Inhibitory effect of PYY on vagally stimulated acid secretion is mediated predominantly by Y1 receptors

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 1 33-1, 1996, Pages

  Lloyd, K C K ^a   Grandt, D ^b   Aurang, K ^b   Eysselein, V E ^b   Schimiczek, M ^b   Reeve Jr , J R ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

cephalic phase; gastric acid secretion; insulin induced hypoglycemia; peptide tyrosine tyrosine

Indexed keywords

ATROPINE; PEPTIDE YY; PEPTIDE YY [34 PROLINE]; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; INHIBITION KINETICS; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RABBIT; STOMACH ACID SECRETION; VAGUS NERVE STIMULATION;

EID: 0030060667     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.1.g123     Document Type: Article

References (36)

1. Adrian, T. E., A. P. Savage, G. R. Sagor, J. M. Allen, A. J. Bacarese-Hamilton, K. Tatemoto, J. M. Polak, and S. H. Bloom. Effect of peptide YY on gastric, pancreatic, and biliary function in humans. Gastroenterology 89: 494-499, 1985.
2. Bonaz, B., I. Taylor, and Y. Taché. Peripheral peptide YY induces c-fos-like immunoreactivity in the rat brain. Neurosci. Lett. 163: 77-80, 1993.
3. Clave, P., F. Lluis, J. C. Thompson, and G. H. Greeley, Jr. Peptide YY inhibits gastric acid secretion stimulated by the autonomic nervous system. Biol. Signals 1: 40-45, 1992.
4. Eberlein, G. A., V. E. Eysselein, M. Schaeffer, P. Layer, D. Grandt, H. Goebell, W. Niebel, M. Davis, T. D. Lee, J. E. Shively, and J. R. Reeve, Jr. A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36) Peptides 10: 797-803, 1989.
5. Eissele, R., H. Koop, and R. Arnold. Effect of peptide YY on gastric acid secretion, gastrin and somatostatin release in the rat. Z. Gastroenterol. 28: 129-131, 1990.
6. Eysselein, V. E., G. A. Eberlein, D. Grandt, M. Schaeffer, B. Zehres, U. Behn, D. Schaefer, H. Goebell, M. Davis, T. D. Lee, J. E. Shively, H. E. Meyer, and J. R. Reeve, Jr. Structural characterization of canine PYY. Peptides 11: 111-116, 1990
7. Ghilardi, J. R., C. J. Allen, S. R. Vigna, D. C. McVey, and P. W. Mantyh. Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons. Brain Res. 633: 33-40, 1994.
8. Grabner, P., L. S. Semb, and J. Myren. Comparison of gastric secretory response in man to duodenal and jejunal liver extract perfusion. Scand. J. Gastroenterol. 14: 385-388, 1979.
9. Grandt, D., B. Burckhardt, M. Schimiczek, C. Beglinger, J. R. Reeve, Jr., and V. E. Eysselein. Human PYY 3-36 inhibits gastric acid secretion in man (Abstract). Regul. Pept. 40: 158, 1992.
10. Grandt, D., P. Dahms, M. Schimiczek, V. E. Eysselein, J. R. Reeve, Jr., and R. Mentlein. Proteolytic processing by dipeptidyl aminopeptidase IV generates receptor selectivity for peptide YY (PYY). Med. Klin. 88: 143-145, 1993.
11. 1-selective agonist at peptide YY/neuropeptide Y receptors. Eur. J. Pharmacol. 269: 127-132, 1994.
12. Grandt, D., M. Schimiczek, C. Beglinger, P. Layer, H. Goebell, V. E. Eysselein, and J. R. Reeve, Jr. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY(1-36) and PYY(3-36). Regul. Pept. 51: 151-159, 1994
13. 2 selective agonist and a major molecular form of PYY in circulating blood in man (Abstract). Gastroenterology 102: A734, 1992.
14. Grandt, D., M. Schimiczek, K. Struk, J. Shively, V. E. Eysselein, H. Goebell, and J. R. Reeve, Jr. Characterization of two forms of peptide YY, PYY(1-36) and PYY(3-36), in the rabbit. Peptides 15: 815-820, 1994.
15. Grandt, D., S. Teyssen, M. Schimiczek, J. R. Reeve, Jr., F. Feth, W. Rascher, H. Hirche, M. V. Singer, P. Layer, H. Goebell, F. J. Ho, and V. E. Eysselein. Novel generation of hormone receptor specificity by amino terminal processing of peptide YY. Biochem. Biophys. Res. Commun. 186: 1299-1306, 1992.
16. Greeley, G. H., Jr., Y. S. Guo, G. Gomez, F. Lluis, P. Singh, and J. C. Thompson. Inhibition of gastric acid secretion by peptide YY is independent of gastric somatostatin release in the rat. Proc. Soc. Exp. Biol. Med. 189: 325-328, 1988.
17. Guo, Y. S., M. Fujimura, F. Lluis, Y. Tsong, G. H. Greeley, Jr., and J. C. Thompson. Inhibitory action of peptide YY on gastric acid secretion. Am. J. Physiol. 253 (Gastrointest. Liver Physiol. 16): G298-G302, 1987.
18. Guo, Y. S., P. Singh, G. Gomez, G. H. Greeley, Jr., and J. C. Thompson. Effect of peptide YY on cephalic, gastric, and intestinal phases of gastric acid secretion and on the release of gastrointestinal hormones. Gastroenterology 92: 1202-1208, 1987.
19. Hashimoto, Y., I. Sano, Y. Nagahata, Z. T. Wang, A. Itoh, K. Takeda, T. Ichihara, H. Moritomo, T. Urakawa, and Y. Saitoh. Inhibitory effect of peptide YY on gastric acid output in rats. Scand. J. Gastroenterol. Suppl. 162: 134-137, 1989.
20. Hernandez, E. J., D. C. Whitcomb, S. R. Vigna, and I. L. Taylor. Saturable binding of circulating peptide YY in the dorsal vagal complex of rats. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G511-G516, 1994.
21. Inui, A., M. Okita, T. Inoue, N. Sakatani, M. Oya, H. Morioka, K. Shii, K. Yokono, N. Mizuno, and S. Baba. Characterization of peptide YY receptors in the brain. Endocrinology 124: 402-409, 1989.
22. Kolbel, C. B., D. Grandt, G. Holtmann, S. Scholer, J. R. Reeve, Jr., and V. E. Eysselein. Y1 receptors mediate inhibitory and stimulatory effects of peptide YY in isolated small intestine and large intestine muscles of the rabbit. Med. Klin. 88, Suppl. 1: 9-14, 1993.
23. Leth, R., L. Lundell, and L. Olbe. Effects of some gastrointestinal peptides on isolated human and rabbit gastric glands. Scand. J. Gastroenterol. 26: 89-96, 1991.
24. Lloyd, K. C. K., J. R. Reeve, Jr., V. Maxwell, and J. H. Walsh. The amino-terminus of PYY is important for PYY mediated inhibition of gastric acid secretion in dogs (Abstract). Gastroenterology 100: A653, 1991.
25. Lluis, F., G. Gomez, M. Fujimura, G. H. Greeley, Jr., C. M. Townsend, Jr., and J. C. Thompson. Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion. Regul. Pept. 18: 155-163, 1987.
26. Mannon, P. J., E. J. Hernandez, S. J. Mervin, S. R. Vigna, and I. L. Taylor. Characterization of peptide YY receptors in rabbit colonic mucosa. Peptides 14: 567-572, 1993.
27. Mulvihill, S. J., T. N. Pappas, and H. T. Debas. Characterization of in vivo acid secretory responses of rabbit with comparison to dog and rat. Dig. Dis. Sci. 34: 895-904, 1989.
28. Ohkubo, T., M. Niwa, K. Yamashita, Y. Kataoka, and K. Shigematsu. Neuropeptide Y (NPY) and peptide YY (PYY) receptors in rat brain. Cell. Mol. Neurobiol. 10: 539-552, 1990.
29. Pappas, T. N., H. T. Debas, Y. Goto, and I. L. Taylor. Peptide YY inhibits meal-stimulated pancreatic and gastric secretion. Am. J. Physiol. 248 (Gastrointest. Liver Physiol. 11): G118-G123, 1985.
30. Pappas, T. N., H. T. Debas, and I. L. Taylor. Enterogastrone-like effect of peptide YY is vagally mediated in the dog. J. Clin. Invest. 77: 49-53, 1986.
31. Sheikh, S. P., R. Håkanson, and T. W. Schwartz. Y1 and Y2 receptors for neuropeptide Y. FEBS Lett. 245: 209-214, 1989.
32. Sheikh, S. P., A. P. Hansen, and J. A. Williams. Solubilization and affinity purification of the Y2 receptor for neuropeptide Y and peptide YY from rabbit kidney. J. Biol. Chem. 266: 23959-23966, 1991.
33. 2 receptors for neuropeptide Y and peptide YY by affinity cross-linking. J. Biol. Chem. 265: 8304-8310, 1990.
34. Tatemoto, K. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA 79: 2514-2518, 1982.
35. Voisin, T., A. Couvineau, C. Rouyer-Fessard, and M. Laburthe. Solubilization and hydrodynamic properties of active peptide YY receptor from rat jejunal crypts. Characterization as a Mr 44,000 glycoprotein. J. Biol. Chem. 266: 10762-10767, 1991.
36. Yoshinaga, K., T. Mochizuki, N. Yanaihara, K. Oshima, M. Izukura, M. Kogire, S. Sumi, G. Gomez, T. Uchida, J. C. Thompson, and G. H. Greeley, Jr. Structural requirements of peptide YY for biological activity at enteric sites. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G695-G701, 1992.