Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling

Journal of Neuroscience

Volumn 27, Issue 46, 2007, Pages 12664-12674

  Kyriakatos, Alexandros ^a   El Manira, Abdeljabbar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Endocannabinoids; Lamprey; Locomotion; mGluRs; Modulation; Plasticity; Spinal cord

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ENDOCANNABINOID; METABOTROPIC RECEPTOR 1; NITRIC OXIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INTERNEURON; LAMPREY; LOCOMOTION; LONG TERM DEPRESSION; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SPINAL CORD; SYNAPSE; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

ANIMALS; ENDOCANNABINOIDS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; LAMPREYS; MOTOR ACTIVITY; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONAL PLASTICITY; NITRIC OXIDE; PIPERIDINES; PYRAZOLES; RECEPTORS, CANNABINOID; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SPINAL CORD; SYNAPTIC TRANSMISSION; TIME;

EID: 36249009648     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3174-07.2007     Document Type: Article

References (43)

1. Abbott LF, Regehr WG (2004) Synaptic computation. Nature 431:796-803.
2. Buchanan JT (1982) Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: synaptic interactions and morphology. J Neurophysiol 47:961-975.
3. Buchanan JT (2001) Contributions of identifiable neurons and neuron classes to lamprey vertebrate neurobiology. Prog Neurobiol 63:441-466.
4. Buchanan JT, Grillner S (1987) Newly identified "glutamate interneurons" and their role in locomotion in the lamprey spinal cord. Science 236:312-314.
5. Chevaleyre V, Takahashi KA, Castillo PE (2006) Endocannabinoid-mediated synaptic plasticity in the CNS. Annu Rev Neurosci 29:37-76.
6. Cochilla AJ, Alford S (1998) Metabotropic glutamate receptor-mediated control of neurotransmitter release. Neuron 20:1007-1016.
7. Dale N (1985) Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord. J Physiol (Lond) 363:61-70.
8. Dale N, Grillner S (1986) Dual-component synaptic potentials in the lamprey mediated by excitatory amino acid receptors. J Neurosci 6:2653-2661.
9. Dale N, Roberts A (1985) Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos. J Physiol (Lond) 363:35-59.
10. Dan Y, Poo MM (2006) Spike timing-dependent plasticity: from synapse to perception. Physiol Rev 86:1033-1048.
11. Destexhe A, Marder E (2004) Plasticity in single neuron and circuit computations. Nature 431:789-795.
12. Dietz V, Harkema SJ (2004) Locomotor activity in spinal cord-injured persons. J Appl Physiol 96:1954-1960.
13. Edgerton VR, Tillakaratne NJ, Bigbee AJ, de Leon RD, Roy RR (2004) Plasticity of the spinal neural circuitry after injury. Annu Rev Neurosci 27:145-167.
14. El Manira A, Kettunen P, Hess D, Krieger P (2002) Metabotropic glutamate receptors provide intrinsic modulation of the lamprey locomotor network. Brain Res Brain Res Rev 40:9-18.
15. Feldman JL, Mitchell GS, Nattie EE (2003) Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci 26:239-266.
16. Freund TF, Katona I, Piomelli D (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017-1066.
17. Frigon A, Rossignol S (2006) Functional plasticity following spinal cord lesions. Prog Brain Res 157:231-260.
18. Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706.
19. Grillner S (2003) The motor infrastructure: from ion channels to neuronal networks. Nat Rev Neurosci 4:573-586.
20. Grillner S, McClellan A, Sigvardt K, Wallen P, Wilen M (1981) Activation of NMDA-receptors elicits "fictive locomotion" in lamprey spinal cord in vitro. Acta Physiol Scand 113:549-551.
21. Kettunen P, Krieger P, Hess D, El Manira A (2002) Signaling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network. J Neurosci 22:1868-1873.
22. Kettunen P, Hess D, El Manira A (2003) mGluR1, but not mGluR5, mediates depolarization of spinal cord neurons by blocking a leak current. J Neurophysiol 90:2341-2348.
23. Kettunen P, Kyriakatos A, Hallen K, El Manira A (2005) Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron 45:95-104.
24. Kiehn O (2006) Locomotor circuits in the mammalian spinal cord. Annu Rev Neurosci 29:279-306.
25. Kim J, Isokawa M, Ledent C, Alger BE (2002) Activation of muscarinic acetylcholine receptors enhances the release of endogenous cannabinoids in the hippocampus. J Neurosci 22:10182-10191.
26. Kreitzer AC, Regehr WG (2001) Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 29:717-727.
27. Krieger P, Grillner S, El Manira A (1998) Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network. Eur J Neurosci 10:3333-3342.
28. Krieger P, Hellgren-Kotaleski J, Kettunen P, El Manira AJ (2000) Interaction between metabotropic and ionotropic glutamate receptors regulates neuronal network activity. J Neurosci 20:5382-5391.
29. Maejima T, Hashimoto K, Yoshida T, Aiba A, Kano M (2001) Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron 31:463-475.
30. Makara JK, Katona I, de Vente, Freund TF, Hajos N (2005) Interaction of nitric oxide and cannabinoid signaling in hippocampal depolarization-induced suppression of inhibition. Soc Neurosci Abstr 31:720.8.
31. Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21.
32. Marder E, Goaillard JM (2006) Variability, compensation and homeostasis in neuron and network function. Nat Rev Neurosci 7:563-574.
33. McLean DL, Sillar KT (2002) Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion. J Neurosci 22:4175-4184.
34. McLean DL, Sillar KT (2004) Metamodulation of a spinal locomotor network by nitric oxide. J Neurosci 24:9561-9571.
35. McLean DL, Merrywest SD, Sillar KT (2000) The development of neuromodulatory systems and the maturation of motor patterns in amphibian tadpoles. Brain Res Bull 53:595-603.
36. Micheva KD, Buchanan J, Holz RW, Smith SJ (2003) Retrograde regulation of synaptic vesicle endocytosis and recycling. Nat Neurosci 6:925-932.
37. Prast H, Philippu A (2001) Nitric oxide as modulator of neuronal function. Prog Neurobiol 64:51-68.
38. Ramirez JM, Viemari JC (2005) Determinants of inspiratory activity. Respir Physiol Neurobiol 147:145-157.
39. Safo PK, Regehr WG (2005) Endocannabinoids control the induction of cerebellar LTD. Neuron 48:647-659.
40. Safo PK, Cravatt BF, Regehr WG (2006) Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum 5:134-145.
41. Wallen P, Williams TL (1984) Fictive locomotion in the lamprey spinal cord in vitro compared with swimming in the intact and spinal animal. J Physiol (Lond) 347:225-239.
42. Wilson RI, Nicoll RA (2002) Endocannabinoid signaling in the brain. Science 296:678-682.
43. Wilson RI, Kunos G, Nicoll RA (2001) Presynaptic specificity of endocannabinoid signaling in the hippocampus. Neuron 31:453-462.