Differential effects of metaboreceptor and chemoreceptor activation on sympathetic and cardiac baroreflex control following exercise in hypoxia in human

Journal of Physiology

Volumn 585, Issue 1, 2007, Pages 165-174

  Gujic, Marko ^a   Laude, Dominique ^b   Houssière, Anne ^a   Beloka, Sofia ^a   Argacha, Jean François ^a   Adamopoulos, Dionysios ^a   Xhaët, Olivier ^a   Elghozi, Jean Luc ^b   van de Borne, Philippe ^a  

^a ERASME HOSPITAL   (Belgium)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

METABOTROPIC RECEPTOR; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CARDIOVASCULAR REFLEX; CARDIOVASCULAR RESPONSE; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; EXERCISE; HAND GRIP; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MUSCLE ISOMETRIC CONTRACTION; NORMAL HUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RANDOMIZATION; RECORDING; RESPIRATORY FUNCTION; RR INTERVAL; SYMPATHETIC REFLEX; VOLUNTARY MOVEMENT; ADRENERGIC SYSTEM; CARDIAC PRESSORECEPTOR REFLEX; CHEMORECEPTOR; ELECTRIC ACTIVITY; HEART ARREST; METABORECEPTOR; MUSCLE CONTRACTION; OXYGEN SATURATION; SENSITIVITY ANALYSIS; SYMPATHETIC NERVE;

ADULT; ANOXIA; BAROREFLEX; BLOOD PRESSURE; CHEMORECEPTORS; EXERCISE; HEART; HUMANS; MALE; MECHANORECEPTORS; NITROPRUSSIDE; PHENYLEPHRINE; REST; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 36248980965     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.141002     Document Type: Article

References (40)

1. Bristow JD, Brown EB Jr, Cunningham DJ, Goode RC, Howson MG & Sleight P (1971). The effects of hypercapnia, hypoxia and ventilation on the baroreflex regulation of the pulse interval. J Physiol 216, 281-302.
2. Cooper VL, Pearson SB, Bowker CM, Elliott MW & Hainsworth R (2005). Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hypercapnia -a mechanism for promoting hypertension in obstructive sleep apnoea. J Physiol 568, 677-687.
3. Coote JH, Hilton SM & Perez-Gonzalez JF (1971). The reflex nature of the pressor response to muscular exercise. J Physiol 215, 789-804.
4. Cui J, Wilson TE, Shibasaki M, Hodges NA & Crandall CG (2001). Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans. J Appl Physiol 91, 1679-1686.
5. Eckberg DL, Bastow H III & Scruby AE (1982). Modulation of human sinus node function by systemic hypoxia. J Appl Physiol 52, 570-577.
6. Gandevia SC & Hobbs SF (1990). Cardiovascular responses to static exercise in man: Central and reflex contributions. J Physiol 430, 105-117.
7. Gladwell VF & Coote JH (2002). Heart rate at the onset of muscle contraction and during passive muscle stretch in humans: A role for mechanoreceptors. J Physiol 540, 1095-1102.
8. Gonzalez C, Almaraz L, Obeso A & Rigual R (1994). Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol Rev 74, 829-898.
9. Halliwill JR & Minson CT (2002). Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans. J Appl Physiol 93, 857-864.
10. Halliwill JR, Morgan BJ & Charkoudian N (2003). Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans. J Physiol 552, 295-302.
11. Hanada A, Sander M & Gonzalez-Alonso J (2003). Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise. J Physiol 551, 635-647.
12. Houssiere A, Najem B, Ciarka A, Velez-Roa S, Naeije R & van de Borne P (2005). Chemoreflex control during static hypoxic exercise. Am J Physiol Heart Circ Physiol 288, H1724-H1729.
13. Houssiere A, Najem B, Cuylits N, Cuypers S, Naiije R & van de Borne P (2006a). Hyperoxia enhances metaboreflex sensitivity during static exercise in humans. Am J Physiol Heart Circ Physiol 291, H210-H215.
14. Houssiere A, Najem B, Pathak A, Xhaet O, Naeije R & van de Borne P (2006b). Chemoreflex and metaboreflex responses to static hypoxic exercise in aging humans. Med Sci Sports Exerc 38, 305-312.
15. Ichinose M, Saito M, Wada H, Kitano A, Kondo N & Nishiyasu T (2004). Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans. J Physiol 544, 939-948.
16. Ichinose M, Saito M, Wada H, Kitano A, Kondo N & Nishiyasu T (2004). Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol 286, H701-H707.
17. Iellamo F, Pizzinelli P, Massaro M, Raimondi G, Peruzzi G & Legramante JM (1999). Muscle metaboreflex contribution to sinus node regulation during static exercise: Insights from spectral analysis of heart rate variability. Circulation 100, 27-32.
18. Iriki M, Dorward P & Korner PI (1977). Baroreflex 'resetting' by arterial hypoxia in the renal and cardiac sympathetic nerves of the rabbit. Pflugers Arch 370, 1-7.
19. Kamiya A, Michikami D, Fu Q, Niimi Y, Iwase S, Mano T & Suzumura A (2001). Static handgrip exercise modifies arterial baroreflex control of vascular sympathetic outflow in humans. Am J Physiol Regul Integr Comp Physiol 281, R1134-R1139.
20. Kara T, Narkiewicz K & Somers VK (2003). Chemoreflexes - physiology and clinical implications. Acta Physiol Scand 177, 377-384.
21. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH & Mitchell JH (1983). Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55, 105-112.
22. Korner PI, Shaw J, West MJ, Oliver JR & Hilder RG (1973). Integrative reflex control of heart rate in the rabbit during hypoxia and hyperventilation. Circ Res 33, 63-73.
23. Malpas SC, Bendle RD, Head GA & Ricketts JH (1996). Frequency and amplitude of sympathetic discharges by baroreflexes during hypoxia in conscious rabbits. Am J Physiol Heart Circ Physiol 271, H2563-H2574.
24. Mark AL, Victor RG, Nerhed C & Wallin BG (1985). Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57, 461-469.
25. Miura M & Reis DJ (1972). The role of the solitary and paramedian reticular nuclei in mediating cardiovascular reflex responses from carotid baro- and chemoreceptors. J Physiol 223, 525-548.
26. Parati G, Di Rienzo M & Mancia G (2000). How to measure baroreflex sensitivity: From the cardiovascular laboratory to daily life. J Hypertens 18, 7-19.
27. Pelletier CL & Shepherd JT (1975). Effect of hypoxia on vascular responses to the carotid baroreflex. Am J Physiol 228, 331-336.
28. Pisarri TE & Kendrick JE (1984). Reduced effectiveness of the carotid baroreflex during arterial hypoxia in dogs. Am J Physiol Heart Circ Physiol 247, H623-H630.
29. Potts JT, Lee SM & Anguelov PI (2002). Tracing of projection neurons from the cervical dorsal horn to the medulla with the anterograde tracer biotinylated dextran amine. Auton Neurosci 98, 64-69.
30. Potts JT & Mitchell JH (1998). Rapid resetting of carotid baroreceptor reflex by afferent input from skeletal muscle receptors. Am J Physiol Heart Circ Physiol 275, H2000-H2008.
31. Rotto DM & Kaufman MP (1988). Effect of metabolic products of muscular contraction on discharge of group III and IV afferents. J Appl Physiol 64, 2306-2313.
32. Rowell LB & O'Leary DS (1990). Reflex control of the circulation during exercise: Chemoreflexes and mechanoreflexes. J Appl Physiol 69, 407-418.
33. Rudas L, Crossman AA, Morillo CA, Halliwill JR, Tahvanainen KU, Kuusela TA & Eckberg DL (1999). Human sympathetic and vagal baroreflex responses to sequential nitroprusside and phenylephrine. Am J Physiol Heart Circ Physiol 276, H1691-H1698.
34. Sagawa S, Torii R, Nagaya K, Wada F, Endo Y & Shiraki K (1997). Carotid baroreflex control of heart rate during acute exposure to simulated altitudes of 3,800 m and 4,300 m. Am J Physiol Regul Integr Comp Physiol 273, R1219-R1223.
35. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S & Moore RL (1994). Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol Heart Circ Physiol 267, H770-H778.
36. Smith SA, Mitchell JH & Garry MG (2006). The mammalian exercise pressor reflex in health and disease. Exp Physiol 91, 89-102.
37. Somers VK, Mark AL, Zavala DC & Abboud FM (1989 a). Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 67, 2095-2100.
38. Somers VK, Mark AL, Zavala DC & Abboud FM (1989 b). Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67, 2101-2106.
39. Uther JB, Hunyor SN, Shaw J & Korner PI (1970). Bulbar and suprabulbar control of the cardiovascular autonomic effects during arterial hypoxia in the rabbit. Circ Res 26, 491-506.
40. Velez-Roa S, Kojonazarov B, Ciarka A, Godart P, Naeije R, & Somers VK & van de Borne P (2003). Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans. Am J Physiol Heart Circ Physiol 285, H1356-H1361.