patients with short bowel syndrome. Ann Surg 222:243-255, 1995
3. 3. Dharmasathaphorn K, Binder HJ, Dobbins JW: Somatostatin stimulates sodium and chloride absorption in rabbit ileum. Gastroenterology 78:1559-1565, 1980
4. 4. Opleta-Madsen K, Hardin J, Gall DG: Epidermal growth factor upregulates intestinal electrolyte and nutrient transport. Am J Physiol 260:807-814, 1991
5. 5. Liu CD, Aloia T, Adrian TE, Newton TR, Bilchik AJ, Zinner MJ, Ashley SW, McFadden DW: Peptide YY: A potential proabsorptive hormone for the treatment of malabsorptive disorders. Am Surg 62:232-236, 1996
6. 6. Bilchik AJ, Hines OJ, Adrian TE, McFadden DW, Berger JJ, Zinner MJ, Ashley SW: Peptide YY is a physiological regulator of water and electrolyte absorption in the canine small bowel in vivo. Gastroenterology 105:1441-1448, 1993
7. 7. Bilchik AJ, Hines OJ, Zinner MJ, Adrian TE, Berger JJ, Ashley SW, McFadden DW: Peptide YY augments postprandial small intestine absorption in the conscious dog. Am J Surg 167:570-574, 1994
8. 8. Liu CD, Hines OJ, Whang EE, Balasubramaniam A, Newton TR, Zinner MJ, Ashley SW, McFadden DW: A novel synthetic analog of peptide YY, BIM-43004, given intraluminally, is proabsorptive. J Surg Res 59:80-84, 1995
9. 9. Sakamoto T, Greeley GH Jr: Pancreatic polypeptide analogues: Peptide YY and neuropeptide Y. In Gastrointestinal Endocrinology. JC Thompson, GH Greeley Jr, PL Rayford, CM Townsend Jr (eds). New York, McGraw-Hill, 1987, pp 332-337
10. 10. Taylor IL: The pancreatic polypeptide family: Pancreatic polypeptide, neuropeptide Y, and peptide YY. In Handbook of Physiology - The Gastrointestinal System II. GM Makhlouf (ed). Bethesda, Maryland, American Physiology Society, 1989, p 476
11. 11. Greeley GH Jr, Jeng Y-J, Gomez G, Hashimoto T, Hill FLC, Kern K, Kurosky T, Chuo H-F, Thompson JC: Evidence for regulation of peptide-YY release by the proximal gut. Endocrinology 124:1438-1443, 1989
12. 12. Evers BM, Townsend CM Jr, Uchida T, Greeley GH Jr, Allen E, Thompson JC: Effect of total jejunoileal denervation on fat-stimulated release of peptide YY and cholecystokinin. Surgery 108:248-253, 1990
13. 13. Guo Y-S, Singh P, Gomez G, Greeley GH Jr, Thompson JC: Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones. Gastroenterology 92:1202-1208, 1987
14. 14. Pappas T, Debas H, Goto Y, Taylor I: Peptide YY inhibits meal stimulated pancreatic and gastric secretion. Am J Physiol 248:118-123, 1985
15. 15. Savage AP, Adrian TE, Carolan G, Chatterjee VK, Bloom SR: Effects of PYY on mouth to caecum transit time and on the rate of gastric emptying in healthy volunteers. Gut 28:166-170, 1987
16. 16. Gomez G, Zhang T, Rajaraman S, Thakore KN, Yanaihara N, Townsend CM Jr, Thompson JC, Greeley GH Jr: Intestinal peptide YY: Ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel. Am J Physiol 268:G71-G81, 1995
17. 17. Spiller RC, Trotman IF, Higgins BE: The ileal brake: inhibition of jejunal motility after ileal fat perfusion in man. Gut 15:365-374, 1984
18. 18. Laburthe M, Chenut B, Rouyer-Fessard C, Tatemoto K, Couvineau A, Servin A, Amiranoff B: Interaction of peptide YY with rat intestinal epithelial plasma membranes: Binding of the radioiodinated peptide. Endocrinology 118:1910-1917, 1986
19. 19. Eberlein GA, Eysselein VE, Schaeffer M, Layer P, Grandt D, Goebell H, Niebel W, Davis M, Lee TD, Shively JE, Reeve JR Jr: A new molecular form of PYY: Structural characterization of human PYY(3-36) and PYY(1-36). Peptides 10:797-803, 1989
20. 20. Servin AL, Rouyer-Fessard C, Balasubramaniam A, Saint Pierre S, Laburthe M: Peptide-YY and neuropeptide-Y inhibit vasoactivc intestinal peptide-stimulated adenosine 3′,5′-monophosphate production in rat small intestine: Structural requirements of peptides for interacting with peptide-YY-preferring receptors. Endocrinology 124:692-700, 1989
21. 21. Grudemar L, Hakanson R: Effects of various neuropeptide Y/peptide YY fragments on electrically evoked contractions of the rat vas deferens. Br J Pharmacol 100:190-192, 1990
22. 22. Souli A, Chariot J, Voisin T, Presset O, Tsocas A, Balasubramaniam A, Laburthe M, Roze C: Several receptors mediate the antisecretory effect of peptide YY, neuropeptide Y, and pancreatic polypeptide on VIP-induced fluid secretion in the rat jejunum in vivo. Peptides 18:551-557, 1997
23. 23. Balasubramaniam A, Cox HM, Voisin T, Laburthe M, Stein M, Fisher JE: Structure of peptide YY(22-36) :N-alpha-Ac[Phe27]PYY(22-36), a potent antisecretory peptide in rat jejunum. Peptides 14:1011-1016, 1993
24. 24. Balasubramaniam A, Servin AL, Rigel DF, Rouyer-Fessard CR, Laburthe M: Synthesis and receptor affinities of partial sequences of peptide YY (PYY). Pept Res 1:32-35, 1988
25. 25. Evers BM, Izukura M, Townsend CM Jr, Uchida T, Thompson JC: Neurotensin prevents intestinal mucosal hypoplasia in rats fed an elemental diet. Dig Dis Sci 37:426-431, 1992
26. 26. Chu KU, Evers BM, Ishizuka J, Townsend CM Jr, Thompson JC: Role of bombesin on gut mucosal growth. Ann Surg 222:94-100, 1995
27. 27. Drucker DJ, Ehrlich P, Asa SL, Brubaker PL: Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc Natl Acad Sci 93:7911-7916, 1996
28. 28. Litvak DA, Hellmich MR, Evers BM, Banker NA, Townsend CM Jr: Glucagon-like peptide 2 is a potent growth factor for small intestine and colon. J Gastrointest Surg 2:146-150, 1998
29. 29. Chance WT, Foley-Nelson T, Thomas I, Balasubramaniam A: Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2. Am J Physiol 273(Gastrointest Liver Physiol 36):G559-G563, 1997
30. 30. Playford RJ, Domin J, Beacham J, Parmar KB, Tatemoto K, Bloom SR, Calam J: Preliminary report: Role of peptide YY in defense against diarrhea. Lancet 335:1555-1557, 1990
31. 31. Chance WT, Zhang X, Balasubramaniam A, Fischer JE: Preservation of intestine protein by peptide YY during total parenteral nutrition. Life Sci 58:1785-1794, 1996