Egfr amplification specific gene expression in phyllodes tumours of the breast

Cellular Oncology

Volumn 29, Issue 6, 2007, Pages 443-451

  Agelopoulos, Konstantin ^a   Kersting, Christian ^a   Korsching, Eberhard ^a   Schmidt, Hartmut ^a   Kuijper, Arno ^b   August, Christian ^a   Wülfing, Pia ^a   Tio, Joke ^a   Boecker, Werner ^a   Van Diest, Paul J ^b   Brandt, Burkhard ^c   Buerger, Horst ^a,d  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF HAMBURG   (Germany)

^d Institute of Pathology   (Germany)

Author keywords

Caveolin 1; egfr; Eps15; Phyllodes tumours

Indexed keywords

CAVEOLIN 1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN MDM2; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; BREAST CARCINOGENESIS; CANCER GENETICS; CANCER GRADING; CONTROLLED STUDY; CYSTOSARCOMA PHYLLOIDES; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRON; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASE 3; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYLLODES TUMOR; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, NEOPLASM; TISSUE ARRAY ANALYSIS;

EID: 36248936581     PISSN: 15705870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. J.I. Bardos and M. Ashcroft, Negative and positive regulation of HIF-1: a complex network, Biochim. Biophys. Acta 1755 (2005), 107.
2. J.I. Bardos, N.M. Chau and M. Ashcroft, Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression, Mol. Cell Biol. 24 (2004), 2905.
3. H. Buerger, F. Gebhardt, H. Schmidt, K. Hutmacher, A. Beckmann, R. Simon, W. Boecker and B. Brandt, Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and EGFR-expression, Cancer Res. 60 (2000), 854.
4. R. Carbone, S. Fre, G. Iannolo, F. Belleudi, P. Mancini, P.G. Pelicci, M.R. Torrisi and P.P. Di Fiore, eps15 and eps15R are essential components of the endocytic pathway, Cancer Res. 57 (1997), 5498.
5. R. Fukuda, K. Hirota, F. Fan, Y.D. Jung, L.M. Ellis and G.L. Semenza, Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells, J. Biol. Chem. 277 (2002), 38205.
6. S.L. Harris and A.J. Levine, The p53 pathway: positive and negative feedback loops, Oncogene 24 (2005), 2899.
7. T. Hasebe, S. Imoto, S. Sasaki, Y. Tsubono and K. Mukai, Proliferative activity and tumor angiogenesis is closely correlated to stromal cellularity of fibroadenoma: proposal fibroadenoma, cellular variant, Pathol. Int. 49 (1999), 435.
8. A. Husdal, G. Bukholm and I.R. Bukholm, The prognostic value and overexpression of cyclin A is correlated with gene amplification of both cyclin A and cyclin E in breast cancer patient, Cell. Oncol. 28 (2006), 107.
9. C. Kersting, A. Kuijper, H. Schmidt, J. Packeisen, C. Liedtke, N. Tidow, C. Gustmann, B. Hinrichs, P. Wulfing, J. Tio, W. Boecker, P. Van Diest, B. Brandt and H. Buerger, Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression, Lab. Invest. 86 (2006), 54.
10. C. Kersting, J. Packeisen, B. Leidinger, B. Brandt, R. von Wasielewski, W. Winkelmann, P.J. van Diest, G. Gosheger and H. Burger, Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas, J. Clin. Pathol. 59 (2006), 585.
11. D. Kim, H.C. Dan, S. Park, L. Yang, Q. Liu, S. Kaneko, J. Ning, L. He, H. Yang, M. Sun, S.V. Nicosia and J.Q. Cheng, AKT/PKB signaling mechanisms in cancer and chemoresistance, Front Biosci. 10 (2005), 975.
12. Y.N. Kim, P. Dam and P.J. Bertics, Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation, Exp. Cell. Res. 280 (2002), 134.
13. J. Kononen, L. Bubendorf, A. Kallioniemi, M. Barlund, P. Schraml, S. Leighton, J. Torhorst, M.J. Mihatsch, G. Sauter and O.P. Kallioniemi, Tissue microarrays for high-throughput molecular profiling of tumor specimens [see comments], Nat. Med. 4 (1998), 844.
14. V. Kuenen-Boumeester, S.C. Henzen-Logmans, M.M. Timmermans, I.L. van Staveren, A. van Geel, H.J. Peeterse, J. Bonnema and E.M. Berns, Altered expression of p53 and its regulated proteins in phyllodes tumours of the breast, J. Pathol. 189 (1999), 169.
15. A. Kuijper, G.P. van der, W.E. Van Der and P.J. van Diest, Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast, Breast Cancer Res. 7 (2005), R808.
16. E. Laughner, P. Taghavi, K. Chiles, P.C. Mahon and G.L. Semenza, HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression, Mol. Cell. Biol. 21 (2001), 3995.
17. L. Li, C.H. Ren, S.A. Tahir, C. Ren and T.C. Thompson, Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A, Mol. Cell. Biol. 23 (2003), 9389.
18. P.K. Majumder and W.R. Sellers, Akt-regulated pathways in prostate cancer, Oncogene 24 (2005), 7465.
19. L.D. Mayo and D.B. Donner, The PTEN, Mdm2, p53 tumor suppressor- oncoprotein network, Trends Biochem. Sci. 27 (2002), 462.
20. C. Mineo, G.L. James, E.J. Smart and R.G. Anderson, Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane, J. Biol. Chem. 271 (1996), 11930.
21. C.J. Moffat, S.E. Pinder, A.R. Dixon, C.W. Elston, R.W. Blamey and I.O. Ellis, Phyllodes tumours of the breast: a clinicopathological review of thirty-two cases, Histopathology 27 (1995), 205.
22. P.M. Navolanic, L.S. Steelman and J.A. McCubrey, EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review), Int. J. Oncol. 22 (2003), 237.
23. J. Packeisen, E. Korsching, H. Herbst, W. Boecker and H. Buerger, Demystified. . . tissue microarray technology, Mol. Pathol. 56 (2003), 198.
24. D. Ravid, S. Maor, H. Werner and M. Liscovitch, Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling, Oncogene 24 (2005), 1338.
25. S. Repetto, B. Salani, D. Maggi and R. Cordera, Insulin and IGF-I phosphorylate eNOS in HUVECs by a caveolin-1 dependent mechanism, Biochem. Biophys. Res. Commun. 337 (2005), 849.
26. E.J. Sawyer, A.M. Hanby, R. Poulsom, R. Jeffery, C.E. Gillett, I.O. Ellis, P. Ellis and I.P. Tomlinson, Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast, J. Pathol. 200 (2003), 627.
27. E.J. Sawyer, R. Poulsom, F.T. Hunt, R. Jeffery, G. Elia, I.O. Ellis, P. Ellis, I.P. Tomlinson and A.M. Hanby, Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit, J. Pathol. 200 (2003), 59.
28. D.G. Sedding and R.C. Braun-Dullaeus, Caveolin-1: dual role for proliferation of vascular smooth muscle cells, Trends Cardiovasc. Med. 16 (2006), 50.
29. T. Sorkina, A. Bild, F. Tebar and A. Sorkin, Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors, J. Cell. Sci. 112 (1999), 317.
30. F. Tebar, T. Sorkina, A. Sorkin, M. Ericsson and T. Kirchhausen, Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits, J. Biol. Chem. 271 (1996), 28727.
31. N. Tidow, A. Boecker, H. Schmidt, K. Agelopoulos, W. Boecker, H. Buerger and B. Brandt, Distinct Amplification of an Untranslated Regulatory Sequence in the egfr Gene Contributes to Early Steps in Breast Cancer Development, Cancer Res. 63 (2003), 1172.
32. M.M. Vleugel, R. Bos, H. Buerger, P. van der Groep, O.R. Saramäki, T. Visakorpi, E. van der Wall and P.J. van Diest, No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study, Cell. Oncol. 26 (2004), 347.
33. H. Waterman and Y. Yarden, Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases, FEBS Lett. 490 (2001), 142.
34. P.V. Woolley, S.M. Gollin, W. Riskalla, S. Finkelstein, D.F. Stefanik, L. Riskalla, W.P. Swaney, L. Weisenthal and R.J. McKenna, Jr., Cytogenetics, immunostaining for fibroblast growth factors, p53 sequencing, and clinical features of two cases of cystosarcoma phyllodes, Mol. Diagn. 5 (2000), 179.
35. K.R. Zalata, W.A. Nasif, S.C. Ming, M. Lotfy, N.A. Nada, N. Gad El-Hak and S.H. Leech, p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt, Cell. Oncol. 27 (2005), 245.