Pharmacophore pattern identification of tachykinin receptor selective peptide agonists: Implications in receptor selectivity

American Journal of Biochemistry and Biotechnology

Volumn 3, Issue 4, 2007, Pages 180-186

  Dike, Anjali ^a   Chandrashekaran, Indu R ^b   Mantha, Anil K ^c   Baquer, Najma Z ^a   Cowsik, Sudha M ^a,d  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Neurokinin receptor; Neuropeptide; Pharmacophore pattern; Solution conformation; Tachykinin

Indexed keywords

BIOACTIVITY; CONFORMATIONS; MUSCLE; PEPTIDES; PHARMACODYNAMICS;

NEUROKININ RECEPTORS; NEUROPEPTIDE; PHARMACOPHORE PATTERN; SOLUTION CONFORMATION; TACHYKININ;

PATTERN RECOGNITION;

MAMMALIA;

EID: 36249019115     PISSN: 15533468     EISSN: None     Source Type: Journal    
DOI: 10.3844/ajbbsp.2007.180.186     Document Type: Article

References (35)

1. Pennefather J. N, Lecci A., Candenas M. L., Patak E., Pinto F. M. and Maggi C. A. 2004. Tachykinins and tachykinin receptors: a growing family. Life Sc. 74:1445-1463.
2. Schwyzer, R. 1987. Membrane-assisted molecular mechanism of neurokinin receptor subtype selection. EMBO J. 6: 2255-2259
3. Severini, C., Improta, G., Falconieri-Erspamer, G., Salvadori, S. and Erspamer, V. 2002. The tachykinin peptide family. Pharmacol. Rev. 54 (2): 285-322
4. Satake, H and Kawada, T. 2006. Overview of the primary structure, tissue-distribution, and functions of Tachykinins and their receptors. Current Drug Targets, 7, 963-974.
5. Nakanishi, S. 1991. Mammalian tachykinin receptors. Annu Rev Neurosci. 14:123-136
6. Masu, Y., Nakayama, K., Tamaki, H., Harada, M., uno, Y. and Nakanishi, S. 1987. cDNA cloning of bovine substance-K receptor through oocyte expression system Nature. 329: 836-838.
7. Hanley, M.R., and Jackson, T. 1987. Substance K receptor: return of the magnificent seven. Nature. 329: 766-767.
8. Maggi, C.A., Patacchini, R., Rovero, P and Giachetti, A. 1993. Tachykinin receptors and Tachykinin receptor antagonists. J. Auton. Pharmacol. 13, 23.
9. Watson, S.P. and Guard, S., 1991. Tachykinin receptor types: classification and membrane signaling mechanisms. Neurochem. 18, 149.
10. Maurer, T., and Rüterjans, H. 1994. Solution structure of seminal plasmin in the presence of micelles. Eur. J. Biochem. 220: 111-116.
11. Inooka, H., Ohtaki, T., Kitahara, O., Ikegami, T., Endo, S., Chieko, K., Ogi, K., Onda, H., Fujino, M. and Shirakawa, M. 2001. Conformation of a peptide ligand bound to its G-protein coupled receptor. Nature structural Biology. 8(2): 161-165
12. Convert, O., Ploux, O., Lavielle, S., Cotrait, M. and Chassaing, G. 1988. Analysis of tachykininbinding site interactions using NMR and energy calculation data of potent cyclic analogues of substanceP. Biochim. Biophys. Acta. 954: 287-302
13. Convert, O., Duplaa, H., Levielle, S. and Chassaing, G. 1991. Influence of the replacement of amino acid by its D-enantiomer in the sequence of substance P:Conformational analysis by NMR and energy calculations. Neuropeptides. 19: 259-270
14. Seelig, A. 1992. Interaction of a substance P agonist and of substance P antagonists with lipid membranes: A thermodynamic analysis. Biochemistry. 31: 2897-2904
15. 2+: implications for hormone action. Biopolymers. 32: 1765-1773
16. Home, J., Sadek, M. and Craik, D. J. 1993. Determination of the solution structure of neuropeptideK by high-resolution nuclear magnetic resonance spectroscopy. Biochemistry. 32: 7406-7412.
17. Cowsik, S. M., Lucke, C. and Ruterians, H. 1997. Lipid-induced conformation of substance P. J. Biomol. Struct. Dyn. 15: 27-36
18. Whitehead, T. L., McNair, S. D., Hadden, C. E., Young, J. K and Hicks, R. P. 1998. Membraneinduced secondary structures of neuropeptides: a comparison of the solution conformations adopted by agonists and antagonists of the mammalian tachykinin NK-I receptor. J. Med. Chem. 41: 1497-1506
19. Grace, C. R., Lynn, A. M. and Cowsik, S. M. 2001. Lipid induced conformation of tachykinin peptide kassinin. J. Biomolecular Str. And Stereodynamics. 18(4): 611-625
20. Grace, C. R., Chandrashekar, I. R. and Cowsik, S. M. 2003. Solution structure of the tachykinin peptide eledoisin. Biophysical. J. 84(1): 655-664
21. Chandrashekar, I. R. and Cowsik, S. M. 2003. Three dimensional structure of the mammalian tachykinin peptide Neurokinin A bound to lipid micelles. Biophys. J. 85(6): 4002-4011
22. Mantha, A. K., Chandrashekar, I. R., Baquer, N. Z. and Cowsik, S. M. 2004. Three Dimensional Structure of the Mammalian Tachykinin Peptide Neurokinin B Bound to Lipid Micelles. J. Biol. Str. Dyn .22(2): 137-147.
23. Chandrashekar, LR., Dike, A and Cowsik, S.M. 2004. Membrane induced structure of the mammalian Tachykinin neuropeptide gamma. J. Structural Biology. 148: 315-325.
24. Dike, A and Cowsik, S.M. 2005. MembraneInduced structure of Scyliorhinin I: A dual NK1/NK2 agonist. Biophysical Journal. 88:3592-3600.
25. Dike, A and Cowsik, S.M. 2006(a). ThreeDimensional structure of Neuropeptide K bound to dodecyl phosphocholine micelles. Biochemistry. 45(9): 2994-3004.
26. Dike, A and Cowsik, S.M. 2006(b).Solution structure of Amphibian tachykinin Uperolein bound to DPC micelles. J Structural Biology. 156(3): 442-452.
27. Mahajan, S., Lucke, C and Ruterjans, H. 1993. Lipid induced conformation of physaelamin, J. Biomolecular Str. and Stereodynamics, 113.
28. Seelig, A., and Macdonald, P. M. 1989. Binding of a neuropeptide, substance P, to neutral and negatively charged lipids. Biochemistry. 28: 2490-2496.
29. Seelig, A., Alt, T., Lotz, S. and Holzemann, G. 1996. Binding of substance P agonists to lipid membranes and to the neurokinin-1 receptor. Biochemistry. 35:4365-4374.
30. Wilson J.C, Nielsen K.J, McLeish M.J, Craik D.J. 1994. A determination of the solution conformation of the nonmammalian tachykinin eledoisin by NMR and CD spectroscopy.Biochemistry. 33(22):6802-11.
31. Beusen, D.D. and Marshall, G.R. 2000. In Pharmacophore perception, development, and use in drug design; Guner, O.F., Ed; International University Line; La Jolla, CA. 21-45.
32. Cascieri, M.A., Huang, R.R., Fong, T.M., Cheung, A.H., Sadowski, S., Ber, E and Strader, C.D. 1992. Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors. Mol Pharmacol. 41(6): 1096-1099.
33. Buck, S.H and Shatzer, S.A. 1988. Agonist and antagonist binding to tachykinin peptide NK2 receptors. Life Sci. 42(26):2701-2708.
34. Schwyzer, R., Erne, D. and Rolka, K. 1986. Prediction of preffered conformation, orientation and accumulation of Substance P on lipid membranes. Helv. Chim. Acta. 69: 1789-1797.
35. Marshall, R.G. 2001. Peptide interactions with Gprotein coupled receptors. Biopolymers. 60:246277.