Chemoreflex and metaboreflex responses to static hypoxic exercise in aging humans

Medicine and Science in Sports and Exercise

Volumn 38, Issue 2, 2006, Pages 305-312

  Houssiere, Anne ^a   Najem, Boutaina ^a   Pathak, Atul ^a   Xhaët, Olivier ^a   Naeije, Robert ^a   Van De Borne, Philippe ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

Chemoreceptors; Elderly; Handgrip; Hypoxia; Metaboreceptors

Indexed keywords

LACTIC ACID; RECEPTOR;

ADULT; AGED; AGING; ARTICLE; CHEMORECEPTOR REFLEX; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; EXERCISE; FEMALE; FOREARM BLOOD FLOW; HAND GRIP; HEART ARREST; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; ISOMETRIC EXERCISE; LACTATE BLOOD LEVEL; LUNG MINUTE VOLUME; MALE; METABOREFLEX; MUSCLE BLOOD FLOW; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; REFLEX; SYMPATHETIC NERVE; SYMPATHETIC REFLEX; SYSTOLIC BLOOD PRESSURE;

ADULT; AGING; ANALYSIS OF VARIANCE; ANOXIA; BLOOD PRESSURE; CHEMORECEPTORS; EXERCISE; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; LACTATES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; SYMPATHETIC NERVOUS SYSTEM;

EID: 33144458583     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.mss.0000187426.93464.81     Document Type: Article

References (28)

1. CONWAY, J., R. WHEELER, and R. SANNERSTEDT. Sympathetic nervous activity during exercise in relation to age. Cardiovasc. Res. 5:577-581, 1971.
2. DAVY, K. P., P. P. JONES, and D. R. SEALS. Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans. Am. J. Physiol. 273:R690-R695, 1997.
3. DELIUS, W., K. E. HAGBARTH, A. HONGELL, and B. G. WALLIN. General characteristics of sympathetic activity in human muscle nerves. Acta Physiol. Scand. 84:65-81, 1972.
4. DINENNO, F. A., N. M. DIETZ, and M. J. JOYNER. Aging and fore-arm postjunctional alpha-adrenergic vasoconstriction in healthy men. Circulation 106:1349-1354, 2002.
5. ESLER, M. D., J. M. THOMPSON, D. M. KAYE, et al. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to Stressors. Circulation 91:351-358, 1995.
6. GRASSI, G., R. DELL'ORO, A. FACCHINI, T. F. QUARTI, G. B. BOLLA, and G. MANCIA. Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J. Hypertens. 22:2363-2369, 2004.
7. HANADA, A., M. SANDER, and J. GONZALEZ-ALONSO. Human skeletal muscle sympathetic nerve activity, heart rate and limb haemodynamics with reduced blood oxygenation and exercise. J. Physiol. 551:635-647, 2003.
8. HOUSSIERE, A., B. NAJEM, A. CIARKA, S. VELEZ-ROA, R. NAEIJE, and P. VAN DE BORNE. Chemoreflex and metaboreflex control during static hypoxic exercise. Am. J. Physiol Heart Circ. Physiol. 228:H1724-H1729, 2005.
9. ICHINOSE, M., M. SAITO, H. WADA, A. KITANO, N. KONDO, and T. NISHIYASU. Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans. J. Physiol. 544:939-948, 2002.
10. KRONENBERG, R. S., and C. W. DRAGE. Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J. Clin. Invest. 52:1812-1819, 1973.
11. MARK, A. L., R. G. VICTOR, C. NERHED, and B. G. WALLIN. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ. Res. 57:461-469, 1985.
12. MARKEL, T. A., J. C. DALEY, III, C. S. HOGEMAN, et al. Aging and the exercise pressor reflex in humans. Circulation 107:675-678, 2003.
13. NG, A. V., R. CALLISTER, D. G. JOHNSON, and D. R. SEALS. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 21:498-503, 1993.
14. NG, A. V., R. R. CALLISTER, D. G. JOHNSON, and D. R. SEALS. Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans. J. Appl. Physiol. 77:1366-1374, 1994.
15. NG, A. V., R. CALLISTER, D. G. JOHNSON, and D. R. SEALS. Sympathetic neural reactivity to stress does not increase with age in healthy humans. Am. J. Physiol. 267:H344-H353, 1994.
16. POULIN, M. J., D. A. CUNNINGHAM, D. H. PATERSON, J. M. KOWALCHUK, and W. D. SMITH. Ventilatory sensitivity to CO2 in hyperoxia and hypoxia in older aged humans. J. Appl. Physiol. 75:2209-2216, 1993.
17. RAY, C. A., and A. L. MARK. Sympathetic nerve activity to nonactive muscle of the exercising and nonexercising limb. Med. Sci. Sports Exerc. 27:183-187, 1995.
18. ROTTO, D. M., and M. P. KAUFMAN. Effect of metabolic products of muscular contraction on discharge of group III and IV afferents. J. Appl. Physiol. 64:2306-2313, 1988.
19. ROWELL, L. B., and J. R. BLACKMON. Human cardiovascular adjustments to acute hypoxaemia. Clin. Physiol. 7:349-376, 1987.
20. SAITO, M., H. ABE, S. IWASE, K. KOGA, and T. MANO. Muscle sympathetic nerve responsiveness to static contraction is not altered under hypoxia. Jpn. J. Physiol. 41:775-783, 1991.
21. SEALS, D. R., D. G. JOHNSON, and R. F. FREGOSI. Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J. Appl, Physiol. 71:1032-1040, 1991.
22. SEALS, D. R., J. A. TAYLOR, A. V. NG, and M. D. ESLER. Exercise and aging: autonomic control of the circulation. Med. Sci. Sports Exerc. 26:568-576, 1994.
23. SINOWAY, L. I., M. B. SMITH, B. ENDERS, et al. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am. J. Physiol. 267:H770-H778, 1994.
24. SOWERS, J. R., L. Z. RUBENSTEIN, and N. STERN. Plasma norepinephrine responses to posture and isometric exercise increase with age in the absence of obesity. J. Gerontol. 38:315-317, 1983.
25. TAFIL-KLAWE, M., F. RASCHKE, A. KUBLIK, R. STOOHS, and P. VON WICHERT. Attenuation of augmented ventilatory response to hypoxia in essential hypertension in the course of aging. Respiration 56:154-160, 1989.
26. VELEZ-ROA, S, B. KOJONAZAROV, A. CIARKA, et al. Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans. Am. J. Physiol Heart Circ. Physiol. 285:H1356-H1361, 2003.
27. VICTOR, R. G., L. A. BERTOCCI, S. L. PRYOR, and R. L. NUNNALLY. Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J. Clin. Invest. 82:1301-1305, 1988.
28. WILSON, T. E., K. D. MONAHAN, D. S. SHORT, and C. A. RAY. Effect of age on cutaneous vasoconstrictor responses to norepinephrine in humans. Am. J. Physiol Regul. Integr. Comp. Physiol. 287:R1230-R1234, 2004.