X chromosome inactivation in females with multiple sclerosis

European Journal of Neurology

Volumn 14, Issue 12, 2007, Pages 1392-1396

  Knudsen, G P S ^a   Harbo, H F ^a,b   Smestad, C ^b   Celius, E G ^b   Akesson E ^c   Oturai, A ^d   Ryder, L P ^e   Spurkland, A ^a   Orstavik K H ^a,f  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d Danish Multiple Sclerosis Registry   (Denmark)

^e Mental Health Services CPH   (Denmark)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Multiple sclerosis; X chromosome inactivation

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; WOMEN'S HEALTH; X CHROMOSOME INACTIVATION;

EID: 36248946058     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2007.01987.x     Document Type: Article

References (33)

1. Compston A. The genetic epidemiology of multiple sclerosis. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences 1999 354: 1623 1634.
2. Barcellos LF, Sawcer S, Ramsay PP, et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Human Molecular Genetics 2006 15: 2813 2824.
3. Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991 38: 1 15.
4. Sawcer S, Ban M, Maranian M, et al. A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics 2005 77: 454 467.
5. The Transatlantic Multiple Sclerosis Genetics Cooperative. A meta-analysis of genomic screens in multiple sclerosis. The Transatlantic Multiple Sclerosis Genetics Cooperative. Multiple Sclerosis 2001 7: 3 11.
6. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996 46: 907 911.
7. Lyon MF. Gene action in the X-chromosome of the mouse (Mus musculus L.). Naturwissenschaften 1961 190: 372 373.
8. Belmont JW. Genetic control of X inactivation and processes leading to X-inactivation skewing. American Journal of Human Genetics 1996 58: 1101 1108.
9. Migeon BR, Haisley-Royster C. Familial skewed X inactivation and X-linked mutations: unbalanced X inactivation is a powerful means to ascertain X-linked genes that affect cell proliferation. American Journal of Human Genetics 1998 62: 1555 1557.
10. Naumova AK, Plenge RM, Bird LM, et al. Heritability of X chromosome-inactivation phenotype in a large family. American Journal of Human Genetics 1996 58: 1111 1119.
11. Puck JM, Willard HF. X inactivation in females with X-linked disease. New England Journal of Medicine 1998 338: 325 328.
12. Busque L, Mio R, Mattioli J, et al. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age. Blood 1996 88: 59 65.
13. Christensen K, Kristiansen M, Hagen-Larsen H, et al. X-linked genetic factors regulate hematopoietic stem-cell kinetics in females. Blood 2000 95: 2449 2451.
14. Kristiansen M, Knudsen GP, Bathum L, et al. Twin study of genetic and aging effects on X chromosome inactivation. European Journal of Human Genetics 2005 13: 599 606.
15. Chitnis S, Monteiro J, Glass D, et al. The role of X-chromosome inactivation in female predisposition to autoimmunity. Arthritis Research 2000 2: 399 406.
16. Kyewski B, Klein L. A central role for central tolerance. Annual Review of Immunology 2006 24: 571 606.
17. Chatila TA, Blaeser F, Ho N, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. The Journal of Clinical Investigation 2000 106: R75 R81.
18. Coffey AJ, Brooksbank RA, Brandau O, et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nature Genetics 1998 20: 129 135.
19. Brix TH, Knudsen GP, Kristiansen M, Kyvik KO, Orstavik KH, Hegedus L. High frequency of skewed X-chromosome inactivation in females with autoimmune thyroid disease: a possible explanation for the female predisposition to thyroid autoimmunity. The Journal of Clinical Endocrinology and Metabolism 2005 90: 5949 5953.
20. Davies TF. Editorial: X versus X - the fight for function within the female cell and the development of autoimmune thyroid disease. The Journal of Clinical Endocrinology and Metabolism 2005 90: 6332 6333.
21. Ozbalkan Z, Bagislar S, Kiraz S, et al. Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis and Rheumatism 2005 52: 1564 1570.
22. Celius EG, Vandvik B. Multiple sclerosis in Oslo, Norway: prevalence on 1 January 1995 and incidence over a 25-year period. European Journal of Neurolology 2001 8: 463 469.
23. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Annals of Neurology 1983 13: 227 231.
24. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. American Journal of Human Genetics 1992 51: 1229 1239.
25. Anderson CL, Brown CJ. Variability of X chromosome inactivation: effect on levels of TIMP1 RNA and role of DNA methylation. Human Genetics 2002 110: 271 278.
26. Azofeifa J, Waldherr R, Cremer M. X-chromosome methylation ratios as indicators of chromosomal activity: evidence of intraindividual divergencies among tissues of different embryonal origin. Human Genetics 1996 97: 330 333.
27. Gale RE, Wheadon H, Boulos P, Linch DC. Tissue specificity of X-chromosome inactivation patterns. Blood 1994 83: 2899 2905.
28. Sharp A, Robinson D, Jacobs P. Age- and tissue-specific variation of X chromosome inactivation ratios in normal women. Human Genetics 2000 107: 343 349.
29. Tan SS, Williams EA, Tam PP. X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo. Nature Genetics 1993 3: 170 174.
30. Selmi C, Invernizzi P, Gershwin ME. The X chromosome and systemic sclerosis. Current Opinion in Rheumatology 2006 18: 601 605.
31. Ozcelik T, Uz E, Akyerli CB, et al. Evidence from autoimmune thyroiditis of skewed X-chromosome inactivation in female predisposition to autoimmunity. European Journal of Human Genetics 2006 14: 791 797.
32. Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain 2006 129: 606 616.
33. Ebers GC. Prognostic factors for multiple sclerosis: the importance of natural history studies. Journal of Neurology 2005 252 (Suppl. 3 iii15 iii20.